No abstract available.
Organ Transplantation* ; Transplants*

No abstract available.
Aneurysm, Infected

Multiple involvement of arterial fibromuscular dysplasia is unusal and such a case is quite limited in the literature. We present a case of multiple arterial fibromuscular dysplasia with aneurysm formation in a 38-year-old non-hypertensive man. Angiographic study showed multiple aneurysmal dilatations of the right renal, superior mesenteric, celiac axis, and left colic arteries. The resected right kidney demonstrated an aneurysm of the main renal artery and extensive infarction in the midportion of the renal parenchyma. The segmentally resected superior mesenteric artery disclosed a similar nature of aneurysm occluded by recent thrombi. Microscopically, all the resected arterial walls showed both intimal and medial fibroplasia together with periadventitial fibrosis resulting in marked narrowing of the lumen and subsequent thrombus formation.

BACKGROUND: This study aimed to investigate bradycardia as an adverse effect after administration of dexmedetomidine during 33degrees C target temperature management. METHODS: A retrospective study was conducted on patients who underwent 33degrees C target temperature management in the emergency department during a 49-month study period. We collected data including age, sex, weight, diagnosis, bradycardia occurrence, target temperature management duration, sedative drug, and several clinical and laboratory results. We conducted logistic regression for an analysis of factors associated with bradycardia. RESULTS: A total of 68 patients were selected. Among them, 39 (57.4%) showed bradycardia, and 56 (82.4%) were treated with dexmedetomidine. The odds ratio for bradycardia in the carbon monoxide poisoning group compared to the cardiac arrest group and in patients with higher body weight were 7.448 (95% confidence interval [CI] 1.834-30.244, p = 0.005) and 1.058 (95% CI 1.002-1.123, p = 0.044), respectively. In the bradycardia with dexmedetomidine group, the infusion rate of dexmedetomidine was 0.41 +/- 0.15 microg/kg/h. Decisions of charged doctor's were 1) slowing infusion rate and 2) stopping infusion or administering atropine for bradycardia. No cases required cardiac pacing or worsened to asystole. CONCLUSIONS: Despite the frequent occurrence of bradycardia after administration of dexmedetomidine during 33degrees C target temperature management, bradycardia was completely recovered after reducing infusion rate or stopping infusion. However, reducing the infusion rate of dexmedetomidine lower than the standard maintenance dose could be necessary to prevent bradycardia from developing in patients with higher body weight or carbon monoxide poisoning during 33degrees C targeted temperature management.
Atropine ; Body Weight ; Bradycardia* ; Carbon Monoxide Poisoning ; Dexmedetomidine* ; Diagnosis ; Emergency Service, Hospital ; Heart Arrest ; Humans ; Hypothermia, Induced ; Logistic Models ; Odds Ratio ; Retrospective Studies

No abstract available
Mycosis Fungoides*

Hepatitis C virus (HCV) E2 protein is known to be one of putative envelope proteins. To develop a sensitive detection method for HCV infected tissues and cells, monoclonal antibodys (MAbs) to the E2 protein of HCV were prepared from mice immunized with recombinant baculovirus-expressing E2 protein (Bac-E2). Several hybridoma clones secreting various levels of MAb were isolated and isotypes of these MAb were determined. One clone (L.2.3.3) was used for ascites production and the E2-MAb was purified and characterized. The L.2.3.3 reacted well with both Bac-E2 and E. coli expressed glutathione-5-transferase-E2 (GST-E2) fusion proteins. Using HCV patient sera, E2 envelope protein was found to be localized in the cell membrane boundary both in CHO cells and insect cells which express HCV E2 protein. Similar result was obtained when same cells were treated with the MAb L.2.3.3. These results demonstrated that Bac-E2 protein is capable of eliciting high titer antibody production in mice.
Animals ; Antibody Formation ; Ascites ; Cell Membrane ; CHO Cells ; Clone Cells ; Cricetinae ; Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Humans ; Hybridomas ; Insects ; Mice

No abstract available.
Hyperoxaluria, Primary* ; Kidney Transplantation* ; Kidney*

We studied anti-HBs titer, positive and effective rate in relation to dosages(5microgram, 10microgram) and time interval after third vaccination in 23 infants born to HBsAg negative mother. The babies were divided into two groups. In one group(n=12), 5microgram of Hepavax was administered intramusculary at 1 month, 2 months and 6 months of age, in other group (n=11), 10microgram of Hepavax at same time interval. And the anti-HBs was studied at 2 months and 3 year after third vaccination by radioimmunoassay. The results were as follows: 1) The anti-HBs positive rate was 100% in two groups at 2 months and 3 years after vaccination. 2) The geometric mean anti-HBs titer at 2 months after third vacciantion was 9418.3+/-13041.5 IU/L in 5microgram group and 12750.0+/-12750.5 IU/L in 10microgram group, and 3 year after vaccination, 949.4+/-1404.0 IU/L in 5microgram group, 1067.4+/-1067.7 IU/L in 10microgram group. There were no significant difference between two groups, although mean anti-HBs titer decreased significantly after 3 years. 3) The effective rate at 3 years after vaccination was 66.7% in 5 microgram group and 72.8% in 10microgram group. There was no statistical significant difference between two groups.
Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Hepatitis B* ; Hepatitis* ; Humans ; Infant ; Infant, Newborn* ; Mothers ; Radioimmunoassay ; Vaccination*

OBJECTIVES: REM sleep behavior disorder (RBD) has received little attention in epidemiologic studies. This study aimed to determine the prevalence of probable REM sleep behavior disorder (pRBD) in the elderly population and its clinical features. METHODS: A random sample of 1,588 was selected from a roster of 14,050 elderly population living in Osan city. The subjects were asked to fill out the REM sleep behavior disorder screening questionnaire (RBDSQ). Subjects whose score were 5 or higher on RBDSQ underwent a diagnostic phase of person-to-person assessment by experts in RBD. RESULTS: Among 1,588 subjects, 886 elderly subjects participated in the screening phase and 123 subjects were assessed in the diagnostic phase. Eleven subjects were diagnosed as having pRBD, so prevalence was 1.5% (95% CI=0.70-2.30%). The frequency of depression and cognitive decline was significantly increased in patients with pRBD compared to subjects without pRBD, and there was no difference in sleep disturbances between two groups. CONCLUSIONS: Probable REM sleep behavior disorder is not rare in the elderly but frequently under-recognized. More attention should be paid to evaluation and treatment of RBD.
Aged ; Depression ; Epidemiologic Studies ; Humans ; Mass Screening ; Prevalence ; Surveys and Questionnaires ; REM Sleep Behavior Disorder ; Sleep, REM

OBJECTIVES: This study aimed to identify the essential symptoms for diagnosing Hwabyung. METHODS: We assessed 221 patients with depressive disorders, anxiety disorders, somatoform disorders, adjustment disorder, and so-called Hwabyung, using a structured diagnostic interview schedule that included the Korean version of SCID-I and the preliminary diagnostic criteria for Hwabyung. To select essential symptoms for diagnosing Hwabyung, we performed statistical analyses including factor analysis and logistic regression RESULTS: Statistical analysis revealed that sensations of heat, an epigastric mass, and something pushing up in the chest ; feelings of unfair treatment ; anger ; respiratory stuffiness ; palpitations; headaches ; sighing ;"haan" ; depressive mood ; frightening easily ; dry mouth; and many thoughts were the essential symptoms for a diagnosis of Hwabyung. CONCLUSION: Based on these results, we suggest a research diagnostic criteria for Hwabyung.
Adjustment Disorders ; Anger ; Anxiety Disorders ; Appointments and Schedules ; Depressive Disorder ; Discrimination (Psychology) ; Headache ; Hot Temperature ; Humans ; Logistic Models ; Sensation ; Somatoform Disorders ; Thorax