Squamous cell carcinoma of the bulbar conjunctiva is a rare disease and usually arise at the limbus and spread to the cornea and adjacent bulbar conjunctiva. The authers experienced two cases of squamous cell carcinoma of the bulbar conjunctiva. In the first case, a 30-year old male visited our hospital in February, 1969 with a congested granulomatous hypertrophy in the nasal side of the bulbar conjunctiva(OD) which had showed progressive enlargement of 3 months duration. An excisional biopsy was carried out and histopathological examination revealed bulbar squamous cell carcinoma. In second case, a 51-year old female visited our hospital in January, 1977 with recurrent mild conjunctival injection and a small whitish elevated mass in the temporal side of the bulbar conjunctiva(OD) which had showed progressive enlargement of 7 months duration. The elevated mass was resected and histopathological examination revealed bulbar squamous cell carcinoma. We had a study of the histopathological finding for two cases of squamous cell carcinoma of the bulbar conjunctiva with a brief review of relating literatures.
Adult ; Biopsy ; Carcinoma, Squamous Cell* ; Conjunctiva* ; Cornea ; Estrogens, Conjugated (USP) ; Female ; Humans ; Hypertrophy ; Male ; Middle Aged ; Rare Diseases

Syphilitic interstitial keratitis is known as a rare disease in recent time. Authors experienced 5 cases of interstitial keratitis due to congenital syphilis. All the cases sh owed positive serologic test for syphilis (VDRL), 4 cases showed Hutchinson's teeth and 2 cases showed iritis. A brief review and relating literatures are presented.
Iritis ; Keratitis* ; Rare Diseases ; Serologic Tests ; Syphilis ; Syphilis, Congenital*

In Korea, every worker should undergo a preemployment medical examination according to Law for Occupational Safety and Health. But evaluation of it has not been previously carried out. Thus a telephone survey of 213 establishments of Inchon area for evaluation of preemployment medical examination in Korea was conducted. One hundred and fourteen companies(46.5% of all the subjects) were examined medically on preemployment, 47 establishments(41.2% of this study subjects) reevaluated workers by each establishment's medical criteria, and only less than half of diseased workers(DM 38.6% ; hypertension 42.1%, HBV carrier 28.0 % ; active pulmonary tuberculosis 7.9 %; back pain 12.3 %, and noise induced hearing loss 18.4 %) were employed. Employee's fees for preemployment medical examination were covered by 53.5 % of all the subjects. From our survey, it is clear that preemployment medical examination plays discriminating role on the employment of workers based on health status. We thus proposed to change over from preemployment medical examination to preplacement examination based on the evaluation of essential job functions and reasonable accommodation.
Back Pain ; Employment ; Fees and Charges ; Hearing Loss ; Hypertension ; Incheon ; Jurisprudence ; Korea* ; Noise ; Occupational Health ; Telephone ; Tuberculosis, Pulmonary

This study aimed to investigate the independent and interactive influences of apolipoprotein E (APOE) epsilon4 and beta-amyloid (Abeta) on multiple cognitive domains in a large group of cognitively normal (CN) individuals and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Participants were included if clinical and cognitive assessments, amyloid imaging, and APOE genotype were all available from the Alzheimer's Disease Neuroimaging Initiative database (CN = 324, MCI = 502, AD = 182). Individuals with one or two copies of epsilon4 were designated as APOE epsilon4 carriers (epsilon4+); individuals with no epsilon4 were designated as APOE epsilon4 non-carriers (epsilon4-). Based on mean florbetapir standard uptake value ratios, participants were classified as Abeta burden-positive (Abeta+) or Abeta burden-negative (Abeta-). In MCI, APOE epsilon4 effects were predominantly observed on frontal executive function, with epsilon4+ participants exhibiting poorer performances; Abeta positivity had no influence on this effect. Abeta effects were observed on global cognition, memory, and visuospatial ability, with Abeta+ participants exhibiting poorer performances. Measures of frontal executive function were not influenced by Abeta. Interactive effects of APOE epsilon4+ and Abeta were observed on global cognition and verbal recognition memory. Abeta, not APOE epsilon4+, influenced clinical severity and functional status. The influences of APOE epsilon4+ and Abeta on cognitive function were minimal in CN and AD. In conclusion, we provide further evidence of both independent and interactive influences of APOE epsilon4+ and Abeta on cognitive function in MCI, with APOE epsilon4+ and Abeta showing dissociable effects on executive and non-executive functions, respectively.
Aged ; Aged, 80 and over ; Alzheimer Disease/genetics/pathology ; Amyloid beta-Peptides/*metabolism ; Aniline Compounds/chemistry ; Apolipoprotein E4/*genetics ; Brain/radiography ; Cognition ; Databases, Factual ; Demography ; Ethylene Glycols/chemistry ; Female ; Genotype ; Humans ; Male ; Mild Cognitive Impairment/genetics/*pathology ; Positron-Emission Tomography

Gender dysphoria is very rare, but has frequent psychiatric comorbidity. In addition, risk of suicide is higher in patients with gender dysphoria than for the general population. Treatment of gender dysphoria is not determined, and more aggressive treatment is required for patients with suicidal ideation. No case involving electroconvulsive therapy of a gender dysphoria patient has been reported in South Korea. We discuss a 24 year-old man given electroconvulsive therapy for gender dysphoria with severe mood dysregulation and suicidal ideation.
Comorbidity ; Electroconvulsive Therapy* ; Humans ; Republic of Korea ; Suicidal Ideation* ; Suicide ; Young Adult

A 16-year-old woman was referred to us for depression and persistent suicidal and homicidal ideation. From 2010, the patient visited a neurologist due to recurrent grand mal epilepsy, auditory and visual hallucinations, episodic memory loss, and persistent depression. Upon admission, it was revealed through clinical history taking that she had suffered from chronic bullying from same-sex peers and sexual abuse, twice, from an adult male in the neighborhood when she was 10 years old. A brain magnetic resonance imaging study showed left mesial hippocampal sclerosis. The patient exhibited improvement of her psychiatric symptoms after treatment with a combination of fluoxetine (30 mg) and aripiprazole (10 mg). Children and adolescents with epilepsy experience conflicts in the family, challenges at school, stigma, and psychosocial limitations or deprivations due to their comorbid psychiatric symptoms and hence, psychiatric evaluation and early intervention is important when treating these patients.
Adolescent ; Adult ; Brain ; Bullying ; Child ; Depression ; Early Intervention (Education) ; Epilepsy ; Epilepsy, Temporal Lobe* ; Epilepsy, Tonic-Clonic ; Female ; Fluoxetine ; Hallucinations ; Humans ; Magnetic Resonance Imaging ; Male ; Memory, Episodic ; Residence Characteristics ; Sclerosis* ; Sex Offenses ; Suicidal Ideation ; Aripiprazole

OBJECTIVES: The purpose of this study was to examine the psychiatric characteristics of outpatients with tinnitus. METHODS: A total of 88 subjects were included in this study. According to Tinnitus Handicap Inventory (THI) scores, the subjects were classified into two group ; a mild tinnitus symptoms (mild-tinnitus) group and a severe tinnitus symptoms (severe-tinnitus) group. A questionnaire was used for an assessment of demographic characteristics, and the THI, the Visual Analogue Scale (VAS) about tinnitus, the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI) are applied for evaluation of other clinical psychiatric characteristics. RESULTS: Higher THI scores were positively correlated with tinnitus course, the number of accompanying symptoms, and the VAS. BDI total scores, BDI factors, and BAI total scores were significantly higher in the severe-tinnitus group than in the mild-tinnitus group. Also suicidal ideation, interpersonal problems, sleep problems, occupational impairment, and fatigue were significantly higher in the severe-tinnitus group than in the mild-tinnitus group. CONCLUSIONS: Tinnitus is a common disorder of hearing which is associated frequently with psychiatric problems. This study suggests that psychiatric interventions should be taken into consideration in the treatment of patients suffering from tinnitus.
Anxiety ; Depression ; Fatigue ; Hearing ; Humans ; Outpatients ; Suicidal Ideation ; Tinnitus*

PURPOSE: This study aimed to identify the neural basis of executive function (EF) in amnestic mild cognitive impairment (aMCI) according to beta-amyloid (Aβ) positivity. Furthermore, we explored if the identified brain areas could serve as predictors for clinical progression. MATERIALS AND METHODS: We included individuals with aMCI using data from [¹⁸F]-florbetapir-positron emission tomography (PET), fluorodeoxyglucose-PET, and EF scores, as well as follow-up clinical severity scores at 1 and 5 years from baseline from the Alzheimer's Disease Neuroimaging Initiative database. The correlations between EF score and regional cerebral glucose metabolism (rCMglc) were analyzed separately for aMCI with low Aβ burden (aMCI Aβ−, n=230) and aMCI with high Aβ burden (aMCI Aβ+, n=268). Multiple linear regression analysis was conducted to investigate the associations between rCMglc and clinical progression. RESULTS: Longitudinal courses differed between aMCI Aβ− and aMCI Aβ+ groups. On average, aMCI Aβ− subjects maintained their level of clinical severity, whereas aMCI Aβ+ subjects showed progression. EF impairment in aMCI Aβ− was related to the anterior cingulate cortex (ACC), whereas that in aMCI Aβ+ was related to Alzheimer's Disease-vulnerable brain regions. ACC and the posterior cingulate cortex were associated with clinical progression in aMCI Aβ− and aMCI Aβ+, respectively. CONCLUSION: Our findings suggest that although MCI subjects showed similar behavioral phenotypes at the time of diagnosis, EF and further progression were associated with different brain regions according to Aβ burden. Clarification of the etiologies and nature of EF impairment in aMCI are critical for disease prognosis and management.
Alzheimer Disease ; Amyloid ; Brain ; Cognition ; Diagnosis ; Executive Function ; Follow-Up Studies ; Glucose ; Gyrus Cinguli ; Linear Models ; Metabolism ; Mild Cognitive Impairment ; Neuroimaging ; Phenotype ; Positron-Emission Tomography ; Prognosis

PURPOSE: We compared CT findings of thickened wall-type gallbladder cancer with those of complicated cholecystitis. MATERIALS AND METHODS: We retrospectively reviewed abdominal CT scans of ten patients with thickened wall-type gallbladder cancer and eight patients with complicated cholecystitis, from March 1991 to November 1995. RESULTS: CT findings of thickened wall-type gallbladder cancer showed diffuse or focal wallthickening. Wall thickness was 5.3-18.0 mm(mean value, 12.2mm ; n=10). Gallbladder wall thickness of complicatedcholecystitis was 3.0-14.0mm (mean value, 6.6mm ; n=8). Statistical significance was noted between thickened wall-type gallbladder cancer and complicated cholecytitis(p<0.0029). Irregular wall thickening was noted in 7/10cases of thickened wall-type gallbladder cancer(70%). Regular wall thickening was noted in 6/8 cases of complicated cholecystitis(75%). The luminal diameter of thickened wall-type gallbladder cancer was 3.3-5.4cm (meanvalue, 4.2cm ; n=10). The luminal diameter of complicated cholecystitis was 5.2-8.0cm (mean value, 6.5cm ; n=8).Statistical significance was noted between thickened wall-type gallbladder cancer and complicated cholecystitis(p<0.0003). The halo sign was noted in only 3/8 cases of complicated cholecystitis(38%). Secondary findings of thickened wall-type gallbladder caner was lymphadenopathy in 3/10 cases(30%), and liver invasion in 2/10 cases(20%). Secondary findings of complicated cholecystitis were liver abscess in 2/8 cases(25%), and RLQ abdominal fluid collection and pleural effusion in 4/8 cases(50%). CONCLUSION: Differential factors of thickened wall-type gallbladder cancer from complicated cholecystits are gallbladder wall thickness, regularity of wall thickness, halo sign, secondary findings and luminal distention.
Cholecystitis* ; Gallbladder ; Gallbladder Neoplasms ; Humans ; Liver ; Liver Abscess ; Lymphatic Diseases ; Phenobarbital ; Pleural Effusion ; Retrospective Studies ; Tomography, X-Ray Computed

BACKGROUND: All tissue components in the nasal mucosa, including the epithelium, goblet cells, excretory glands, and blood capillaries participate in nasal secretory response. In vivo studies have suggested that, of these components, submucosal glands are thought to play an important role in nasal mucus secretion. These studies, however, are limited in dealing with pure secretory activity of submucosal glands. Therefore, in vitro study using cultured nasal submucosal glands is required to evaluate the pathophysiological mechanisms of nasal mucus secretion. The present study draws on experience obtained from the culture of human submucosal glands isolated from nasal mucosa. MATERIALS AND METHODS: To obtain isolated submucosal gland cells, the uncinate process mucosa was stripped of surface epithelum by stroking the luminal surface with cotton tip applicator and minced into small fragments. By enzymatic treatment, thereafter, the submucosal gland cells were isolated and plated on culture flasks containing media. Using millipore inserts and cover slide, culuted cell was stained AB-PAS to identify that confluent monolayer cells were submucosal gland cell. RESULTS: The uncinate process mucosa were appropriate for the isolation of submucosal gland cell. An average of 1.2X106 cells were obtained in every preparation of cells. The exclusion ratio of trypan blue was 95%. The isolated cells were strongly stained in AB-PAS, suggesting that cells are of glandular origin. Plated gland cell formed colony on the 3rd day and became confluent after 5-7 days. The proportion of the stained cells to the total cells decreased depending the duration of cell culture. CONCLUSION: We succeeded in isolation and culture of submucosal gland cells which can provide model systems for studying the mechanisms of nasal glandular cell secretion in vivo.
Capillaries ; Cell Culture Techniques* ; Epithelium ; Goblet Cells ; Humans* ; Mucous Membrane ; Mucus ; Nasal Mucosa ; Phenobarbital ; Stroke ; Trypan Blue