No abstract available.
Female ; Lactation*

No abstract available.
Jaundice, Chronic Idiopathic*

No abstract available.
Carcinoma, Small Cell* ; Female ; Ovary*

We performed simple and successful canalicular reconstruction with smooth tip pigtail probe in 56 cases of inferior canalicular laceration. After general anesthesia or local anesthesia in inferior and superior canthal area, upper lacrimal sac area and lacerated inferior eyelid, methylcellulose mixed fluorescein was injected through the superior canaliculus under the surgical microscope with cobalt blue filter and simply found cutting end of the inferior canalicullus. Smooth tip pigtail probe was inserted and silicone stent was connected the superior and inferior canaliculi and the peri canalicular sheath was sutured with and to end anastomosis. Silicone tube was removed after postoperative 8 weeks and 86% of the patients(48/56 cases) was successful without epiphora. Smooth tip pigtail probe, methylcellulose mixed fluorescein, silicone stent, and end to end anastomosis of pericanalicular sheath under the surgical microscope would increase the success rate of pigtail probe canalicular reconstruction.
Anesthesia, General ; Anesthesia, Local ; Cobalt ; Eyelids ; Fluorescein ; Lacerations ; Lacrimal Apparatus Diseases ; Methylcellulose* ; Silicones* ; Stents

Sertoli-Leydig cell tumors of the ovary are rare, accounting for no more than 0.5% of all ovarian neoplasms. These tumors occur predominantly in women 10 to 30 years of age. Heterologous elements are found in over 20% of the moderately and poorly differentiated Sertoli- Leydig cell tumors. The most common element is gastrointestinal mucin-secreting epithelium, found in approximately 20% of all cases. Approximately 4% of Sertoli-Leydig cell tumors contain immature skeletal muscle and/or cartilaginous elements. The origin of these neoplasms is regarded as neometaplasia of the mesodermal neoplastic element. While the degree of differentiation of Sertoli-Leydig cell tumors is probably of greater importance in determining prognosis than the presence of heterologous components, recent evidence does point to an unfavorable effect on clinical outcome when heterologous mesenchymal components such as cartilage and striated muscle are present. We experienced two cases of ovarian heterologous Sertoli-Leydig cell tumors with gastrointestinal type epithelium and striated skeletal muscle in 20 and 21 year-old females, respectively. One case involved a patient who had complained of amenorrhea for 3 years while the other case involved a patient who had complained of left lower abdominal tenderness and amenorrhea for one and one half years. It was determined by ultrasonography of the pelvis that the two patients suffered from right and left ovarian masses. Both patients underwent adnexectomy. These tumors were large with partly solid and partly cystic areas. Based on light microscopic examination one case was classified as an intermediate Sertoli-Leydig cell tumor with heterologous gastrointestinal type epithelium, while the other case was classified as a poorly differentiated Sertoli-Leydig cell tumor with heterologous striated skeletal muscle.
Female ; Humans

The authors experienced a case of the monomorphic adenoma of lacrimal gland. Monomorphic adenoma is an extremely rare salivary gland tumor. A fifty eight year old Korean female was admitted to our Dept. of Ophthalmology because of multiple small nodular masses on her right upper eyelid and a large hard solitary mass in the supraorbital area since one year ago. On B-scan ultrasonogtaphy, round echo-free zone was detected in the superiortemporal orbit. Well defined hyperdense, enhanced round extraconal mass in the superiororbital area was detected by orbital CT scan. Two large well encapsulated, dark brown colored masses were extracted by supraorbital approach and lateral orbitotomy under general anesthesia. After removal of the masses, histopathologic examination confirmed the lacrimal monomorphic adenoma.
Adenoma* ; Anesthesia, General ; Eyelids ; Female ; Humans ; Lacrimal Apparatus ; Ophthalmology ; Orbit ; Salivary Glands ; Tomography, X-Ray Computed

BACKGROUND: Several differences in basal cell carcinomas (BCCs) were found, according to the ethnic group; for example, pigmented BCCs was more common in Asian or Hispanic patients. However, there are few reports on the subclinical extension of the BCC in Asian patients. OBJECTIVE: The aim of this study was to evaluate the subclinical infiltration of the basal cell carcinoma in Asian patients. METHODS: All patients with BCC who visited the department of dermatology at Korea University Ansan Hospital were treated with Mohs micrographic surgery. In 81 patients, 83 tumors of BCC were completely eradicated by Mohs micrographic surgery (MMS) from April 2001 to August 2008, and were reviewed in this study. Information recorded included the total margin and the number of stages of Mohs micrographic surgery, anatomic location, tumor size, presence of pigmentation, clinical type, and pathological subtype. We divided the clinical types into nodular, ulcerated, and pigmented, and the pathological types into nodular, micronodular, morpheaform, and adenoid. The BCC was of pigmented type if pigmentation covered more than 25% of the tumor, regardless of whether pigmentation was distinct, or if there was apparent pigmentation that covered more than 10% of the tumor. RESULTS: The nose and cheek were the most common sites requiring more than one stage of surgery. In tumors smaller than 1 cm, 91.7% required only one stage of excision, compared with 60.6% in tumors larger than 1 cm. More than two Mohs stages were required in 25% of non-ulcerated BCCs and in 46.2% of ulcerated BCCs. Sixty eight percent of pigmented BCCs required only one stage of Mohs micrographic surgery. In cases of non-pigmented BCCs, only 45% required one Mohs stage. More than one Mohs stage was required in 19.2% of non-aggressive BCCs and in 42.9% of aggressive BCCs. CONCLUSION: Subclinical infiltration differed between the two groups according to the size of the BCC (1 cm threshold) and most of the BCCs were located in the head and neck area. Considering this result, indication for MMS can be extended for BCCs larger than 1 cm in Asian patients. Ulcerated BCCs required more Mohs stages than non-ulcerated BCCs. Pigmented BCCs might show lesser subclinical infiltration than non-pigmented BCCs. Aggressive pathological subtypes showed more subclinical infiltration than the non-aggressive types; however, after evaluation of the border that was excised with MMS, mixed histologic types were found to be more frequent than generally accepted. Therefore, we consider that, when planning surgery, dermatologists should not place too much confidence in the pathologic subtypes identified by biopsy.
Adenoids ; Asian Continental Ancestry Group ; Biopsy ; Carcinoma, Basal Cell ; Cheek ; Dermatology ; Head ; Hispanic Americans ; Humans ; Hypogonadism ; Korea ; Mitochondrial Diseases ; Mohs Surgery ; Neck ; Nose ; Ophthalmoplegia ; Pigmentation ; Ulcer

No abstract available.
Humans ; Perfusion* ; Prenatal Diagnosis*

PURPOSE: Heat shock protein (HSP) 70 has been known to have neuroprotective effect on the retinal ganglion cells (RGCs) in vitro and in a rat glaucoma model. This study was to evaluate the inducible HSP70 expresseion in the retinal ganglion cell (RGC) after partial crush injury in mice and to determine the effect of hsp70.1 on the RGCs in the normal condition and after partial crush injury of the optic nerve. METHODS: The optic nerve was crushed by clipping optic nerve with aneurysm clip (110G) for 30 seconds. H and E staining and immunohistochemical staining for inducible HSP70 was performed in the hsp70.1 knockout mice and wild type mice. The RGC counts before crush injury were compared and the losses of RGCs after 3 weeks were compared between the two groups. Loss of RGCs was monitored as a percentage of cells decreased relative to the contralateral sham-operated eye. RESULTS: Immunohistochemical staining showed HSP70 induction in the RGC layer after optic nerve crush injury in both hsp70.1 knockout mice and wild type mice. RGC count before crush injury showed no significant difference (n=8, Mann-Whitney test), and the loss of RGCs was 31.0%+/-0.1% (mean+/-SD) in the hsp70.1 knock-out mice and 32.6%+/-0.1% in the wild type mice without any significant difference between the two groups (n=8, Mann-Whitney test). CONCLUSIONS: HSP70 was induced in the mice RGC layer by optic nerve crush injury and the hsp70.1 gene didn't affect the RGC counts in normal condition and RGC survival after optic nerve crush injury in the mouse.
Aneurysm ; Animals ; Glaucoma ; Heat-Shock Proteins* ; Hot Temperature* ; Mice* ; Mice, Knockout ; Neuroprotective Agents ; Optic Nerve* ; Rats ; Retinal Ganglion Cells* ; Retinaldehyde*

The nineteen patients(20 eyes) of traumatic optic neuropathy were investigated to evaluate the effectiveness of high dose corticosteroid for the visual improvernent in the early treatment of this disease. The relationships between the affected region and visual improvement, the interval to treatment and final visual acuity, the initial visual acuity and final visual acuity were studied. 250mg of methylprednisolone was administered intravenously every 6 hours followed by tapering using oral prednisone. The optic canal decompression was performed in five patients suspected swelling of optic nerve or optic canal fracture revealed by orbital CT. It is difficult to know the relationships between the affected region and visual improvement, the interval to treatment and final visual acuity. The vision was improved in nine of eleven patients who had an initial visual acuity of above light perception, but in the two of nine patients who had an initial visual acuity of no light perception. The two of five patients treated with a combina tion of high dose corticosteroid and optic canal decompression showed improved visual function. In initial treatment of traumatic optic neuropathy, high dose corticosteroid was effective and combined optic canal decompression was helpful, if indicated.
Decompression ; Humans ; Methylprednisolone ; Optic Nerve ; Optic Nerve Injuries* ; Orbit ; Prednisone ; Visual Acuity