1.The significance of DNA content, histological grades, cathepsin-D, and PCNA in advanced breast cancers.
Jeoung Won BAE ; Hee Sang KIM ; Cheung Wung WHANG
Journal of the Korean Surgical Society 1993;45(5):633-644
No abstract available.
Breast*
;
DNA*
;
Proliferating Cell Nuclear Antigen*
2.A Case of Plexiform Neurofibroma of the Right Upper Eyelid and Orbit in Neurofibromatosis.
Dong Seok KIM ; Sang Won KIM ; Han Ik BAE
Korean Journal of Dermatology 1986;24(5):734-738
We have experienced a case of plexiform neurofibrorna of the right upper eyelid and orbit in a 12-year-old girl who had typical skin features of neurofibromatosis and no family history. The non-pulsating proptosis of the right eye and diffuse thickening with hypertrophy of the upper lid, had increased insiduciusly since the birth on. Biopsy taken from eyelirl lesion showed the features of plexiform neurofibroma. Skull X-ray and brain computerized tomogram showed that the right orbit was wider, with the enlarged mass and defects in orbital roof and lesser and greater wings of the sphenoid bone. The surgical excision of the right eyelid lesion was performed.
Biopsy
;
Brain
;
Child
;
Exophthalmos
;
Eyelids*
;
Female
;
Humans
;
Hypertrophy
;
Neurofibroma, Plexiform*
;
Neurofibromatoses*
;
Orbit*
;
Parturition
;
Skin
;
Skull
;
Sphenoid Bone
3.Modulatory effects of the fruits of Tribulus terrestris L. on the function of atopic dermatitis-related calcium channels, Orai1 and TRPV3
Nam Hyun Joo ; Jung Won Hyo ; Chin Young-Won ; Kim Kyung Woo ; Bae Sang Hyo
Asian Pacific Journal of Tropical Biomedicine 2016;6(7):580-585
Objective: To examine the effects of Tribulus terrestris L. (T. terrestris) extract on the modulation of calcium channels to evaluate its use in topical agents for treatment of atopic dermatitis. Methods: The 70% methanol extract of T. terrestris was prepared. Human HEK293T cells with over-expressed calcium release-activated calcium channel protein 1 (Orai1), transient receptor potential vanilloid 1, or transient receptor potential vanilloid 3 (TRPV3) were treated with T. terrestris extract. Modulation of ion channels was measured using a conventional whole-cell patch-clamp technique. Results: T. terrestris extract (100 mg/mL) significantly inhibited Orai1 activity in Orai1-stromal interaction molecule 1 co-overexpressed HEK293T cells. In addition, T. terrestris extract significantly increased the TRPV3 activity compared with 2-Aminoethyl diphe-nylborinate (100 mmol/L), which induces the full activation of TRPV3. Conclusions: Our results suggest that T. terrestris extract may have a therapeutic po-tential for recovery of abnormal skin barrier pathologies in atopic dermatitis through modulating the activities of calcium ion channels, Orai1 and TRPV3. This is the first study to report the modulatory effect of a medicinal plant on the function of ion channels in skin barrier.
4.Application of Gait Analysis to the Patients with Cervical Myelopathy.
Sang Won YOON ; Seung Chul RHIM ; Sung Woo ROH ; Jong Youn YU ; Sang Bae HA
Journal of Korean Neurosurgical Society 2000;29(4):528-535
No abstract available.
Gait*
;
Humans
;
Spinal Cord Diseases*
5.The association of Vitamin D and Parathyroid Hormone with Bone Mineral Density in Korean Postmenopausal Women.
Won Cheol CHANG ; In Soon KWON ; Byung Joo PARK ; Sang Hoon BAE ; Sang Chul PARK
Journal of the Korean Geriatrics Society 2003;7(3):194-205
BACKGROUND: Osteoporosis results from bone loss due to menopause [estrogen(E) deficiency] and aging. Initial skeletal effect of menopause is accelerated bone resorption with an increase in seurm calcium(Ca) and compensatory but inadequate bone formation. Secretion of parathyroid hormone(PTH) is suppressed at this time. Postmenopausal osteoporosis results in fractures predominantly of trabecular bone, i.e., vertebra. With aging, secondary hyperparathyroidism by low serum Ca and vitamin D deficiency superim poses. Senile osteoporosis produces hip fractures, area of cortical bone. The aim of this study was to- examine the association of vitamin D[25(OH)D] and intact(i) PTH with bone mineral density(BMD) after controlling for suggested confounding factors, and the possibility of low serum vitamin D and high serum iPTH concentration could impact bone loss in Korean postmenopausal women. METHODS: Data from 188 postmenopausal Korean women aged 42 to 69 were analyzed through BMD, serum 25(OH)D, iPTH, Ca, phosphorus(P), alkaline phosphatase(ALP) and clinical characteristics. Factors affecting BMD was determined by Pearson correlation and the relationship between lumbar and femoral neck BMD and vitamin D[25(OH)D] and iPTH was assessed by multiple regression analysis after adjus- ting for suggested confounding factors. RESULTS: Lumbar and femoral neck BMD, serum Ca, P were decresaed and serum iPTH was increased with aging. In Pearson`s correlation, significant contributing factors to lumbar BMD was age, height, weight, menarche, year since menopause(YSM) and ALP. And significant contributing factors to femoral neck BMD was age, height, weight, menarche, YSM and iPTH. No relationship could be demonstrated between serum vitamin D[25(OH)D] and lumbar and femoral neck BMD. How ever, after controlling for potential confounding factors, a correlation was found between vitamin D[25(OH)D] and both of lumbar (p=0.013) and femoral neck BMD(p=0.077). iPTH was inversely related to femoral neck BMD(p=0.004) only in multiple linear regression. CONCLUSION: Serum vitamin D[25(OH)D] was influencing both of vertebral and femoral neck BMD, which suggests a significant role of vitamin D deficiency in the pathogenesis of postmenopausal osteo- porosis. In age related remodeling and loss of bone, increased serum iPTH might have additive role in cortical bone of femur. These findings suggest that vitamin D is very important for optimal bone health and a deleterious effect of increased iPTH on cortical bone loss. Adequate calcium and vitamin D status have to be maintained to prevent osteoporosis in postmenopausal Korean women.
Aging
;
Bone Density*
;
Bone Resorption
;
Calcium
;
Female
;
Femur
;
Femur Neck
;
Hip Fractures
;
Humans
;
Hyperparathyroidism, Secondary
;
Linear Models
;
Menarche
;
Menopause
;
Osteogenesis
;
Osteoporosis
;
Osteoporosis, Postmenopausal
;
Parathyroid Hormone*
;
Spine
;
Tolnaftate
;
Vitamin D Deficiency
;
Vitamin D*
;
Vitamins*
6.A case of acute megakaryoblastic leukemia with chloroma in infant.
Jin Seop SHIM ; Hye Kyeong NAM ; Won Suk SUH ; Sang Man SHIN ; Sang Jhoo LEE ; Won Bae KIM
Korean Journal of Hematology 1991;26(1):201-208
No abstract available.
Humans
;
Infant*
;
Leukemia, Megakaryoblastic, Acute*
;
Sarcoma, Myeloid*
7.A Case of Transient Acantholytic Dermatosis.
Sang Bae LEE ; Baik Kee CHO ; Won HOUH ; Dae Gyoo BYUN
Korean Journal of Dermatology 1988;26(2):226-230
We report herein a case of transient acantholytic dermatosis. The patient was a 24-year-old pregnant woman in the last trimester, who had pruritic, discrete, erythematous or brownish papules on the lateral aspect of the neck. Histopathologic findings of the skin lesion showed changes resembling Darier's disease showing well circumseribed, small foci of acantholysis with acantholytic and dyskeratotic cells over the suprahasal clefts. The patient showed good response to isotretinoin(Roaccutane) therapy, 20mg/day, for 30 days.
Acantholysis
;
Darier Disease
;
Female
;
Humans
;
Neck
;
Pregnancy
;
Pregnancy Trimester, Third
;
Pregnant Women
;
Skin
;
Skin Diseases*
;
Young Adult
8.A Case of Xeroderma Pigmentosum with Various Skin Tumors.
Sang Bae LEE ; Gun Bok LEE ; Baik Kee CHO ; Won HOUH
Korean Journal of Dermatology 1988;26(2):206-211
A 24-year-old female was seen with multiple, pinkish to skin colored and brownish to black pigmented macules, papules, patch and plaque on the face, neck, upper chest, extensor surface of both forearms and dorsal hands. Histopathological diagnoses from the 75 skin biopsy specimens taken during the follow-up period of 22 months include 29 skin tumors : one malignant melanoma, one precancerous melanosis, 16 basal cell carcinamas, four squamous cell carcinomas, four actinic keratoses, one melanoacanthoma, one keratoacanthoma and one angiofibroma. It was discussed that melanoacanthoma would be considered as the one of the associated beniign skin tumors in xeroderma pigmentosum.
Angiofibroma
;
Biopsy
;
Carcinoma, Squamous Cell
;
Diagnosis
;
Female
;
Follow-Up Studies
;
Forearm
;
Hand
;
Humans
;
Ichthyosis*
;
Keratoacanthoma
;
Keratosis, Actinic
;
Melanoma
;
Melanosis
;
Neck
;
Skin*
;
Thorax
;
Xeroderma Pigmentosum*
;
Young Adult
9.Bacteriolysis and variation on the O-side chain lengths of lipopolysaccharides of salmonella typhi Ty21a with respective to the concentrations of galactose.
Jong Bae KIM ; Won Yong LEE ; Sang Hee PARK ; Min Kyung LIM ; Jin Yuen CHANG
Journal of the Korean Society for Microbiology 1992;27(5):419-425
No abstract available.
Bacteriolysis*
;
Galactose*
;
Lipopolysaccharides*
;
Salmonella typhi*
;
Salmonella*
10.Contralateral Vesicoureteral Reflux in Children with Abnormal Unilateral Renal Development.
Sung Wook OH ; Jae Seung LEE ; Myoung Jun KIM ; Sang Won HAN ; Ki Soo BAE
Journal of the Korean Society of Pediatric Nephrology 1997;1(1):53-59
A total of 48 cases of tuberculous lesion in the lymph nodes (43 cases), lung (3 cases) and soft tissue (2 cases), was subjected to fine needle aspiration cytology(FNAC). The age of the patients ranged from 19 to 77 year-old (average 33.6 years in age) and the male to female ratio was 1: 4. Thirty-four cases (70.8%) demonstrated distinct granulomatous reaction with or without caseation necrosis, nine cases (18.8%) showed no granulomas, but large amount of necrotic debris with numerous polymorphonuclear cells and histiocytes, and five cases (10.4%) revealed acellular material only. The overall AFB positivity in smears was 62.5%. In areas associated with granulomatous reaction and necrosis, AFB positivity was 55.8%, while it was 80.0% in cases with acellular necrotic material. There were 2 cases of parasitic infestation which could not be easily differentiated from tuberculosis based on aspiration smears only.
Aged
;
Biopsy, Fine-Needle
;
Child*
;
Female
;
Granuloma
;
Histiocytes
;
Humans
;
Lung
;
Lymph Nodes
;
Male
;
Necrosis
;
Tuberculosis
;
Vesico-Ureteral Reflux*