1.A New Embedding Method for Optimal Tissue Preparation for Mohs Mierographic Surgery.
Sang Wook SON ; Chil Hwan OH ; Il Hwan KIM
Korean Journal of Dermatology 1999;37(3):332-338
BACKGROUND: The principle of Mohs micrographic surgery is to examine microscopically the entire peripheral margin of an excised tissue specimen to precisely localize the site of any residual tumor and enable its subsequent removal. In processing in the tissue for frozen horizontal sections, a technical difficulty arises in manipulating the deep and lateral margins into the same flat plane. OBJECTIVE: Our aim was to develop a new method allowing the optimal tissue preperation for Mohs micrographic smgery and to evaluate the usefulness of this methad. METHODS: The technique involves conversion of a non-planar surgical margin to a planar surface by applying and freezing the specimen against a flat glass surface. We compared this modified method used in our laboratory with standard methods for tissue preparation of Mohs micrographic surgery.
Freezing
;
Glass
;
Mohs Surgery
;
Neoplasm, Residual
2.Ender nailing for tibial shaft fractures.
In Hwan JEONG ; Jeong Hwan OH ; Eui Hwan AHN ; Sang Moon WEE
The Journal of the Korean Orthopaedic Association 1993;28(2):741-753
No abstract available.
3.A Study on Lighting in school.
Kyung Hwan OH ; Woo Ryung LEE ; Sang Cheol PARK ; Dong Hwan LEE ; Sang Jhoo LEE
Journal of the Korean Pediatric Society 1990;33(12):1623-1630
No abstract available.
Humans
4.A double-blind study of amantadine sulfate versus benztropine mesylate in antipsychotic drug-induced extrapyramidal symptoms.
Sang Ook KIM ; Byung Hwan YANG ; Dong Yul OH
Journal of Korean Neuropsychiatric Association 1991;30(2):278-288
No abstract available.
Amantadine*
;
Benztropine*
;
Double-Blind Method*
5.Purification of porcine bone morphogenetic protein.
Nam Hyun KIM ; Kyu Hyun YANG ; Hwan Mo LEE ; Sang Hwan OH
The Journal of the Korean Orthopaedic Association 1991;26(1):232-238
No abstract available.
Bone Morphogenetic Proteins*
6.A Case of Favre-Racouchot Syndrome Treated with Retinoic Acid and Surgical Excision.
Kyoung Moon KIM ; Sang Wook SON ; Gil Joo LEE ; Seung Hyun HONG ; Il Hwan KIM ; Chil Hwan OH
Korean Journal of Dermatology 1998;36(2):313-316
Favre-Racouchot syndrome is a disease of senile or actinic processes and another name is nodular elastosis with cysts and comedones. Clinically, facial skin shows, especially lateral to the eyes, multiple open and cystically dilatated comedones and can be defined as cutaneous disturbances characterized by a degenerative process of the dermis associated with cysts and comedones. Sunlight is a strong causative factor and dermal degenerative processes result in this condition. We report the case of a 78-year-old man who showed multiple yellowish papules on both sides of cheeks, the periorbital and, malar areas. He had had this condition for 25-years. His job used to involve physical labor and much exposure to sunlight. An excisional biopsy specimen from the facial malar lesion showed cystically dilated comedones with basophilically degenerated dermal tissue. We performed a therapeutic excision on the two large nodular lesions on both malar areas and applied topical tretinoin. The Patients clinical appearance was much improved 2 months later.
Actins
;
Aged
;
Basophils
;
Biopsy
;
Cheek
;
Dermis
;
Facial Dermatoses*
;
Humans
;
Skin
;
Sunlight
;
Tretinoin*
7.A Case of Inflammatory Metastatic Carcinoma of the Breast.
Chang Geun CHO ; Sang Wook SON ; Seung Hyun HONG ; Gil Ju YI ; Ill Hwan KIM ; Chil Hwan OH
Annals of Dermatology 1998;10(1):28-31
A 51-year-old Korean woman presented with a non-tender, well-demarcated, reddish, edematous patch on the right anterior chest where a previous mastectomy and radiation therapy had been performed. She had been diagnosed as having infiltrating ductal carcinoma of the right breast about 1 year ago. Histopathological findings of the skin lesions were consistent with inflammatory metastatic carcinoma of the breast. Inflammatory carcinoma or carcinoma erysipeloides is a well-established entity most frequently associated with carcinoma of the breast. It is characterized by dermal lymphatic invasion by malignancy and clinically should be distinguished from erysipelas or cellulitis. We describe a case of inflammatory metastatic carcinoma derived from an infiltrating ductal carcinoma of the breast which can be clinically confused with radiation dermatitis.
Breast*
;
Carcinoma, Ductal
;
Cellulitis
;
Dermatitis
;
Erysipelas
;
Erysipeloid
;
Female
;
Humans
;
Mastectomy
;
Middle Aged
;
Skin
;
Thorax
8.A Clinical Review of the HELLP Syndrome.
Sang Tae AHN ; Haeng Soo KIM ; Jeong In YANG ; Joon Hwan OH ; Ki Su HAN ; Seong Cheon YANG ; Kie Suk OH
Korean Journal of Perinatology 2001;12(2):122-130
No abstract available.
Female
;
HELLP Syndrome*
;
Pregnancy
9.Properties of Hepatitis B Virus Associated DNA Polymerase.
Yonsei Medical Journal 1985;26(2):175-183
The nature of hepatitis B virus (HBV) particle associated DNA polymerase was studied in relation to various enzyme inhibitors including antiviral agents. HBV DNA polymerase required high concentration of MgCl2(> 30 mM) and neutral pH for its full activity. p-chloromercuribenzoate was a strong inhibitor (85% inhibition at 1 mM) but N-ethylmaleimide had much less inhibitory effect (20% inhibition at 10 mM). Phosphonoformic acid showed the greatest inhibitory effect on HBV-DNA polymerase (almost complete inhibition at 100 microM) among phosphocompounds tested. Adenine arabinoside triphosphate (ara-ATP) and cytosine arabinoside triphosphate (ara-CTP) were competitive inhibitors with respect to their respective deoxyribonucleoside triphosphate (dATP and dCTP). Ara-CPT was a stronger inhibitor of HBV-DNA polymerase compared to ara-ATP. Ki values for ara-ATP and ara-CTP were 15.0 microM and 11.7 microM , respectively. HBV-DNA polymerase is characteristic in its ionic requirements and susceptibilities to certain inhibitors.
DNA-Directed DNA Polymerase/antagonists & inhibitors
;
DNA-Directed DNA Polymerase/metabolism*
;
Hepatitis B Virus/enzymology*
;
Human
10.Interaction between Inorganic Mercury and Selenium on Tissue Sulfhydryl Groups and Glutathione-linked Enzymes in Rats.
Yonsei Medical Journal 1981;22(2):122-126
The effect of selenium on the tissue sulfhydryl group content and lipid peroxide-destorying enzyme system in the liver, kidney and testis of rat treated with mercury was investigated. The male rats were injected s.c. with HgCl2 (10 micromoles/kg BW) and orally received Na2SeO3 (13 micromoles/kg BW) simultaneously. After 3 days, liver, kidney and testis were removed and analyzed. Mercury decreased the total sulfhydryl group content in the kidney by 25% and the total glutathione content in the kidney and testis by 50% and 36%, respectively, with no changes in other tissues. There was 12% increase in the total sulfhydryl group but not in the total glutathione content in kidney by a simul-taneous treatment of Se and Hg. Glutathione peroxidase (GSH-Px) activities were decreased by 63% in the liver and 69% in the kidney, and glutathione reductase (GSH-Rd) activity was increased in the tests by 16% by the Hg treatment with no changes in Other tissues. Hg had no effect upon glutathione-S-transferase activities in all organs examined. Simultaneous Se treatment increased GSH-Rd activity in the kidney by 23% and GSH-Px activities in liver and kidney by 24% and 21%, respectively, compared to the Hg-treated group. These data indicate that the alleviation of Hg toxicity by Se treatment is well correlated with the protein sulfhydryl group content and GSH-Px activity.
Animal
;
Glutathione/metabolism*
;
Glutathione Peroxidase/analysis
;
Glutathione Reductase/analysis
;
Male
;
Mercury/toxicity*
;
Rats
;
Selenium/pharmacology*
;
Sulfhydryl Compounds/analysis*