Alopecia areata(AA) is a common dermatologic disease, the origin of which is still unknown. At least, it has been associated with some genetic influences in the etiopathogenesis. We have now evaluated AA patients to study the actual association of the genetic role by fingerprint analysis. The incidences of six or more arches were determined in 74 female and 86 male patients excluding alopecia totalis and universalis, and in healthy 167 female controls, based on Selmanowitz's thesis (1974). The results of this study are follows: 1. The difference between the frequency in AA patients(7. 5%) and in controls (3.3%) reaches the statistical significance(p<0.05 by x2-test). 2. The association of genetic background in AA is strengthened in the group of female patients(p<0. 01), recurrent episode(p<0.01). and multiplex farm (p<0.01). 3. Twenty patients(12. 5%) have family history. The incidence in 3(15.0%) of these patients is considerably common but not statistically significant. A correlation of biologic relevance and family predisposition in AA is not precluded. 4. The frequency of arches in patients and in controls is increased on both second fingers and decreased on both fourth fingers. It is more common on both second and left third fingers in female patients. The incidence of arches averages about 6 67% in patients and 4. 58% in controls.
Alopecia Areata* ; Alopecia* ; Dermatoglyphics* ; Female ; Fingers ; Humans ; Incidence ; Male

A mating study was performed by crossing 333 isolates of Trichophyton mentugrophytes with+and tester strains of Arthroderma vanbreuseghemii, A. benhamiae and A. simit from January 1980 to December 1983 Three hundred and thiirteen were compatible with A. vanbreuseghemri consisting of 167 of+type and 146 of type and twenty were indeterminate. The cleistothecia formed by crossing the isolates with tester strains of A. vanbreaseghemii were fewer in number and smaller in size than those of tester strains. The sexual dogeneration was observed in all of the isolates compared with tester strains. The colonial morphological features of the isolates of T. mentagrophytes were observed as 24p isolates of the granulosum-asteroides form, 66 of the powdery form and 7 of the downy form on 1/10 Sabouraud agar with salts in culture. The mat- ing type showed the higher type in the granulosumasteroides forrn and + type in the powdery and downy forms. The + type increased from 1981 to 1983, and the type showed a marked increase in 1983. The + type was predominant in tinea pedis et unguim and tinea cruris, and type in tinea faciale and tinea manuurn. The + type showed nearly equal incidence in the spring, winter and summer, and the lowest in the autumn, compared to the highest in the winter and the lowest in the summer in the type.
Agar ; Arthrodermataceae ; Incidence ; Salts ; Tinea ; Tinea Pedis ; Trichophyton*

Microsporurn canis was fjrst reportaR m Korea in 1957, but no animal contacts were reported and since then, only sporadic occurrences of M. canis have reported. However, cat and human infections from M. canis have gradually become rnore prevalent lately. Recently author reported 3 cases of T. capitis, 2 cases of Kerion Celsi, 13 cascs of T. e,orporis in human and 4 cases of infected kittens, with M. canis isolated as the causative organisrn. Clinical and mycological observations of both patients and kittens were reported as follows: The infections with M. canis were exclusively reported in kittens, not in adult cats. Two of the infected kittens showed obvious signs of undernourishment, physical retardation and prostration. Infectivity among cats or kittens was very low while cat to human infectivity was very high. The human T. capitis exhibited. round, erythematous lesions with complete 1oss of hair, very similar to lesions of alopecia areata, These lesions were uniformly smaller than a walnut in size. The T. corporis exhibited typical, moderately inflamed ringshaped, singular or multiple lesions. The incubation period was estirnated at approximately 3-7 days. In humans, ectothrix growth was reported while the opposite endothrix growth was observed in the kitten and rabbit. Experimental animal inoculations were performed: Rabbit inocuIated with M. can- is resulted in typical ringshaped Iesions appearing 10 days after inoculation. T4ese lesians were cornpletely gone in 4 weeks but infected hairs still remained. Guinea pig inoculation resultel in non-typical lesions covered with serosanguinous crusts, but rat inoculztion showed no signs of infectivity.
Adult ; Alopecia Areata ; Animals ; Cats ; Guinea Pigs ; Hair ; Humans ; Juglans ; Korea ; Microsporum* ; Rats ; Tinea Capitis

Non-lymphatic sporotrichosis is more difficult in diagnosis, lower in incidence and more variable in clinical picture than the classical lymphatic one. A case of non-lymphatic type affecting a female baby aged 2 months is presented, The patient has been suffering from the shallow ulcerated, crusted impetiginous lesian on the cheek area just below the right eye. The lesion has developed progreasively since about 1 month after birth. Clinically, its diagnosis was not easy, but was confirmed by culture on Sabouraud's media. It is thought that the age of initial onset in this case we experienced, is the lowest in recorded Korean literature.
Cheek ; Diagnosis ; Female ; Humans ; Incidence ; Parturition ; Sporotrichosis ; Ulcer

We report herein a case of polymorphic pemphigoid in a 65-year-old woman, who had one-year history of generlized polymorphic eruption with intensely pruritic excoriated vesicobiullous lesions and residual pigmentation. Face and oral mucosa were spared. The skin biopsy specimen showed a subepidermal blister containing many eosinophils. Linear deposition of 1gG and C3 along the basement membrane was noticed on direct irnmunofluorescerice. Polyclonal garnmopathy with a tendency of beta-gamma bridging and increased IgG, IgA and kappachain, was frund on serum protein electrophoresis and immunoelectrophoresis. Skin lesions were well coritrolled by a combined therapy of prednisolone(20 mg/d), dapsone(100 mg/d) and cyclophosphamide(100 mg/d) for 4 months. Direct immunofluorescence performed 11 rnonths after the cnmpletion of the therapy was negative.
Aged ; Basement Membrane ; Biopsy ; Blister ; Electrophoresis ; Eosinophils ; Female ; Fluorescent Antibody Technique, Direct ; Humans ; Immunoelectrophoresis ; Immunoglobulin A ; Immunoglobulin G ; Mouth Mucosa ; Pemphigoid, Bullous* ; Pigmentation ; Skin

No abstract available.
Denture, Partial, Fixed*

We experienced a case of granulation tissue occuring in lateral sulci of the right thumb, index, middle and left thumb, middle finger nails in 71-year-old psoriatic male patient taking 5pmg daily(0.6mg/kg/day) during 4th week of etretinate therapy. The excision of the granulation lesion and partial nail ablation was performed and his doses was lowered to 25mg daily (0. 3mg/kg/day). The condition were resolved with no recurrence 4 weeks later after the operation.
Acitretin* ; Aged ; Etretinate* ; Fingers ; Granulation Tissue* ; Humans ; Male ; Nails ; Recurrence ; Thumb

Dermstomyositis is a disease mainly of the skin, muscle and blood vessels in which erythematous and edematous changes in the skin are associated with muscle weakneas and inflammation. In adult the disease is commonly associated with underlying malignancy or reticulosis. A 23 year-old male had generalized weakness, intermittent fever, myalgia and purplish red patches on the face. Diagnosis of dermatomyositis was established by clinical manifestations, electromyogram, histologic findings of skin and muscle. He was treated with systemic steroid, with some improvement. Seven months after the onset of dermatomyositis, ecchymoses was noted on the eyelids and forearms. Bone marrow aspiration showed many immature lymphoblasts, characteristic of acute lymphocytic leukemia, He was treated with systemic steroid and vincristine, but no favorable effect was noted. He died of sepsis due to retal abscess on the 34th day in the hospital
Adult ; Male ; Female ; Humans

No abstract available.
Hepatitis B virus* ; Hepatitis B* ; Hepatitis*

No abstract available.
Hepatitis B virus* ; Hepatitis B* ; Hepatitis*