2.Cognitive deficits of the schizophrenics.
Jae Joong SHIN ; Min Kyou LEE ; Sang Hag PARK
Journal of Korean Neuropsychiatric Association 1991;30(5):815-823
No abstract available.
3.Cognitive deficits of the schizophrenics.
Jae Joong SHIN ; Min Kyou LEE ; Sang Hag PARK
Journal of Korean Neuropsychiatric Association 1991;30(5):815-823
No abstract available.
4.Experience of directed donor program in surgery of patients with primary liver cancer.
Seon Ho LEE ; Nam Yong LEE ; Kyou Sup HAN ; Han Ik CHO ; Sang In KIM
Korean Journal of Blood Transfusion 1992;3(2):129-136
No abstract available.
Humans
;
Liver Neoplasms*
;
Liver*
;
Tissue Donors*
5.Supplement of Incomplete Apoptosis Through CD8/Fas Chimeric Molecule by PMA of IFN-gamma.
Sang Kyou LEE ; Jae Hyuck SHIM ; Jung Hee LIM ; Jae Young LEE ; Young Sub SONG
Korean Journal of Immunology 1998;20(2):203-209
No abstract available.
6.Immunosuppressive Effects of Tautomycetin on T Cells.
Heug Kyu LEE ; Kyung Min CHO ; Hyoung Sik CHUN ; Hyeog Jin SON ; Sang Kyou LEE
Korean Journal of Immunology 1998;20(2):85-90
T cell activation is a critical event for initiation and regulation of immune responses and inhibitors of such signaling pathways are clinically useful for the treatment of patients received allogratt and autoimmune disease. In the course of screening soil microorganisms from the forest of Cheju island in Korea for new immunosuppressive agent, one of Streptomyces species (CK-95441) was found to produce a new immunosuppressant, tautomycetin which also had antifungal activity. Tautomycetin showed the inhibition of T cell proliferation in murine mixed lymphocyte reaction (MLR) and T cell activation induced by concanavalin A. Tautomycetin also blocked the induction of IL-2 gene expression which was examined in Jurkat TAg cell line in which multiple NFAT-binding sites and minimal IL-2 promoter drive the production of B-galactosidase. Also, the level of inhibition in activation-induced IL-2 receptor expression by tautomycetin was greater than those by cyclosporin A measured by flow cytometry. But, Fas ligand-induced apoptosis in Jurkat cells was unaffected by tautomycetin which was measured by DNA fragmentation assay. These results suggested that tautomycetin will be able to be used as a potent immunosuppressive drug following organ transplantation.
7.Presence of anti-D in the patient with the D/u phenothype: case report.
Nam Yong LEE ; Seog Woon KWON ; Kyou Sup HAN ; Sang In KIM
Korean Journal of Blood Transfusion 1991;2(2):215-217
No abstract available.
Humans
8.Experience of therapeutic plasma exchanges in Seoul National University Hospital.
Tae Hyun UM ; Nam Yong LEE ; Hyo Soon PARK ; Kyou Sup HAN ; Sang In KIM
Korean Journal of Blood Transfusion 1993;4(2):199-205
No abstract available.
Plasma Exchange*
;
Plasma*
;
Seoul*
9.Experience of therapeutic plasma exchanges in Seoul National University Hospital.
Tae Hyun UM ; Nam Yong LEE ; Hyo Soon PARK ; Kyou Sup HAN ; Sang In KIM
Korean Journal of Blood Transfusion 1993;4(2):199-205
No abstract available.
Plasma Exchange*
;
Plasma*
;
Seoul*
10.Functions of Ich-1(L). and Ich-1(S) in Apoptotic Signaling Pathway of jurkat T Cells.
Sang Kyou LEE ; Jae Hyuck SHIM ; Hyun Jung KIM ; Jung Hee LIM
Korean Journal of Immunology 1998;20(2):91-99
Human caspase-2, Ich-1 (Ice and Ced-3 homolog), has two different forms of mRNA species derived from alternative splicing, which encodes Ich-1 and Ich-1s. Ich-1v which induces apoptosis is antagonist of Ich-1s which suppresses Rat-1 cell death by serum deprivation. To investigate functions of Ich-1 and Ich-1s in T celi apoptosis, the fusion DNA constructs were made with the ecto and transmembrane of CDB and Ich-lv or Ich-1s and CDS-Ich-1 or CD8-Ich-1s chimeric protein was transiently expressed on Jurkat T cells. Tyrosine phosphorylation of intracellular proteins was induced in these transfectans when activated shortly by anti-CDB Ab. CDB-Ich-li transfectant in serum-rich condition and CDB-Ich-ls transfectant in serum-deprived condition underwent apoptosis when treated with anti-CDS Ab or incubated with NIH3T3 cells expressing stably Fas-L on their surface. We also made six antisense DNA constructs which could specifically inhibit the expression of Ich-1v, Ich- 1s, and then they were transiently transfected into Jurkat T cell. The overexpression of both of the antisese- Ich-1 against N-terminal 42 bp and against C-terminal 366 bp inhibited apoptosis through Fas signalling. But, when three different forms of antisense-Ich-1s were overexpressed in their transfectants, antisense-DNA against N-terminal 197 bp increased knd the one against C-terminal 66 bp inhibited apoptosis, instead the full size of antisense-DNA did not give any effects on apoptosis through Fas pathway.
Humans
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