1.A Case of Angiomatoid Fibrous Histiocytoma.
Sang Jin KWON ; Chan Kum PARK ; Young Suck RO
Korean Journal of Dermatology 1997;35(3):604-608
No abstract available.
Histiocytoma, Benign Fibrous*
2.A Case of Calcinosis Cutis due to Intravenous Administration of Calcium Gluconate.
Young Tae KIM ; Sang Jin KWON ; Chan Kum PARK
Korean Journal of Dermatology 1997;35(3):532-535
We report a case of calcinosis cutis following administration of 10% calcium gluconate, used for the treatment of a hypocalcemic seizure in a 5-week-old neonate. After administration of 10% calcium gluconate, subcutaneous induration developed at the infusion site. The histopathological findings taken from the dorsum of the left foot showed multiple foci of calcium deposits with infiltration of epitheloid histiocytes between collagen bundles and foreign body giant cells phagocyting calcific granules throughout the reticular dermis and subcutis.
Administration, Intravenous*
;
Calcinosis*
;
Calcium Gluconate*
;
Calcium*
;
Collagen
;
Dermis
;
Foot
;
Giant Cells, Foreign-Body
;
Histiocytes
;
Humans
;
Infant, Newborn
;
Seizures
3.The Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 in Wilms' Tumor.
Seong Jin JEONG ; Eun Chan PARK ; Cheol KWAK ; Ren jie JIN ; Sang Eun LEE ; Hwang CHOI
Korean Journal of Urology 2001;42(3):265-272
PURPOSE: With the process of neoangiogenesis being linked to the growth and metastasis of various tumors, anticancer therapeutics with a basis in the suppression of neoangiogenesis has recently been receiving attention. In this study, we tried to clarify the immunoreactivities of vascular endothelial growth factor (VEGF), major angiogenic inducer and thrombospondin-1 (TSP-1), major angiogenic inhibitor in human Wilms' tumor and its clinicopathological significance. MATERAILS AND METHODS: Utilizing immunohistochemical staining, we assessed the immunoreactivities of VEGF and TSP-1 in archival tissues of 29 Wilms' tumors and 25 normal kidneys. Also, we assessed the relationship between expression of each factor and clinicopathological parameters in 29 cases of Wilms' tumors. RESULTS: Immunoreactivities of VEGF and TSP-1 were detected mainly in the cytoplasm of the tubular cells in normal kidneys. In Wilms' tumors, whereas VEGF was detected in the cytoplasm of the tumor cells and peritumoral stromal tissues, but TSP-1 only in the peritumoral stromal tissues. Immunohistochemical expression patterns of each factor were divided into two groups according to the area of immunoreactivity (negative:<10%, positive: > OR =10%). VEGF immunoreactivity was detected in 25 (100%) normal kidneys and in 20 (69%) Wilms' tumors. However, TSP-1 immunoreactivity was detected in 24 (97%) normal kidneys and in 3 (10%) Wilms' tumors. Therefore, although no significant difference was observed between the expressions of VEGF and TSP-1 in normal kidney, the TSP-1 immunoreactivity was significantly lower than VEGF immunoreactivity in Wilms' tumors. A relatively higher rate of positive expression of TSP-1 was observed in the patients with no demonstrable lymph node metastasis. Also, as for the VEGF, maximal diameter of the tumor was larger in the positive expression group. However, it proved otherwise for TSP-1 as the negative expression group demonstrated tumors with larger maximal diameters. CONCLUSIONS: Our study demonstrated that the TSP-1 immunoreactivity was significantly lower than VEGF immunoreactivity in Wilms' tumors, and disease progression has a tendency to be found in the VEGF-positive cases and TSP-1 negative cases. We suggest that the growth and metastasis of Wilms' tumor may be influenced mainly by TSP-1 decrease rather than VEGF increase.
Cytoplasm
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Disease Progression
;
Humans
;
Kidney
;
Lymph Nodes
;
Neoplasm Metastasis
;
Thrombospondin 1
;
Vascular Endothelial Growth Factor A*
;
Wilms Tumor*
4.Clinical Experience of the Ilizarov Application for Correction of Ulnar Defect with a Dislocated Radial Head: 2 Cases report
Kwang Jin LEE ; Sang Rho AHN ; Chan Hee PARK ; Jin Sun JEONG ; Kee Young OH
The Journal of the Korean Orthopaedic Association 1995;30(5):1267-1271
2 patients of forearm deformities with ulnar defect and radial head dislocation were treated with the Ilizarov apparatus at Chungnam University Hospital. One patient had a severe hypoplastic remnant-like ulnar fragment and a anterolaterally dislocated radial head due to complicated osteomyelitis of ulnar. We applied an Ilizarov apparatus to transport the radial head distally, and fixed to remaining proximal ulnar fragment. The other had a large bony defect at the ulnar shaft and a dislocated radial head due to complicated osteomyelitis of ulna. We performed internal transport of ulna to decreased the ulnar defect and to descend the dislocated radial head. The clinical-radiological features and functional results of those 2 forearm deformities were described with brief review of the articles about the Ilizarov method for correction of forearm defor- mities.
Chungcheongnam-do
;
Congenital Abnormalities
;
Dislocations
;
Forearm
;
Head
;
Humans
;
Ilizarov Technique
;
Osteomyelitis
;
Ulna
5.Population pharmacokinetics and bayesian feedback method for nortriptyline dosage optimisation.
Sang Goo SHIN ; Jong Inn WOO ; In Jin JANG ; Chan Woong PARK ; Jae Jin KIM ; Jin Pyo HONG ; Kyeong Hun LEE
Journal of Korean Neuropsychiatric Association 1992;31(5):884-894
No abstract available.
Nortriptyline*
;
Pharmacokinetics*
6.Effects of Hyperosmolar Solution on the Twitch Force, Membrane Potential, and Intracellular Sodium Activity in Purkinje Fibers and Ventricular Muscles.
Jin Sang KIM ; Jea Ki GHO ; Chan Uhng JOO ; Soo Wan CHAE
Korean Circulation Journal 1995;25(4):838-847
BACKGROUND: Hypertonic solutions are using in emergency patients including refractory shock. The effects of the hyperosmotic solutions for the cardiac contractile effect has remained unclear. To study the mechanism of increase in twitch force by hypertonic solution, memberane potential, intracellular sodium activities(aNia), and twitch force were measured simultaneously in 1 Hz-driven canine Purkinje fibers and guinea pig papillary muscles. METHODS: To increase osmolarity, 20, 40, and 80 mOsm glucose, NaCl or mannitol was added to normal Tyrode solution. We used the conventional and Na(+)-selective microelectrodes, to study the membrane potential and intracellular sodium activity. Changes in twitch force were evaluated also by tension tranducer. RESULTS: 1) Hyperosmolar glucose or NaCl added to normal Tyrode solution produced membrane pontential hyperpolarization, increase in aNia, and increase in twitch force in dog Purkinje fibers. Increase in twitch force was related to decrease in the ratio of aNia to extracellular sodium activity(aNoa). NaCl-inducedd aNia increase was not blocked by 10(-5)M tetrodotoxin, a fast sodium channel blocker. 2) Hyperosmolar glucose or mannitol added to normal Tyrode solution produced membrane potential hyperpolarization, increase in aNia, and increase in twitch force in guinea pig papillary muscles. However, the addition of hyperosmolar NaCl did not affect on membrane potential, but produced increase in aNia, and decrease in twitch force. 3) Prolonging effect of hyperosmolar glucose on duration of action potential was smaller than that of NaCl or mannitol in Purkinje fibers and papillary muscles. 4) Increase in twich force produced by ECF Na+reduction or by hyperosmotic solution was reated to decrase in the aNia ratio. 5) Relationship curve between increase in twitch force and aNoa/aNia ratio in hyperosmolr solution was less steeper than that in ECF Na(+)-reduced solution. CONCLUSION: The above results suggested that hyperosmolar solution-induced twitch force change was related to aNoa/aNia ratio change which influenced intracellular calcium activity via Na(+)-Ca(2+)exchange.
Action Potentials
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Animals
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Calcium
;
Dogs
;
Emergencies
;
Glucose
;
Guinea Pigs
;
Humans
;
Hypertonic Solutions
;
Mannitol
;
Membrane Potentials*
;
Membranes*
;
Microelectrodes
;
Muscles*
;
Osmolar Concentration
;
Papillary Muscles
;
Purkinje Fibers*
;
Shock
;
Sodium Channels
;
Sodium*
;
Tetrodotoxin
7.A Clinical Analysis of 200 Cases of Pediatric Inguinal Hernia.
Jin Woo PARK ; Sang Jeon LEE ; Lee Chan JANG
Journal of the Korean Surgical Society 1999;56(6):898-905
BACKGROUND: Inguinal hernia is one of the most common surgical diseases in pediatric patients. We reviewed pediatric inguinal hernia cases retrospectively to analyze the clinical characteristics. METHODS: We reviewed 200 herniorrhaphies in 194 patients who were under the age of 15 and who were operated on at Chungbuk National University Hospital from January 1992 to July 1997. RESULTS: 1) All of the cases were indirect inguinal hernias. Sliding hernias were noticed in 6 cases. High ligations were performed in all cases except 2 cases of Bassini operations. 2) Boys were affected 3.4 times more often than girls. 56.2% of the hernias occurred on the right side, 35.0% on the left side, and 8.8% bilaterally. Bilateral inguinal hernias occurred more often in girls (13.6%) than in boys (7.3%). 3) Hernias were noticed under the age of 1 year (47.9% of the cases). In most of those cases, operations were delayed. Especially, the operations were delayed more than 3 months for 82.1% of patients with hernias and under the age of 6 months. 4) On admission, most patients complained of inguinal or scrotal swelling and inguinal pain or discomfort. 5) Hospitalization occurred in 20.6% of the cases, 3 of which needed emergency operations. Hospitalization occurred in 47.5% of the cases under the age of 1 year; in those cases, hernias were noticed within the first 6 months, and in most of those cases, operations were delayed more than 3 months. 6) Postoperative complications occurred in 9 cases, i.e., 8 cases of scrotal swelling and 1 case of scrotal hematoma. There were no recurrent cases after operation (average follow-up of 33 months). 7) After unilateral inguinal hernia repairs, contralateral hernias developed in 10 patients including 4 patients who had had received their first hernia operations at other hospitals. The sex ratio was 9:1. Laterality of the first hernias were right in 5 cases and left in 5 cases. Contralateral hernias developed within an average of 4.8 months after the first operation; however, 6 cases developed within 6 months after the first operation. CONCLUSIONS: Education for early operation to prevent complications of hernias and careful evaluation of contralateral inguinal hernias in unilateral hernias are needed in the treatment of pediatric inguinal hernias.
Chungcheongbuk-do
;
Education
;
Emergencies
;
Female
;
Follow-Up Studies
;
Hematoma
;
Hernia
;
Hernia, Inguinal*
;
Herniorrhaphy
;
Hospitalization
;
Humans
;
Ligation
;
Postoperative Complications
;
Retrospective Studies
;
Sex Ratio
8.Eczema within a Capillary Malformation: A Case of Meyerson Phenomenon.
Annals of Dermatology 2016;28(6):781-782
No abstract available.
Capillaries*
;
Eczema*
9.Surgical acute abdomen in geriatrics over 65 years old: 193 cases.
Byung Chan LEE ; Nam Kyu KIM ; Hoon Sang CHI ; Byong Ro KIM ; Jin Sik MIN
Journal of the Korean Surgical Society 1991;41(6):814-818
No abstract available.
Abdomen, Acute*
;
Aged*
;
Geriatrics*
;
Humans
10.Clinical Evaluation of Endoscopic Microwave Coagulation Therapy for Upper Gastrointestinal Bleeding.
Jong Su KIM ; Sang Bok LIM ; Jin Hong KIM ; Sung Woo CHO ; Chan Sup SHIM
Korean Journal of Gastrointestinal Endoscopy 1988;8(2):127-132
The hemostatic effect of endoscopic microwave coagulation method for upper gastrointestinal bleeding was evaluated clinically. Hemostasis over 72 hours was achieved in 18 of 20 cases (90%) with upper gastrointestinal bleeding by the endoscopic microwave coagulation method. It is noteworthy that this method was effective in all 4 cases of pulsatile bleeding from exposed vessels. We conclude that this method is useful for emergency endoscopic hemostasis on upper gastrointestinal bleeding, especially bleeding from exposed vessels.
Emergencies
;
Hemorrhage*
;
Hemostasis
;
Hemostasis, Endoscopic
;
Microwaves*