No abstract available.
Human Growth Hormone* ; Humans*

To evaluate the effect of a new topical anesthetic cream (EMLA : Eutectic mixture of local anesthetics) on reducing pain associated with DPT vaccination, we conducted a clinical observation on eighty infants who were brought to well baby clinic of Yeungnam University Hospital for DPT vaccination. 80 Infants, who were between 2 months and 8 months in age, were divided into two groups. EMLA treated group and control group. Male to femle sex ratio was 1.4 to 1. EMLA cream was applied 60 minutes before DPT vaccination, the effect of reducing pain was assessed by using McGrath's face scale, Oucher pain scale and modified behavioral pain scale (MBPS) and also evaluated by measuring the duration and time of crying (the time of the first crying after iniection, duration of the first crying, total duration of crying). The scores of those scales were lower in EMLA treated group than in control group significantly (P<0.01 in McGrath's face scale. MBPS and p<0.05 in Oucher pain scale). There was no difference in the time of the first crying after vaccination in both groups. The duration of the first crying was shorter in EMLA treated group than control group of crying was also shorter in EMLA treated group (EMLA treated group 9.0±12.5 sec, p<0.05). Transient skin erythema was noted in 5 infants after EMLA application, but no other adverse effects were observed. We conclude that the application of EMLA cream before vaccination seems to be an effective and safe way to reduce the pain from vaccination, but it takes usually 60 minutes to get the anesthetic effect of EMLA and it is expensive, so EMLA cream can not be recommended in routine vaccination in infants now.
Anesthetics ; Crying ; Erythema ; Humans ; Infant ; Male ; Sex Ratio ; Skin ; Vaccination* ; Weights and Measures

Congenital vertical talus associating tarsal coalition, which is a very anomalous condition and causes severe rigid flat foot, is presented with literary reviews. This case was treated with soft tissue release and triple arthrodesis.
Arthrodesis ; Flatfoot ; Talus

In order to investigate the mechanism of antibacterial effect of electrical stimulation on bone and joint infection, 5, 50 and 500 µA constant currents were passed through the silver electrodes and stainless electrodes on the Brain Heart Infusion agar culture plates which contained Staphylococcus aureus, Pseudomonas aeruginosa, and Lscherichia coli. After 24 hours of incubation, the widths of inhibitory zone around the electrodes were measured. The broth dilution susceptibility test was also used to verify the antibacterial effects of electrically generated silver in the Brain Heart Infusion broth. The results were as follows. 1. Silver anodes using constant currents manifested antibacterial effects definitely on the three bacterias, but stainless anodes showed none. 2. Antibacterial effects of silver anodes on the three bacterias increased in proportion to current density. However, antibacterial effects were negligible when current density was under 2 nA/mm2. 3. When current density was between 6.6 and 660 nA/mm2, there were no statistically significant differences in the antibacterial effects among 5, 50 and 500µA constant currents. 4. The culture broth containing silver ions generated by constant current electrolysis also manifested antibacterial effects. The retentate showed stronger antibacterial effects than the filtrate. Form these results, following conclusions were drawh. 1. The antibacterial eff ct of silver electrode using constant current was due to silver ions rather than electricity itself. 2. The substance which showed most effective antibactericity effects was silver complex larger than 2,000 m.w. and heat-unstable.
Agar ; Bacteria ; Brain ; Electric Stimulation ; Electricity ; Electrodes ; Electrolysis ; Heart ; Ions ; Joints ; Pseudomonas aeruginosa ; Silver ; Staphylococcus aureus

PURPOSE: To analyze the affecting factor of lens in pathogenesis of acute primary angle-closure glaucoma (APACG) and the effect of selected cataract extraction with intraocular lens (IOL) implantation. METHODS: A survey was conducted on 25 eyes of 21 patients with acute angle-closure glaucoma accompanied by senile cataract against 21 eyes of 16 age-matched normal persons. Biometric measurements were made in both groups in order to analyze an affecting factor of lens in APACG. Before and after selected cataract extraction, other clinical findings were also evaluated. RESULTS: Biometric measurements such as anterior chamber depth (ACD), lens thickness (LT), ACD/axial length (AXL), LT/AXL, and relative lens position (RLP) were significantly larger for the 25 eyes of the 21 patients with APACG than the 21 eyes of the 16 age-matched normal persons (P<0.05). After selecting cataract extraction with IOL implantation, improved biometric measurements and clinical findings revealed the effectiveness of that operation. CONCLUSIONS: Selected cataract extraction with IOL implantation could be successful as primary surgery in APACG accompanied by senile cataract over intraocular pressure control and visual acuity improvement for lens factor removal of APACG.

Congenital pseudarthroses and non-unions have been recognized as some of the most challenging problems in orthopaedic surgery. with a standard surgical procedure, such as bone grafting, nailing, plating or a combination of these, it was frequently failed to unit. After repeated surgical failures, amputation has been the main course. With the advent of an electrical control of osteogenesis, however, this dismal outlook is brightening. The earliest report of the use of electrical energy to directly stimulate bone healing seems to be in 19th century, but it was not reliable. In this century, the electrical properties of bone were first described by Yasuda et al in 1953. After then, several investigators have shown that the application of small amounts of the electrical current to bone stimulates osteogenesis at the site of the cathode. Clinical trials using various froms in the treatment of delayed union, non-union, and congenital-pseudarthrosis began early in the 1970's. Constant direct current, pulsed current, and electromagnetically induced current have all been used clinically to heal bone defects with varying degrees of success. But, to-this date it is unknown what is the mechanism of stimulating bone healiag with electricity, and which from of electricity is most efficient in stimulating osteogenesis. We have experienced direct current stimulation to promote osteogenesis in 9 cases of non-union and 4 cases of congenital pseudarthses of the tibia from august, 1978 to december, 1980. Of 9 non-unions, 7 (77.8%) achieved solid bony union. We had obtained bony union in 4cases of non-union only with the electrical stimulation. In 4 cases of congenital pseudarthses of the tibia, all cases achieved solid bony union with the electrical stimulation and bone graft, but in 3 cases, refractures were occurred. At this moment, our conclusions from this study are as followa. I. Direct current stimulation is one of the reliable methods inducing ostengenesis. 2. Regular follows-up and determination of the stimulator integrity are essential steps in the electrical stimulation. 3. Combined treatment with the electrical stimulation and bone graft have markedly improved the success rate. 4. In direct current stimulation of congenital pseudarthsis, the mechanically sound bony alignment, massive bone graft and protection using long leg brace seem to be mandatory procedures.
Amputation ; Bone Transplantation ; Braces ; Electric Stimulation ; Electricity ; Electrodes ; Humans ; Leg ; Magnets ; Osteogenesis ; Pseudarthrosis ; Research Personnel ; Tibia ; Transplants

Experiment of electrical stimulation using direct current on the tibia of normal adult rabbits was performed for the duration of 1 week, 2 weeks, 3 weeks, 4 weeks, 6 weeks, and 8 weeks. The cathodic electrode, Teflon coated Kirschner wire used in clinical work was introduced into the medullary cavity of the proximal tibia from the tibial tuberosity and the anodic electrode was introduced transversely in the metaphysis of distal tibia on the same side. Twenty micro-ampere of direct current was passed continuously through the fixed wires between the proximal and distal tibia on left side. At the end of first week, second week, third week, fourth, sixth, and eighth week, anodic and cathodic electrode were removed and animals were sacrificed and tibia was obtained for specimen, and then X-rays were taken, and the specimens were decalcified and stained with hematoxylin and eosin. The new bone formation in the medullary canal were measured by the degree of filling in the marrow canal as percentage by the point counting method. The results were as follows. First, Endosteal new bone formation is a main feature, and also periosteal reaction was noted in 27 % of cases. Second, In the first week group, new bone formation is minimal and difference between groups, that is, second, third, fourth, sixth and eight week group, the degree of new bone formation is statistically insignificant. Therefore possibility of short term electrical stimulation of duration of two week or four week is contemplated clinically.
Adult ; Animals ; Bone Marrow ; Electric Stimulation ; Electrodes ; Eosine Yellowish-(YS) ; Hematoxylin ; Humans ; Methods ; Osteogenesis ; Polytetrafluoroethylene ; Rabbits ; Tibia

No abstract available.
Animals ; Mucous Membrane* ; Rats*

Corneoscleras were stored in 4 degrees C, 98% glycerin and were examined histologically at various storage periods. There were no remarkable pathologic changes in the stainability or arrangement of collagen fibers in stored corneoscleras from one month to 33 months. 12 eyes of 12 patients underwent tectonic or therapeutic keratoplasty with them. The integrity of the globe was maintained in all cases and vision improved in three cases without the second operation. One case achieved visual improvement by optical keratoplasty. In four cases, the vision may be improved by the second operation, such as optical keratoplasty and keratoprosthesis.
Collagen ; Corneal Transplantation ; Glycerol ; Humans

Postoperative (pressure) alopecia is the temporary or permanent loss of hair that occurs following a prolonged immobilization during and/or after general anesthesia and intubation. The cause is considered to be pressure-induced ischemia. Although not an uncommon condition, it is frequently overlooked as a minor complication relative to a causative surgical procedure. We report a 22-year-old woman who was presented with focal hair loss of two weeks' duration after a 9-hour operation for a left brachial plexus injury. Histopathologic examination showed that nearly all terminal follicles were in catagen phase with marked atrophic change of subcutaneous fat.
Alopecia* ; Anesthesia, General ; Brachial Plexus ; Female ; Hair ; Humans ; Immobilization ; Intubation ; Ischemia ; Subcutaneous Fat ; Young Adult