1.Special Issue.
Seon Cheol PARK ; Yu Sang LEE ; Jun Soo KWON
Journal of Korean Neuropsychiatric Association 2011;50(3):167-171
No abstract available.
2.The Relationship of Maternal Disorder with Neonatal Cord Blood Leptin - Preeclampsia, Diabetes Mellitus, Antenatal Steroid Treatment -.
Seon Mi PARK ; Eun Young KIM ; Yeong Bong PARK ; Sang Kee PARK
Journal of the Korean Pediatric Society 2001;44(10):1119-1126
PURPOSE: Leptin, the product of the ob gene is primarily by adipose tissue but also by the human placenta. Leptin may also have a role as a regulator of fetal growth and development during normal pregnancy as well as in pregnancies associated with anomalous fetal growth. Our study aimed to discover whether or not leptin concentration in neonatal cord blood correlates with maternal disorder(preeclampsia, antenatal steroid). METHODS: Seventy newborns - twenty of preeclampsia, twenty of antenatal steroid treatment, ten of diabetes mellitus, twenty of neonatal asphyxia- and their mother were enrolled in this study. Gestational age, birth weight, length and placental weight were measured. Maternal age and weight were measured. Cord blood and maternal venous samples were collected and serum was separated and stored at -70dgreesC. Leptin was measured by radioimmunoassay. RESULTS: Neonatal cord leptin concentration was significantly elevated in infants whose mothers received antenatal steroid, preeclamptic mothers and diabetic mothers Also, neonatal cord leptin concentration was correlated with maternal serum leptin concentration in those maternal disorders. Cord blood leptin concentration in neonatal asphyxia group was significantly elevated, but wasn't significantly correlated with their maternal serum leptin concentration. CONCLUSION: Neonatal cord leptin concentration was significantly increased in mothers with preeclampsia, diabetes mellitus, and exposure of the antenatal steroid. We find that maternal disorders affected leptin concentration in cord blood, and that increased cord blood leptin in neonatal asphyxia was shown to be a product of fetus.
Adipose Tissue
;
Asphyxia
;
Birth Weight
;
Diabetes Mellitus*
;
Fetal Blood*
;
Fetal Development
;
Fetus
;
Gestational Age
;
Humans
;
Infant
;
Infant, Newborn
;
Leptin*
;
Maternal Age
;
Mothers
;
Placenta
;
Pre-Eclampsia*
;
Pregnancy
;
Radioimmunoassay
3.Executive Dysfunction and It's Relation to K-WAIS Scores in Mild Traumatic Brain Injury Patients with Normal Intelligence Quotient.
Dae Bo LEE ; In Seon YOON ; Seon Kyung KIM ; Seung Ho RHO ; Min Cheol PARK ; Sang Yeol LEE
Korean Journal of Psychosomatic Medicine 2012;20(1):50-58
OBJECTIVES: This study examined the selective deficits of executive function in patients with mild traumatic brain injury that in normal range of general intelligence level and aimed to analysis of the correlation between K-WAIS result and executive function. METHODS: 59 subjects were included in this study, who were diagnosed as mild traumatic brain injury(MTBI) and they have visited in neuropsychiatric department of Wonkwang University Hospital during from March, 2005 to September, 2010. For measurement of general intelligence quotient, the Korean-Wechsler Adults Intelligence Scale(K-WAIS) was administered and for measurement of executive intelligence quotient(EIQ), Executive Intelligence Test(EXIT) was administered. RESULTS: Of patients, 50.8% included at abnormal EIQ group. The patients of abnormal EIQ showed poorer full scale IQ(FIQ), performance IQ(PIQ) and in subscale that picture arrangement, digit symbol, digit span, block design, object assembly and comprehension were significantly different. In terms of relationships between K-WAIS and EIQ, FIQ and PIQ have positive correlation with EIQ. And in subscale, picture arrangement, digit symbol, digit span, block design, object assembly and comprehension show positive correlation with EIQ. CONCLUSION: This study suggest that MTBI patients with have normal range of general intelligence level may have deficit of executive function is common. The decline of FIQ, PIQ and some subscales of K-WAIS may suggest executive dysfunction in MTBI patients.
Adult
;
Brain
;
Brain Injuries
;
Comprehension
;
Executive Function
;
Humans
;
Intelligence
;
Reference Values
;
Wechsler Scales
4.Serum Insulin-like Growth Factor-1(IGF-1) and Insulin-like Growth Factor Binding Proteins in Hyperthyroidism and Hypothyroidism
Hyun Mo SONG ; Sang Seok PARK ; Tae Seon PARK ; Hong Sun BAEK ; Dae Yeol LEE
Journal of Korean Society of Endocrinology 1996;11(1):52-60
Backgrounds: Thyroid hormones play a fundamental role in the initiation and maintenance of somatic growth in mammalian species, and the insulin-like growth factors(IGFs) occupy a position of central importance in the growth of all tissues. To evaluate the changes in serum insulin-like growth factor-I(IGF-I) and insulin-like growth factor binding proteins in hyperthyroid and hypothyroid patients, sera was obtained from 19 hyperthyroid patients, 9 hypothyroid patients, and 10 healthy volunteers. Methods: IGF-I concentration was determined by radioimmunoassay, and changes in IGFBPs were assesed by Western Ligand Blotting. To evaluate the binding pattern of IGF-I & IGFBPs, autoradiographs were obtained. Results & Conclusion: IGF-I levels were increased significantly in hyperthyroid patients(mean ±SE, 267.88±9.80 ng/ml, p<0.05) and decreased significantly in hypothyroid patients(154.81±1.43 ng/ml, p<0.01) compaired to healthy control group(209.45±.60 ng/ml). Autoradiograph of serum IGFBPs from patients with hyperthyroidism and hypothyroidism did not show any change in the intensity of IGFBP-3 bands(40-45 KD) and IGFBP-1 bands, but in hyperthyroid patients, it showed increased intensity of IGFBP-2 band compared to healthy control group and hypothyroid patients.
Equidae
;
Healthy Volunteers
;
Humans
;
Hyperthyroidism
;
Hypothyroidism
;
Insulin-Like Growth Factor Binding Protein 1
;
Insulin-Like Growth Factor Binding Protein 2
;
Insulin-Like Growth Factor Binding Protein 3
;
Insulin-Like Growth Factor Binding Proteins
;
Insulin-Like Growth Factor I
;
Radioimmunoassay
;
Thyroid Hormones
6.A Case of Sezary Syndrome.
Sung Wook PARK ; Sang Suk LEE ; Seon Wook HWANG ; Han Young WANG
Korean Journal of Dermatology 2000;38(5):650-654
No Abstract Available.
Sezary Syndrome*
7.Platelet alloimmunization after multiple blood transfusions.
Kyou Sup HAN ; Sang In KIM ; Byoung Kook KIM ; Seon Yang PARK ; Young Chul OH
Korean Journal of Blood Transfusion 1991;2(1):19-27
No abstract available.
Blood Platelets*
;
Blood Transfusion*
8.DNA ploidy as a predictive index of therapeutic response in lung cancer.
In Seon CHOI ; Shin Seok LEE ; Jae Beom YANG ; Kyung Ok PARK ; Sang Woo JUNG
Tuberculosis and Respiratory Diseases 1992;39(2):150-158
No abstract available.
DNA*
;
Lung Neoplasms*
;
Lung*
;
Ploidies*
9.The clinico-pathological study of the torsion of the uterine adnexa.
Hee Dong YANG ; Hyun Jik PARK ; Choong Sik HA ; Seon Je HWANG ; Jung Sang GWAK
Korean Journal of Obstetrics and Gynecology 1993;36(7):1470-1474
No abstract available.
10.Use of the Cell Saver in Orthopedic Spinal Surgery.
Hong Seon LEE ; Kyo Sang KIM ; Jae Lim CHO ; Ye Soo PARK
Korean Journal of Anesthesiology 1997;33(2):277-282
BACKGROUND: Methods to reduce the amount of blood transfusion include perioperative hemodilution, hypotensive anesthesia, the transfusion of previously deposited autologous blood, and intraoperative autotransfusion used the cell saver. The purpose of this study is to evaluate the effect of the use of the cell saver in orthopedic spinal surgery. METHODS: One hundred and one patients for orthopedic spinal surgery were involved in this study and divided into two groups: group 1 (no used cell saver, n=51) and group 2 (used cell saver, n=50). We checked transfusion amounts during operation and the changes of hematocrit after operation. RESULTS: The amount of blood obtained from cell saver apparatus was 1220 +/- 651 ml (mean SD). Hematocrit of the autologous blood from this apparatus was 48.5 +/- 2.5%. Amounts of blood transfusion during operation were 4.1 +/- 0.9 IU (400 ml/IU) in group 1 and 2.5 +/- 0.7 IU in group 2 (p<0.05). The hematocrit was markedly decreased at the postoperative 2 and 3 days in group 2 (p<0.05). CONCLUSIONS: This study suggested that intraoperative salvage technique with cell saver apparatus could decrease the use of bank blood by 40% in orthopedic spinal surgery. However, we should be prepare the blood for the decrease of the hematocrit at the postoperative 2 and 3 days.
Anesthesia
;
Blood Transfusion
;
Blood Transfusion, Autologous
;
Hematocrit
;
Hemodilution
;
Humans
;
Orthopedics*