No abstract available.
Child* ; Humans ; Tuberculosis, Renal*

BACKGROUND AND PURPOSE: A variety of sensory disturbances such as tingling, numbness, muscle cramp, pain and burning are recognized in Parkinson's disease. There is a hypothesis that sensory symptoms of Parkinson's disease could be related to "release" of sensory centers from extrapyramidal systems. We investigated the characteristic features of sensory symptoms in Parkinsonian patients and the possibilities that sensory symptoms may be related to dopaminergic pathways. METHODS: We included 130 patients with Parkinson's disease. The patients with medical illness such as diabetes, arthritis or musculoskeletal disease were excluded. We studied 38 Parkinsonian patients with sensory complaints using electrophysiologic studies and neuroimaging. RESULTS: 1) Thirty-eight(29.2%) of 130 Parkinsonian patients(mean age ; 57.9 +/- 10.1 ; 13 men, 25 women) had sensory symptoms. 2) Among thirty-eight Parkinsonian patients with sensory symptoms, 19 patients had pain, 10 tingling sensation, 3 burning sense, and 2 muscle cramp. 3) The arm and leg were most common sites for sensory symptoms 4) Sensory complaints preceded motor symptoms in 17 patients(21.1 +/- 19.1 months) and followed in 13 patients(26.7 +/- 41.9 months). 5) In 25 patients(66%), sensory symptoms were improved with levodopa. 6) There was no significant correlation between sensory symptoms and motor disabilities. CONCLUSIONS: Many Parkinsonian patients had various sensory complaints as well as motor symptoms. In some patients, sensory symptoms preceded motor disabilities. It was also suggested that sensory symptoms in some patients with Parkinson's disease be related to dopaminergic pathways.
Arm ; Arthritis ; Burns ; Humans ; Hypesthesia ; Leg ; Levodopa ; Male ; Muscle Cramp ; Musculoskeletal Diseases ; Neuroimaging ; Parkinson Disease* ; Sensation

PURPOSE: In Korea due to cultural background (food, life style) and environmental factors, type of obesity and previously defined operative indication is different from western country. Therefore, surgical procedure also must be applied differently under pattern of obesity. In this report we are trying to introduce our early results of laparoscopic sleeve gastrectomy without duodenal switch in Korean morbid obesity. METHODS: We retrospectively reviewed 60 consecutive patients who underwent laparoscopic sleeve gastrectomy between January 2003 and May 2004. Four 12mm ports and one 15mm port are placed. The sleeve gastrectomy was done as routine fashion using ligasure and endo-GIA stapler to create a lesser curve gastric tube over 48 French bougie. RESULTS: Excess weight loss was achieved in 71.6% during first six months postoperatively and 83.3% within 12 months. Body mass index (kg/cm2) was decreased average 9.2 during first 12 months postoperatively. Median weight loss at 12 months was 24.6 kg. Postoperative dyslipidemia was improved in 75% of patient within 12 months of operation. Diabetes as a co-morbidity was disappeared 100% of patient within 6 months postoperatively. Hypertension was disappeared in 92.9%, improved in 100% of patients within 12 months postoperatively. Arthritis and joint pain were improved 100% of patient within 12 months postoperatively. Weight loss plateaued at 12 months for the majority of patients. CONCLUSION: Additional studies and further follow up are needed to determine the best surgical treatment for Korean morbid obesity patient. However sleeve gastrectomy without duodenal switch operation can be an effective single weight loss procedure especially in Korea
Arthralgia ; Arthritis ; Body Mass Index ; Dyslipidemias ; Follow-Up Studies ; Gastrectomy* ; Humans ; Hypertension ; Korea ; Laparoscopy ; Obesity ; Obesity, Morbid* ; Retrospective Studies ; Weight Loss

PURPOSE: Obesity is a frequent cause of insulin resistance and poses a major risk for diabetes. The effects of sleeve gastrectomy on diabetes have not elucidated. This report documents that the sleeve gastrectomy provides control for diabetes, prior to significant body weight losses. METHODS: We retrospectively reviewed 14 type 2 diabetic patients who underwent laparoscopic isolated sleeve gastrectomy between May 2003 and October 2004. Fourteen patients had type 2 diabetes treated by oral hypoglycemic agents. Preoperative, 4 weeks and 3 months following surgery, all patients checked weight, body mass index(BMI), waist circumference, hip circumference, blood pressure, HbA1c and fasting glucose. RESULTS: Fourteen patients with a mean preoperative body mass index (BMI) of 39.1+/-4.2 kg/m2 (31.9~47.5 kg/m2) underwent laparoscopic sleeve gastrectomy. Changes in mean BMI were minimal (preop: 39.1+/-4.2 kg/m2, postop (4 week): 35.5+/-3.8 kg/m2), but there are significant decrease in blood fasting glucose (P<0.001), HbA1c (P<0.001), systolic blood pressure (P<0.001), diastolic blood pressure (P=0.009). Ten patient did not require medications after surgery (4 week), the other 4 patient stop the medications after surgery (3 month). CONCLUSION: Further evaluation is needed to analyze effect of sleeve gastrectomy in treating type 2 diabetes mellitus. But just with restrictive procedures as isolated sleeve gastrectomy also can control early type 2 diabetes mellitus in morbidly obese patients.
Blood Pressure ; Body Mass Index ; Body Weight ; Diabetes Mellitus, Type 2* ; Fasting ; Gastrectomy* ; Glucose ; Hip ; Humans ; Hypoglycemic Agents ; Insulin Resistance ; Obesity ; Obesity, Morbid* ; Retrospective Studies ; Waist Circumference

PURPOSE: In Asia, the types and the main causes of morbid obesity are different from those in western society. Therefore, the treatment plan should be different, and surgery for morbid obesity should be carefully chosen. The 3-year results for isolated laparoscopic sleeve gastrectomy (LSG) performedin the Korean population are reported. METHODS: We retrospectively reviewed 112 patients that underwent LSG from January 2003 to July 2006. Eighty-three of these patients had more than 3 years follow-up, and represent the subjects of this report. Sleeve gastrectomy was performed laparoscopicaly using the Endo-GIA stapler to create a lesser curve gastric tube over a 48-Fr bougie. RESULTS: The preoperative body mass index (BMI) was 36.4+/-5.2 (30.0~56.1). The mean excess BMI was 13.4+/-5.2. The percentage of excess weight loss (%EWL) in the postoperative first, second, and third year was 72.4+/-23.5, 69.5+/-29.4, and 66.8+/-33.4. The percentage of excess BMI loss (%EBMIL) was 74.1+/-25.6, 71.4+/-32.0, and 68.7+/-32.7. In 83 patients postoperatively after 3 years, 37 patients (44.6%) had >75% EBMIL, 22 patients (26.5%) had 50~75% EBMIL, 14 patients (16.9%) had 25~50% EBMIL, and 10 patients (12.0%) had less than 25% EBMIL. There was no 30-day peri-operative mortality. Two major complications (1 delayed bleeding, 1 leakage) occurred. CONCLUSION: LSG without the duodenal switch operation has been an effective single weight reducing surgical procedure thus far in most of the Korean patients.
Asia ; Body Mass Index ; Follow-Up Studies ; Gastrectomy* ; Hemorrhage ; Humans ; Korea ; Mortality ; Obesity, Morbid* ; Retrospective Studies ; Weight Loss

Purpose: Generally, morbid obesity has accompany with co-morbidities including dyslipidemia. Bariatric operation has shown various degree of effectiveness and different mechanism on weihgt loss. The effectiveness of sleeve gastrectomy in lipid profile is not revealed until now. Therefore, we have investigated and evaluated the efficacy of sleeve gastrectomy on weight loss and serum lipid profile. METHODS: We retrospectively reviewed 42 patients who underwent laparoscopic sleeve gastrectomy. All the patient was divided into two groups (group A (n=35): >50% excessive weight loss (EWL) in 6 months postoperatively, and group B (n=7): <50% (EWL)). Anthropometric Indices and serum lipid profile were measured before sleeve gastrectomy and postoperatively in 6 months. RESULTS: EWL of all the patients was 74.1+/-21.9% in 6 months postoperatively, group A was 80.4+/-18.2%, group B was 39.7+/-6.4%. Waist circumference, hip circumference, percent of body fat and visceral fat area were decreased in group A than B (P <0.05). Especially the visceral fat area of group A was reduced (-38.6%). Significant reduction of atherogenic index and triglyceride was observed (P <0.001) and increment of HDL cholesterol (P <0.001) was observed in both Groups. The moderate reduction of total cholesterol was observed in group A (P <0.05) but in not group B. LDL cholesterol level was mildly decreased but not statistically significant (group A: P=0.82, group B: P=0.746). Conclusion: Isolated vertical sleeve gastrectomy in morbid obesity patients is a effective surgical procedure. It offers excellent results in weight loss, anthropometric Indices and lipid profiles in short period of time. Eventually, it reduces the risk of coronary disease.
Adipose Tissue ; Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Coronary Disease ; Dyslipidemias ; Gastrectomy* ; Hip ; Humans ; Intra-Abdominal Fat ; Obesity, Morbid* ; Retrospective Studies ; Triglycerides ; Waist Circumference ; Weight Loss

The oocyte quality is of great importance in infertility as it reflects the follicle developmental potential and further affects the embryo development, clinical pregnancy outcomes. The analysis of gene expression in somatic cells is an important study to better clinical in vitro fertilization (IVF) outcomes in embryo selection reflecting the appropriate communication between the oocyte and somatic cells. Specifically, somatic cell transcriptomic technology can help assess biomarkers of oocyte and embryo ability. The present article aims to overview the basic aspect of folliculogenesis and review studies involving changes in candidate gene expression of cumulus or granulosa cell related to clinical outcomes in human IVF.

The oocyte quality is of great importance in infertility as it reflects the follicle developmental potential and further affects the embryo development, clinical pregnancy outcomes. The analysis of gene expression in somatic cells is an important study to better clinical in vitro fertilization (IVF) outcomes in embryo selection reflecting the appropriate communication between the oocyte and somatic cells. Specifically, somatic cell transcriptomic technology can help assess biomarkers of oocyte and embryo ability. The present article aims to overview the basic aspect of folliculogenesis and review studies involving changes in candidate gene expression of cumulus or granulosa cell related to clinical outcomes in human IVF.

OBJECTIVES: To report on the skin discoloration experienced by three workers handling 2 , 5 -hexanedione METHODS: Three workers, who showed orange-brown discoloration of the palms during observation under the Kumi occupational disease surveillance system, had their history evaluated and underwent physical examination. A workplace survey was performed by an occupational physician and an industrial hygienist. RESULTS: The three workers were determined to have been experiencing skin discoloration since the introduction of a new cleaning solvent. The new solvent contained 2,5-hexanedione, which is reported in the literature to be possibly capable of causing orangebrown discoloration of the skin. After discontinuation of solvent use, the workers recovered within a week. CONCLUSIONS: These cases demonstrate that 2,5-hexanedione can produce skin pigmentation.
Gyeongsangbuk-do ; Occupational Diseases ; Physical Examination ; Skin Pigmentation* ; Skin*

Intrathecal administration of methotrexate(IT-MTX) has constituted the standard approach to prophylaxis and treatment of central nevous system(CNS) leukemia. We experienced a quadriplegia and motor aphasia in a 14-year-old boy following repeated IT-MTX for the prophylaxis of meningeal leukemia. He was diagnosed as ALL without CNS involvement and treated by CCG- 1882 protocol. IT-MTX was administered for CNS prophylaxis. The patient began complaining of urinary incontinence, motor aphasia and weakness in his right leg from 12 days after the 5th dose of the IT-MTX therapy. Even though the IT-MTX was discontinued, loss of muscle power progressed upward resulting in quadriplegia. The patient showed slow and partial recovery on right extremities over 3 months. We report this case with brief review of literature.
Adolescent ; Aphasia, Broca* ; Extremities ; Humans ; Leg ; Leukemia ; Male ; Methotrexate* ; Quadriplegia* ; Urinary Incontinence