1.Amplification of c-myc oncogene and detection of point mutation of c-K-ras oncogene by paired polymerase chain reaction in human colorectal carcinoma.
Cho Hyun PARK ; Won Il CHO ; Suk Kyun CHANG ; Sang Yong CHOO
Journal of the Korean Cancer Association 1991;23(4):683-692
No abstract available.
Colorectal Neoplasms*
;
Humans*
;
Oncogenes*
;
Point Mutation*
;
Polymerase Chain Reaction*
2.The relationship of the transvaginal sonographic findings & serum ?hCG levels in early intrauterine pregnancy.
Young Kyun SHIN ; Keum Ho HAM ; Sang Hun CHA ; Tae Ho CHO
Korean Journal of Obstetrics and Gynecology 1993;36(7):1924-1930
No abstract available.
Pregnancy*
;
Ultrasonography*
3.A Case of Cutaneous Metastasis from Pancreatic Adenocarcinoma.
Yong Sang KIM ; Seong Kyun IHM ; Jin Ho CHO ; Kee Chan MOON ; Soo Nam KIM
Korean Journal of Dermatology 1984;22(2):226-229
Cutaneous metastases from internal carcinomas are relatively rare, especially from pancreatic carcinoma. Pancreatic carcinomas are usually adenocarcinomas which arise in the head of the gland, and are known to rapidly metastasize to the lymphatic system by permeation and embolization. We report a case of cutaneous metastasis from pancreatic adenocarcinoma. in 74-year-old male patient who have two pea sized, slight erythematous nodules on the lower abdomen and posterior side of the neck.
Abdomen
;
Adenocarcinoma*
;
Aged
;
Head
;
Humans
;
Lymphatic System
;
Male
;
Neck
;
Neoplasm Metastasis*
;
Peas
4.Feasibility, Safety and Prognostic Factors for Computed Tomography Guided Aspiration and Thrombolysis of Intracerebral Hematoma - Clinical Analysis -.
Sung Kyun HWANG ; Do Sang CHO ; Sung Hak KIM ; Dong Bin PARK
Korean Journal of Cerebrovascular Surgery 2005;7(1):24-30
OBJECTIVE: The authors reviewed experience with patients harboring intracerebral hematoma (ICH) treated by stereotactic computed tomography (CT) guided thrombolysis and aspiration and evaluated feasibility, safety and prognostic factors of this procedure. METHODS: One hundred and ten patients with supratentorial ICH >25 ml without underlying structural etiology or coagulopathy were recruited. The patients with Glasgow Coma Scale (GCS) <5 were excluded. A catheter was directed stereotactically into the ICH under CT guidance. Hematoma aspiration was followed by instillation of urokinase. This was repeated every 6 hours until less than half of its initial volume remained. For analysis of prognostic factors, we classified them into two groups;good (Glasgow Outcome Scale (GOS) > or =4) and bad (GOS<4) prognosis group, and performed comparative analysis between two groups. RESULTS: Mean age was 59.8 years. The baseline hematoma size ranged from 15 to 72 mL. ICH volume reduced by an average of 74.2%. At 6 months after the procedure, 56 patients had achieved a good recovery, 29 patients were dependent, and 10 remained vegetative. Fifteen patients died in hospital. The main good prognostic factors were young age, small ICH volume, high GCS, absence of rebleeding, underlying disease and complications. CONCLUSION: CT-guided thrombolysis and aspiration appears safe and effective in the reduction of ICH volume. Patients of ICH presenting with bad prognostic factors should require frequent radiological investigation and more meticulous procedure. Further studies are needed to assess optimal thrombolytic dosage and must include controlled comparisons of mortality, and disability outcome.
Catheters
;
Glasgow Coma Scale
;
Hematoma*
;
Humans
;
Mortality
;
Prognosis
;
Urokinase-Type Plasminogen Activator
5.Total Knee Replacement in Rheumatoid Arthritis
Dae Kyung BAE ; Yong Jae KIM ; Sang Yeol CHO ; Ok Kyun AHN
The Journal of the Korean Orthopaedic Association 1994;29(3):847-854
The symptoms of the rheumatoid arthritis are variable enough to be ranged from mild to severe case. Synovectomy, fusion, and total knee replacement are to be applied according to the site and degree of involvement as surgical treatments. In the analysis, we compare the result of PCL retention TKR patients with those of PCL sacrificing TKR patients and of cemented TKR patients with those of cementless TKR patients. Function of the knee was evaluated using the knee score system of the Hospital for Special Surgery. From Nov, 1982 to Nov. 1990, total knee replacment was performed on 128 knees in 77 patients with rheumatoid arthritis at the Kyung Hee University Hospital and were followed for from two to ten years(average, four years eleven months). 1. The age at operation was ranged from 21 years to 72 years(average 53.2 years). There were seventy one female and six male patients. 2. The cruciate sacrificing prosthesis(group I ) were 42 cases and cruciate retention prosthesis(group II) were 86 cases. 3. The average preoperative range of motion was 85. 5 degree and the average post-operative range of motion was 107. 7 degree. Group I changed from 74. 7 degree to 105. 8 degree and Group II changed from 90. 5 degree to 108. 5 degree. 4. The average preoperative flexion contracture was 28. 7 degree and average post-operative flexion contracture was 7.8 degree. Group I changed from 37 degree to 8.4 degree and Group II changed from 24. 7 degree to 7. 5 degree. 5. The average preoperative tibiofemoral angle was varus 7. 4 degree in 69 cases and valgus 7. 6 degree in 59 cases. The average postoperative tibiofemoral angle was valgus 7. 2 degree. 6. The average preoperative knee Rating Score was 35. 2 point and the average postoperative score improved to 82. 7 point. Group I changed from 31. 3 point to 79. 4 point and Group II changed from 37 point to 84. 2 point. 7. 107 cases were cemented TKR and the 21 cases were cementless. There was no significant difference in those groups. 8. Additional operations were THR in eight cases, TER in five cases, TAR in four cases, TSR in one case, TWR in one case, Swanson prosthesis in one case, knee synovectomy in two cases, elbow synovectomy in three cases, and wrist synovectomy in two cases. 9. Complication included loosening in one case, partial ankylosis in three cases, and deep infection in one case.
Ankylosis
;
Arthritis, Rheumatoid
;
Arthroplasty, Replacement, Knee
;
Contracture
;
Elbow
;
Female
;
Humans
;
Knee
;
Male
;
Prostheses and Implants
;
Range of Motion, Articular
;
Wrist
6.Mandibular Fracture Masking Hyoid Bone Fracture.
Moon Kyun CHO ; Je Min AN ; Chul Han KIM ; Sang Gue KANG
Archives of Plastic Surgery 2014;41(1):93-95
No abstract available.
Hyoid Bone*
;
Mandibular Fractures*
;
Masks*
7.Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue.
Moon Kyun CHO ; Je Min AN ; Chul Han KIM ; Sang Gue KANG
Archives of Plastic Surgery 2014;41(1):35-39
BACKGROUND: Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. METHODS: Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. RESULTS: Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. CONCLUSIONS: Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
Aurora Kinase A*
;
Blotting, Western
;
Cytokinesis
;
Diabetes Mellitus
;
DNA Damage
;
Humans
;
Mitosis
;
Skin*
8.A Comparison of Laparoscopic and Open Adrenalectomy in Patients with Pheochromocytoma.
Deok Hyun CHO ; Eun Sang YOO ; Tae Kyun KWON
Korean Journal of Urology 2006;47(6):614-619
PURPOSE: While the safety and efficacy of laparoscopic adrenalectomy are relatively well documented, this procedure remains challenging for pheochromocytoma. The purpose of our investigation was to assess the perioperative profiles of laparoscopic adrenalectomy (LA) with those of open adrenalectomy (OA) in patients with pheochromocytoma. MATERIALS AND METHODS: Between January 1997 and October 2005, 31 patients with pheochromocytoma underwent surgical removal, including 15 LA and 16 OA. The LA was performed via a lateral decubitus transperitoneal approach. The mean tumor size was similar in both groups (LA 6.0cm vs. OA 5.7cm). All patients underwent extensive preoperative medical preparation with alpha-blockers. The intraoperative hemodynamic instabilities and perioperative profiles were retrospectively analyzed. RESULTS: No conversion to open surgery was required with either procedure and no mortality was observed. Hypertensive crisis (systolic blood pressure>200mmHg) and severe tachycardia (heart rate>100/min) were more common in the OA group (LA 13.3 and 26.7% vs. OA 56.3 and 62.5%). The mean operating times for both groups were similar (LA 182.0+/-47.0 min vs. OA 183.1+/-66.5 min), but the duration of hospitalization was shorter in the LA group (LA 5.3+/-2.2 days vs. OA 6.8+/-1.0 days). The estimated blood loss was greater in the OA group (LA 103.3+/-44.2ml vs. OA 159.4+/-66.8ml). Intravenous morphine was needed in 56.3% of the OA, but in only 13.3% of the LA group. There were no significant differences in the postoperative complications between the two groups. CONCLUSIONS: The laparoscopic resection of pheochromocytomas can be accomplished safely and effectively. A short hospital stay, with minimal perioperative morbidity and the eradication of endocrinopathy, support the minimally invasive approach for adrenalectomy in patients with pheochromocytoma.
Adrenalectomy*
;
Conversion to Open Surgery
;
Hemodynamics
;
Hospitalization
;
Humans
;
Laparoscopy
;
Length of Stay
;
Morphine
;
Mortality
;
Pheochromocytoma*
;
Postoperative Complications
;
Retrospective Studies
;
Tachycardia
9.Can Multiple Short-Term SunreiUances Replace Long-Term Sunreillance for Estimating Nosocomial Infection Rate?.
Yong Kyun CHO ; Sang Oh LEE ; Shin Young PARK ; Eun Sun LEE ; Sue Yun KIM ; Yiel Hae SEO
Korean Journal of Nosocomial Infection Control 2006;11(1):21-26
BACKGROUND: To determine whether multiple short-term surveillances are as effective as long-term surveillance for estimating the incidence rates of nosocomial infections (NIs), we prospectively performed 9-month surveillance in four intensive care units (ICUs). METHODS: NI surveillance was performed prospectively from November 2002 through July 2003, with long-term surveillance performed over the 9-month period, and short-term surveillance performed during the middle 3 weeks of each calendar quarter. The incidence rate of NIs or device-associated infections was calculated as the number of infections per 1,000 patient-days or device-days. RESULTS: We observed no significant differences between the incidence rates of total NIs determined from these two methods (9.6 [CI95 8.2-11.3] vs 10.4 [CI95 7.5-14.4], P=.66). In addition, these two methods did not differ significantly in estimating the rates of ventilator-associated pneumonia (5.1 [CI95 3.4-7.6] vs 7.5 [CI95 3.8-15.0], P=.35), catheter-associated urinary tract infection (2.4 [CI95 1.7-3.4] vs 1.7 [CI95 0.7-4.1], P=.47), and central line-associated bloodstream infection (2.2 [CI95 1.4-3.4] vs 3.7 [CI95 1.9-7.4], P=.21). Plotting of the NI rates showed that the trends in multiple short-term surveillances were similar to those in long-term surveillance, except in one ICU. CONCLUSION: Our findings suggest that multiple short-term surveillances could replace long-term surveillance in estimating the baseline incidence rates of NIs in the circumstances of the relatively large number of patients in the ICUs, which would be especially useful in countries with limited resources.
Cross Infection*
;
Epidemiology
;
Humans
;
Incidence
;
Infection Control
;
Intensive Care Units
;
Pneumonia, Ventilator-Associated
;
Prospective Studies
;
Urinary Tract Infections
10.Reference Values of Transcranial Doppler Ultrasonography Measurements of Healthy Adults with Normal MRI and MRA Findings..
Soo Jin CHO ; Chin Sang CHUNG ; Kwang Ho LEE
Journal of the Korean Neurological Association 1998;16(3):264-270
BACKGROUND AND PURPOSE: We present reference values of flow velocities of the intracranial and extracranial cerebral arteries for transcranial Doppler ultrasonography of healthy adults with normal MRI and MRA findings. METHODS: We selected 131 presumed normal subjects among 220 visitors of our stroke prevention clinic by strict exclusion criteria based on clinical, MRI, and MRA findings. We excluded those with history of migraine, infarct (s) on MRI, significant stenosis on MRA (more than 50% in diameter), and abnormal hematocrit levels. RESULTS: The age of the subjects ranged from 33 to 69 years (mean+SD: 53.5+7.60). Mean flow velocities in men at their 6 decades are 50.6+8.42 cm/sec in MCA, 46.6+9.40 cm/sec in ACA, 29.2+6.70 cm/sec in PCA and 35.3+9.28 cm/sec in BA. The upper limit of normal left-right velocity ratio was 1.43 in MCA, 1.50 in ACA, and 1.51 in PCA. The upper limit of normal range of hemispheric index was 2.96. CONCLUSION: This is the first report of references values of transcranial Doppler ultrasonography in healthy subjects with the normal MRI and MRA findings.
Adult*
;
Cerebral Arteries
;
Constriction, Pathologic
;
Hematocrit
;
Humans
;
Magnetic Resonance Angiography
;
Magnetic Resonance Imaging*
;
Male
;
Migraine Disorders
;
Passive Cutaneous Anaphylaxis
;
Reference Values*
;
Stroke
;
Ultrasonography, Doppler, Transcranial*