No abstract available.
Marfan Syndrome*

PURPOSE: The proximal femoral morphology of normal Koreans was studied by radiographs. MATERIALS AND METHODS: Proximal femoral morphology and ratio of lever arm in abductor muscle in 101 normal adults were measured and their correlations were comparatively analyzed. RESULTS: The femoral head diameter was 48.7+/-4.0 mm. The femoral neck shaft angle was 127.8+/-5.2 degree. The medial trabeculae angle was 20.0+/-1.2 degree. The femoral offset was 36.5+/-3.9 mm. Also, the tip of the greater trochanter relative to the level of femoral head center lay higher in 91 of 101 subjects (90.1%), upon examination and in average, located 3.8+/-3.4 mm higher. The ratio of the abductor lever arm to the distance between the femoral head center and the body midline was 1: 2.1+/-0.2. CONCLUSIONS: The relationship between the tip of the greater trochanter of femur and the center of femoral head appeared to have wide individual differences with 0.89 coefficient of variation. Therefore, the tip of the greater trochanter was an unreliable anatomical indicator of femoral head center. The femoral neck shaft angle and the length of the medial trabeculae showed a significant correlation (P=0.001). However, a significant negative correlation existed between the femoral neck shaft angle and the femoral offset (P=0.024)
Adult* ; Arm ; Femur ; Femur Neck ; Head ; Humans ; Individuality

BACKGROUND: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses. This experiment was aimed to evaluate the effects of flecainide on sepsis induced acute lung injury in a rat model. METHODS: Rats were treated with subcutaneous infusion of saline or flecainide (0.1 or 0.2 mg/kg/hr) by a mini-osmotic pump. Subcutaneous infusion was started 3 hours before and continued until 8 hours after intraperitoneal injection of saline or endotoxin. Animals were sacrificed for analyses of severity of acute lung injury with wet to dry (W/D) ratio and lung injury score (LIS) in lung and inflammatory responses with level of leukocyte, polymorphonuclear neutrophils (PMNs) and inteleukin-8 (IL-8) in bronchoalveolar lavages fluid (BALF). RESULTS: Flecainide markedly improved dose dependently sepsis induced acute lung injury as analysed by W/D ratio (from 2.24 ± 0.11 to 1.76 ± 0.09, p < 0.05) and LIS (from 3 to 1, p < 0.05), and inflammatory response as determined by leukocyte (from 443 ± 127 to 229 ± 95, p < 0.05), PMNs (from 41.43 ± 17.63 to 2.43 ± 2.61, p < 0.05) and IL-8 (from 95.00 ± 15.28 to 40.00 ± 10.21, p < 0.05) in BALF. CONCLUSIONS: Flecanide improve sepsis induced acute lung injury in rats by controlling inflammatory responses.
Acute Lung Injury* ; Animals ; Arrhythmias, Cardiac ; Bronchoalveolar Lavage ; Flecainide* ; Infusions, Subcutaneous ; Injections, Intraperitoneal ; Interleukin-8 ; Leukocytes ; Lung ; Lung Injury ; Models, Animal ; Neutrophils ; Rats ; Sepsis*