The author had published the first report of the above subject in May, 1964. The mode of operation was detailly explained, and the discussion was given briefly at last report. The conclusion are as follows. 1. Pterygium is a benign condition in itself. so that it's operation is very simple and easy. 2. The operated eye became good cosmetic result, and became occasionally clearer than the sound eye through this operation. 3. Regardless of primary or recurrent one, or the size, similarly good result was obtained to after pterygiam operation. As Pinguecula is seemed to be very close to pterygium, Also good results was obtained through same operative procedures as pterygium. 4. Scarcely recurrency was found if one do not make a fault in this operation.
Pinguecula ; Pterygium* ; Surgical Procedures, Operative

This communication is concerned with a new method of operation for pterygium of which the author has had experience in over 2,000 cases of the various types of pterygia. Post-operative recurrence was few and the cosmetic end-result is satisfactory so far. In order to avoid the recurrence of the pterygium, the technique is much improved. The characteristics of the method are as follows: a. The removal of the pterygium is complete combined with the extensive excision of the subconjunctival tissue up to beneath the plica semilunaris. No suture is put on any places around the exposured sclera. b. The temporary lateralization of the eye-ball at least for 48 hours by means of a traction suture is of important.
Pterygium* ; Recurrence ; Sclera ; Sutures ; Traction

The author suppose the etiology of the pterygium as combination of following various factors. 1) Irritation of the sun light, wind and dust. 2) Pterygium is frequently encroachment of a pinguecula onto the cornea. 3) Continuous movement of the eye may influence upon the formation of the pterygium. 4) Constiant rubbing of the semilunar fold against bulbar conjunctiva of the internal palpebral fissure. 5) Conjunctival fold due to resistance of the caruncle in ocular movement cause the pressure to the medial limbus. This fact may largely influence upon the formation of the pterygium. 6) Frequent mechanical irritation to the internal palpebal fissure in washing one's face and other daily works. 7) Accumulation of the tear film and dusts on the inner canthal region constantly irritate bulbar conjunctiva. 8) Subconjunctival connective tissue and subconjunctival hypertrophied tissue (a kind of subconjunctival pathologic connective tissue) near the caruncle play great role of the formation and recurrent of the pterygium. This hypothesis based on the fact that extensive and large amount of removal of the subconjunctival pathologic connective tissue according to the author's new operation method revealed complete prevention of the recurrence of pterygium. 9) Incidence of the pterygium on the medial side is over 98% in spite of same condition of the lateral and medial conjunctiva. The author suppose this fact is due to above prescripted various factors.
Conjunctiva ; Connective Tissue ; Cornea ; Dust ; Incidence ; Pinguecula ; Pterygium* ; Recurrence ; Solar System ; Tears ; Wind

This is to emphasize the important role of surgical consideration of the epiblepharop or ectropion as the supplemental method, in adequate treatment of the corneal involvement especially for the corneal ulcer. The author has felt that the surgical correction of the intumed or intuming tendency of the margin of the lower-lid has been much more effective to cure the corneal ulcers which prevalently seen in lower portion of the cornea. This is confirmed through his 4D years clinical experiences.
Cornea ; Corneal Diseases* ; Corneal Ulcer* ; Ectropion ; Ulcer

No abstract available.
Coal* ; Mucous Membrane*

Epidural hematoma associated with epidural anesthesia is rare. We describe a case of a epidural hematoma after continuous epidural anesthesia and analgesia for arthroscopic patella shaving. Anesthesia was indudced with 8 ml lidocaine, 2.0% with epinephrine, 1:200,000 and surgery proceeded. When additional boluses of bupivacaine were administered later, aspiration of the epidural catheter still yielded no blood. At the end of the operation, an epidural infusion of 0.125% bupivacaine was done 2 ml/hr by two-day infusor. In the third postoperative day, the patient suffered from acute myocardial infarction and then heparin was infused. In the fourth postoperative day, she complained lumbar back pain and developed depressed dorsiflexion (Grade II) of great toe in left foot during the infusion of heparin. Sagittal MRI showed posterior thickened epidural hematoma along the segments of T12-L4. Despite the delayed laminectomy and decompression, which was performed six days after her initial operation, she had a good postoperative response, followed by a complete neurological recovery.
Analgesia ; Anesthesia ; Anesthesia, Epidural* ; Back Pain ; Bupivacaine ; Catheters ; Decompression ; Epinephrine ; Foot ; Hematoma* ; Heparin ; Humans ; Infusion Pumps ; Laminectomy ; Lidocaine ; Magnetic Resonance Imaging ; Myocardial Infarction ; Patella ; Toes

No abstract available.
Organ Transplantation* ; Transplants*

Cytotoxic T lymphocytes (CTL) playing an important role in e cell-mediated immune response kill the target cells by the special contact-dependent mechanism. It has been known that CTL and NK cells utilize two different pathways in removing specific target cells: apoptotic cell death and osmotic lysis by the pore forming protein. Interaction of CTL with target cells results in the ligand-induced, receptor-mediated, nonsecretory lytic process and lethal hit is delivered by the transducing molecule, Fas (CD95, APO-1), one of the TNFR/NGFR superfamily. In addition, ligation of TNF receptor and CD40 also induced the apoptosis of B cell and epithelial cells. However, recognition of target cells, the triggering mechanism, cytotoxic mediators, internal metabolic pathway and signal transduction behind apoptosis remain undefined and have been elucidated only in part. ...continue...
Apoptosis* ; Cell Death ; Epithelial Cells ; Genistein ; Ice ; Killer Cells, Natural ; Ligation ; Metabolic Networks and Pathways ; Receptors, Tumor Necrosis Factor ; Signal Transduction ; T-Lymphocytes, Cytotoxic*

This study was carried out to demonstrate the mode of ADR-induced cell death(apoptosis) on the light and electron microscopic features, to measure the apoptotic index dependent on various doses of ADR, to investigate the possible mechanism of apoptosis induced by ADR, and to evaluate ISNT method for the detection of DNA strand break. HeLa cells were treated with various doses of ADR 0.1~100.0 microgram/ml and observed under the light and transmission electron microscopes at 6 hours, 1 day and 3 days after ADR treatment. In addition, DNA strand breaks induced by ADR were detected in HeLa cells using the in situ nick translation(ISNT) method. The results were as follows: 1) The cell viability of HeLa cells decreased and the apoptotic index increased following exposure to ADR in a dose-dependent manner, resulting in about 44% of apoptotic index at 100.0 microgram/ml of ADR treatment. 2) Light microscopically, HeLa cells treated with ADR showed shrinkage or condensation of nucleus and cytoplasm. There were various unclear changes showing irregular, large, delineated masses of condensed chromatin abutting on the nuclear envelopes. Later stage of apoptosis revealed contracted and condensed cytoplasm with irregular cell membrane. Electron microscopically, margination of condensed chromatin, dilatation of endoplasmic reticulum under the plasma membrane, aggregation of cytoplasmic organelles with morphologically intact mitochondria, and irregular cell surface with blebbing were observed. 3) ISNT using biotinylated dUTP exhibited strong positive nuclear staining in HeLa cells treated with ADR. There was a marked response at 10.0~20.0 microgram/ml of ADR treatment. It is concluded from the above results that the death of HeLa cells induced by ADR was apoptotic in type based on light and electron microscopic appearance. The apoptotic index correlated with the increasing dose of ADR. ISNT with biotinylated dUTP led to visible evidence of DNA strand breaks following ADR treatment of HeLa cells. ISNT can be used for detection of DNA degradation, caused by activation of endogenous endonuclease, which is an early and specific characteristic of apoptosis.

No abstract available.
Adult* ; Doxycycline ; Humans ; Tooth*