Proliferating trichilemmal tumor is a relatively uncommon tumor which develops preferentially as a solitary tumor on the scalp of elderly women. Histologically, the tumor i epresents a proliferation of the outer root sheath epithelium in a characteristic pattern, but the presense of cellular atypia, dyskera.totic cells and mitotic figures may lead to a false impression of squamous cell carcinoma. We report a case of proliferating trichliemmal tumor in a 70-yeiir-old male who presented with a slowly growing tumor on his right inguinal area for 2 years. This case is unusual in that the tumor occurred on the inguinal are anoher than the scalp in a male.
Aged ; Carcinoma, Squamous Cell ; Epithelium ; Female ; Humans ; Male ; Scalp

No abstract available.
Cerebrospinal Fluid* ; Child* ; Humans ; Lactic Acid*

118 Cases of open tibia fractures treated in Chosun university Hospital were survayed and evaluated. Results: 1. The cases are predominantly male(80%) and most often in their 4th decade. 2. They were very often comminuted(44%) 3. Treatments consists of debridement with or without initial internal(plate and screws) or external (Hoffmann's device) fixations. The end results seems to be better in cases with initial fixations of bone(internal or external)than those treated with initial debridement and plaster cast immobilization only and osteosynthesis later.
Casts, Surgical ; Clinical Study ; Debridement ; Fractures, Open ; Immobilization ; Tibia

Dysplasia epiphysialis punctata is a rare congenital disorder of infancy affecting in particular cartilage, muscle, jointtcapsules and the eyes. A case of dysplasia epiphysialis punctata with involvement of all epiphyses of extremities, spine and pelvis in 2 days old male is to be reported with review of literature.
Cartilage ; Chondrodysplasia Punctata ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Epiphyses ; Extremities ; Humans ; Male ; Pelvis ; Spine

Thirty-three cases of the fracture of the femur and tibia on the same limb were treated at the Orthopedic Department of the Chosun University Hospital during the period from January 1977 to December 1983. The following results were obtained. 1. The incidence of trauma was high in the young man, most frequent in the third decade (45.4%). 2. The most common cause of the fracture was traffic accident (81;8%). 3. The most common shape of the fracture was comminuted in both femur and tibia. 4. The common fracture site were middle one-third in both femur and tibia. 5. Eight patients were treated by conservative means on both femxr and tibia. The patients were treated by internal fixation on femur and by conservative means on tibia. Internal fixation was .done in ten patients on both femur and tibia. Two patients were treated by inteinal fixation on tibia and by conservative means on femur. Three patients were amputated. 6. Average healing time of fracture was 21 weeks in femur and 24.2 weeks in tibia. 7. Functional end results were assessed and rated with satisfactory results in rigid internal fixation of the femur and tibia.
Accidents, Traffic ; Clinical Study ; Extremities ; Femur ; Humans ; Incidence ; Inteins ; Orthopedics ; Tibia

Mycosis fungoides is an unusual malignancy of helper T-lymphocyte origin which presents initiaily with skin disease and progresses to the lymph nodes, peripheral blood. and viseral organs, and frequently results in death. A 51-year-old woman was admitted to the hospital in October, 1930 for the evaluation of a painful reddish brown tumor with ulceration of 6 months duration on the abdomen. Lymphadenopathy was not present, and routine laboratory examinations revealed negative or, within normal limits. She was diagnosed as mycosis fungoides with stage IIb according to the commirtee on staging and classification of cutaneous T-cell lymphoma, and treated with chemotherapy;regimen, BAM-M consisted of Bleomycin, Adriamycin, Methotrexate and topical nitrogen mustard. she achieved complete remission of the tumor with five cycles of BAM-M chemotherapy. We report favorable response after BAM-M chemotherapy in a pacent with advanced stage of mycosis fungoides(TNM IIb).
Abdomen ; Bleomycin ; Classification ; Doxorubicin ; Drug Therapy* ; Female ; Humans ; Lymph Nodes ; Lymphatic Diseases ; Lymphoma, T-Cell, Cutaneous ; Mechlorethamine ; Methotrexate ; Middle Aged ; Mycosis Fungoides* ; Skin Diseases ; T-Lymphocytes, Helper-Inducer ; Ulcer

Epidermal growth factor(KGF) and transforming growth factor arpha(TGF-a) are polypeptides of 53 amd 50 amino acid residuies. Both bind to epidermal growth factor receptor (EGR-R) leading to phosphorylation of the receptor, enhancement of its tyrosine-specific kinase activity and ultimately to stimulation of cell growth. To study he role of EGF, TGF-a, and EGF-R in differentiation and hyperproliferation of cell, we se lected psoriasis vulgaris, because the affected keratinocyte may house both an abnormally increased proliferative capacity and an abnormally differentiated state. The biopsy specimens were taken from involved and uninvolved skin of 20 patients with psoriasis and immunoperoxidase studies with formalin-fixed paraffin-embedded tissues were performed with EGF, TGF-a and EGF-R useing the Vectastain ABC irnmunoperoxidase stain system. The antibodies were used at a concentration of 6 ug/ml In involved psoriatic skin, distributions of TGF-a and EGF-R were increased in all layers of epidermis as compared to normal, uninvolved psoriatic skin, in which chev were showed to the basal and parabasal layers. However, distribution of EGF was weekly positive in the basal layers of epidermis in both involved and uninvolved skin with no difference between toem. These results suggest that increased distribution of TGF-a and EGF-R may be involved in hypoproliferative state of epidermal keratinocytes in psoriatic lesion.
Antibodies ; Biopsy ; Epidermal Growth Factor ; Epidermis* ; Humans ; Keratinocytes ; Peptides ; Phosphorylation ; Phosphotransferases ; Psoriasis ; Receptor, Epidermal Growth Factor ; Skin ; Transforming Growth Factors

No abstract available.
Hematoma, Subdural, Spinal* ; Spinal Puncture*

PURPOSE: To determine whether neoadjuvant androgen deprivation therapy (NADT) improves clinical outcomes in patients with prostate cancer treated with definitive radiotherapy. MATERIALS AND METHODS: We retrospectively reviewed medical records of 201 patients with prostate cancer treated with radiotherapy between January 1991 and December 2008. Of these, 156 patients with more than 3 years of follow-up were the subjects of this study. The median duration of follow-up was 91.2 months. NADT was given in 103 patients (66%) with median duration of 3.3 months (range, 1.0 to 7.7 months). Radiation dose was escalated gradually from 64 Gy to 81 Gy using intensity-modulated radiotherapy technique. RESULTS: Biochemical relapse-free survival (BCRFS) and overall survival (OS) of all patients were 72.6% and 90.7% at 5 years, respectively. BCRFS and OS of NADT group were 79.5% and 89.8% at 5 years and those of radiotherapy alone group were 58.8% and 92.3% at 5 years, respectively. Risk group (p = 0.010) and radiation dose > or =70 Gy (p = 0.017) affected BCRFS independently. NADT was a significant prognostic factor in univariate analysis, but not in multivariate analysis (p = 0.073). Radiation dose > or =70 Gy was only an independent factor for OS (p = 0.007; hazard ratio, 0.261; 95% confidence interval, 0.071-0.963). CONCLUSION: NADT prior to definitive radiotherapy did not result in significant benefit in terms of BCRFS and OS. NADT should not be performed routinely in the era of dose-escalated radiotherapy.
Follow-Up Studies ; Humans ; Medical Records ; Multivariate Analysis ; Prostatic Neoplasms* ; Radiotherapy* ; Radiotherapy, Intensity-Modulated ; Retrospective Studies

The effects of treatment with mercury chloride on the nitrite and nitrate syntheses were observed in peritoneal macrophages from Balb/c mice and EMT-6 cells in vitro. The cells were cultured in Dulbecco's modified Eagle's medium(DMEM) with cytokines. Amounts of nitrite and nitrate in the culture media after 24 and 36 hours of culture were about 2-fold, and 3-fold of those measured after 12 hours respectively. There were very close associations between the amounts of nitrite and nitrate measured in the culture media according to culture time. The survival rate of peritoneal macrophages was significantly decreased by mercury chloride added into the media in dose-dependent manner, however the survivals of EMT-6 cells were not influenced by mercury chloride concentration in media. Nitrite and nitrate syntheses were dose-dependently decreased by mercury chloride added in culture media. ATP synthesis also decreased in EMT-6 cells by mercury chloride. These results reported here suggest that the disorder of cell mediated immunity by mercurials could be related to the inhibition of nitric oxide synthesis which seems to be caused by the inhibition of ATP synthesis.
Adenosine Triphosphate ; Animals ; Culture Media ; Cytokines ; Immunity, Cellular ; Macrophages ; Macrophages, Peritoneal* ; Mice* ; Nitric Oxide* ; Survival Rate