1.A Case of Plexiform Neurofibroma of the Right Upper Eyelid and Orbit in Neurofibromatosis.
Dong Seok KIM ; Sang Won KIM ; Han Ik BAE
Korean Journal of Dermatology 1986;24(5):734-738
We have experienced a case of plexiform neurofibrorna of the right upper eyelid and orbit in a 12-year-old girl who had typical skin features of neurofibromatosis and no family history. The non-pulsating proptosis of the right eye and diffuse thickening with hypertrophy of the upper lid, had increased insiduciusly since the birth on. Biopsy taken from eyelirl lesion showed the features of plexiform neurofibroma. Skull X-ray and brain computerized tomogram showed that the right orbit was wider, with the enlarged mass and defects in orbital roof and lesser and greater wings of the sphenoid bone. The surgical excision of the right eyelid lesion was performed.
Biopsy
;
Brain
;
Child
;
Exophthalmos
;
Eyelids*
;
Female
;
Humans
;
Hypertrophy
;
Neurofibroma, Plexiform*
;
Neurofibromatoses*
;
Orbit*
;
Parturition
;
Skin
;
Skull
;
Sphenoid Bone
2.A 5-year follow-up visual evoked potentials and nerve conduction study in young adults with type 1 diabetes mellitus
Heon-Seok Han ; Heon Kim ; Sang-Soo Lee
Neurology Asia 2016;21(4):367-374
Central nervous system impairment is common in diabetic patients, even in the early stages of the
disease, and could be associated with peripheral neuropathy. The aims of this study were to prospectively
investigate central nerve conduction in young adults with type 1 diabetes using pattern-reversal visual
evoked potentials (PRVEP) and to determine how those results were related to clinical risk factors and
the parameters of the peripheral nerve conduction study (NCS). A total of 36 type 1 diabetic patients
(15 males) 5-24 years of age (mean 14.5 ± 4.7) underwent PRVEP and NCS annually for five years.
For comparison, 39 healthy age and sex matched individuals (mean 14.8 ± 5.0) were evaluated as
the control group. The P100 latencies of the PRVEP were prolonged at the study entry in the patients
compared with the controls (p< 0.001). Significant correlations were not found between any of the
parameters of PRVEP and the glycosylated hemoglobin levels; however, the changes in the parameters
of the peripheral NCS were well correlated with metabolic control. The latencies and amplitudes of
the P100 were not related to the majority of the parameters of the NCS. A prolonged PRVEP latency
may be a sign of optic pathway dysfunction, which begins before apparent diabetic retinopathy. Poor
glycemic control proved to be an important risk factor over the 5 years in terms of its relation to
the development of peripheral neural pathway abnormalities. However, once central conduction was
delayed, its changes were poorly related to diabetic control and the attributes of the peripheral nerve
conduction study over the 5-year follow-up.
Diabetes Mellitus
3.A Clinical Study on Pathologic Fractures
Han Koo LEE ; Jang Seok CHOI ; Sang Chul SUNG
The Journal of the Korean Orthopaedic Association 1977;12(3):439-445
Pathologic fracture occurs in a bone with preexisting stuctual weakness. The author reviewed 30 cases of pathologic fractures in which admission record and X-ray finding was well preserved among 53 cases admitted patients in the department of Orthopaedic Surgery, Seoul National Universty Hospital for 10 years from 1967. The results were as follows: 1.Age & Sex incidence showed even distribution. 2. The most frequent involved site was femur (40%) 3. The underlying etiology was as follows: 2 chronic osteomyelitis 1 homophilia 7 benign tumor 20 malignant tumor 4. metastatic tumor was the most frequent cause in 30 cases. 5. Treatment was as follows: Conservative treatment 4 cases Surgery 21 cases.
Clinical Study
;
Femur
;
Fractures, Spontaneous
;
Humans
;
Incidence
;
Osteomyelitis
;
Seoul
4.Rapid Diagnosis of Isoniazid Resistance by Detection of Mutations in katG and inhA of Mycobacterium tuberculosis from Korea.
Sang Jae KIM ; Seok Yong KIM ; Ji Youn LEE ; Sang Ryeol RYU ; Gil Han BAI
Journal of the Korean Society for Microbiology 1997;32(5):569-576
29 isoniazid (INH) resistant isolated strains and INH sensitive reference strain (H37Rv) of Mycobacterium tuberculosis were analysed by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and NciI restriction mapping for the detection of mutations in katG gene and inhA gene. The katG gene was divided into 3 parts (Akat, Bkat, Ckat; each part is about 800 bp) and amplified, inhA gene was amplified as a whole. Each of the amplified 800 bp DNA was digested into small fragments of less than 400 bp with restriction enzymes for the direct PCR-SSCP analysis. Firstly, 10 strains were analysed. All the 10 isolates showed clearly distinct SSCP patterns in Bkat from that of the reference strain, but only two isolates showed distinct SSCP patterns in Akat, and no isolated strain showed any distinct SSCP patterns in Ckat. 10 isolates also showed distinct SSCP patterns in inhA. NciI restriction mapping of Bkat showed mutation in codon 463 in 7 strains among 10 isolated strains. With these results an early detection strategy for the INH resistant M. tuberculosis was applied to the rest of 19 isolated INH resistant strains. Firstly, isolates were screened by Ncsl mapping in Bkat, and 13 strains showed mutations in codon 463. Secondly, the rest of 6 INH resistant isolates were analysed by PCR-SSCP with restriction enzyme digestion (PCR-SSCP-RE) in Bkat, and all the strains showed distinct SSCP patterns from that of the INH sensitive reference strain. This proved our strategy as effective and economic and time saving method in early detection of INH resistant M. tuberculosis.
Codon
;
Diagnosis*
;
Digestion
;
DNA
;
Isoniazid*
;
Korea*
;
Mycobacterium tuberculosis*
;
Mycobacterium*
;
Polymorphism, Single-Stranded Conformational
;
Restriction Mapping
;
Tuberculosis
5.Frequency of Js/a, Js/b, Kp/a, Kp/b, M/g and Xga/ blood group antigens among Koreans.
Seok Lae CHAE ; Kyou Sup HAN ; Han Il CHO ; Sang In KIM
Korean Journal of Blood Transfusion 1991;2(1):69-72
No abstract available.
Blood Group Antigens*
6.Melorheostosis: Report of 2 Cases
Myung Sang MOON ; Han Joo KIM ; Byeong Han KONG ; Seok Whan SONG
The Journal of the Korean Orthopaedic Association 1985;20(1):190-194
Melorheostosis is a rare disease entity of bone with an etiology and pathogenesis. It cause pain and stiffness in an affected limb, and dense bone formation along the side of bone resembles the flow of candle dripping. Two cases of the disease involving left hand and wrist, and right lower leg are reported with the review of literature.
Extremities
;
Hand
;
Hyperostosis
;
Leg
;
Melorheostosis
;
Osteogenesis
;
Rare Diseases
;
Wrist
7.Study on Macrosomia Based on Birth Certificate Data.
Sang Hwa PARK ; Jung Ho HAN ; Kyung Sil LIM ; Seung Yup KU ; Seok Hyun KIM
Korean Journal of Obstetrics and Gynecology 2000;43(9):1611-1615
No abstract available.
Birth Certificates*
;
Parturition*
8.Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Report of an Autopsy Case.
Sang Yong LEE ; Joo Han LEE ; Joong Seok SEO
Korean Journal of Legal Medicine 2003;27(1):101-105
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized histologically by massive infilteration of right ventricular wall by fat tissue with surviving strands of cardiomyocytes bordered by or embedded in fibrosis. ARVC has been recognized as a cause of sudden death, especially in the young. We report an autopy case of ARVD/C in a 35-year-old female. She was found dead in her house under apparently natural circumstances. The autopsy revealed a dilated 340-gram heart with a fibrofatty replacement of the right ventricular myocardium. On the review of her past medical history, she had taken medical examination for prolonged general weakness about 1 year prior to death. At that time the echocardiogram revealed dilatation of right ventricular cavity size and moderately decreased left ventricular systolic function, the electrocardiogram revealed R>S at V1 lead and T-wave inversion at V1-V3 leads. To the best of our knowledge, this is the second autopsy case of ARVD/C, reported in the literature of Korea.
Adult
;
Autopsy*
;
Death, Sudden
;
Dilatation
;
Electrocardiography
;
Female
;
Fibrosis
;
Heart
;
Humans
;
Korea
;
Myocardium
;
Myocytes, Cardiac
9.Choroidal Metastasis of Adenocarcinoma of the Lung: A case report.
Seong Hwan PARK ; Ju Han LEE ; Jeong Seok MOON ; Jong Sang CHOI
Korean Journal of Pathology 1999;33(6):471-473
Choroidal metastatic carcinoma is very rare. We recently experienced a case of lung adenocarcinoma which presented to the clinic with ocular symptoms. This 57-year-old Korean male patient visited the department of ophthalmology due to decreased visual acuity and pain of the left eye. On MRI scan, a nodule was attached to the retina of the left eyeball. On simple chest radiograph, a large amount of pleural effusion was noted in the left pleural cavity. Emergency enucleation of the left eyeball was done with an impression of malignant melanoma causing an intractable ocular pain. Grossly, the lesion in the eyeball was rising from the choroid. On histologic examination, tumor cells formed many irregular, small gland-like structures. The tumor cells showed alcian blue-positive mucin in the cytoplasm and glandular lumens and were positive for CEA. Chest CT scan was performed postoperatively and showed a huge mass in the left lower lobe and multiple nodular opacities in both lung fields. Bronchoscopic biopsy revealed moderately differentiated adenocarcinoma similar to that of the eyeball.
Adenocarcinoma*
;
Biopsy
;
Choroid*
;
Cytoplasm
;
Emergencies
;
Humans
;
Lung Neoplasms
;
Lung*
;
Magnetic Resonance Imaging
;
Male
;
Melanoma
;
Middle Aged
;
Mucins
;
Neoplasm Metastasis*
;
Ophthalmology
;
Pleural Cavity
;
Pleural Effusion
;
Radiography, Thoracic
;
Retina
;
Tomography, X-Ray Computed
;
Visual Acuity
10.Papillary Serous Cystadenoma of Borderline Malignancy Arising from a Paramesonephric Parovarian Cyst: A case report.
Ji Han JUNG ; Youn Soo LEE ; Seok Jin KANG ; Byung Kee KIM ; Sang In SHIM
Korean Journal of Pathology 1999;33(6):457-459
Primary malignant parovarian epithelial tumors are extremely rare, with only 56 cases previously reported in the world literature. Most parovarian epithelial tumors are of paramesonephric (Mullerian) origin. In this article, we report the first case in the Korean literature of papillary serous cystadenoma of borderline malignancy from paramesonephric parovarian cyst. This case presented here is of particular interest since this neoplasm is rare. A 48-year-old female underwent a hysterectomy with bilateral adnexectomy and pelvic lymph node dissection for a cystic tumor of the right parovarian area. The tumor, measuring 13 cm in diameter, was apart from the ovaries, fallopian tubes and uterus. The cyst wall had well-developed smooth muscle layers. The cyst was lined with mildly atypical ciliated and non-ciliated low columnar cells compatible with those of paramesonephric origin. From the inner surface of the cyst several cauliflower-like structures projected into the lumen. They were of a predominantly papillary architecture covered by atypical epithelial cells with piling-up and occasional glandular growth. No destructive stromal invasion was identified.
Cystadenoma, Serous*
;
Epithelial Cells
;
Fallopian Tubes
;
Female
;
Humans
;
Hysterectomy
;
Lymph Node Excision
;
Middle Aged
;
Muscle, Smooth
;
Ovary
;
Parovarian Cyst*
;
Uterus