1.The Effect of Tumor Removal and Administration of OK432 on the Splenic Natural Killer Cell Activity in the Subcutaneous Tumor Bearing Rats.
Kyu Yun JANG ; Hyun Sang YOON ; Myoung Jae KANG ; Ho Yeul CHOI ; Sang Ho KIM
Korean Journal of Pathology 2000;34(2):105-112
To investigate the effect of tumor removal and administration of OK432 on the splenic natural killer (NK) cell activity in the subcutaneous tumor bearing rats, NK cell activity assay using a 4-hour 51Cr release assay and flow cytometric analysis for NK cell population were performed. The results were as follows: 1. Splenic NK cell activity and population in the subcutaneous tumor bearing rats decreased along with the growth of the tumor. 2. The rats with subcutaneous tumor removal showed decrease of splenic NK cell activity, but splenic NK cell population was not decreased. 3. In the rats with subcutaneous tumor removal and OK432 administration, splenic NK cell activity was significantly increased 1 week after administration of OK432 and then gradually returned to normal, whereas increase of NK cell population was not significant. In the present study, splenic NK cell activity was significantly decreased despite removal of subcutaneous tumor. But with the administration of OK432, splenic NK cell activity returned to normal. Considering the role of NK cells on the first line of defense against the metastatic implantation of circulating tumor emboli, we suggest that perioperative administration of immunopotentiator such as OK432 may improve the patient's outcome after surgery of human neoplasm.
Animals
;
Humans
;
Killer Cells, Natural*
;
Picibanil*
;
Rats*
;
Spleen
2.Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response.
Jia SONG ; Young Joong SUH ; Hyun Jung LEE ; Eun A JANG ; Hong Beom BAE ; Sang Hyun KWAK
Korean Journal of Critical Care Medicine 2016;31(3):194-201
BACKGROUND: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses. This experiment was aimed to evaluate the effects of flecainide on sepsis induced acute lung injury in a rat model. METHODS: Rats were treated with subcutaneous infusion of saline or flecainide (0.1 or 0.2 mg/kg/hr) by a mini-osmotic pump. Subcutaneous infusion was started 3 hours before and continued until 8 hours after intraperitoneal injection of saline or endotoxin. Animals were sacrificed for analyses of severity of acute lung injury with wet to dry (W/D) ratio and lung injury score (LIS) in lung and inflammatory responses with level of leukocyte, polymorphonuclear neutrophils (PMNs) and inteleukin-8 (IL-8) in bronchoalveolar lavages fluid (BALF). RESULTS: Flecainide markedly improved dose dependently sepsis induced acute lung injury as analysed by W/D ratio (from 2.24 ± 0.11 to 1.76 ± 0.09, p < 0.05) and LIS (from 3 to 1, p < 0.05), and inflammatory response as determined by leukocyte (from 443 ± 127 to 229 ± 95, p < 0.05), PMNs (from 41.43 ± 17.63 to 2.43 ± 2.61, p < 0.05) and IL-8 (from 95.00 ± 15.28 to 40.00 ± 10.21, p < 0.05) in BALF. CONCLUSIONS: Flecanide improve sepsis induced acute lung injury in rats by controlling inflammatory responses.
Acute Lung Injury*
;
Animals
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Arrhythmias, Cardiac
;
Bronchoalveolar Lavage
;
Flecainide*
;
Infusions, Subcutaneous
;
Injections, Intraperitoneal
;
Interleukin-8
;
Leukocytes
;
Lung
;
Lung Injury
;
Models, Animal
;
Neutrophils
;
Rats
;
Sepsis*
3.THE POSTOPERATIVE ANALYSIS OF CLOSED REDUCTED NASAL BONE FRACTURE.
Jang Ho KIM ; Sang Hyun PARK ; Han Ho CHU ; Jin Whan CHO ; Yoo Hyun BANG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(6):1343-1351
No abstract available.
Nasal Bone*
4.Serological and antigenic analysis against borrelia burgdorferi of febrile patients in Korea.
Kyung Hee PARK ; Seung Hyun LEE ; Won Jong JANG ; Sang Mahn KIM ; Woo Hyun CHANG
Journal of the Korean Society for Microbiology 1993;28(5):397-408
No abstract available.
Borrelia burgdorferi*
;
Borrelia*
;
Humans
;
Korea*
5.The Validity and Reliability of Korean Fall Efficacy Scale(FES) and Activities-specific Balance Confidence Scale(ABC).
Soong Nang JANG ; Sung Il CHO ; Sang Woo OU ; Eon Sook LEE ; Hyun Wook BAIK
Journal of the Korean Geriatrics Society 2003;7(4):255-268
BACKGROUND: The purpose of this study was to evaluate the applicability of the Korean version of Fall Efficacy scale(FES) and Activities-specific Balance Confidence Scale(ABC) to Korean older adult through an examination of instrument`s internal consistency and validity METHOD: A sample of 90 Korean older adults who lived in a community completed a survey instrument which included Korean version of FES and ABC. Because of comparable data derived from each scale, fear of falling and quality of life, activity daily living were included. Concurrent validity, criterion validity and correlational validity were tested. Reliability was tested by internal consistency, test-retest method. RESULTS: Cronbach`s alpha was 0.9043 in FES, and 0.99623 in ABC. Test-retest correlations in all scales were higher than 7.0. Statistically significant association was found between fear of falling and both scales. Correlation coefficient between Quality of life(SF-8) and ABC was -0.142(p=0.049). Both FES and ABC are correlated significantly each other. CONCLUSION: The Korean version of FES and ABC appears to be a reliable and valid method for meas- uring fear of falling. These instruments may be useful in assessing the independent contribution of fear of falling. ABC scale may be more useful to detect loss of balance confidence in more highly functioning seniors.
Adult
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Humans
;
Quality of Life
;
Reproducibility of Results*
;
Weights and Measures
6.A Case of Spindle Cell Hemangioendothelioma.
Jun Gyu JANG ; Hyun Chul KIM ; Young Soo CHAE ; Kee Suck SUH ; Sang Tae KIM
Korean Journal of Dermatology 1997;35(2):322-326
Spindle cell hemangioendothelioma was first described in 1986 by Weiss and Enzinger as a low grade angiosarcoma resr mbling a cavernous hemangioma and kaposis sarcoma. Recently, it is suggested to be non neoplastic lesion or reactive process arising from pre-existing vascular mal- formation. We report a case of spindle cell hemangioendothelioma in a 9-month-old boy. He had multiple, variable sized, colorful, cutaneous or subcutaneous nodules on the forearm and hand. The tumor first appeared on the forearm as erythematous patches at birth and grew rapidly with- in 3 months. Histopatholgical findings showed that the lesion was composed of thin walled cavernous spaces mixed with spindle cells and occasional epithelioid endothelial cells containing intracytoplasmic vacuole. Most af the endothelial cells lining the cavernous spaces and intracytoplasmic lumina, were positive for factor VIII associated antigen. But the spindle cells were negative. Atypical vascular structures resembling arteriovenous shunts were noted around the tumor suggesting a reactive proliferation due to disturbance of local blood flow. Several turnors were excised. No recurrence has been recognized in the one year- follow-up period.
Endothelial Cells
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Factor VIII
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Follow-Up Studies
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Forearm
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Hand
;
Hemangioendothelioma*
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Hemangioma, Cavernous
;
Hemangiosarcoma
;
Humans
;
Infant
;
Male
;
Parturition
;
Recurrence
;
Sarcoma, Kaposi
;
Vacuoles
7.Usefulness of Dipyridamole and Dobutamine Stress Echocardiography in Myocardial Infarction.
Sang Wook LIM ; Hyuck Moon KWON ; Yang Soo JANG ; Hyun Seung KIM
Korean Circulation Journal 1994;24(1):86-98
BACKGROUND: The dipyridamole and dobutamine stress echocardiography have been studied as a non-invasive diagnostic test in coronary artery disease. Recently, some authors have extended the usefulness of these tests to predicting the prognosis of myocardial infarction patients. But as far as we know, there was no literature which tried boh tests to the same infarcted patients group. So, we performed both tests in the 23 infarcted patients to compare and evaluate both tests as predicting the prognosis in myocardial infarction. METHODS: Patients underwent (1) two-dimensional echocardiography under basal condition and after dipyridamole infusion for 4 minites at the dose of 0.14mg/kg/min, (2) another two dimensional echocardiography under basal and during dobutamine infusion at each dose of 5 to a maximum of 20microg/kg/min at 1 or 2 days after dipyridamole stress echocardiography, and (3) coronary and left ventricular angiography. Preinfusion and peak infusion images were analyzed independently by two different observers using Nova Micro Sonic soft were(DataVueII and ColorVue II analysis system). The segmental wall motions were scored as follows ; hyperkinetic : 1, normal : 2, hypokinetic : 3, akinetic : 4. THe test response was considered positive if abnormal wall motion and reduced myocardial thickening were observed during drug infusion at the vascular distributions except the akinetic infarcted segment identified during basal condition. The coronary angiography was analyzed by measuring the maximal luminal diameter stenosis with caliper and 50% or greater diameter narrowing was considered significant. The sensitivity and specificity were calculated by comparing echocardiographic prediction and angiographic findings. RESULTS: 1) Among 22 patients with sufficient image in dipyridamole stress echocardiography, 13 patients have myltivessel coronary disease without resting akinesia of non-infarcted segments. Only 5 patients showed positive findings in dipyridamole stress echocardiography(sensitivity, 38.4%). Among 9 patients who has single or minimal disease, 9 patients were negative finding(specificity, 100%). 2) Among 21 patients with sufficient image in dobutamine stress echocardiography, 12 patients have multivessel coronary disease without resting akinesia of non-infarcted segments. 7 patients showed positive finding in dobutamine stress echocardiography(sensitivity, 58.3%). Among 9 patients who has single or minimal disease, 8 patients showed negative finding(specificity, 88.8%). 3) In hemodynamic changes, dipyridamole stress echocardiography showed significant changes in heart rates and double products and dobutamine stress echocardiography showed significant changes in heart rates, systolic blood pressure and double products. 4) There was no significant side effect during both stress tests inacute and old myocardial infarction patients. CONCLUSION: 1) The dobutamine and dipyridamole stress echocardiography are safe and easy test for myocardial infarction patients. 2) The dobutamine stress echocardiography has higher sensitivity than dipyrdamole stress echocardiography for identifying multivessel coronary disease in myocardial infarction patients but the dose of both drugs were relatively small to get the adequate results. So the high dose of drugs must be tried in feature study.
Angiography
;
Blood Pressure
;
Constriction, Pathologic
;
Coronary Angiography
;
Coronary Artery Disease
;
Coronary Disease
;
Diagnostic Tests, Routine
;
Dipyridamole*
;
Dobutamine*
;
Echocardiography
;
Echocardiography, Stress*
;
Exercise Test
;
Heart Rate
;
Hemodynamics
;
Humans
;
Myocardial Infarction*
;
Phenobarbital
;
Prognosis
;
Sensitivity and Specificity
8.A case of thanatophoric dysplasia.
Tae Wook SONG ; Sang Chul HAN ; Jang Hyun NAM ; Keun Young LEE ; Sung Won KANG
Korean Journal of Obstetrics and Gynecology 1992;35(5):765-773
No abstract available.
Thanatophoric Dysplasia*
9.A Case of a Follicular Hybrid Cyst (Epidermal Cyst and Pilomatricoma).
Hyo Chan JANG ; Joon Soo PARK ; Gun PARK ; Hyun CHUNG ; Sang Won KIM
Annals of Dermatology 2005;17(1):45-47
No abstract available.
Epidermal Cyst
;
Pilomatrixoma
10.Management of Essential Blepharospasm: Botulinum Toxin A Treatment and Orbicularis Myectomy Operation.
Hyun Dong LEE ; Jae Woo JANG ; Sang Yeul LEE
Journal of the Korean Ophthalmological Society 1999;40(12):3246-3252
To investigate results of treatment with essential blepharospasm, patients were evaluated by results of treatment with botulinum toxin A and myectomy operation. Seventy patients of the essential blepharospasm who received local injection of botulinum toxin or orbicularis muscle extirpative surgery were evaluated according to results and complications of the treatment modality over a 7-year period. Fifty-six patients[80%] were primarily treated with botulinum toxin and 14 patients[20%] underwent myectomy operation as the primary treatment. Of the 56 patients, 8[14.3%] were treated later with myectomy operation. In botulinum toxin treatment, the mean subjective improvement was found in 89.2% of the patients, and the mean effective durations of essential blepharospasm were 12.7 weeks. Severity and frequency grades in eyelid spasm were significantly lower after injection[P=.000]. Tearing, dry eye, and headche were the most frequent complications and ptosis was observed in 2 cases[2.0%]. In the orbicularis myectomy operation, 13 patients[59.1%] were carried out through a brow incisions, 1[4.5%] through a blepharoplasty incisions, and 8[36.4%] through both. Fourteen patients[63.6%] had acceptable control of blepharospasm throughout follow-up after the upper lid orbicularis stripping procedure alone. We believe that botulinum toxin is the treatment of first choice because of its higher acceptance rate. Surgery is reserved for botulinum toxin failure. In otherwise fit patients, myectomy is the treatment of first choice.
Blepharoplasty
;
Blepharospasm*
;
Botulinum Toxins*
;
Eyelids
;
Follow-Up Studies
;
Humans
;
Spasm