No abstract available.
Antibodies* ; Humans ; Leprosy*

No abstract available.
Heart* ; Thoracic Surgery*

Clinical trials were done to obtain ifnormation on the clinical efficacy, tolerance and side effects of a new antihistarnine, Mecloprodine(Tavegyl), in various skin disordetrs. A total of 48 patients suffered from various skin disorders as urticaria, eczema etc. v ere treated with 2mg. daily for 3 days to 15 days according to state of disorders. The results are as follows. 1. Improvement was noticed in 79.2% of total patients(38/48). 2. Tavegyl was efiective in all 8 cases of acute urticaria and most cases(7/8) of urticaria factitia. 3. Among 19 cases of chronic urticaria, improvement was noticed in 13 cases(68. 49). Improvement was alsa noticed in all 6 cases of eczema. 5. Drowsiness and weakness cccurred in 6.2% of cases(3/48).
Clemastine* ; Eczema ; Humans ; Skin ; Sleep Stages ; Urticaria

No abstract available.
Penicillins* ; Pneumonia* ; Sepsis* ; Streptococcus pneumoniae* ; Streptococcus*

No abstract available.
Penicillins* ; Pneumonia* ; Sepsis* ; Streptococcus pneumoniae* ; Streptococcus*

Kikuchi-Fujimoto's disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign and self-limiting disease. KFD are confused with systemic autoimmune disease as they present with localized lymphadenopathy, fever, fatigue, arthritis, leukopenia. Furthermore as KFD can occur associated with other autoimmune disease, we need to diagnose carefully. Here, we describe a case of 27-year-old female patient, diagnosed as KFD, who subsequently developed adult onset Still's disesase (AOSD). As far as we know, this is the first case of KFD with AOSD in Korea.
Adult ; Male ; Female ; Humans

No abstract available.
Female ; Ovary* ; Teratoma*

Purpose: The aim of this study was to investigate the effects of long-term immobilization stress on spermatogenesis and testosterone production in a rat model. Materials and Methods: Thirty randomly selected adult male rats were divided into 6 groups: immobilization stress groups (I, III, V) and control groups (II, IV, VI). In the immobilization stress groups, 15 rats were immobilized in a steel cage for 6 hours per day for 14 days. Groups I and II were sacrificed just after finishing the immobilization session. Groups III and IV were sacrificed after a 1 week resting period. Groups V and VI were sacrificed after a 2 week resting period. The serum concentrations of corticosterone, luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone were measured. Specimens of the testis were stained with hematoxylin-eosin and Masson's trichrome. Results: Following 2 weeks of immobilization, the serum concentration of corticosterone was significantly increased; whereas, the serum concentrations of LH and testosterone were decreased. However, the serum FSH concentration remained unchanged. After the 1 week resting period, there were significant recoveries in the serum concentrations of corticosterone, LH and testosterone. From the histology of the immobilization group, the mean testicular biopsy score (Johnsen score) was significantly decreased, but the mean value of the seminiferous tubule luminal diameter was significantly increased; whereas, that of the seminiferous tubule diameter remained unchanged. These changes slowly recovered after the resting period. Conclusions: These results suggest that the exposure to long-term immobilization impairs spermatogenesis and androgenic testicular functions in rats.
Adult ; Animals ; Biopsy ; Corticosterone ; Follicle Stimulating Hormone ; Humans ; Immobilization* ; Male ; Models, Animal ; Phenobarbital ; Rats ; Seminiferous Tubules ; Spermatogenesis* ; Steel ; Testis ; Testosterone*

A high incidence of a T cell phenotype of sinonasal lymphomas in other Asian countries has been associated with a high incidence of Epstein Barr virus (EBV) infection. We analyzed 13 sinonasal and 18 Waldeyer's ring lymphomas for the prevalence of EBV encoded RNA (EBER) using a sensitive and specific in situ hybridization. In addition, we examined the relationship of histologic findings and immunophenotype as well as the location of the lymphomas to the presence of EBV. The EBER was detected in each of 12 sinonasal lymphomas with a T cell immunophenotype. One B cell sinonasal lymphoma was EBER negative. Four of 18 Waldeyer's ring lymphomas were positive for EBER, including two T cell lymphomas. Two of 16 B cell Waldeyer's ring lymphomas were EBER positive. Morphologically, 11 of 20 diffuse large cell lymphomas, 2 diffuse mixed small and large cell lymphomas, 2 of 4 immunoblastic lymphomas and 1 lymphoplasmacytic lymphoma were EBER positive. Four follicular large cell lymphomas were EBER negative. A characteristic angiocentric or angiodestructive pattern was found in most T cell lymphomas and EBER positive cases. These findings indicate that EBV infection is more strongly associated with the T cell immunophenotype, angiocentric pattern and sinonasal location of the lymphoma.
Adult ; Aged ; B-Lymphocytes/immunology ; Female ; Herpesviridae Infections/*virology ; Herpesvirus 4, Human/genetics/*isolation & purification ; Human ; Immunophenotyping ; In Situ Hybridization ; Incidence ; Lymphoid Tissue/virology ; Lymphoma, Non-Hodgkin/epidemiology/immunology/mortality/*virology ; Male ; Maxillary Neoplasms/epidemiology/immunology/mortality/*virology ; Middle Age ; Nasopharyngeal Neoplasms/epidemiology/immunology/mortality/*virology ; Nose Neoplasms/epidemiology/immunology/mortality/*virology ; Prevalence ; RNA, Viral/*analysis ; Support, Non-U.S. Gov't ; Survival Rate ; T-Lymphocytes/immunology ; Tonsillar Neoplasms/epidemiology/immunology/mortality/*virology ; Tumor Virus Infections/*virology

OBJECTIVE: To determine possible similarities and differences in clinical and laboratory features and prognosis between patients with inflammatory myopathies diagnosed at Kangnam St. Mary's hospital and other reported series. METHODS: Medical records of 52 patients diagnosed as inflammatory myopathies by Bohan and Peter criteria who were admitted to Kangnam St. Mary's hospital between January 1989 and August 1994, were reviewed. The patients were further classified into 5 groups proposed by Bohan and Peter ; group I primary polymyositis(PM), group II primary dermatomyositis(DM), group III polymyositis/dermatomyositis(PM/DM) with neoplasia, group IV juvenile PM/DM, group V PM/DM associated with connective tissue disease. RESULTS: 1) There were 52 PM/DM cases with mean age at diagnosis of 34. 4 ranging from 6 to 67 years, and significantly more females(male:female = 9:43). 2) Of 52 patients, group II was the most frequent group(36.5%), and the next were as follows ; group I 28.8%, group V 25%, group IV 5.7%, group 3.8%. Systemic lupus erythematosus(SLE) was the commonest connective tissue disease, and malignancy was associated in 2 cases including breast cancer and small cell carcinoma of lung. 3) At presentation, 86.5% had proximal muscle weakness, 61.5% had arthralgia/arthritis and 44. 2% had Raynaud phenomenon. 4) The elevated serum LDH, aldolase and creatine kinase were found in 84. 6%, 84. 1%o, 71.2% of the patients respectively. Positive electromyography and muscle biopsy consistent with inflammatory myopathy were also found in 91.4%, 88.8% respectively. 5) Positive antinuclear antibody, rheumatoid factor, anti-Ro, anti-nRNP were found in 59.6%, 17.3%, 16.7%, 8.3% of patients respectively, mainly in group V. Anti-Jo-1 antibody was present in 25.8% of patients tested(8/31), including group II 4 cases, group V 3 cases and group I I case. 6) All 8 patients with anti-Jo-1 antibody had interstitial lung disease(ILD) and Raynaud phenomenon with statistical significance, compared with those without anti-Jo-1 antibody(P<0.01). 7) Among the 43 patients in whom follow up was available, 10 patients died(mortality rate 23.2%). The main cause of death were infection(4 cases), and respiratory muscle weakness, respiratory failure due to ILD, malignancy 2 cases respectively. CONCLUSION: The results of the study demonstrated that clinical expression of PM/DM were similar to previously reported series except relatively high frequency of primary dermatomyositis in this study. Anti-Jo-1 antibody was main autoantibody in inflammatory myopathies, which was associated with extramuscular manifestations, such as ILD and Raynaud's phnomenon.
Antibodies, Antinuclear ; Biopsy ; Breast Neoplasms ; Carcinoma, Small Cell ; Cause of Death ; Connective Tissue Diseases ; Creatine Kinase ; Dermatomyositis ; Diagnosis ; Electromyography ; Follow-Up Studies ; Fructose-Bisphosphate Aldolase ; Humans ; Lung ; Medical Records ; Muscle Weakness ; Myositis* ; Prognosis ; Raynaud Disease ; Respiratory Insufficiency ; Respiratory Muscles ; Rheumatoid Factor