1.A Case of Angiomatoid Fibrous Histiocytoma.
Sang Jin KWON ; Chan Kum PARK ; Young Suck RO
Korean Journal of Dermatology 1997;35(3):604-608
No abstract available.
Histiocytoma, Benign Fibrous*
2.A Case of Calcinosis Cutis due to Intravenous Administration of Calcium Gluconate.
Young Tae KIM ; Sang Jin KWON ; Chan Kum PARK
Korean Journal of Dermatology 1997;35(3):532-535
We report a case of calcinosis cutis following administration of 10% calcium gluconate, used for the treatment of a hypocalcemic seizure in a 5-week-old neonate. After administration of 10% calcium gluconate, subcutaneous induration developed at the infusion site. The histopathological findings taken from the dorsum of the left foot showed multiple foci of calcium deposits with infiltration of epitheloid histiocytes between collagen bundles and foreign body giant cells phagocyting calcific granules throughout the reticular dermis and subcutis.
Administration, Intravenous*
;
Calcinosis*
;
Calcium Gluconate*
;
Calcium*
;
Collagen
;
Dermis
;
Foot
;
Giant Cells, Foreign-Body
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Histiocytes
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Humans
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Infant, Newborn
;
Seizures
3.The Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 in Wilms' Tumor.
Seong Jin JEONG ; Eun Chan PARK ; Cheol KWAK ; Ren jie JIN ; Sang Eun LEE ; Hwang CHOI
Korean Journal of Urology 2001;42(3):265-272
PURPOSE: With the process of neoangiogenesis being linked to the growth and metastasis of various tumors, anticancer therapeutics with a basis in the suppression of neoangiogenesis has recently been receiving attention. In this study, we tried to clarify the immunoreactivities of vascular endothelial growth factor (VEGF), major angiogenic inducer and thrombospondin-1 (TSP-1), major angiogenic inhibitor in human Wilms' tumor and its clinicopathological significance. MATERAILS AND METHODS: Utilizing immunohistochemical staining, we assessed the immunoreactivities of VEGF and TSP-1 in archival tissues of 29 Wilms' tumors and 25 normal kidneys. Also, we assessed the relationship between expression of each factor and clinicopathological parameters in 29 cases of Wilms' tumors. RESULTS: Immunoreactivities of VEGF and TSP-1 were detected mainly in the cytoplasm of the tubular cells in normal kidneys. In Wilms' tumors, whereas VEGF was detected in the cytoplasm of the tumor cells and peritumoral stromal tissues, but TSP-1 only in the peritumoral stromal tissues. Immunohistochemical expression patterns of each factor were divided into two groups according to the area of immunoreactivity (negative:<10%, positive: > OR =10%). VEGF immunoreactivity was detected in 25 (100%) normal kidneys and in 20 (69%) Wilms' tumors. However, TSP-1 immunoreactivity was detected in 24 (97%) normal kidneys and in 3 (10%) Wilms' tumors. Therefore, although no significant difference was observed between the expressions of VEGF and TSP-1 in normal kidney, the TSP-1 immunoreactivity was significantly lower than VEGF immunoreactivity in Wilms' tumors. A relatively higher rate of positive expression of TSP-1 was observed in the patients with no demonstrable lymph node metastasis. Also, as for the VEGF, maximal diameter of the tumor was larger in the positive expression group. However, it proved otherwise for TSP-1 as the negative expression group demonstrated tumors with larger maximal diameters. CONCLUSIONS: Our study demonstrated that the TSP-1 immunoreactivity was significantly lower than VEGF immunoreactivity in Wilms' tumors, and disease progression has a tendency to be found in the VEGF-positive cases and TSP-1 negative cases. We suggest that the growth and metastasis of Wilms' tumor may be influenced mainly by TSP-1 decrease rather than VEGF increase.
Cytoplasm
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Disease Progression
;
Humans
;
Kidney
;
Lymph Nodes
;
Neoplasm Metastasis
;
Thrombospondin 1
;
Vascular Endothelial Growth Factor A*
;
Wilms Tumor*
4.Clinical Experience of the Ilizarov Application for Correction of Ulnar Defect with a Dislocated Radial Head: 2 Cases report
Kwang Jin LEE ; Sang Rho AHN ; Chan Hee PARK ; Jin Sun JEONG ; Kee Young OH
The Journal of the Korean Orthopaedic Association 1995;30(5):1267-1271
2 patients of forearm deformities with ulnar defect and radial head dislocation were treated with the Ilizarov apparatus at Chungnam University Hospital. One patient had a severe hypoplastic remnant-like ulnar fragment and a anterolaterally dislocated radial head due to complicated osteomyelitis of ulnar. We applied an Ilizarov apparatus to transport the radial head distally, and fixed to remaining proximal ulnar fragment. The other had a large bony defect at the ulnar shaft and a dislocated radial head due to complicated osteomyelitis of ulna. We performed internal transport of ulna to decreased the ulnar defect and to descend the dislocated radial head. The clinical-radiological features and functional results of those 2 forearm deformities were described with brief review of the articles about the Ilizarov method for correction of forearm defor- mities.
Chungcheongnam-do
;
Congenital Abnormalities
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Dislocations
;
Forearm
;
Head
;
Humans
;
Ilizarov Technique
;
Osteomyelitis
;
Ulna
5.Population pharmacokinetics and bayesian feedback method for nortriptyline dosage optimisation.
Sang Goo SHIN ; Jong Inn WOO ; In Jin JANG ; Chan Woong PARK ; Jae Jin KIM ; Jin Pyo HONG ; Kyeong Hun LEE
Journal of Korean Neuropsychiatric Association 1992;31(5):884-894
No abstract available.
Nortriptyline*
;
Pharmacokinetics*
6.Effects of plateletpheresis on platelet aggregation in healthy donors.
Heon Chan PARK ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Ryong KIM ; Sang Kyun PARK
Korean Journal of Blood Transfusion 1993;4(1):55-60
No abstract available.
Blood Platelets*
;
Humans
;
Platelet Aggregation*
;
Plateletpheresis*
;
Tissue Donors*
7.A Case of Pulmonary Squestration.
Byung Sook PARK ; Jin Oh KIM ; Beyong Sang CHOI ; Chan Uhng JOO ; Dae Yeol LEE
Journal of the Korean Pediatric Society 1988;31(10):1390-1393
No abstract available.
8.Role of Computed Tomography in Blunt Chest Trauma.
Sang Jin KIM ; Jae Hyun CHO ; Chan Wha LEE ; Hae Kyoon KIM
Journal of the Korean Radiological Society 1994;30(6):1045-1049
PURPOSE: In patient with blunt trauma of chest, supine AP x-ray cannot differenciate the lung contusion, laceration, atelectasis, and hemothorax definitely. Therefore, computed tomographic evaluation is needed for accurate evaluation of the injuries. In our knowledge, there are few reports about CT findings of blunt chest trauma, in our country, therefore we tried to fiud the characteristic CT findings in patients with blunt trauma. MATERIALS AND METHODS: We analyzed the plain x-ray and CT image of 4 patient with blunt chest trauma. Location and morphology of lung parenchymal contusion and laceration, hemopneumothorax, chest wall injuries and location of chest tube. RESULTS: Lung parenchymal contusion was noted in 53 segments. of 16 patiants'infiltration(n=27 segment), and multiple nodular pattern was noted in 15 segment, pattern of consolidation along the lung periphery was seen in 11 segment. Laceration was noted in 18 lesion and most commonly located in paravertebral area(b=8). CONCLUSION: CT scan of chest in patient with blunt chest trauma, provides accurate informations of the pattern of injuries, and localization, therefore, should be performed as po9ssible.
Chest Tubes
;
Contusions
;
Hemopneumothorax
;
Hemothorax
;
Humans
;
Lacerations
;
Lung
;
Pulmonary Atelectasis
;
Thoracic Wall
;
Thorax*
;
Tomography, X-Ray Computed
9.A Case of Cutaneous Metastasis from Pancreatic Adenocarcinoma.
Yong Sang KIM ; Seong Kyun IHM ; Jin Ho CHO ; Kee Chan MOON ; Soo Nam KIM
Korean Journal of Dermatology 1984;22(2):226-229
Cutaneous metastases from internal carcinomas are relatively rare, especially from pancreatic carcinoma. Pancreatic carcinomas are usually adenocarcinomas which arise in the head of the gland, and are known to rapidly metastasize to the lymphatic system by permeation and embolization. We report a case of cutaneous metastasis from pancreatic adenocarcinoma. in 74-year-old male patient who have two pea sized, slight erythematous nodules on the lower abdomen and posterior side of the neck.
Abdomen
;
Adenocarcinoma*
;
Aged
;
Head
;
Humans
;
Lymphatic System
;
Male
;
Neck
;
Neoplasm Metastasis*
;
Peas
10.Effects of Hyperosmolar Solution on the Twitch Force, Membrane Potential, and Intracellular Sodium Activity in Purkinje Fibers and Ventricular Muscles.
Jin Sang KIM ; Jea Ki GHO ; Chan Uhng JOO ; Soo Wan CHAE
Korean Circulation Journal 1995;25(4):838-847
BACKGROUND: Hypertonic solutions are using in emergency patients including refractory shock. The effects of the hyperosmotic solutions for the cardiac contractile effect has remained unclear. To study the mechanism of increase in twitch force by hypertonic solution, memberane potential, intracellular sodium activities(aNia), and twitch force were measured simultaneously in 1 Hz-driven canine Purkinje fibers and guinea pig papillary muscles. METHODS: To increase osmolarity, 20, 40, and 80 mOsm glucose, NaCl or mannitol was added to normal Tyrode solution. We used the conventional and Na(+)-selective microelectrodes, to study the membrane potential and intracellular sodium activity. Changes in twitch force were evaluated also by tension tranducer. RESULTS: 1) Hyperosmolar glucose or NaCl added to normal Tyrode solution produced membrane pontential hyperpolarization, increase in aNia, and increase in twitch force in dog Purkinje fibers. Increase in twitch force was related to decrease in the ratio of aNia to extracellular sodium activity(aNoa). NaCl-inducedd aNia increase was not blocked by 10(-5)M tetrodotoxin, a fast sodium channel blocker. 2) Hyperosmolar glucose or mannitol added to normal Tyrode solution produced membrane potential hyperpolarization, increase in aNia, and increase in twitch force in guinea pig papillary muscles. However, the addition of hyperosmolar NaCl did not affect on membrane potential, but produced increase in aNia, and decrease in twitch force. 3) Prolonging effect of hyperosmolar glucose on duration of action potential was smaller than that of NaCl or mannitol in Purkinje fibers and papillary muscles. 4) Increase in twich force produced by ECF Na+reduction or by hyperosmotic solution was reated to decrase in the aNia ratio. 5) Relationship curve between increase in twitch force and aNoa/aNia ratio in hyperosmolr solution was less steeper than that in ECF Na(+)-reduced solution. CONCLUSION: The above results suggested that hyperosmolar solution-induced twitch force change was related to aNoa/aNia ratio change which influenced intracellular calcium activity via Na(+)-Ca(2+)exchange.
Action Potentials
;
Animals
;
Calcium
;
Dogs
;
Emergencies
;
Glucose
;
Guinea Pigs
;
Humans
;
Hypertonic Solutions
;
Mannitol
;
Membrane Potentials*
;
Membranes*
;
Microelectrodes
;
Muscles*
;
Osmolar Concentration
;
Papillary Muscles
;
Purkinje Fibers*
;
Shock
;
Sodium Channels
;
Sodium*
;
Tetrodotoxin