1.Suppression of the Ly6 antigens expression on P815 mastocytoma cells by expressing antisense RNA.
Chung Hee SONN ; Mee Rang PARK ; Young Sang KIM
Korean Journal of Immunology 1993;15(2):209-215
No abstract available.
Mastocytoma*
;
RNA, Antisense*
2.Correlation of the Intestinal Metaplasia Subtypes and Gastric Carcinoma.
Hwa Eun OH ; Mee Ja PARK ; Jong Sang CHOI
Korean Journal of Pathology 1997;31(12):1272-1281
Helicobacter pylori, loss of basement membrane, atrophy, type III intestinal metaplasia, adenomatous polyposis coli (APC) gene mutations and altered p53 function were believed as a factor to develop the gastric adenocarcinomas. To investigate the incidence and prevalence of Helicobacter pylori, intestinal metaplasia and atrophy, 120 gastrectomy specimens collected from patients with gastric adenocarcinoma (100 cases) and non-neoplastic conditions (20 cases) were studied. Intestinal metaplasia can be classified as type I (complete), type II (incomplete, sulfomucin-negative) and type III (incomplete, sulfomucin-positive) by Filipe and Jass. The incidence of intestinal metaplasia of gastric adenocarcinoma was 96% compared with the incidence of 75% in non-neoplastic conditions. The type I and type II were more common than type III and were present in both non-neoplastic conditions (75%) and adenocarcinoma (74%). In contrast, type III intestinal metaplasia was seen in only 20% of intestinal metaplasia-positive cases, all of which (22 of 22) were from patients with adenocarcinoma. The high specificity of type III intestinal metaplasia might be acceptable for screening purposes, but its sensitivity of 22% for gastric adenocarcinoma is low. Helicobacter pylori were detected in 96% of adenocarcinoma cases and 100% of non-neoplastic cases. Atrophy was detected in 50% of non-neoplastic cases and in 57% of adenocarcinoma cases. The data thus confirms a significant relation between incomplete sulfomucin-secreting intestinal metaplasia (type III) and gastric carcinoma, especially intestinal type (p<0.01). Thus, the type III intestinal metaplasia should be considered a risk factor and its presence in a biopsy specimen should prompt close surveillance.
Adenocarcinoma
;
Adenomatous Polyposis Coli
;
Atrophy
;
Basement Membrane
;
Biopsy
;
Gastrectomy
;
Helicobacter pylori
;
Humans
;
Incidence
;
Mass Screening
;
Metaplasia*
;
Prevalence
;
Risk Factors
;
Sensitivity and Specificity
3.Driving of Motor Vehicles of the Epileptic Patients.
Yeung Ju BYUN ; Mee Young PARK ; Jung Sang HA
Yeungnam University Journal of Medicine 1994;11(1):16-29
No abstract available.
Humans
;
Motor Vehicles*
4.Three cases of Chronic Meningitis.
Soon Mee PARK ; In Sang JEON ; Hyung Ro MOON
Journal of the Korean Pediatric Society 1990;33(4):544-552
No abstract available.
Meningitis*
5.Partial purification and characterization of host celluar protease of chicken embryo infected with influenza virus.
Mee Yoen PARK ; Chul Yong SONG ; Sang In CHUNG
Journal of the Korean Society of Virology 1993;23(1):47-55
No abstract available.
Chickens*
;
Embryonic Structures*
;
Influenza, Human*
;
Orthomyxoviridae*
6.Clear Cell Hidradenoma: Report of three cases.
Sang Mee SEOK ; Chun Wook PARK ; Jong Min KIM
Annals of Dermatology 1996;8(4):282-286
Clear cell hidradenoma, generally as an eccrine sweat gland origin, is a fairly uncommon tumor and occurs as a slowly growing, usually solitary nodule. The histological patterns vary from one tumor to another and in different parts of the same tumor. We experienced three cases of clear cell hidradenoma which were diagnosed by the histopathologic examination of the tumor mass removed by surgical excision. Clinical and histopathologic features of each case were reviewed and compared.
Acrospiroma*
;
Sweat Glands
7.Localized Trichorrhexis Nodosa Arising From Habitual Rubbing.
Duk Kyu CHUN ; Sang Man PARK ; Jae Ju JO ; Ho Chul CHOI ; Sang Mee SEOK
Annals of Dermatology 1999;11(4):232-235
Trichorrhexis nodosa(TN) denotes small node-like swelling with a loss of cuticle of the hair shaft through which the hair readily fractures. The basic cause of TN is mechanical or chemical trauma, and a contributing factor is an inherent weakness of the hair shaft. We report a case of localized TN in a 37-year-old male. He had an ovoid hair patch with multiple small white-gray dotted and stubby hairs localized to the right occipital scalp. TN is known to be the commonest of all hair shaft anomalies (Price, 1975). However TN is rarely reported, and there have been only four reports in Korean dermatological literature, to our knowledge, which might be due to underdiagnosis of this disorder. We postulated that diagnostic difficulty lies in the discrepancy between terminology and gross morphological findings.
Adult
;
Fibrinogen
;
Hair
;
Humans
;
Male
;
Scalp
8.Genotype and animal infectivity of a human isolate of Cryptosporidium parvum in the Republic of Korea.
Sang Mee GUK ; Tai Soon YONG ; Soon Jung PARK ; Jae Hwan PARK ; Jong Yil CHAI
The Korean Journal of Parasitology 2004;42(2):85-89
Cryptosporidium parvum oocysts were isolated from a child suffering from acute gastroenteritis and successfully passaged in a calf and mice (designated hereafter SNU-H1) in the Republic of Korea; its molecular genotype has been analyzed. The GAG microsatellite region was amplified by a polymerase chain reaction (PCR), with a 238 base pair product, which is commonly displayed in C. parvum. The isolate was shown to be a mixture of the genotypes 1 (anthroponotic) and 2 (zoonotic). To study its infectivity in animals, 2 calves and 3 strains of mice were infected with the SNU-H1; in these animals, the propagation of both genotypes was successful. In immunosuppressed (ImSP) BALB/c and C57BL/6 mice the number of oocysts decreased after day 10 post-infection (PI) ; but in ImSP ICR mice, they remained constant until day 27 PI. The results show that both the C. parvum genotypes 1 and 2 can be propagated in calves and ImSP mice.
Animals
;
Cattle
;
Child
;
Cryptosporidiosis/microbiology
;
Cryptosporidium parvum/*genetics/immunology
;
Diarrhea/parasitology
;
Feces/parasitology
;
Genotype
;
Human
;
Korea
;
Male
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Mice, Inbred ICR
;
Oocysts
;
Polymerase Chain Reaction
;
Support, Non-U.S. Gov't
;
Zoonoses/parasitology
9.Clinical Study of CT-diagnosed Olivopontocerebellar Atrophies.
Mee Yeong PARK ; Khyoung Yhun O ; Jung Sang HAH ; Yeung Ju BYUN ; Choong Suh PARK
Yeungnam University Journal of Medicine 1988;5(2):87-93
The diagnosis of OPCA could be made clinically with important aid of brain CT scanning, although the definite and conclusive diagnosis only by postmortem pathological determination. We reviewed, clinically and with brain CT examination, 12 cases of patients with OPCA who were admitted to the Yeungnam University Hospital for a recent 5 years. The result were as following: 1. The distribution of age is from 49 to 72, mainly 50 to 60. Man is more frequent than women at the 4.5 times. 2. The interval period from Sx. Onset to diagnosis is 1 year to 6 years. 3. The usual initial Sxs. Were dizziness (58%), ataxia (33%), and other less frequent Sxs. Were weakness of low extremities, dysarthria, headache and urinary incontinence. The clinical manifestations at the initial diagnosis were cerebellar disturbance (100%), dysarthria (83%), and increased deep tendon reflexes (58%). 4. The results of brain CT finding are like this: the width of cerebellar sulci is more than 1mm, other 4 cases more than 2mm. the width of cerebellar pontine cistern of the patient if usually 3 to 4mm, other 2 cases extended to the 5 mm. the A. P and lateral lengths of 4th. ventricle is 4 mm and 4 to 8 mm respectively. 6 cases of whole patients show coincidentally cerebral atrophy.
Ataxia
;
Atrophy
;
Brain
;
Clinical Study*
;
Diagnosis
;
Dizziness
;
Dysarthria
;
Extremities
;
Female
;
Headache
;
Humans
;
Olivopontocerebellar Atrophies*
;
Reflex, Stretch
;
Tomography, X-Ray Computed
;
Urinary Incontinence
10.A clinical study of acute carbon monoxide intoxication.
Kyong Chan CHOI ; Mee Yeung PARK ; Jung Sang HAH ; Yeung Ju BYUN ; Choong Suh PARK
Yeungnam University Journal of Medicine 1991;8(1):86-97
To obtain the basic data of prognosis of acute carbon monoxide (CO) intoxication, one hundred and sixteen cases of CO intoxication defined by carboxyhemoglobin (COHb) and admitted via emergency room of Yeungnam University Hospital from Oct. '85 to April' 89 have been clinically analyzed and evaluated, including delayed postanoxic encephalopathy (DPE) and the following results were obtained. 1. The ratio of male to female was 1:1.5 and mental state was drowsy mostly (26.2% of 116 cases) 2. The more disturbed the mental state, the more decreased was the arterial pH and PaCO₂, which may be the result of metabolic acidosis. 3. The early laboratory findings in patients of CO intoxication were as follows: leukocytosis-65.5%, increase of hematocrit-23.3%, hyperglycemia-19.8%, increase of GPT-19.8% increase of creatinine-0.9% and glucosuria-12.1%. 4. The early findings of EKG were abnormal in 35.3%: change of rhythm-25.0%, abnormal ST segment 15.5% (change of rhythm and abnormal ST segment-5.2%) but the conduction disorder was not present. 5. The abnormal EEG above mild degree was 93.1%, of which moderate was most frequent (80.2%). 6. The incidence of DPE was 7.8% among all admitted CO patients. DPE cases had long duration of exposure time (8 hours), severe leukocytosis (20,000) and an abnormal EEG (MA).
Acidosis
;
Blood Gas Analysis
;
Brain Diseases
;
Carbon Monoxide*
;
Carbon*
;
Carboxyhemoglobin
;
Clinical Study*
;
Electrocardiography
;
Electroencephalography
;
Emergency Service, Hospital
;
Female
;
Humans
;
Hydrogen-Ion Concentration
;
Incidence
;
Leukocytosis
;
Male
;
Prognosis