Tbe presence of certain HPV types in the female genital tract was associated with a number of diseases, including condyloma, cervical, vaginal and vulvar intraepithelial neoplasia and carcinoma. It is generally accepted that these viruses are predominantly sexually transmitted. HPV cannot be cultured in vitro, and immunological tests are inadequate. Indirect evidence of anogenital HPV infection can be obtained through the physical examination and by the presence of characteristic cellular changes associated with viral replication in Pap smear or biopsy specimens. Alternately cervical scrapes can be analyzed by nucleic acid hybridization to directly detect the presence of HPV DNA, Historically, HPV 16 and HPV 18 have been regarded as high risk cancer associated HPVs and HPV types 6, 11, 42, 43 and 44 as low risk HPVs. Subsequently HPV types 31, 33, 34, 35, 45, 51, 52, 56 and 58 have been demonstrated to have and intemediate association with cancer, This study was performed for high and intermediate types HPV DNA detection on cervical carcinoma with Virapap Probe B. HPV DNA were detected 82.3% on cervical carcinoma and 7,1% on control samples. HPV DNA test will be apply as a triage for cervical cancer detecting test.
Biopsy ; DNA ; Female ; Human papillomavirus 16 ; Human papillomavirus 18 ; Human Papillomavirus DNA Tests ; Humans* ; Immunologic Tests ; Nucleic Acid Hybridization ; Papilloma* ; Physical Examination ; Triage ; Uterine Cervical Neoplasms*

No abstract available.
Congenital Hypothyroidism* ; Thyroid Dysgenesis*

No abstract available.
Animals ; Langerhans Cells* ; Mice ; Mice, Inbred C3H*

Seminal biochemical compositions are to be affected during inflammatory conditions of seminal tract such as chronic prostatitis. Especially chronic prostatitis induces changes in composition of prostatic fluid, and the chronic nature of disease also induces atrophy of prostatic secretory acini and the inflammation of seminal vesicle. We investigated the change of the seminal composition and the possible effect in sperm motility of chronic prostatitis patients. Sperm motility and seminal levels of zinc, citric acid, prostatic acid phosphatase(PAP) and fructose were measured on 12 healthy males and 21 chronic prostatitis patients. Sperm motility in chronic prostatitis patients was decreased and seminal levels of zinc, citric acid, PAP and fructose in control and chronic prostatitis patients were 143+/-10/102+/-7(ug/L), 389+/-17/293+/-25(mg/dl), 446+/-61/ 382+/-28(U/ml), 306+/-7/297+/-6(mg/dl), respectively. The change of zinc was statistically significant. In conclusion, although decrease of seminal zinc in patients with chronic prostatitis was found, there was no convincing evidence to suggest that alterations in seminal composition due to chronic prostatitis lead to decrease of sperm motility.
Atrophy ; Citric Acid ; Fructose ; Humans ; Inflammation ; Male ; Prostatitis* ; Semen ; Seminal Vesicles ; Sperm Motility ; Zinc

Inflammatory white blood cells in semen is related to semen quality affecting fertility. The role of inflammatory cells on the seminal levels of various cytokines associated with inflammation and sperm motility is evaluated. Semens from 10 healthy males and 20 chronic prostatitis patients were evaluated for the levels of interleukin(IL)-1a, IL-6, IL-8 and tumor necrosis factor(TNF)-a. Motility parameters were recorded using Hamilton-Thorne computer semen analysis system. Sperm motility parameters such as including average path velocity(VAP), straight line velocity(VSL), curvilinear velocity(VCL), lateral head displacement(ALH), beat frequency(BCF), straightness(STR), linearity(LIN), elongation and area in control and chronic prostatitis patients were 44.9+/-2.5/38.8+/-1.3(um/sec), 36.4+/-2.4/30.5+/-1.1(um/sec), 64.2+/-3.9/ 58.0+/-2.4(Fm/sec), 3.3+/-0.2/4.8+/-0.3tm), 19.8+/-3.7/13.9+/-0.3(Hz), 77.7+/-5.1/78.8+/-1.2(%), 50.6+/-17.5/53.5+/-1.9(%), 66.8+/-5.4/57.8+/-1.1(9%), 2.9+/-0.3/3.8+/-0.1(um/sec), respectively. Statistical significance was noted in VAP, VSL, ALH, BCF, elongation and area. Semen levels of IL-1a, IL-6, IL-8 and TNF-a in control and chronic prostatitis patients are 15.1+/-1.5/52.9+/-14.2 (pg/ml), 10.5+/-2.2/38.3+/-12.2 (pg/ml), 1.60+/-0.38/ 6.02+/-0.26 (ug/L), 11.8+/-2.5 / 21.7+/-4.0(pg/ml) statistically significant in all. For combined parameters, the correlation coefficient of IL-1a and VSL, ALH, Area were 0.40, 0.41, 0.37 respectively which were significant. The correlation coefficient of IL-8 and VAP, VSL, VCL, ALH, BCF, Elongation, Area were 0.48, 0.49, 0.39, 0.41, 0.55, 0.59, 0.66 respectively which were also significant. Seminal inflammatory cytokines are present in increased quantities if inflammatory white blood cells are present in semen and this increase might be related to sperm motility.
Cytokines* ; Fertility ; Head ; Humans ; Inflammation ; Interleukin-6 ; Interleukin-8 ; Leukocytes ; Male ; Necrosis ; Prostatitis ; Semen ; Semen Analysis ; Sperm Motility* ; Spermatozoa*

One hundred sixteen C57 BL mice were painted with either 8-MOP, 5-MOP or TMP solution in concentrations of 0.02%, 0.1%, and 0.5% each and UVA irradiated. Skin biopsies were performed at 1, 3, 5 and 7 weeks after LJVA irradiation. The results measuring the number, area, and perimeter of the melanocytes after topical PLJVA were higher in the TMP-painted group than in the 8-MOP or 5-MOP painted groups. In all groups, the weekly changes showed an increasing value through five weeks. In comparing the drug concentrations used, 0.1% of chemicals produced the same or higher values than 0.5%. There have been few studies on the effects of 5-MOP in photochemotherapy. In tho study 5-MOP produced a pigment-producing effect similar to 8-MOP. Therefore, if topical PIJVA with 5-MOP is used in clinical practice, we could expect a significant therapeutic effect in vitiligo.
Animals ; Biopsy ; Melanocytes* ; Methoxsalen ; Mice* ; Paint ; Photochemotherapy ; Skin ; Thymidine Monophosphate ; Vitiligo

From 1980 to 1989, 144 patients underwent radical nephrectomy for renal cell carcinoma. Survival was analyzed in terms of pathologic stage and histologic grade. Data revealed that M category was the most important prognostic factor followed by, in order of importance, T category, N category, and grade. But grade as prognostic factor in renal cell carcinoma needs additional investigation. Stage pT1 and pT2 showed similar survival rate. The separation of pT1 and pT2 according to size of the primary tumor may not be a meaningful prognostic variable. Because vascular invasion may occur with tumors of various size, separating components into a description of the tumor (T), nodes (N), metastases (M) and renal vein involvements (V) makes good sense. The prognostic value of lymphadenectomy is limited by the fact that the tumor metastasizes through the blood stream and the lymphatic system with equal frequency.
Carcinoma, Renal Cell* ; Humans ; Lymph Node Excision ; Lymphatic System ; Neoplasm Metastasis ; Nephrectomy ; Renal Veins ; Rivers ; Survival Rate

To evaluate the etiology and treatment of options in patients with hemospermia, we retrospectively reviewed 21 patients who had both transrectal ultrasound and MRI and have been followed for more than 6 months after initiation of treatment. Mean age was 40 years (range 20 - 50 years) with duration of infliction being 24 months (range 1 week to 16 years). Among the 14 patients with prostatic cyst, 9 patients underwent transurethral unroofing (TUUR) of cyst. All 9 patients were completely cured, but one patient developed postoperative epididymitis. Among the 6 patients with prostatitis, hemospermia was resolved in 4 patients after mean treatment of 12 weeks with antibiotics. In DES (Diethylstilbestrol) group, 50 % showed resolution of symptoms among 6 patients after 4 weeks of treatment, and two patients complained breast discomfort which were developed after medication. In conclusion, the antibiotic treatment is advisable in hemospermia patients with prostatitis. Prostatic cystic lesion is believed to be a factor in hemospermia, thus TUUR of cyst wall and removal of stone and hematoma in cyst can be a viable option.
Anti-Bacterial Agents ; Breast ; Epididymitis ; Hematoma ; Hemospermia* ; Humans ; Magnetic Resonance Imaging ; Male ; Prostatitis ; Retrospective Studies ; Ultrasonography

The spindle and epithelioid cell nevus, is known also as Spitz's nevus or benign juvenile melanoma. The histologic picture of the lesion often closely resembles that of a malignant melanoma, but spindle and epithelioid cell nevus hehaves benignly. Criteria for accurate histological diagnosis of this nevus now exist. However, a difficult lesion occasionally brings one to the worrisome situation even now. We experienced four cases (three children and one adult) of spindle and epithelioid cell neveus with nodular or macular skin lesions. In children (7/F, 9/F, 4/M), all of the lesion show a solitary pinkish red or light brown nodular firm masses, 0.7 cm to 1.0 cm in greatest dimension, which are located at the left posterior thigh, posterior neck and right anterior neck region, respectively. In adult (36/F), the lesion shows a light brown, erythematous macule, 0.8 cm in greatest diameter, in the skin of the back. Microscopically, both spindle and epithelioid cells are found in all the four cases, but epithelioid cells predominate in children and spindle cells predominate in adult.
Child ; Adult ; Male ; Female ; Humans

A study was made on 657 cases of skin tumors, which were obtained mainly as surgical pathology specimens during the period of 12 years and 4 months from January, 1960 to April, 1972, at Departments of Dermatology and Clinical Pethology, Catholic Medical Center in Seoul, and the results were as follow; 1) Of the 657 cases of skin tumors, 470 cases (71. 5%) were benign tumors, 26 casea (4.0%) premalignant lesions and 161 cases (24. 5%) malignant tumors. 2) The ratio of male vs. female was 1: 1 for benign tumor, 1: 1.9 for premalignant lesion and 1. 9: 1 for malignant tumor. 3) Among the benign tumors were 144 cases of cysticercosis, 68 cases of epidermal inclusion cyst, 46 cases of hemangioma and 45 cases of lipoma. 4) Arnong the premalignant lesions were 13 cases of leukoplakia, 5 cases of Nevus sebaceous (Jadassohn) and 4 cases of Bowen's disease. 5) The average age of malignant tumor was 53. 2 years for squamous cell carcinoma, 57. 2 years for basal cell carcinoma, and 35. 6 years for malignant melanoma. 6) The sites of predilection of the squamous cell carcinomas were penis (30. 6%), face (27. 4%) and upper and lower extremities (12.9%). The site of predilection of the basal cell carcinomas was face (88. 5%)., 7) The ratio of squamous cell carcinoma vs. basal cell carcinoma was 2. 4: 1. 8) Among the metastatic cancers of the skin the more frequent primary sites were stomach (3 cases), lung (2 cases) and liver (2 cases).
Bowen's Disease ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Cysticercosis ; Dermatology ; Female ; Hemangioma ; Humans ; Leukoplakia ; Lipoma ; Liver ; Lower Extremity ; Lung ; Male ; Melanoma ; Nevus ; Pathology, Surgical ; Penis ; Seoul ; Skin* ; Stomach