BACKGROUND: With increasing number of female pilots who fly high-performance aircraft, the gender specific factors have become one of the most important aeromedical considerations. It has been raised that the changes of serum female hormone levels by menstrual cycle may affect vasoregulation and female G-tolerance ultimately. However, the exact relationship between serum female hormone levels and G-tolerance is still unknown. Moreover, well-controlled subjects without taking oral contraceptives are needed to examine the possible effect of menstrual cycle on female G-tolerance. The purpose of this study was to determine how female hormones and menstrual cycle affect female relaxed G-tolerance. METHODS: Eight female subjects were studied to test their relaxed G-tolerance. Seven out of 8 subjects had regular menstrual cycle during the study period. Each subject were exposed to human centrifuge once a week for 4 weeks (one complete menstrual cycle) and blood samplings were performed twice at 2nd and 4th week just before exposure to human centrifuge. The profile of centrifuge training consisted of gradual-onset run (0.1 G/sec) acceleration to the visual endpoint. RESULTS: The changes of 4 different serum female hormone levels failed to show any trend related to relaxed G-tolerance including estrogen. There was no significant difference in relaxed G-tolerance in any menstrual cycle time points. CONCLUSION: We conclude that the changes of female hormone levels and the menstrual cycle have no effect on female relaxed G-tolerance.
Acceleration ; Aircraft ; Contraceptives, Oral ; Diptera ; Estrogens ; Female* ; Humans ; Menstrual Cycle*

Sister chromatid exchanges (SCEs) observed by means of bromodeoxyuridine substitution and fluorescence plus Giemsa (FPG) technique were proposed as a sensitive and quantitative assay for mutagenicity and cytotoxicity in short-term cultures of phytohaemagglutinin (PHA)-stimulated human lymphocytes. Therefore, this study was carried out to investigate the relation between anticancer agents and cytotoxic effects. Chromosomal analysis was performed on metaphase cells that had divided one, two, or three or more times after treatment for SCEs, mitotic indices (MI) and cell cycle kinetics by FPG technique. The results indicate that anticancer agents led to a dose dependent increase in SCE frequency except methotrexate. But, highly inhibited mitotic indices and delayed cell cycle kinetics were observed except for cyclophosphamide. The author suggest that the difference of SCE frequency is due to the differences in the cytotoxic action of anticancer agents, but although the induction of SCEs has a correlation with cell cycle delay, in some cases the induction of SCEs is not always related to cell cycle delay because of different cytotoxic action of anticancer agents.
Antineoplastic Agents* ; Bromodeoxyuridine ; Cell Cycle* ; Cyclophosphamide ; Fluorescence ; Humans ; Humans* ; Kinetics* ; Lymphocytes* ; Metaphase ; Methotrexate ; Mitotic Index ; Siblings* ; Sister Chromatid Exchange*

No abstract available.
Carcinoma, Small Cell* ; Female ; Ovary*

No abstract available.
Female ; Lactation*

PURPOSE: To analyze the characteristies of traumatic brainstem injury by CT and MR MATERIALS AND METHODS: CT and MR studies of 10 patients with traumatic brainstem lesion in MR were retrospectively reviewed, particularly attended to location, signal intensity and associated lesions. RESULTS: CT failed to depict 8 of 10 brainstem lesions. All lesions were detected in MR images with T2-weighted images showing higher detection rate (n=10) (100%) than Tl-weighted images (n=3) (30%) or CT (n=2) (20%). The brainstem lesions located in the dorsolateral aspects of the rostral brainstem(mid brain and upper pons)in 7 (70%) cases, in ventral aspects of rostral brain in 2 (20%) cases and in median portion of pons in 1 (10%) case. Corpus callosal (n=5), Iobar white matter(n=5) diffuse axonal injury, and 2 hemorrhagic lesions in basal ganglia were the associated findings. CONCLUSION: MR imaging is more helpful than CT in the detection of brainstem injury, especially T2 weighted images. Primary brainstem lesions were typically located in the dorsolateral aspect of rostral brainstem(midbrain and upper pons). Corpus callosum and white matter lesions were frequently associated.
Basal Ganglia ; Brain ; Brain Stem* ; Corpus Callosum ; Diffuse Axonal Injury ; Humans ; Magnetic Resonance Imaging ; Pons ; Retrospective Studies

No abstract available.
Carotid Artery, Common* ; Rupture*

We noticed a group of thoracolumbar and lumbar spine fractures showing a unique fracture pattern that consisted of 1) superior disc injury, 2) crush fracture of the upper half of the vertebral body, 3) sagittal fracture of the lower half of the vertebral body, 4) bone fragments in the spinal canal, and 5) lamina fracture. Some of these fracture patterns were present in type B burst fracture of Denis classification. The purpose of this study was to compare the difference between crush-cleavage fracture and type B burst fracture in the viewpoint of neural canal involvement and neurologic status, and functional outcome with surgical treatment. Ten cases were identified as crush-cleavage fractures in 22 type B burst fractures during a 5 year period from Mar. 1989 to Jun. 1993 at the Department of Orthopedic Surgery of Chonbuk National University Hospital. Four out of 10 crush-cleavage fractures and 4 out of 12 type B burst fractures were paraparetic. Crush-cleavage fracture must be an unstable thoracolumbar comminuted fracture, but there were no significant differences in the neural canal involvement, incidence of neurologic deficit, and in the functional outcome, compared with type B burst fracture (P>0.05). It could be classified as a progressed form of type B burst fracture in Denis classification, or as a burst-split fracture in Magerl classification in the anatomical viewpoint. In conclusion, crush-cleavage fracture must be a variant of burst fracture.
Classification ; Fractures, Comminuted ; Incidence ; Jeollabuk-do ; Neural Tube ; Neurologic Manifestations ; Orthopedics ; Spinal Canal ; Spine

No abstract available.
Thromboangiitis Obliterans

No abstract available.
DNA Topoisomerases* ; DNA*

No abstract available.
Child* ; Humans ; Rheumatic Fever*