Pseudomyxoma peritonei is a rare disorder chracterized by abdominal distension resulting from the accumulation of a mucinous, gelatinous, translucent material which arises from rupture of pre-existing mucinous cystadenomas and cystadenocarcinomas of the ovary and mucocele of the appendix. We report 11 cases of pseudomyxoma peritonei which were diagnosed by surgical and pathological findings. The results were as follows. 1) The mean age of 11 cases was 51 years and 5 cases were male and 6 cases were female and male to female ratio was 1 to 1.2. 2) Clinical manifestations in 11 cases were abdominal distension in 5 cases (45.5%), palpable mass in 4 cases(36.6%), abdominal pain in 4 cases(36.6%), nausea in 3 cases(27.3%), weight loss in 3 cases(27.3%), diarrhea in 2 cases(18.2%), constipation in 1 case(9.0%), anal bleeding in 1 case(9.0%) and defecation difficulty in 1 case(9.0%). The duration of symptoms was 2 days to 1 year. 3) The primary sites of pseudomyxoma peritonei were ovarian cancer in 3 cases(27.2%), appendiceal cancer in 2 cases(18.2%), gastric cancer in 2 cases(18.2%), rectal cancer in 1 case(9.1%), cecal cancer in 1 case(9.1%) and unknown origin in 2 cases(18.2%). 4) Following surgical interventions were performed; right hemicolectomy in 2 cases, palliative gastrojejunostomy in 2 cases, oophorectomy in 1 case, omentectomy in 1 case and right hemicolectomy with gastrojejunostomy in 1 case. 5) The adjunctive anti-cancer chemotherapy was done in 4 cases(36.4%) by combination of actinomycin D, adriamycin, CCNU, cisplatin, cytoxan and fluorouracil, And chemotherapy only was done in 2 cases and hyperthermia was done in 1 case.
Abdominal Pain ; Appendiceal Neoplasms ; Appendix ; Cecal Neoplasms ; Cisplatin ; Constipation ; Cyclophosphamide ; Cystadenocarcinoma ; Cystadenoma, Mucinous ; Dactinomycin ; Defecation ; Diarrhea ; Doxorubicin ; Drug Therapy ; Female ; Fever ; Fluorouracil ; Gastric Bypass ; Gelatin ; Hemorrhage ; Humans ; Lomustine ; Male ; Mucins ; Mucocele ; Nausea ; Ovarian Neoplasms ; Ovariectomy ; Ovary ; Pseudomyxoma Peritonei* ; Rectal Neoplasms ; Rupture ; Stomach Neoplasms ; Weight Loss

BACKGROUND: Although epidural block has been widely used to control post operative pain, still there are many problems to be solved such as inadequate pain control and difficulty in its techniques. Subarachnoid morphine and clonidine injection also has been used to control postoperative pain and as adjuvant to spinal anesthesia. We compared subarachnoid morphine or morphine and clonidine injection with epidural morphine and bupivacaine injection for postoperative pain control. METHOD: The effect of the different types of postoperative pain control method in low abdominal surgery were investigated. 30 patients were randomly divided into one of three groups; single intrathecal morphine injection (group M), single intrathecal morphine and clonidine injection (group M/C) and continuous epidural morphine and bupivacaine injection (group M/B) prior to induction of general anesthesia. Visual analogue scale (VAS), Prince-Henry Hospital score (PHS), patient satisfaction score and the side effects were investigated at emergence, 1, 2, 4, 8, 12, 24 and 48 hours after emergence of anesthesia. The blood pressure and heart rate were monitored 0, 5, 10 and 30 min, 1, 2, 24 and 48 hours after block for monitor the hemodynamic changes. RESULT: In group M/C, the VAS showed statistically significant decrease till first 24 hours after block and in group M/B after then (p<0.05). PHS and patient satisfaction scores were similar in all groups. The side effects, pruritis and nausea, by the opioids were more frequent in subarachnoid groups versus epidural group but that were tolerable without medication in most cases. In spite that systolic and diastolic blood pressures and heart rate were significantly low (p<0.05) in group M/C, there were no severe hypotension or bradycardia that need treatment. CONCLUSION: From these results, it seems that intrathecal morphine and clonidine combination therapy can be used as an another choice for postoperative pain control in low abdominal surgery.
Analgesics, Opioid ; Anesthesia ; Anesthesia, General ; Anesthesia, Spinal ; Blood Pressure ; Bradycardia ; Bupivacaine* ; Clonidine* ; Heart Rate ; Hemodynamics ; Humans ; Hydrogen-Ion Concentration ; Hypotension ; Morphine* ; Nausea ; Pain, Postoperative* ; Patient Satisfaction ; Pruritus

No abstract available.
Herpesvirus 1, Suid* ; Pseudorabies*

No abstract available.
Animals ; Axis, Cervical Vertebra* ; Herpesvirus 1, Suid* ; Pseudorabies* ; Rats* ; Uterus*

We have investigated in vitro proliferative responses of peripheral blood mononuclear cells and productions of interferon-gamma and soluble interleukin-2 receptors by these cells from 6 patients with chronic active hepatitis B immediately before and 24 hours after a single intravenous injection of 100 mg of polyadenylic.polyuridylic acid. Cell proliferations were assessed by the technique of tritiated-thymidine incorporation and productions of interferon-gamma and soluble interleukin-2 receptors were measured by enzyme-linked immunosorbent assay. The administration of polyadenylic.polyuridylic acid to the patients has resulted in significant increases of in vitro proliferations of their peripheral blood mononuclear cells as well as productions of interferon-gamma by these cells. However, in vitro productions of soluble interleukin-2 receptors were not changed significantly. These results suggest that the enhanced cellular responses by polyadenylic.polyuridylic acid might be due to the increased sensitivity rather than the increased expression of cellular interleukin-2 receptor.
Adult ; Hepatitis B/*immunology ; Hepatitis, Chronic/*immunology ; Human ; Immunity, Cellular/drug effects ; Interferon Type II/biosynthesis ; Leukocytes, Mononuclear/*drug effects/immunology ; Male ; Middle Age ; Poly A-U/*pharmacology ; Receptors, Interleukin-2/biosynthesis ; Solubility

Percutaneous transhepatic biliary drainge (PTBD) is a widely accepted technique for the decotnn of biliary obstruction. However, PTBD is most frequently performed in patients whose prognosis is poor becauase of unresectable malignancy, sepsis, or advanced age. And this technique has disadvantages which inclusdes loss of biliary fluids, fat malabsorption, discomfort and psychologic problem for many patients. A 68-year-old man admitted to the hospital because of obstructive jaundice. He had received cholectystectomy two yeas ageo due to the perforation of gallbladder caused by adenocarcinoma of cystic duct. An external PTBD was placed. But because of the chronic bile loss, a percutaneous endoscopic gastrostomy (PEG) was inserted and drainge of bile into the stomach through an extracoporeal circuit utilizing the PTBD as an exit and PEG as an entrance was achieved.
Adenocarcinoma ; Aged ; Bile ; Cystic Duct ; Drainage* ; Gallbladder ; Gastrostomy* ; Humans ; Jaundice, Obstructive ; Prognosis ; Sepsis ; Stomach

No abstract available.
Lymphoma* ; Thyroid Gland* ; Thyroiditis*

PURPOSE: The laparoscopic adrenalectomy (LA) has become the preferred procedure for adrenal tumors due to many advantages; a more rapid and comfortable recovery, shortened hospitalization period, and fewer complications. This study reports on an initial 4 year period of experience with LA and describes various unusual findings encountered during the treatment. METHODS: From February 1997 to November 2000, a total of 20 LA were performed. Of the several LA techniques previously described we prefer the transabdominal approach in the lateral decubitus position utilizing 3 or 4 trocars, and this method was employed in all the cases presented here. RESULTS: All 20 patients had a unilateral tumor. The pathological findings consisted of 11 aldosteronomas, 6 Cushing adenomas, 2 pheochromocytomas and 1 cortical carcinoma. Of the 20 patients, 18 were successfully operated with the laparoscopic procedure and the remaining 2 cases were converted to open adrenalectomy. The reasons for conversion were sudden cardiac arrest of unknown origin in one and intraoperative bleeding due to periadrenal massive fat in the other. During LA, 2 patients with non-catecholamine-secreting cortical adenomas pathologies displayed abnormal EKG findings, which reverted to normal after the operation. The average complete LA operation times was 186 minutes in the first 9 cases and 132 minutes in the next 9 cases. The first oral intake was started within 24 hours in all cases. There were no postoperative complications, operative morbidity or mortality. The average hospital stay was 6.2 days in the first 9 cases and 4.2 days in the next 9 cases. CONCLUSION: LA is a relatively fast and safe method and has become is accepted as the preferred procedure for adrenal tumors but it requires good perioperative preparation. Surgeons and anesthesiologists need to be aware of the possible cardiovascular complications and of the problems inherent in the manipulation of the adrenal gland during LA.
Adenoma ; Adrenal Glands ; Adrenalectomy* ; Death, Sudden, Cardiac ; Electrocardiography ; Hemorrhage ; Hospitalization ; Humans ; Length of Stay ; Mortality ; Pathology ; Pheochromocytoma ; Postoperative Complications ; Surgical Instruments

BACKGREOUND: The endotracheal intubation for inhalational anesthesia induces hypertension and tachycardia and these hemodynamic changes cause many cardiovascular complications. Propofol has hemodynamic stability compared with thiopental sodium as an induction agent of general anesthesia. Clonidine, an 2-adrenergic receptor agonist, blunts hemodynamic changes when administered as premedicant. We evaluated the hemodynamic stability during endotracheal intubation after clonidine premedication and each induction with thiopental sodium or propofol. METHODS: The 40 male and 40 female patients who scheduled for elective surgery, were randomly assigned in 4 groups (Group I, II, III and IV). In Group II and IV, the patients were administered 150 microgram of oral clonidine 90 minutes before induction of general anesthesia. Thiopental sodium was used as induction agents in Group I and II, propofol in Group III and IV. We measured systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate at ward before administration of oral clonidine premedication (baseline value), before induction, after administration of induction agent, just after intubation, 1, 2, 3 and 5 minutes after endotracheal intubation. RESULTS: The systolic, diastolic and mean arterial pressure and heart rate were increased significantly in all 4 groups (P<0.05) when compared to baseline value of each group but lower in Group IV (P<0.05) compared to Group I, II, III. CONCLUSION: Clonidine 150 microgram premedication and induction of general anesthesia with propofol blunts hemodynamic changes induced by endotracheal intubation.
Anesthesia ; Anesthesia, General ; Arterial Pressure ; Blood Pressure* ; Clonidine* ; Female ; Heart Rate* ; Heart* ; Hemodynamics ; Humans ; Hypertension ; Intubation ; Intubation, Intratracheal* ; Male ; Premedication* ; Propofol ; Tachycardia ; Thiopental

PURPOSE: The laparoscopic adrenalectomy (LA) has become the preferred procedure for adrenal tumors due to many advantages; a more rapid and comfortable recovery, shortened hospitalization period, and fewer complications. This study reports on an initial 4 year period of experience with LA and describes various unusual findings encountered during the treatment. METHODS: From February 1997 to November 2000, a total of 20 LA were performed. Of the several LA techniques previously described we prefer the transabdominal approach in the lateral decubitus position utilizing 3 or 4 trocars, and this method was employed in all the cases presented here. RESULTS: All 20 patients had a unilateral tumor. The pathological findings consisted of 11 aldosteronomas, 6 Cushing adenomas, 2 pheochromocytomas and 1 cortical carcinoma. Of the 20 patients, 18 were successfully operated with the laparoscopic procedure and the remaining 2 cases were converted to open adrenalectomy. The reasons for conversion were sudden cardiac arrest of unknown origin in one and intraoperative bleeding due to periadrenal massive fat in the other. During LA, 2 patients with non-catecholaminesecreting cortical adenomas pathologies displayed abnormal EKG findings, which reverted to normal after the operation. The average complete LA operation times was 186 minutes in the first 9 cases and 132 minutes in the next 9 cases. The first oral intake was started within 24 hours in all cases. There were no postoperative complications, operative morbidity or mortality. The average hospital stay was 6.2 days in the first 9 cases and 4.2 days in the next 9 cases. CONCLUSION: LA is a relatively fast and safe method and has become is accepted as the preferred procedure for adrenal tumors but it requires good perioperative preparation. Surgeons and anesthesiologists need to be aware of the possible cardiovascular complications and of the problems inherent in the manipulation of the adrenal gland during LA.
Adenoma ; Adrenal Glands ; Adrenalectomy* ; Death, Sudden, Cardiac ; Electrocardiography ; Hemorrhage ; Hospitalization ; Humans ; Length of Stay ; Methods ; Mortality ; Pathology ; Pheochromocytoma ; Postoperative Complications ; Surgeons ; Surgical Instruments