BACKGROUND AND OBJECTIVES: Coronary collateral circulation is known to have beneficial effects in patients with angina pectoris and myocardial infarction. The purpose of this study is to determine the predictors of collateral vessels development, the pathways of collateral circulation and the changes in collateral flow after coronary intervention and its functional significance in patients with total occlusion. MATERIALS AND METHODS: One hundred thirty five patients who underwent coronary angiogram between Jan '97 and Dec '97 in Chonnam University Hospital (out of 3,264 cases) had total occlusion of one coronary artery were classified into two groups: angina pectoris (Group I:50 M, 19 F, 62.4+/-11.0 years) and acute myocardial infarction (Group II: 47 M, 19 F, 62.0+/-9.5 years). RESULTS: Among 135 patients, 123 patients had collateral circulation. Collaterals were more frequently observed and better developed (grade 2 or 3) in Group I than Group II. Proximal and ostial lesions were associated with well developed collaterals. Collateral circulation was more frequently observed and well developed in proportion to the duration of angina in Group I. In 123 patients with collateral circulation, 247 collateral circulations were observed. Right coronary artery (RCA) and Left circumflex coronary artery (LCX) were more frequent recipient arteries than left anterior descending coronary artery (LAD)(RCA:2.20+/-1.02, LCX:1.88+/-0.94, LAD:1.29+/-0.8 respectively, RCA vs. LAD:p<0.001, LCX vs. LAD:p=0.014). Coronary interventions were performed in 50 out of 135 patients, collateral flow of Group II decreased much more than Group I after intervention (Group I: 5/14, Group II: 24/36, p=0.046). The wall motion score was lower in patients with well developed than poorly developed collaterals (20.7+/-4.91 vs. 23.7+/-6.22, p=0.015). CONCLUSION: Proximal or ostial lesion and duration of angina are major predictive factors for the development of collateral circulation. Collateral circulation is associated with preserved myocardial contractility.After coronary intervention in patients with acute myocardial infarction, recruitment of preexisting collaterals may be more important mechanism rather than neoangiogenesis.
Angina Pectoris ; Arteries ; Collateral Circulation* ; Coronary Vessels* ; Humans ; Jeollanam-do ; Myocardial Infarction

No abstract available.
Dementia* ; Primary Health Care*

BACKGROUND: The purpose of this study was to assess the prevalence of orthostatic hypotension(OH) and its associations with demographic characteristics, body mass index, medications, disease and activities of daily living. METHODS: Orthostatic hypotension was assessed at 1 minutes after the patients arose from a supine position among the 183 elderly patients aged 60 years or older in a mental hospital. RESULTS: The prevalence of orthostatic hypotension defined by changes in systolic or diastolic blood pressure was 41.0% and the prevalence of systolicorthostatic hypotension was 13.1%. Body mass index and serum sodium concentration were lower in women with orthostatic hypotension than those without orthostatic hypotension, but there were no differences among men. Orthostatic hypotension was significantly associated with the level of supine systolic and diastolic blood pressure. Through multiple logistic regression analysis, orthostatic hypotension seerned to be associated with factors such as body mass index, supine diastolic blood pressure and serum sodium concentration. There was no association between orthostatic hypotension and factors such as sex, age and medications. CONCLUSIONS: Orthostatic hypotension was common in the long-term hospitalized elderly patients. It was associated with hypertension, hyponatremia and low body weight.
Activities of Daily Living ; Aged* ; Blood Pressure ; Body Mass Index ; Body Weight ; Female ; Hospitals, Psychiatric ; Humans ; Hypertension ; Hyponatremia ; Hypotension ; Hypotension, Orthostatic* ; Logistic Models ; Male ; Prevalence ; Risk Factors* ; Sodium ; Supine Position

BACKGROUND: The purpose of this study was to assess the prevalence of orthostatic hypotension(OH) and its associations with demographic characteristics, body mass index, medications, disease and activities of daily living. METHODS: Orthostatic hypotension was assessed at 1 minutes after the patients arose from a supine position among the 183 elderly patients aged 60 years or older in a mental hospital. RESULTS: The prevalence of orthostatic hypotension defined by changes in systolic or diastolic blood pressure was 41.0% and the prevalence of systolicorthostatic hypotension was 13.1%. Body mass index and serum sodium concentration were lower in women with orthostatic hypotension than those without orthostatic hypotension, but there were no differences among men. Orthostatic hypotension was significantly associated with the level of supine systolic and diastolic blood pressure. Through multiple logistic regression analysis, orthostatic hypotension seerned to be associated with factors such as body mass index, supine diastolic blood pressure and serum sodium concentration. There was no association between orthostatic hypotension and factors such as sex, age and medications. CONCLUSIONS: Orthostatic hypotension was common in the long-term hospitalized elderly patients. It was associated with hypertension, hyponatremia and low body weight.
Activities of Daily Living ; Aged* ; Blood Pressure ; Body Mass Index ; Body Weight ; Female ; Hospitals, Psychiatric ; Humans ; Hypertension ; Hyponatremia ; Hypotension ; Hypotension, Orthostatic* ; Logistic Models ; Male ; Prevalence ; Risk Factors* ; Sodium ; Supine Position

No abstract available.
Malacoplakia* ; Urinary Bladder*

No abstract available.
Endometriosis* ; Female

The molecular mechanisms that regulate glossal muscle cell cycle and terminal differentiation remain largely unknown. To determine which cyclins, cyclin dependent kinases (CDKs), cyclin dependent kinase inhibitors (CKIs) are important for glossal cell proliferation, we have examined expression of cyclins CDKs, CKIs during normal glossal muscle development in the rat. All cyclins, CDKs, and KIP/CIP family of CKIs were highly expressed during fetal glossal muscle development, then they decreased at different rates after birth. While the mRNAs of cyclin Dl, D3, E , A, and B decreased gradually in glossal muscle during all stages of development, the protein levels of these cyclins decreased differently in tongue during pre- and postnatal development. While the functionally active formed of cyclin Dl, cyclin D3 and E proteins were observed until 7 days after birth, cyclin A and B proteins were decreased more slowly. While the CDK4, CDK6, CDK2, cdc2, and proliferating cell nuclear antigen (PCNA) proteins were higllly present during fetal glossal muscle development and gradually decreased during postnatal development. Particularly, cdc2 levels decreased markedly after birth. Immunohistochemical data for PCNA was consistent with Western blotting data for PCNA temporally and spatially. The mRNA and protein levels of p21, p27, and p57 were high, then their levels changed differently during glossal development. While the mRNA levels of p21 and p57 decreased gradually, the mRNA level of p27 did not change during glossal development. While the protein levels of p21 and p57 in tongue decreased markedly after birth, the protein levels of p27 increased slightly after birth, then decreased at adulthood. These findings suggest that the all cyclins and CDKs observed are involved in glossal muscle cell cycle, and reduction of cyclins and CDKs and induction of p21 are associated with the withdrawal of glossal muscle cell cycle after birth.
Animals ; Blotting, Western ; Cell Proliferation ; Cyclin A ; Cyclin D3 ; Cyclin-Dependent Kinases* ; Cyclins* ; Humans ; Muscle Cells ; Muscle Development ; Parturition ; Phosphotransferases* ; Proliferating Cell Nuclear Antigen ; Rats* ; RNA, Messenger ; Tongue

The osteochondroma is a common benign tumor with osteocartilaginous exostosis. It may arise from any bone, but is observed most often on long tubular bones, particularly on their metaphyseal region. Osteochondroma may also arise from the rib but seldom grow to giant size. We experienced a rare case of giant osteochondroma arising from the left 5th rib. The patient, 41 years old man, had an adult fist sized mass on the left lower chest with mild aching pain on respiration. The large mass was examined by biopsy. It showed characteristic microscopic findings of osteochondroma. No evidence of malignant change was seen in this large tumor.
Adult ; Biopsy ; Humans ; Osteochondroma ; Respiration ; Ribs ; Thorax

No abstract available.
Facial Bones*

No abstract available.
Thumb* ; Toes*