No abstract available.
Breast* ; DNA* ; Proliferating Cell Nuclear Antigen*

Linear focal elastosis was first described by Burket et al. in 1989 in three elderly men with palpable striae-like yellow bands on their backs. Microscopic examination revealed many fine wavy bundles of elastic fibers separating the collagen in the mid to reticular dermis. The patients' ages range a from 17 to 87 years but this disease seems to be more common in younger age; men are more commonly affected. The cause of this disease has been suggested to be hereditary predisposition, unusual form of striae distensae or keloidal repair of striae distensae. We report linear focal elatosis with typical clinical and pathological features in a 15-year-old boy.
Adolescent ; Aged ; Collagen ; Dermis ; Elastic Tissue ; Humans ; Keloid ; Male ; Striae Distensae

STUDY DESIGN: This study analyzes the results of selective thoracic fusion by segmental pedicle screw fixation in King type II adolescent idiopathic scoliosis(AIS). OBJECTIVES: To verify the efficacy of selective thoracic fusion by segmental pedicle screw fixation in King type II adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Decompensations following selective thoracic fusion in King type II adolescent idipathic scoliosis have been attributed to relative inability of the lumbar curves to accommodate correction of the thoracic curves. However, with segmental pedicle screw fixation, selective thoracic fusions yielded satisfactory results in most of the patients regardless of the lumbar curve characteristics. MATERIALS AND METHODS: Eighty patients subjected to selective thoracic fusion by segmental pedicle screw fixation were analyzed after a minimum follow-up of 2 years for deformity correction and spinal balance. Deformity correction was performed by derotation of rod contoured to the normal sagittal curve without additional compression or distraction. RESULTS: Mean preoperative thoracic curve of 53.3 was corrected to 20.3 showing a correction of 63.2%. The mean preoperative lumbar curve was 34.4 with a flexibility of 97.2% and mean lumboapical distance(LAD)of 18.0mm, L4 tilt of 8.0, and lumbar apical rotation (LAR) of 10.9. It was corrected to 16.5 showing a correction of 55.5%. All the patients were balanced clinically and radiologically. CONCLUSIONS: Selective thoracic fusion with segmental pedicle screw fixation and rod rotation offers a satisfactory correction of the deformity and maintenance of spinal balance in King type g AIS regardless of lumbar curve magnitude, LAD, L4 tilt or LAR.
Adolescent* ; Congenital Abnormalities ; Follow-Up Studies ; Humans ; Pliability ; Scoliosis*

The employment of segmental pedicle screw instrumentation has greatly enhanced the correction of scoliotic deformity. However there is still much controversy on the ability of the system to correct the rotational deformity. This prospective study with 12 idiopathic throacic scoliosis patients subjected to segmental pedicle screw instrumentation was performed to determine the effect of the system on the rotational deformity of idiopathic throacic scoliosis. In addition to the standing films to measure the magnitude of scoliotic curvatures, preand postoperative CT were utilized for the measurement and comparison of angle of rotation relative to the sagittal plane(RAsag.), relative rotation with reference to the upper and lower end vertebrae(RAend), relative rotation with reference to the sacrum(RAsac.), frontal translation(TF) and sagittal translation(TS) for the apical vertebrae. Despite the high correction rate obtained in the frontal plane(average 71.1%) and normalization of sagittal contour, the rotational corrections were statistically insignificant in all parameters and showed no significant correlation to the correction of the curvatures nor horizontal plane displacement as represented by the frontal and sagittal displacement. In conclusions, the segmental pedicle screw instrumentation with rod derotation does not produce significant derotation by itself.
Congenital Abnormalities ; Employment ; Humans ; Prospective Studies ; Scoliosis* ; Spine

Objective: This study aimed to investigate the impact of reduced bed capacity in the intensive care unit (ICU) on emergency department (ED) length of stay (LOS) and prognosis of critically ill patients. Methods: This retrospective observational study included patients who presented to a university hospital ED and were admitted to the ICU between August 2017 and July 2019. In our center, the number of beds in the traumatic ICU was maintained, while the number of beds in the non-traumatic ICU was reduced. We comparatively assessed ED LOS and the mortality rate between traumatic and non-traumatic patients over 2 years (1 year before and after the reduced number of beds in the non-traumatic ICU) to determine the impact of reduced ICU bed capacity. Also, a multivariate logistic regression analysis was performed to identify the risk factors related to in-hospital mortality. Results: A total of 2,945 patients were included in this study. In the traumatic ICU patient group, the ED LOS did not change (2.62 [1.95-3.72] hours vs. 2.78 [2.01-3.92] hours, P=0.079) after reducing the number of ICU beds; and no significant difference in mortality rate was noted (19.5% vs. 17.6%, P=0.417). In the non-traumatic ICU patient group, both ED LOS (prolonged by 1.69 hours, 3.46 [2.17-5.66] hours vs. 5.15 [3.43-8.37] hours, P<0.001) and mortality rate (21.6% vs. 25.8%, P=0.003) were significantly increased after reducing the number of ICU beds. In the multivariate logistic regression analysis, ED LOS was identified as a risk factor for in-hospital mortality (odds ratio, 1.035; P<0.001). Conclusion In this study, the reduced ICU bed capacity resulted in prolonged ED LOS of critically ill patients, which consequently contributed to increased in-hospital mortality.

Objective: This study aimed to investigate the impact of reduced bed capacity in the intensive care unit (ICU) on emergency department (ED) length of stay (LOS) and prognosis of critically ill patients. Methods: This retrospective observational study included patients who presented to a university hospital ED and were admitted to the ICU between August 2017 and July 2019. In our center, the number of beds in the traumatic ICU was maintained, while the number of beds in the non-traumatic ICU was reduced. We comparatively assessed ED LOS and the mortality rate between traumatic and non-traumatic patients over 2 years (1 year before and after the reduced number of beds in the non-traumatic ICU) to determine the impact of reduced ICU bed capacity. Also, a multivariate logistic regression analysis was performed to identify the risk factors related to in-hospital mortality. Results: A total of 2,945 patients were included in this study. In the traumatic ICU patient group, the ED LOS did not change (2.62 [1.95-3.72] hours vs. 2.78 [2.01-3.92] hours, P=0.079) after reducing the number of ICU beds; and no significant difference in mortality rate was noted (19.5% vs. 17.6%, P=0.417). In the non-traumatic ICU patient group, both ED LOS (prolonged by 1.69 hours, 3.46 [2.17-5.66] hours vs. 5.15 [3.43-8.37] hours, P<0.001) and mortality rate (21.6% vs. 25.8%, P=0.003) were significantly increased after reducing the number of ICU beds. In the multivariate logistic regression analysis, ED LOS was identified as a risk factor for in-hospital mortality (odds ratio, 1.035; P<0.001). Conclusion In this study, the reduced ICU bed capacity resulted in prolonged ED LOS of critically ill patients, which consequently contributed to increased in-hospital mortality.

BACKGROUND: Some studies has showed that even though reperfusion is essential for the recovery of renal function, it, itself, might be caused of renal injury through liberation of oxygen free radical due to surplus oxygen following reperfusion. If it is so, it can be presumed that oxygen free radical scavenger during reperfusion might be useful drugs to protect renal injury during reperfusion. On the base of this hypothesis, we selected prostaglandin E1 (PGE1) which is vasodilator and cellular protector which act through decreased demand of ATP and N-acetyl-L-cystein (NAC) which is oxygen radical scavenger for the purpose to see oxygen free radical scavenger related drugs will work on protection from renal injury during reperfusion. MATERIALS AND METHODS: To define the efficacy of these drugs, It was evaluated by a serial check of the serum creatinine level, and pathologic change on the light microscopy. And also to investigate the role of HSP 70 and HSP 72 on reperfusion injury, immunohistochemical study and Western blot analysis were performed on the experiment rats. The experimental ischemic renal model was made by clamping hilum of both kidney for 60 minutes on Wistar male rats. After declamping, PGE1, NAC and saline through a tail vein: PGE1 35 microgram/kg/hr, NAC 6 mM/kg/hr and 0.9% saline 1 ml/kg/hr were infused for 60 minutes and then blood samples were obtained from IVC at 1st hour, 2nd hour, 1st day hour, 2nd day and 5th day after reprefusion for creatinine. RESULTS: The serum creatinine was normalized in group receiving PGE1 at 5th day after reperfusion. But creatinine was not normalized in group receiving saline and NAC at 5th day after reperfusion: serum creatinine at 5th day after reperfusion were 0.58 0.08 mg/dl in group receiving PGE1, 2.85 0.65 mg/dl in group receiving saline and 2.96 0.51 mg/dl in group receiving NAC. There was expression of HSP 72 in group receiving PGE1 at 5th day after reperfusion. But not in group receiving NAC and saline at 5th day after reperfusion. It was noted to have prominent expression of HSP 70 in renal cortex in group receiving PGE1 at 2nd and 5th day. On contrary, there were prominent expression of HSP 70 in renal cortex in group receiving NAC at 1st and 2nd hour. CONCLUSION: It is clear that PGE1 has a protective effect for ischemic renal reperfusion injury by showing early regeneration of renal tubule, persistent expression of HSP 72 and HSP 70 and normalization of serum creatinine at 5th day after reperfusion.
Acetylcysteine* ; Acute Kidney Injury ; Adenosine Triphosphate ; Alprostadil* ; Animals ; Blotting, Western ; Constriction ; Creatinine ; Humans ; Kidney ; Male ; Microscopy ; Oxygen ; Rats* ; Regeneration ; Reperfusion Injury* ; Reperfusion* ; Veins

Docetaxel is a new taxoid antineoplastic drug widely used for advanced breast cancer , ovarian cancer . Skin and nail toxicity are one of the more frequent nonhematologic adverse reactions. Especially, nail changes include dark pigmentation, subungual hemorrahage, acute paronychia, onycholysis, Beau s line etc. We have observed a striking example of multiple Beau s lines from all fingernails and toenails in a man receiving a docetaxel infusion for treatment of metastatic cancer with unknown-origin.
Breast Neoplasms ; Nails ; Onycholysis ; Ovarian Neoplasms ; Paronychia ; Pigmentation ; Skin ; Strikes, Employee

OBJECTIVES: To analyze the findings of rectal intussusception and to find the other accompanied functional anorectal diseases. MATERIALS AND METHODS: We analyzed defecograms in 25 patients with rectal intussusception among 77 patients taken with obstructed defecatory symptom. Females were 16 (64%), males were 9 (36%), and the mean age was 55 years old. The changes of anorectal angle (ARA) and movement of anorectal junction were measured, and the morphologic changes of rectal wall during defecation were analyzed. RESULTS: ARAs measured by central axis method (CAM), the mean angles were 114.6, 102.2, and 119.8 degree, respectively in resting, squeezing, and straining period. By posterior wall methods (PWM), those were 86.7, 72.0, 93.3 degree. The differences of ARA between resting and straining period were 5.2, 6.6 degree, respectively by CAM and PWM. The mean descent of anorectal junction during defecation was 0.83 cm. The most frequent finding associated with rectal intussusception was rectocele (12 cases;48%). The other accompanied findings were 9 spastic pelvic floor syndrome (36%) and 4 fecal incontinence (16%). Total 18 patients out of 25 patients were accompanied with other functional anorectal diseases (72%). CONCLUSIONS: Recognition of rectal intussusception with accompanied diseases would be important for the proper treatment planning.
Axis, Cervical Vertebra ; Defecation ; Fecal Incontinence ; Female ; Humans ; Intussusception* ; Male ; Middle Aged ; Muscle Spasticity ; Pelvic Floor ; Rectocele

OBJECTIVES: To analyze the findings of rectal intussusception and to find the other accompanied functional anorectal diseases. MATERIALS AND METHODS: We analyzed defecograms in 25 patients with rectal intussusception among 77 patients taken with obstructed defecatory symptom. Females were 16 (64%), males were 9 (36%), and the mean age was 55 years old. The changes of anorectal angle (ARA) and movement of anorectal junction were measured, and the morphologic changes of rectal wall during defecation were analyzed. RESULTS: ARAs measured by central axis method (CAM), the mean angles were 114.6, 102.2, and 119.8 degree, respectively in resting, squeezing, and straining period. By posterior wall methods (PWM), those were 86.7, 72.0, 93.3 degree. The differences of ARA between resting and straining period were 5.2, 6.6 degree, respectively by CAM and PWM. The mean descent of anorectal junction during defecation was 0.83 cm. The most frequent finding associated with rectal intussusception was rectocele (12 cases;48%). The other accompanied findings were 9 spastic pelvic floor syndrome (36%) and 4 fecal incontinence (16%). Total 18 patients out of 25 patients were accompanied with other functional anorectal diseases (72%). CONCLUSIONS: Recognition of rectal intussusception with accompanied diseases would be important for the proper treatment planning.
Axis, Cervical Vertebra ; Defecation ; Fecal Incontinence ; Female ; Humans ; Intussusception* ; Male ; Middle Aged ; Muscle Spasticity ; Pelvic Floor ; Rectocele