OBJECTIVE: The present study was designed to compare Global field Power Measurement and conventional method in P300 determination. METHOD: The subjects were composed of patients(N=20) with schizophrenia by DSM-IV and normal controls(N=20). The auditory event related potential P300 was measured by "oddball paradigm". P300 components were determined by Global Field Power Measurement and conventional method at 5 electrodes(Fz, Cz, Pz, T3, T4). RESULTS: P300 amplitudes of patients were smaller than those of controls across all electrodes and in both methods, but there was no differential power in P300 determination between two methods. Asymmetry of auditory event-related potential P300 was not shown between patients with schizophrenia and normal controls. CONCLUSION: It is implicated that it depends on clinical situations and research purposes what method of P300 determination will be more appropriate for patients with schizophernia.
Diagnostic and Statistical Manual of Mental Disorders ; Electrodes ; Event-Related Potentials, P300 ; Evoked Potentials ; Humans ; Schizophrenia

No abstract available.
Brain Mapping* ; Evoked Potentials, Visual* ; Schizophrenia*

We report a 72-year-old female patient with spontaneous rupture of the left external iliac vein. She visited our hospital for abdominal and back pain. She had the abnormal finding of hemoperitoneum. We performed an emergency operation with diagnosis of left ovarian cyst rupture though she suffered from spontaneous rupture of the left external iliac vein. This case provides insight to the experience of spontaneous rupture of the left external iliac vein.
Aged ; Back Pain ; Emergencies ; Female ; Hemoperitoneum ; Humans ; Iliac Vein ; Ovarian Cysts ; Rupture ; Rupture, Spontaneous

OBJECTS: This study was designed to investigate the characteristics of components of topographic auditory event-related potential P300 in the patients with schizophrenia and to evaluate the correlation between the findings of components of P300 and psychopathology. METHODS: The subjects consisted of 28 patients with schizophrenia and 28 normal controls who were matched by age and sex. The topographic auditory event-related P300 was recorded in oddball paradigm and analyzed by computerized brain mapping system. The latency of P300 was determined by global field power measurement. The psychopathology of the patients with chizophrenia were rated by PANSS. RESULTS: There were significant differences in both latency(schizophrenia 369.5+/-40.6msec, normal controls 332.6+/-34.8msec) and amplitude(schizophrenia: 4.1+/-3.1micro V, normal controls 6.7+/-3.2micro V). However, there was no difference in the electrode location of maximum area of P300 between the patients with schizophrenia and normal controls. The latency of P300 showed positive correlation and the amplitude showed negative correlation with PANSS scores of the patients with schizophrenia. CONCLUSION: The results implicate that the patients with schizoprenia might have mental dysfunction in the aspects of cognise process affected by both positive and negative symptoms.
Brain Mapping ; Electrodes ; Evoked Potentials* ; Humans ; Psychopathology* ; Schizophrenia*

OBJECTIVE: The present study was designed to investigate whether asymmetry of auditory event-related potential P300 was shown in patients with schizophrenia or not. METHOD: The subjects were composed of patients(N=20) with schizophrenia by DSM-IV and normal controls(N=20). The auditory event related potential P300 was measured by "oddball paradigm". P300 component was determined by classic method at 5 electrodes(Fz, Cz, Pz, T3, T4). RESULTS: P300 amplitudes of patients were smaller than those of controls across all electrodes. Asymmetry of auditory event-related potential P300 was not shown between patients with schizophrenia and normal controls. CONCLUSION: It is implicated that auditory event-related potential P300 and its information processing should not be elicited asymmetrically in schizophrenia.
Automatic Data Processing ; Diagnostic and Statistical Manual of Mental Disorders ; Electrodes ; Event-Related Potentials, P300 ; Evoked Potentials* ; Humans ; Schizophrenia*

Pulmonary vascular hypertension is characterized by migration and proliferation of smooth muscle cells accompanying abnormal synthesis and accumulation of extracellular proteins in vascular wall. The aim of this study is to define the role of endogneous TGF-betas and PDGF in the process of remodeling vessels through determining the temporal and spatial distribution of these growth factors in hypertensive pulmonary vessels in monocrotaline-induced pulmonary hypertension in rat. Sprague-Dawley rats were sacrificed 12 hours, 1, 2, 4, 7, 10, 14, 21, 28, and 56 days after treatment. The morphometric analysis of medial thickening and immunohistochemical study using antibodies to TGF-beta1, TGF-beta2, TGF-beta3, and PDGF were performed. Immunoreactivities for TGF-beta1 and TGF-beta3 were increased from the 14th day in the medial smooth muscle cells and PDGF showed increased expression from the 21st day in the medial smooth muscle cells. No difference in TGF-beta2 immunoreactivity was found between control and experimental groups. The expression of TGF-beta1, TGF-beta3 and PDGF increased in medial layers with the progressive thickening of pulmonary arteries which was considered to have close relation to medial hypertrophy of pulmonary arterioles. In the case of PDGF, however, the morphologic change occurred before increase in immunoreactivity was observed in the medial layer of pulmonary arterioles. Moreover, the function of isoforms of TGF-beta has yet to be completely elucidated; the different affinity to receptors and the degree of expression of these receptors that are supposed to affect the function of growth factors. Thus, further studies are needed.
Animals ; Antibodies ; Arterioles ; Hypertension ; Hypertension, Pulmonary* ; Hypertrophy ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins ; Monocrotaline ; Myocytes, Smooth Muscle ; Protein Isoforms ; Pulmonary Artery ; Rats* ; Rats, Sprague-Dawley ; Transforming Growth Factor beta* ; Transforming Growth Factor beta1 ; Transforming Growth Factor beta2 ; Transforming Growth Factor beta3

Subperiosteal Cortical Defect is a symptomless rarefaction of cortical bone which begins most often on the external surface of the medial and posterior cortical walls of the lower end of the femur in children between the ages of 3 and 6 years. The name of Subperiosteal Cortical Defect was first used by Aegerter who differentiated it from non-osteogenic fibroma. The authors found out 5 positive cases of incidental findings among 62 cases of both knee joint X-ray of which 3 was male and 2 was female. Also we experienced 3 cases which necessiat d a correct diagnosis and differential diagnosis. Because this is a common lesion, it frequently accompanies more serious bone conditions, and because this is self-limited disease, treatment is not necessary. It was emphasized that its nature should be understood by all those dealing with bone disease lest it be overdiagnosed and overtreated.
Bone Diseases ; Child ; Diagnosis ; Diagnosis, Differential ; Female ; Femur ; Fibroma ; Humans ; Incidental Findings ; Knee Joint ; Male

OBJECTS: This study was designed to make a comparison between methods to determine the components of topographic auditory event related potential P300. METHODS: The subjects were consisted of 44 normal controls and 44 patients with schizophrenia diagnosed by DSM-IV. The topographic auditory event related P300 was recorded in oddball paradigm. The components of P300, including latency, amplitude, and location of maximum amplitude in X-Y coordinates, were analized by computerized EP mapping system. The latency of P300 was determined by both global field power measurement and classic method. RESULTS: There was difference between two groups in latency(DF=1, F=35.28, P= 0.0001) and amplitude(DF=1, F=36.62, P=0.0001), but not in X coordinate(DF=1, F=0.37, P=0.55) and Y coordinate(DF=1, F=2.00, P=0.16). There was no difference between two mothods in latency(DF=1, F=0.04, P=0.85), in amplitude(DF=1, F=0.07, P=0.79), in X coordinate(DF=1, F=0.07, P=0.79), and in Y coordinate(DF=1, F=0.03, P=0.86). CONCLUSION: The results suggested that two methods to determine the components of topographic auditory event related potential P300 should be available for both research and clinical application to date.
Brain* ; Diagnostic and Statistical Manual of Mental Disorders ; Event-Related Potentials, P300* ; Humans ; Schizophrenia

OBJECTS: This study was to examine the changes of components of topographic auditory event related potential P300 in normal aging process. METHODS: The subjects were consisted of 85(range of age ; 18-68), who were right handed and had education level at least over 12 years. They had no history of medico-surgical and psychiatric illness which could cause brain dysfunction, and had not any physical and mental illness on examination. The topographic auditory event related P300 was recorded in oddball paradigm and the components of P300 including latency, amplitude, and location of maximum amplitude in X-Y cordinates were analized by computerized EP mapping system. The latency of P300 was determined by both Global Field Power Measurement and classic method. RESULTS: In global field power measurement, the latency has been increased about by 1m sec per year(latency=299.9+1 X AGE). The location of maximum amplitude in X coordinate was moved by 0.018 per year toward left side(X=3.6-0.018 X AGE) and in Y coordinate by 0.017 toward frontal direction(Y=2.15+0.017 X AGE). In classic method the latency has been increased about by 0.82m sec per year(latency=304.76+0.82 X AGE). The location of maximum amplitude in X coordinate was moved by 0.011 per year toward left side(X=3.35-0.011 X AGE) and in Y coordinate by 0.025 toward frontal direction(Y=1.86+0.025 X AGE). The amplitudes were not changed in both methods. CONCLUSION: The results showed strong positive correlation between latency of P300 and aging process, and slight left frontal displacement of the location of maximum amplitude. These finding implicate that psychophysiological function expressed by P300 was declined in aging process and database of formal controls should be necessary for both research and clinical application.
Aging* ; Brain ; Education ; Hand

OBJECTS: Event related potential(ERF) has been recently applied to examine the neurophysiological disturbance in attention deficit hyperactivity disorder(ADHD), particularly with regard to N100 and P300 which are known as one of ERP components closely linked with cognitive function. On the basis of these aspects, this study was designed to evaluate electrophysiologic characteristics and its availability for diagnosis and treatment of ADHD children by comparison of ERP between normal controls and ADHD children before and after methylphenidate (MFD) administration. METHODS: We examined the topographic auditory ERF and T.O.V.A.(Test of variables of attention), a standardized computerized visual continuous performance test following administration of stimulant drug, MPD 10mg in 13 ADHD children and compared these results with those of 11 normal controls. RESULTS: The results were as follows: 1) Thought the difference was not spastically significant(P=0.0548), N100 latencies seemed to be longer in ADHD children than in normal controls. N100 amplitudes also seemed to be larger in ADHD children than in normal controls(P=0.0629). 2) The F300 latencies significantly shortened after MFD administration when compared with those before MPD administration in ADHD group(P<0.01). 3) ADHD group performed significantly less well than normal controls in T.O.V.A.(P<0.05). And T.O.V.A. scores significantly improved after MFD administration in ADHD group(P<0.01). 4) The N100 and P300 latencies and the T.O.V.A. scores were significantly correlated before MPD administration in ADHD group(P<0.05). 5) The F300 latencies before MFD administration were significantly correlated with the amplitudes of changes of T.O.V.A. scores after MFD administration(P<0.05). CONCLUSION: It seems that prolonged N100 latency of ADHD children can be regarded as a relatively enduring trait marker and that F300 latency may reflect attentional response ability along with therapeutic effect by stimulant.
Attention Deficit Disorder with Hyperactivity* ; Child* ; Diagnosis ; Evoked Potentials* ; Humans ; Methylphenidate* ; Muscle Spasticity