The Tripamide(Normonal(R)) is a new derivative of nonthiazide diuretic and hypotensive drug which was claimed to have less side effects than thiazide derivatives. Authors studied on the effect of Tripamide in 30 cases of hypertension. The 15mg of Tripamide daily as single dose was given for the period of 6 weeks and in each week, the blood pressure in sitting position was measured and also checked symptoms and side effects. In 13 cases which were not responded to 15mg, daily dose of 30mg were given. In 13 cases, Hb, Hct, blood sugar, serum uric acid, Na, K, Cl, GOT, GPT and creatinine were measured before and after the 6 week medication. Following results were obtained; 1) After one week medication of Tripamide 15-30mg daily, the hypotensive effect(B.P. more than 5 mmHg decrease) appeared in 83.3% of cases in systolic pressure and 76.7% in diastolic pressure. The marked decrease(more than 20 mmHg) of systolic pressure in 60% and of diastolic pressure in 33.3% of cases. The over-all average systolic and diastolic pressure decreased by 18.7/7.6 mmHg. 2) There were no statistically significant changes of Hb, Hct, fasting blood sugar, uric acid, creatinine, sodium, potassium, chloride, GOT and GPT. However there were one case of significant decrease of potassium and increase of blood sugar respectively by 30mg medication. 3) There was no weakness or fatigue by 15mg medication except 2 cases which complained of weakness by 30mg medication and there was no remarkable side effect such as rash. 4) In 6 cases which were refractory to other antihypertensive drugs including hydrochlorothiazide, there was hypotensive effect by switching hydrochlorothiazide to Tripamide. These observations showed that Tripamide(Normonal(R)) has hypotensive effect with 15 to 30mg per day in one week and thereafter the effect was stationary and there was much less side effect such as weakness than thiazide derivatives.
Antihypertensive Agents ; Blood Glucose ; Blood Pressure ; Creatinine ; Exanthema ; Fasting ; Fatigue ; Hydrochlorothiazide ; Hypertension* ; Potassium ; Sodium ; Uric Acid