1.Treatment of Enchondromas of the Hand with Heterograft Bone.
The Journal of the Korean Orthopaedic Association 2002;37(1):45-50
PURPOSE: To evaluate the effectiveness of treatments for enchondromas of the hand with heterograft bone substitute instead of bone autograft. MATERIALS AND METHODS: We reviewed the radiographs of 15 patients that were followed for a minimum of 6 months. From January 1995 to May, 2000, fifteen patients that were treated with heterograft bone and could be followed-up for at least 6 months were retrospectively studied. Clinical, radiological and histological results were evaluated. RESULTS: Clinically excellent in 5, good in 10. Radiologic result was 12 in Group 1, 3 in Group 2, the average consolidation duration was 8 months (5-11 months). The typical histologic findings of enchondroma by intraoperative specimens were hyaline cartilage, myxoid degeneration, calcification, and enchondral ossification. Grafted heterograft bone was incorporated via physiologic remodelling without significant problems. No signigicant complications occurred. CONCLUSION: We believe that heterograft bone is a good treatment option for enchondromas of the hand, given the disadvantages of bone autografts or allografts.
Allografts
;
Autografts
;
Bone Substitutes
;
Chondroma*
;
Hand*
;
Heterografts*
;
Humans
;
Hyaline Cartilage
;
Retrospective Studies
;
Transplants
2.The bone formation around anodic oxidized titanium implants in the tinbiae of ovarectomized rats.
Sung Hwan PARK ; Suk Young JUNG ; Jae Yeol LEE ; Gyoo Cheon KIM ; Sang Hun SHIN
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2008;34(3):306-318
Anodic spark deposition method(ASD) surface treated titanium implant possesses a considerable osteoconductive potential that promoting a high level of implant osseointegration in normal bone. The purpose of this study was to observe the ASD implant's osseointegration in the osteoporosis-induced animal model. Twenty four rats, 10 weeks of age, were ovarectomized and 5 weeks later divided into two groups : ASD implant group and control implant group. Titanium screw implants (diameter; 2.0 mm, length, 3.5 mm; pitch-height, 0.4 mm) were designed for this study. Experimental implants were ASD treated and no treatment on control implants. ASD implants and control implants were placed in to left tibiae of rats. The rats were sacrificed at different time interval(1, 2, 4 and 8 weeks after implantation) for histopathologic observation and immunohisto -chemistrical observation, with collagen type I, fibronectin, integrin alpha2beta1 and integrin alpha5beta1 antibodies. The results obtained from this study were as follow: 1. Histopathologic findings, overall tissue response and the pattern of bone formation in both groups were similar. In ASD group, more newly formed bone was seen at 1 week and 2weeks than control group. 2. The levels of type I collagen and fibronectin expression were the most abundant at 2weeks and decreased gradually in both groups. Fibronectin and type I collagen expression in ASD group were stronger than control group but no significance. 3. The levels of integrin alpha2beta1 and Integrin alpha5beta1 expression were most abundant at 2 weeks and decreased gradually in both groups. No significant difference was observed in both groups. From this results, anodic oxidized titanium implants were more advantages in early stage of bone formation than control group, but have no significance in tissue responses and late bone formations. It could be stated that although anodic oxidized titanium implant possesses considerable osteoconductive potential but in osteoporotic bone condition dental implant procedure should performed after improving or treating the osteoporotic bone condition.
Animals
;
Antibodies
;
Collagen Type I
;
Dental Implants
;
Fibronectins
;
Implants, Experimental
;
Integrin alpha2beta1
;
Integrin alpha5beta1
;
Models, Animal
;
Osseointegration
;
Osteogenesis
;
Osteoporosis
;
Rats
;
Tibia
;
Titanium
3.Guidelines for the Diagnosis and Treatment of Helicobacter pylori Infection in Korea, 2013 Revised Edition.
Sang Gyun KIM ; Hye Kyung JUNG ; Hang Lak LEE ; Jae Young JANG ; Hyuk LEE ; Chan Gyoo KIM ; Woon Geon SHIN ; Ein Soon SHIN ; Yong Chan LEE
The Korean Journal of Gastroenterology 2013;62(1):3-26
Since the Korean College of Helicobacter and Upper Gastrointestinal Research has first developed the guideline for the diagnosis and treatment of Helicobacter pylori infection in 1998, the revised guideline was proposed in 2009 by the same group. Although the revised guideline was made by comprehensive review of previous articles and consensus of authoritative expert opinions, the evidence-based developmental process was not applied in the revision of the guideline. This new guideline has been revised especially in terms of changes in the indication and treatment of H. pylori infection in Korea, and developed by the adaptation process as evidence-based method; 6 guidelines were retrieved by systematic review and the Appraisal of Guidelines for Research and Evaluation (AGREE) II process, 21 statements were made with grading system and revised by modified Delphi method. After revision, 11 statements for the indication of test and treatment, 4 statements for the diagnosis and 4 statements for the treatment have been developed, respectively. The revised guideline has been reviewed by external experts before the official endorsement, and will be disseminated for usual clinical practice in Korea. Also, the scheduled update and revision of the guideline will be made periodically.
Amoxicillin/therapeutic use
;
Anti-Bacterial Agents/therapeutic use
;
Aspirin/therapeutic use
;
Bismuth/therapeutic use
;
Breath Tests
;
Clarithromycin/therapeutic use
;
Gastroesophageal Reflux/etiology
;
Gastroscopy
;
Helicobacter Infections/complications/*diagnosis/drug therapy
;
*Helicobacter pylori
;
Humans
;
Lymphoma, B-Cell, Marginal Zone/complications
;
Metaplasia/complications
;
Metronidazole/therapeutic use
;
Peptic Ulcer/complications/drug therapy
;
Proton Pump Inhibitors/therapeutic use
;
Republic of Korea
;
Stomach Neoplasms/complications/surgery
;
Tetracycline/therapeutic use
4.Hyperphosphatemia is associated with patency loss of arteriovenous fistula after 1 year of hemodialysis.
Ju Young MOON ; Hyae Min LEE ; Sang Ho LEE ; Tae Won LEE ; Chun Gyoo IHM ; Young Il JO ; Sang Woong HAN ; Sug Gyun SHIN
Kidney Research and Clinical Practice 2015;34(1):41-46
BACKGROUND: The patency of arteriovenous access is important for stable and effective hemodialysis, and long-term technical survival is best achieved with a native arteriovenous fistula (AVF). However, maintaining AVF patency remains a challenge. This study was designed to determine the independent prognostic factors for AVF patency according to hemodialysis duration. METHODS: The primary study end point was unassisted patency of the AVF, which was defined as the time from the first fistula surgery to the first AVF failure. AVF failure was defined as an event that required percutaneous intervention or surgery to revise or replace the fistula, which occurred at least 2 months after fistula formation. RESULTS: We enrolled 478 patients with a mean age of 55.5+/-14.0 years, and mean duration of dialysis was 2.5+/-2.1 years. There were 109 cases (22.8%) of AVF failure. The factors related to AVF patency differed according to hemodialysis duration. Using a Cox-adjusted model, we observed a significant correlation between the incidence of AVF failure and diabetes within the initial 12 months of hemodialysis. Uncontrolled hyperphosphatemia (mean serum phosphorus>5.5 mg/dL during hemodialysis) was associated with patency loss of AVF after 1 year of hemodialysis. CONCLUSION: Various factors were associated with the development of patency loss of AVF as hemodialysis duration differed, and a preventive role of hyperphosphatemia control in AVF survival needs further clinical study.
Arteriovenous Fistula*
;
Dialysis
;
Fistula
;
Humans
;
Hyperphosphatemia*
;
Incidence
;
Renal Dialysis*
5.Characteristics of Mitochondrial Events in Synthetic Bile Acids-induced Apoptosis of Human Osteosarcoma Cells.
Gyoo Cheon KIM ; Yoon HWANG ; Jae Hyun PARK ; Yong Suk MOON ; Young Hyun YOO ; Sang Hun SHIN ; Kyung Il UM ; Bong Soo PARK
Korean Journal of Physical Anthropology 2004;17(4):351-362
ABSTRACT: Apoptosis of osteosarcoma cells induced by bile duct derivates, HS-1200 was investigated with relation to mitochodria. HS-1200 induced cytochrome c and Smac/DIABLO release from mitochondria which are major factors related to apoptosis. In these apoptosis processes, release of cytochrome c was not blocked by caspase inhibitor, but release of Smac/DIABLO was blocked. BKA, a kind of PTP (permeablity transition pore) inhibitor, did not block both of them. Interestingly, the alteration of MMP was not observed by means of using JC-1 dye. Although MitoTracker, DiOC-6 and Rhodamine123 were used to confirm previous results, the decrease of MMP was not observed. In order to investigate whether this phenomenon is apoptosis-specific or cell-specific process, genistein was added to cells which usually decreased MMP. After adding genistein, MMP was not decreased, suggesting this phenomenon is cell-specific process. Conclusionally, HS-1200 induced apoptosis of osteosarcoma cells via mitochondria, cytochrome c and Smac/DIABLO were released from mitochondria without decrease of MMP. The release of Smac/DIABLO was dependent of caspase.
Apoptosis*
;
Bile Ducts
;
Bile*
;
Cytochromes c
;
Genistein
;
Humans*
;
Mitochondria
;
Osteosarcoma*
6.Effect of calcium and vitamin D supplementation on bone formation around titanium implant in osteoporosis-induced rats.
Jae Yeol LEE ; Seok Young JEONG ; Sang Hun SHIN ; Gyoo Cheon KIM ; Yong Deok KIM ; In Kyo CHUNG ; Uk Kyu KIM
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2008;34(3):276-284
PURPOSE: The purpose of this study was to observe the effect of calcium and vitamin D to the titanium implant osseointegration in the osteoporosis-induced animal model. MATERIAL AND METHOD: Thirty-two rats, 10 weeks of age, were divided into two groups: experimental group was ingested additional calcium and vitamin D, and a control group was not. Titanium screw implant(diameter, 2.0 mm; length, 3.5 mm; pitch-height 0.4 mm) were placed into tibia of 32 rats, 16 in the control group and 16 in the experimental group. The rats were sacrificed at 1, 2, 4 and 8 weeks after implantation for histopathologic examination, histomorphometric analysis and immunohistochemistry with fibronectin and collagen type I antibody. RESULT: In histopathological findings, newly formed bone was seen at 2 weeks and became lamellar bone at 4 weeks, and mature trabecullar bone was seen at 8 weeks in experimental group. In control group, thickness of regenerated bone increased till 4 weeks gradually and trabecullar bone was seen at 8 weeks. In histomorphometric analysis, marrow bone density increased significantly in experimental group compared to control group. Fibronectin immunoreactivity was strong at 2 weeks in experimental group and reduced after 4 weeks gradually. But it was maintained continuously from 2 to 8 weeks in control group. Collagen type I immunoreactivity was very strong from 2 to 4 week in experimental group. And the amount of Collagen type I expression was more abundant in experimental group. CONCLUSION: The results of this study suggest that calcium and vitamin D supplementation promote bone healing around titanium implants in osteoporosis induced animals.
Animals
;
Bone Density
;
Bone Marrow
;
Calcium
;
Collagen Type I
;
Fibronectins
;
Immunohistochemistry
;
Models, Animal
;
Osseointegration
;
Osteogenesis
;
Osteoporosis
;
Rats
;
Tibia
;
Titanium
;
Vitamin D
;
Vitamins
7.Relationship between disease stage and renal function in bisphosphonate-related osteonecrosis of the jaw.
Yun Ho KIM ; Han Kyul PARK ; Na Rae CHOI ; Seong Won KIM ; Gyoo Cheon KIM ; Dae Seok HWANG ; Yong Deok KIM ; Sang Hun SHIN ; Uk Kyu KIM
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2017;43(1):16-22
OBJECTIVES: Bisphosphonate is the primary cause of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are eliminated from the human body by the kidneys. It is anticipated that bisphosphonate levels in the body will increase if the kidney is in a weak state or if there is systemic disease that affects kidney function. The aim of this study was to analyze the relevance of renal function in the severity of BRONJ. MATERIALS AND METHODS: Ninety-three patients diagnosed with BRONJ in Pusan National University Dental Hospital from January 2012 to December 2014 were included in this study. All patients underwent a clinical exam, radiographs, and serologic lab test, including urine analysis. The patient's medical history was also taken, including the type of bisphosphonate drug, the duration of administration and drug holiday, route of administration, and other systemic diseases. In accordance with the guidelines of the 2009 position paper of American Association of Oral and Maxillofacial Surgeons, the BRONJ stage was divided into 4 groups, from stage 0 to 3, according to the severity of disease. IBM SPSS Statistics version 21.0 (IBM Co., USA) was used to perform regression analysis with a 0.05% significance level. RESULTS: BRONJ stage and renal factor (estimated glomerular filtration rate) showed a moderate statistically significant correlation. In the group with higher BRONJ stage, the creatinine level was higher, but the increase was not statistically significant. Other factors showed no significant correlation with BRONJ stage. There was a high statistically significant correlation between BRONJ stage and ‘responder group’ and ‘non-responder group,’ but there was no significant difference with the ‘worsened group.’ In addition, the age of the patients was a relative factor with BRONJ stage. CONCLUSION: With older age and lower renal function, BRONJ is more severe, and there may be a decrease in patient response to treatment.
Bisphosphonate-Associated Osteonecrosis of the Jaw*
;
Busan
;
Creatinine
;
Diphosphonates
;
Filtration
;
Holidays
;
Human Body
;
Humans
;
Kidney
;
Oral and Maxillofacial Surgeons
;
Osteomyelitis
;
Renal Insufficiency, Chronic
8.A Case of Benign Metastasizing Pulmonary Leiomyoma.
Shin Ae KANG ; Sang In CHOI ; Yeon A KIM ; Chong Ju KIM ; Dong Gyoo YANG ; Jeong Han KANG ; Jeong Hae KIE ; Yong Kook HONG ; Sun Min LEE
Tuberculosis and Respiratory Diseases 2005;58(6):614-618
A benign metastasizing pulmonary leiomyoma (BMPL) is a rare disease that usually occurs in women with a prior or coincident history of uterine leiomyoma. Although leiomyoma is histologically benign, it has the potential to metastasize to a distant site such as the lung. A 35 year old woman who had undergone a hysterectomy due to uterine leiomyoma 5 years prior was admitted for an investigation of multiple pulmonary nodules on a routine chest roentgenogram. An open lung biopsy was taken to make a pathological diagnosis. The microscopic finding of the nodules was leiomyoma and was similar to those of the uterine leiomyoma that had been resected 5 years ago. The woman underwent wedge resections of all pulmonary nodules. This is the first case of BMPL in Korea, which was treated with wedge resections of all multiple pulmonary nodules.
Adult
;
Biopsy
;
Diagnosis
;
Female
;
Humans
;
Hysterectomy
;
Korea
;
Leiomyoma*
;
Lung
;
Multiple Pulmonary Nodules
;
Rare Diseases
;
Thorax
9.Cases of IgA Nephropathy Associated with Psoriasis Vulgaris.
Jong Shin WOO ; Moon Chan CHOI ; Ju Young MOON ; Kyung Hwan JEONG ; Sang Ho LEE ; Tae Won LEE ; Sun LEE ; Nack In KIM ; Chun Gyoo IHM
Korean Journal of Nephrology 2007;26(3):358-363
IgA nephropathy is recognized worldwide as one of the most common form of primary glomerulonephritis. Clinical manifestations vary, ranging from microscopic hematuria to nephrotic syndrome. Most cases of IgA nephropathy are idiopathic. A variety of additional disorders have been associated with IgA nephropathy, some of which shed light on possible pathogenetic mechanism. Association with psoriasis has been debated for a long time. Secondary renal amyloidosis in psoriatic arthropathy and drug-induced renal lesions secondary to methotrexate or cyclosporine are accepted accompaniments of psoriasis. We report 3 cases of IgA nephropathy which was diagnosed by renal biopsy in a patient with psoriasis.
Amyloidosis
;
Arthritis, Psoriatic
;
Biopsy
;
Cyclosporine
;
Glomerulonephritis
;
Glomerulonephritis, IGA*
;
Hematuria
;
Humans
;
Immunoglobulin A*
;
Methotrexate
;
Nephrotic Syndrome
;
Psoriasis*
10.Normal Value of Mucosal Thickness of Paranasal Sinuses, as Seen on Brain.
Byung Kook CHEON ; Sang Bum SHIN ; Bong Jin CHEON ; Seong Min KIM ; Jong Min KIM ; Kyung Seung OH ; Gyoo Sik JUNG ; Jin Do HUH ; Young Duk JOH
Journal of the Korean Radiological Society 1997;36(2):195-198
PURPOSE: To evaluate incidentally observed thickened mucosa of paranasal sinuses on brain MRI of patients without evidence of sinusitis. MATERIALS AND METHODS: We reviewed brain MRI of 82 adults aged over 20 ; 45 were males and 37 were females. Brain axial MRI was obtained from the hard palate with 8mm thickness and 2mm gap. The mucosal thickness of incidentally observed paranasal sinuses seen on brain MRI was measured at the mostly thickened portion by T2- and T1-weighted images. RESULTS: The mean mucosal thickness at the most thickened portion of paranasal sinuses, regardless of their location was 3.5mm with S.D. of 1.5mm. The mucosal thickening was observed more commonly in maxillary (79 patients, mean 3.0mm, S.D. 1.4mm) and ethmoid sinuses (80 patients,mean 2.7mm, S.D. 1.1mm) than in sphenoid (39 patients, mean 1.6mm, S.D. 1.4mm) or frontal sinuses (38 patients, mean 1.9mm, S.D. 1.4mm). CONCLUSION: Mucosal thickening of up to 6.5mm was a common finding on brain MRI of patients without evidence of sinusitis ; accuracy was 95%.
Adult
;
Brain*
;
Ethmoid Sinus
;
Female
;
Frontal Sinus
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Mucous Membrane
;
Palate, Hard
;
Paranasal Sinuses*
;
Reference Values*
;
Sinusitis