Fibronectin(FN) is a physiologic glycoprotein presenton cell surface and in connective tissue, extracellular matrix and plasma. Increased plasma FN levels have been reported in the patients with psoriasis, connective tissue disease, internal malignancy, squamous cell carcinoma and basal cell carcinoma. The author investigated the plasma FN levels in 30 patients (males 13, female 17) with psoriasis and 23 healthy subjects (male 13, female 10) by gelatin sepharose 4B affinity chromatography and Laurells rocket immunoelectrophoresis method. The results were as follows : Plasrna JN levels were 450.4+/-80.3pg/ml in the patients with psoriasis and 334.0-51.3pg/ml in healthy subjects. There was no relationship between age graups and sex. Plasrna FN levels in the patients with psoriasis were higher than those of healthy subjects(p<0.001). There was no relationship between the levels of plasma FN and clinical severity of psoriasis.
Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Chromatography, Affinity ; Connective Tissue ; Connective Tissue Diseases ; Extracellular Matrix ; Female ; Fibronectins* ; Gelatin ; Glycoproteins ; Humans ; Immunoelectrophoresis ; Plasma* ; Psoriasis* ; Sepharose

Twelve neglected congenital dislocations of the hip in ten patients over the age of eight years were treated by open reduction and chiari osteotomy. Reduction was aided by preoperative traction only in two hips, by femoral shortening with preoperative traction in three and by femoral shortening only in seven. The average follow up period in our series is 3 years, ranging from 1 year and 2 moths to 4 years and 5 months. The overall results were good but one case of avascular necrcsis and one case of redislocation were seen. By our experience it is thought that all old and congenitally dislocated hip in the growing age can be reduced by femoral shortening with soft tissue release, and preoperative traction for its reduction is not undispensable. The most problem in the treatment of the old congenital dislocation of the hip is the postoperative partial ankylosis in the affected hip and this problem would be overcome by delicate operative technique and meticulous hemostasis.
Ankylosis ; Dislocations ; Follow-Up Studies ; Hemostasis ; Hip ; Humans ; Moths ; Osteotomy ; Traction

No abstract available.
Bromodeoxyuridine* ; Cervix Uteri* ; Drug Therapy* ; Female

PURPOSE: Epilepsy is generally defined as a chronic condition characterized by recurrent unprovoked seizure. It is still controversial whether the long-term antiepileptic drugs(AED) treatment will be necessary in children with first unprovoked seizure. Cognitive and behavioral side effects of AEDs are especially important in developing children. Therefore the rationale of AED treatment in the children with first unprovoked seizure depends upon the seizure recurrence rate and presence of risk factors related with seizure recurrence. We are going to evaluate the risk of seizure recurrence and risk factors after a first unprovoked seizure in children. METHODS: One hundred fifty eight patients presented with a first unprovoked seizure from July, 1994 to June, 1999 were prospectively followed by regular epilepsy clinic visit or telephone interview for a mean of 27 months. We analyzed overall recurrence risk and risk factors of seizure recurrence(EEG finding, etiology of seizure, seizure type, history of prior febrile convulsions, neurodevelopmental status prior to first seizure, presence of a Todd's paresis, family history of seizures, a seizure occuring while asleep, and duration of seizure) by Cox's proportional hazards model and Kaplan-Meier survival analysis. RESULTS: In 158 patients with first unprovoked seizure, 61 (39%) patients experienced subsequent seizure. The cumulative risk of seizure recurrence was 28.5, 37.6, and 42.3% at 6, 12, and 18 months. The median time to recurrence was 3 months, with 72% of recurrence occurring within 6 months, 92% within 1 year, and 100% within 2 years. On univariate analysis, risk factors for seizure recurrence included an etiology of seizure and abnormal EEG. In idiopathic cases, the risk factor was an EEG abnormality. CONCLUSION: Many of the children with a first unprovoked seizure will not have recurrences. The recurrence risk of a first unprovoked seizure in children have statistically correlated with the etiology of seizure(cryptogenic and symptomatic) and abnormal EEG. Children with an idiopathic first seizure and a normal EEG have a particularly favorable prognosis.
Ambulatory Care ; Child ; Electroencephalography ; Epilepsy ; Humans ; Interviews as Topic ; Paresis ; Prognosis ; Proportional Hazards Models ; Prospective Studies* ; Recurrence* ; Risk Factors ; Seizures* ; Seizures, Febrile

The present study was undertaken to investigate the relationship between serum lipid and lipoprotein values and cerebrovascular accidents. Serum lipids and lipoproteins were measured in 130 cases of normal Korean, 49 patients with cerebrovascular accidents and 35 patients with uncomplicated essential hypertension. The results were summarized as follows; 1. The mean values of serum lipids in patients with cerebrovascular accidents were 148.3+/-75.3mg% for triglyceride, 189.6+/-37.4mg% for cholesterol, 132.5+/-55.2mg% for phospholipid and 548.8+/-106.3mg% for total lipid. 2. The mean values of serum lipoproteins in patients with cerebrovascular accidents were 255.3+/-81.6mg% for beta-lipoprotein, 118.3+/-73.7mg% for pre-beta-lipoprotein and 183.6+/-65.5mg% for alpha-lipoprotein. 3. There were no significant differences of sex and age in the mean values of serum lipids and lipoproteins in patients with cerebrovascular accidents. 4. In general the mean concentrations of serum lipids and lipoproteins, except phospholipid and alpha-lipoprotein, in patients with cerebrovascular accidents and hypertension were significantly elevated than in normal control subjects. 5. There were no significant differences in serum lipid and lipoprotein values between various types of cerebrocasculr accidents. 6. The change of serum lipid and lipoprotein values had a decreasing tendency till one month after onset, thereafter the values became similar to to\hose of early period of illness. 7. The incidence of hyperlipoproteinemia in patients with cerebrovascular accidents was 64%, and the most frequent type of hyperlipoproteinemia was Type IIa, as the frequency decreased in the order of Type IV, Type IIb and Type III.
Cholesterol ; Humans ; Hyperlipoproteinemias ; Hypertension ; Incidence ; Lipoproteins* ; Stroke* ; Triglycerides

The present study was undertaken to investigate the relationship between serum lipid and lipoprotein values and cerebrovascular accidents. Serum lipids and lipoproteins were measured in 130 cases of normal Korean, 49 patients with cerebrovascular accidents and 35 patients with uncomplicated essential hypertension. The results were summarized as follows; 1. The mean values of serum lipids in patients with cerebrovascular accidents were 148.3+/-75.3mg% for triglyceride, 189.6+/-37.4mg% for cholesterol, 132.5+/-55.2mg% for phospholipid and 548.8+/-106.3mg% for total lipid. 2. The mean values of serum lipoproteins in patients with cerebrovascular accidents were 255.3+/-81.6mg% for beta-lipoprotein, 118.3+/-73.7mg% for pre-beta-lipoprotein and 183.6+/-65.5mg% for alpha-lipoprotein. 3. There were no significant differences of sex and age in the mean values of serum lipids and lipoproteins in patients with cerebrovascular accidents. 4. In general the mean concentrations of serum lipids and lipoproteins, except phospholipid and alpha-lipoprotein, in patients with cerebrovascular accidents and hypertension were significantly elevated than in normal control subjects. 5. There were no significant differences in serum lipid and lipoprotein values between various types of cerebrocasculr accidents. 6. The change of serum lipid and lipoprotein values had a decreasing tendency till one month after onset, thereafter the values became similar to to\hose of early period of illness. 7. The incidence of hyperlipoproteinemia in patients with cerebrovascular accidents was 64%, and the most frequent type of hyperlipoproteinemia was Type IIa, as the frequency decreased in the order of Type IV, Type IIb and Type III.
Cholesterol ; Humans ; Hyperlipoproteinemias ; Hypertension ; Incidence ; Lipoproteins* ; Stroke* ; Triglycerides

No Abstract Available.
Alopecia* ; Telemedicine*

No abstract available.
Cholecystectomy, Laparoscopic*

The syndrome of lower-back pain associated with sciatic pain has probably been a problem since man first assumed the upright position. In 1937 Barr delineated herniation of the nucleu pulposus as a pathologic entity. Since that time, the standard surgical treatment has become laminectomy or laminectomy combined with fusion, with the emphasis on the disc between L4−5 and L5−Sl. Another mode of treatment was suggested when Smith and Brown” reported their clinical experience using intradiskal injection of chymopapain as the definite treatment of lumbar disk disease in 1967. In recent many years investigators in separate clinical studies showed that a benificial result can be achieved in a high percentage of patients treated by chymopapain injection. Our 29 patients who can be observed for more than 6 months after chemonucleolysis were clinically analysed. The results were as follows: 1. Of the 29 patients studied, 15 were males and 14 were females. 11 patients (37.9%) were in age between 41 and 50 years. 2. On clinical symptoms, 24 patients (82.8%) had radicular pain in the lower extremity. All patients had the limitation of the straight leg raising. 3. The most common level of herniated area was L4−5 disk as 22(75.9%) cases. In four cases (13.8 %) two levels of disks (L4−5 and L5−Sl) were involved. 4. On myelography the hour glass appearance was shown in 14 patients (49.3%).Complete block was found in 4 (13.8%) cases. 5. The increase of the straight leg raising was found within 3 weeks after chemonucleolysis in all cases. Motor power were recovered in 20 out of 22 cases and abnormal sensation were recovered in 17 out of 19 cases within 3 months after chemonucleolysis. 6. There were no correlation between persisting low back pain and narrowing of the disk space after chemonucleolysis, statistically. 7. In 23 out of 29 cases discometry test was positive. Among 23 cases, 21 cases recovered from their symptoms successfully after chemonucleolysis. 8. In chymo. R.A.S.T., 9 out of 15 cases were positive in 3 weeks after chemonucleolysis, and 12 out of 15 cases were positive in 3 months after chemonucleolysis.
Chymopapain ; Female ; Glass ; Humans ; Intervertebral Disc ; Intervertebral Disc Chemolysis ; Laminectomy ; Leg ; Low Back Pain ; Lower Extremity ; Male ; Myelography ; Research Personnel ; Sensation

Chordoma is a rare distinctively malignant tumor thought to be histogenetically related to the primitive notochord, It is locally infiltrative but does not metastasize until late. The usual initial symptom is pain or some symptom caused by involvement of the nervous system. Involed in the order of frequency are the sacro-coccygeal area, the spheno-occipital area, and the other vertebral area. This case is a sacro-coccygeal chordoma that is confirmed by histologic examination. The lesion was treated by complete excision.
Chordoma ; Nervous System ; Notochord