1.Correlation of Histologic Findings of Ovarian Epithelial Tumors with Expression of Proliferating Cell Nuclear Antigen and Flow Cytometric DNA Analysis.
Sang Yeop YI ; Soon Hee JUNG ; Kwang Gil LEE
Korean Journal of Pathology 1995;29(1):68-76
The prognosis of malignant ovarian tumor is poorer than that of borderline malignant ovarian tumor, Therefore an accurate diagnosis and estimation of the biologic behavior of the tumor are necessary for proper management of the patient. The histologic investigation of the tumor may provide information on the estimation of the malignant potential of tumor cells, but it may be a questionable method because of the subjective determination of tumor grade. Quantification of proliferative activity of tumor cells may play a role as an objective method to provide an estimation of the malignant potential of tumor cells. An evaluation of histologic findings was done on 84 cases of ovarian mucinous and serous tumors that were surgically resected and diagnosed during the period from January 1981 through July 1992. The proliferating cell nuclear antigen (PCN A) labelling index estimated from the immunohistochemical stain for PCN A and the Sphase fraction and porliferative index obtained from flow cytometric DN A analysis were assessed each other with histologic findings. The results are as follows: The presence of aneuploidy in malignant tumors was statistically significant as compared with benign tumors. The borderline malignant tumors showed no significant difference between the number of diploidy and aneuploidy. The PCNA labelling index, S-phase fraction and proliferative index tended to increase as the histologic grade of tumors went up. They were higher in malignant tumors than in others. The PCN A labelling index, S-phase fraction and proliferative index were higher in tumors with aneuploidy than in those with diploidy. In contrast to borderline malignant tumors, the PCNA labelling index in malignant tumors revealed a significant relation with the mitotic index. The S-phase fraction and proliferative index showed, in malignant tumors, a close correlation with the architectural grade and nucleolar grade, but not in borderline malignant tumors. Considering these results, the presence of aneuploidy, PCNA label.
2.Isolated Crohn's Disease of Appendix: Is It Crohn's Disease or Idiopathic Granulomatous Appendicitis? Report of a case and review of the literature.
Min Young KIM ; Jin Gu BONG ; Sang Yeop LEE
Journal of the Korean Society of Coloproctology 1998;14(2):309-316
A case of isolated Crohn's disease of appendix is reported. It is a rare disease which commonly mimics the symptoms of acute appendicitis. Review of 221 identical cases previously reported in the world literature revealed slight male predominance(1.17:1) and peak age of incidence in the third decade(24.3 yrs). In contrast to typical Crohn's disease, the rate of postoperative fistula and recurrence was minimal; 1.0% and 3.8%, respectively. Due to these differences, many consider it to be a separate disease entity from Crohn, and a new diagnostic term - "Idiopathic Granulomatous Appendicitis" - has gained wide acceptance in recent years.
Appendicitis*
;
Appendix*
;
Crohn Disease*
;
Fistula
;
Humans
;
Incidence
;
Male
;
Rare Diseases
;
Recurrence
3.Torsion of Benign Cystic Teratoma of Ovary at 37 Weeks Gestation.
Chu Yeop HUH ; Sang Wook LEE ; Young Seung OH
Korean Journal of Perinatology 1998;9(4):440-444
Ovarian tumor in pregnancy is not rare and benign cystic teratoma is most common ovarian tumor in pregnancy. Most ovarian tumor in pregnancy is found at first and second trimester but sometimes found at third trimester and it is difficult to make a decision for management. Moreover physician should consider fetal age and mother's condition, and weigh outcome of operation for complicated ovarian tumor in pregnancy. Torsion of ovarian tumor is not an uncommon complication during first trimester of pregnancy and puerperium but rare occurs during the third trimester of pregnancy. We have experienced a case of torsion of benign cystic teratoma of ovary which occurred at 37 weeks gestation in a 25 year-old woman. So we report this case with a brief review of literature.
Adult
;
Female
;
Gestational Age
;
Humans
;
Ovary*
;
Postpartum Period
;
Pregnancy Trimester, First
;
Pregnancy Trimester, Second
;
Pregnancy Trimester, Third
;
Pregnancy*
;
Teratoma*
4.Reduction in the Area of the Anterior Capsular Opening A fter Ac ryl Intraocular Lens Implantation: Diabetics vs Nondiabetics.
Sang Yeop LEE ; Tae Min BAEK ; Kyung Hun LEE
Journal of the Korean Ophthalmological Society 2000;41(5):1158-1163
We compared the rate of continuous curvilinear capsulorhexis[CCC]con traction and degree of postoperative capsular fibrosis between patients with non-proliferative diabetic retinopathy and age-matched non-diabetic patients after phacoemulsification with posterior chamber acryl foldable intraocular lens implantation.Sixty-two eyes of 42 patients of non-proliferative diabetic retinopathy and 78 eyes of 55 patients of control group who underwent cataract surgery with acryl foldable intraocular lens were enrolled in this retrospective study.During follow up examination the rate of CCC contractions were evaluated by NIDEK EAS-1000 System and we measured the area of anterior capsular opening.The diabetic patients average percentage of anterior capsular shirinkage rate was higher than non-diabetic patient's. But no statistically significant difference was found between the two groups. In conclusion, small incision cataract surgery with acryl foldable intraocular lens implantation showed good results in diabetic patients.Further studies will be needed for better clinical safety and efficacy.
Cataract
;
Diabetic Retinopathy
;
Fibrosis
;
Follow-Up Studies
;
Humans
;
Lens Implantation, Intraocular*
;
Lenses, Intraocular*
;
Phacoemulsification
;
Retrospective Studies
;
Traction
5.Corneal Endothelial Change after Clear Corneal Incision and Scleral Pocket Incision.
Sang Yeop LEE ; In Chul PARK ; Kyung Hun LEE
Journal of the Korean Ophthalmological Society 1998;39(12):2932-2937
We evaluate central endothelial cell loss(ECL) following phacoemulsification through a temporal sclera tunnel incision and temporal clear corneal incision. Seventy two eyes that had phacoemulsification surgery were divided into two groups. In group 1(n=41), a foldable silicone intraocular lens(IOL). was implanted through a 3.2mm sutureless clear corneal incision. In group 2(n-31), a 5.5mm sutureless scleral tunnel incision. Cell density of the corneal endothelium in all eyes was recorded preoperatively and 2 months postoperatively. and the percentage of endothelial cell loss was determinded. Percentage of endothelial cell loss were 8.37+/-7.5% in group 1, 6.61+/-7.1% in group 2. Phacoemulsification with 5.5mm scleral tunnel incisions produced slightlyless ECL than Phacoemulsification with 3.2mm clear corneal incisions. No statistically significant difference was observed among these two groups.
Cataract
;
Cell Count
;
Endothelial Cells
;
Endothelium, Corneal
;
Phacoemulsification
;
Sclera
;
Silicones
6.Mortality arter Treatment of Hip Fracture over 80 years old.
Jun Young CHOI ; Hwa Yeop NA ; Young Sang LEE ; Woo Yong LEE ; Jun Weon CHOI
Journal of the Korean Hip Society 2006;18(3):116-120
Purpose: The purpose of this study was to evaluate the mortality of patients over eighty years old with femoral neck fractures that have been treated with bipolar endoprostheses. Materials and Methods: We retrospectively studied 37 patients out of a total of 83, who suffered from hip fractures and were treated with surgery from 2000 through December 2004. We attempted to distinguish the differences between the 8 patients who died (Group A) and the 29 patients who lived (Group B). The variables that we analyzed, were: age, sex, operative time, the time period from admission to surgery, the time period from admission to discharge, the ASA score, and any medical comorbidities. Results: In Group A, 2 patients died within 1 month, 2 died between 1 and 6 months, 1 died between 6 and 12 months, and 3 died after 1 year. There were statistical differences between Group A and Group B with respect to two variables: the time period from admission to, and medical comorbidities. Conclusion: There were significant correlations with an increase in the mortality rate among patients with lung disease, female patients in general, and delays in surgery. Therefore, particular care should be paid to patients with these variables.
Comorbidity
;
Female
;
Femoral Neck Fractures
;
Hip Fractures
;
Hip*
;
Humans
;
Lung Diseases
;
Mortality*
;
Operative Time
;
Retrospective Studies
7.Use of the Levator Muscle as a Frontalis Sling in Monocular Elevation Deficiency.
Journal of the Korean Ophthalmological Society 2010;51(2):282-285
PURPOSE: For the correction of ptosis in monocular elevation deficiency (MED) patients, levator resection or frontalis sling operation with various materials has been used. The authors present a case of a monocular elevation deficiency patient who was treated for ptosis using the levator muscle as a frontalis sling. CASE SUMMARY: A six-year-old male patient with left monocular elevation deficiency underwent a frontalis sling operation using a levator muscle. The patient had received left inferior rectus recession, left medial rectus resection and left lateral rectus recession with transposition. An upper eyelid skin crease incision was made, and the anterior surface of the levator muscle was exposed as far as the Whitnall ligament. A levator muscle flap was then formed from aponeurosis by incising the full width of the levator horizontally, just below the Whitnall ligament and anchored to the frontalis muscle. The surgical result was satisfactory as the preoperative MRD1 was 0.5 mm and the postoperative MRD1 was 2.5 mm. There were no complications such as keratitis or wound problems. CONCLUSIONS: The levator muscle flap can be an effective frontalis suspension material to correct ptosis in an MED patient with poor levator function.
Eyelids
;
Humans
;
Keratitis
;
Ligaments
;
Male
;
Muscles
;
Skin
8.A Case of HELLP Synfrome Developed after Cesarean Section.
Sang Gi SEO ; Jae Ho LEE ; Yoon Seok YUM ; Chu Yeop HUH
Korean Journal of Perinatology 2000;11(3):349-353
No abstract available.
Cesarean Section*
;
Female
;
Pregnancy
9.An Anterior Approach to Entire Length of Humerus and to Distal Shaft for Fracture Fixation.
Chul Hyung LEE ; Hyun CHOI ; Tae In KIM ; Jun Beom KIM ; Sang Yeop SHIN ; Seung Koo RHEE
Clinics in Shoulder and Elbow 2016;19(4):223-228
BACKGROUND: The aim of study was to confirm the clinical effectiveness and results of wide and single anterior approach for fractures occurring along length of humerus. METHODS: A total of 23 patients with humeral fracture were enrolled into our study who were able to participate in at least one year of follow-up. Seven patients had segmental comminuted humeral fractures and 16 patients had distal humeral fractures. We made various tractions of the muscles to expose the proximal and the middle third humerus between the biceps and brachialis and the distal humerus by partial splitting of lateral side of biceps through a single incision. Postoperatively, we measured the Mayo elbow performance index (MEPI). RESULTS: we achieved bone union in all 23 patients. Solid union of the bone was achieved at an average 13.9 weeks. Postoperatively, two complications were observed screw loosening and nonunion. Revision surgery was performed in both patients. The patient with bone nonunion was treated using bone grafts. No postoperative infections or peripheral neuropathies were observed. At the final follow-up (average 20 months), we found that the average MEPI functional score of the patients was 91.7 points regardless of the fracture site. CONCLUSIONS: Our whole humerus with a single incision was effective for the treatment of segmental comminuted and distal fractures. we believe it is a useful alternative to preexisting methods of fracture fixation.
Elbow
;
Follow-Up Studies
;
Fracture Fixation*
;
Humans
;
Humeral Fractures
;
Humerus*
;
Muscles
;
Peripheral Nervous System Diseases
;
Traction
;
Transplants
;
Treatment Outcome
10.A Case of Malignant Glaucoma-like Phenomenon During Cataract Surgery.
Sang Yeop LEE ; Jong Woon PARK
Journal of the Korean Ophthalmological Society 2010;51(8):1150-1154
PURPOSE: Malignant glaucoma is a rare complication of anterior segment surgery. The authors present a case of a malignant glaucoma-like phenomenon during cataract surgery in a primary open-angle glaucoma (POAG) patient. CASE SUMMARY: A 74-year-old man with POAG underwent a cataract surgery in his left eye. After phacoemulsificiation, sodium hyaluronate was used to form the capsular bag for intraocular lens implantation. Following this procedure, the capsular bag space and anterior chamber became shallow. Intraocular pressure (IOP) elevated, and the shallowing of the anterior chamber and capsular bag space continued to a dangerous level. The surgical procedure was stopped and postponed for two days. After two days, IOL was successfully implanted in the posterior bag. CONCLUSIONS: Although the preoperative ophthalmologic examination failed to reveal a zonular problem, there was a possibility for a small area of zonular defect. A malignant glaucoma-like phenomenon was suspected to have occurred due to leakage of sodium hyaluronate or balanced salt solution into the vitreous through a small area of zonular dialysis. If a similar condition, occurs delayed surgery for IOL implantation would be more effective than vitrectomy or laser treatment.
Aged
;
Anterior Chamber
;
Cataract
;
Dialysis
;
Eye
;
Glaucoma
;
Glaucoma, Open-Angle
;
Humans
;
Hyaluronic Acid
;
Intraocular Pressure
;
Lens Implantation, Intraocular
;
Vitrectomy