Sleep disturbances are commonly encountered problems in cancer patients. Sleep has a role in maintenance of immunity, metabolism, and quality of life but little has been known about the prevalence, risk factors, and effects on prognosis of sleep disturbances in patients with cancer. Also little attention has been made on proper assessment and management of sleep disorders in these patients. Recently, there have been some reports that sleep disorders are related with development of many cancers such as breast, colorectal, prostate, and endometrial cancers. An intermittent hypoxia and a disruption of circadian rhythm are considered as one of the possible mechanisms of cancer developments. More aggressive evaluation and meticulous management of sleep disturbances in cancer patients are essential to improve quality of life as well as prognosis.
Anoxia ; Breast ; Circadian Rhythm ; Endometrial Neoplasms ; Female ; Humans ; Prevalence ; Prognosis ; Prostate ; Quality of Life ; Risk Factors ; Sleep Wake Disorders

Retrospective clinicopathologic analysis of 15 patients with the phyllodes tumors(PT) of the breast, diagnosed at SNUH over 6 years period, was done. By light microscopy, 8 cases were diagnosed as benign, and 7 cases were diagnosed as malignant. Mean ages o the patients were 37 and 34 years in malignant and benign, respectively. Most of those cases were presented with a palpable mass of the breast. None of the patients with malignant PT had distant metastasis, Local recurrences were experienced in 3 patients among the malignant PT, and one patient among the benign PT. One of 7 malignant PT was coexisted with simultaneous ipsilateral infiltrating duct carcinoma. The clinical course was not well correlated with pathologic features. The prognostic significances of several histopathologic parameters were assessed for possible correlation with local recurrence, metastasis and death; stromal cellularity, stromal cellular atypism, mitotic activity, tumor contour, necrosis, tumor size and heterologous stromal elements. Immunohistochemistry using antibody to vimentin, proliferating cell nuclear antigen(PCNA) and epidermal growth factor receptor(EGF-R) were analysed. In the 5 cases of benign PT, the stromal cells stained diffusely positive for vimentin and 3 cases of malignant tumors show similar staining for vimentin. The percentage of PCNA-positive cells were higher in the malignant PT than in the benign ones; they were 3.5% to 60% in malignancy, while they were less than 60% in all benign PT. The results of EGF-R staining were correlated with the histologic classification; only 2 cases out of 8 benign PT show diffusely positive staining of EGF-R in the cytoplasm, but 6 cases out of 7 malignant PT show positive findings.
Neoplasm Metastasis

No abstract available.
Bender-Gestalt Test* ; Hallucinations*

Experimental allergic encephalomyelitis (EAE) has been a well established animal model of postvaccinatal demyelinating diseases occurring in humans. Therefore elucidation of its pathogenesis would be very critical for the understanding of various human demyelinating diseases including multiple sclerosis. This study was performed to characterize the infiltrating cells in inflammatory sites and analyze the nature of the damage of blood brain barrier in experimental allergic encephalomyelitis. Experimental allergic encephalomyelitis was produced by administering homologous spinal cord homogenate together with complete Freund's adjuvant in guinea pigs. Immunostainings on guinea pig IgG, IgM, IgA and muramidase were performed by peroxidase-antiperoxidase or indirect immunofluorescent methods. The blood-brain barrier change was assessed by administering fluorescent Evans blue. Following results were made. In juvenile animals, both clinical findings and histopathologic changes were first noted by 3 weeks after injection and progressed during the whole experimental period. However, these findings were delayed in onset and low in incidence in adult animals. The clinical and pathologic changes started from the caudal portions and extended rostrally. The blood-brain barrier (BBB) was damaged and progressed starting also from the caudal portion of the spinal cord. The BBB changes were more severe in young animal than adult animals. Those changes preceded th histologic alterations. It is suggested that the BBB susceptibility is responsible for the caudal onset of histologic changes. Although the lesion has been thought to be induced by T-cell mediated hypersensitivity, infiltrating cells consisted mainly of muramidase positive histiocytes. A few immunoglobulin positive B cells or plasma cells could also be demonstrated in the lesion. The former usually infiltrated the parenchyme and the latter remained around the small or medium-sized vessels.
Adult ; Male ; Female ; Humans ; Animals ; Incidence

Acute hybrid leukemia is an uncommon disease that demonstrates malignant transformation expressing lymphoid and myeloid cell lineage. We experienced a case of 25-year-old man with acute leukemia with unusual characteristics: unclassifiable morphology and undifferentiated cytochemistry by French-American-British (FAB) criteria. Microscopically, it disclosed monotonous tumor cell population in lymph node with vascular plugging and perivascular infiltration, and indian file appearance in capsule and surroun ng adipose tissue. Results of flow cytometry and immunohistochemical studies of frozen sections, cytospins, and formalin fixed lymphoid tissues disclosed hybrid form characterized by myeloid and lymphoid cell lineage. The immunophenotype analysis showed both anti-T cell, anti-B cell and anti-myeloid cell monoclonal antibody reactivity; blast cells were consistently CD7+(94.6%), CD13+(97.1%), and CD19+(85.22%). The normal hematopoietic cells were almost replaced by tumor cells in PB and bone marrow. In preparation of cytospin of peripheral blood(PB) cells separated by a Ficoll-hypaque gradients, blast cells were negative for Sudan black B, myeloperoxidase, periodic acid Schiff, and nonspecific esterase.
Male ; Humans

No abstract available.
Facial Bones*

The present study was undertaken to investigate the relationship between serum lipid and lipoprotein values and cerebrovascular accidents. Serum lipids and lipoproteins were measured in 130 cases of normal Korean, 49 patients with cerebrovascular accidents and 35 patients with uncomplicated essential hypertension. The results were summarized as follows; 1. The mean values of serum lipids in patients with cerebrovascular accidents were 148.3+/-75.3mg% for triglyceride, 189.6+/-37.4mg% for cholesterol, 132.5+/-55.2mg% for phospholipid and 548.8+/-106.3mg% for total lipid. 2. The mean values of serum lipoproteins in patients with cerebrovascular accidents were 255.3+/-81.6mg% for beta-lipoprotein, 118.3+/-73.7mg% for pre-beta-lipoprotein and 183.6+/-65.5mg% for alpha-lipoprotein. 3. There were no significant differences of sex and age in the mean values of serum lipids and lipoproteins in patients with cerebrovascular accidents. 4. In general the mean concentrations of serum lipids and lipoproteins, except phospholipid and alpha-lipoprotein, in patients with cerebrovascular accidents and hypertension were significantly elevated than in normal control subjects. 5. There were no significant differences in serum lipid and lipoprotein values between various types of cerebrocasculr accidents. 6. The change of serum lipid and lipoprotein values had a decreasing tendency till one month after onset, thereafter the values became similar to to\hose of early period of illness. 7. The incidence of hyperlipoproteinemia in patients with cerebrovascular accidents was 64%, and the most frequent type of hyperlipoproteinemia was Type IIa, as the frequency decreased in the order of Type IV, Type IIb and Type III.
Cholesterol ; Humans ; Hyperlipoproteinemias ; Hypertension ; Incidence ; Lipoproteins* ; Stroke* ; Triglycerides

The present study was undertaken to investigate the relationship between serum lipid and lipoprotein values and cerebrovascular accidents. Serum lipids and lipoproteins were measured in 130 cases of normal Korean, 49 patients with cerebrovascular accidents and 35 patients with uncomplicated essential hypertension. The results were summarized as follows; 1. The mean values of serum lipids in patients with cerebrovascular accidents were 148.3+/-75.3mg% for triglyceride, 189.6+/-37.4mg% for cholesterol, 132.5+/-55.2mg% for phospholipid and 548.8+/-106.3mg% for total lipid. 2. The mean values of serum lipoproteins in patients with cerebrovascular accidents were 255.3+/-81.6mg% for beta-lipoprotein, 118.3+/-73.7mg% for pre-beta-lipoprotein and 183.6+/-65.5mg% for alpha-lipoprotein. 3. There were no significant differences of sex and age in the mean values of serum lipids and lipoproteins in patients with cerebrovascular accidents. 4. In general the mean concentrations of serum lipids and lipoproteins, except phospholipid and alpha-lipoprotein, in patients with cerebrovascular accidents and hypertension were significantly elevated than in normal control subjects. 5. There were no significant differences in serum lipid and lipoprotein values between various types of cerebrocasculr accidents. 6. The change of serum lipid and lipoprotein values had a decreasing tendency till one month after onset, thereafter the values became similar to to\hose of early period of illness. 7. The incidence of hyperlipoproteinemia in patients with cerebrovascular accidents was 64%, and the most frequent type of hyperlipoproteinemia was Type IIa, as the frequency decreased in the order of Type IV, Type IIb and Type III.
Cholesterol ; Humans ; Hyperlipoproteinemias ; Hypertension ; Incidence ; Lipoproteins* ; Stroke* ; Triglycerides

The duodenal lipoma is infrequent and few reports deseribed its endoscopic features, We recently encountered one case of duodenal lipoma which was large polypoid one in the descending portion of the duodenum. The patient had been suffred from epigastric dull pain and bloating sensatio for 5 months. We did endoscopic polypectomy of the lipoma successfully.
Duodenum ; Humans ; Lipoma*

No Abstract Available.
Depression* ; Primary Health Care*