1.Two New Scalaranes from a Korean Marine Sponge Spongia sp..
Inho YANG ; Sang Jip NAM ; Heonjoong KANG
Natural Product Sciences 2015;21(4):289-292
Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of 1H-1H coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.
Porifera*
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Statistics as Topic
2.Violapyrone J, alpha-Pyrone Derivative from a Marine-derived Actinomycetes, Streptomyces sp..
Alain S LEUTOU ; Inho YANG ; Chi Nam SEONG ; Jaeyoung KO ; Sang Jip NAM
Natural Product Sciences 2015;21(4):248-250
A new alpha-pyrone derivative, violapyrone J (1), and along with the two known violapyrones B (2) and C (3) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. SC0718. The structure of violapyrone J (1) was elucidated from 1D and 2D NMR spectroscopic analyses.
Actinobacteria*
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Fermentation
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Streptomyces*
3.Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells
Min-Ji RYU ; Eun-Ki BAEK ; Soyeon KIM ; Chi Nam SEONG ; Inho YANG ; Kyung-Min LIM ; Sang-Jip NAM
Biomolecules & Therapeutics 2021;29(1):98-103
AbstractThe demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.