BACKGROUND: Congenital hypotrichosis is a non-specific, descriptive term for structural abnormalities of hairs showing variable clinical features. We recently have encountered a group of eleven patients exhibiting abnormal hairs showing similar patterns. OBJECTIVES: Our purpose was to clarify the entity of this structural hair disorder. METHODS: Dermatologic examination with routine histopathology, trichograms along with scanning electron-microscopic examination and laboratory studies were undertaken. RESULTS: All cases except one were female, and hair abnormalities had developed at birth or within a year. Diffuse distribution of thin, sparse, soft and hypopigmented hairs were noticed. On hair mounts, four patients showed tapering of roots. The majority of the patients exhibited cuticular changes, as well as pitting and longitudinal axial twisting by scanning electron-microscopic examination; one case demonstrated trichorrhexis nodosa, and another, trans-verse fracture. CONCLUSION: Although our cases bear some similar points with woolly hair, some differences were noted between this type of congenital hypotrichosis and other previously described syndromes.
Female ; Hair ; Humans ; Hypotrichosis* ; Parturition

BACKGROUND: Obesity has been accepted as the rusk factor of major chronic diseases in our society. And nutritional assessment is the important issue in respect to obesity evaluation. A self-administrated semiquantitative food frequency questionnaire of which validity is recognized is used in nutritional assessment. But the relationship between nutritional assessment resulted from the questionnaire and the obesity index has not been built until now, so we studied about this relationship. METHODS: Among 324 adults who had visited health screening center from June'95 to August '96, 270 adults were evaluated except who had any chronic disease such as diabetes mellitus, pulmonary tuberculosis, thyroid disease by screening data or low calorie diet for aimed weight loss or inadequate Questionnaire. Nutritional intake was assessed by the self-administrated semiquantitative food frequency questionnaire. We evaluated the activity grade, obesity indices such as body mass index(BMI), waist to hip ratio(WHR), percent body fat using bioelectrical impedance fatness analyzer and serum total cholesterol, HDL-cholesterol, triglyceride. Then we examined the correlation between obesity Indices and nutritional variables each other. We analyzed these results using Pearson's correlation coefficient. RESULTS: We evaluated for a group of 164 men and 106 women whose mean age was 43.9 years, mean BMI was 23.2kg/m2, mean WHR was 0.85 and mean percent body fat was 21.2%. Correlation coefficient between calorie intake to recommended calorie ratio(ICRCR) and BMI was 0.13(P<0.05), WHR was 0.11(P> OR =0.05), and percent body fat was 0.07(P> OR =0.05). Fats intake to recommended fats ratio(IFRFR) and obesity indices didn't show the significant correlation between them. We could not find the significant correlation between cholesterol intake and serum total cholesterol, triglyceride but the significant negative correlation between cholesterol intake and serum HDL-cholesterol(r=-0.14) was found. CONCLUSIONS: Only BMI among obesity indices and ICRCR showed low(r=0.13) correlation coefficient although it is significant. Our results shows that obesity is the complex syndrome influenced by genetic, social, psychological, medical variables besides nutritional impacts.
Adipose Tissue ; Adult ; Caloric Restriction ; Cholesterol ; Chronic Disease ; Diabetes Mellitus ; Electric Impedance ; Fats ; Female ; Hip ; Humans ; Male ; Mass Screening ; Nutrition Assessment* ; Obesity* ; Thyroid Diseases ; Triglycerides ; Tuberculosis, Pulmonary ; Weight Loss ; Surveys and Questionnaires

PURPOSE: Transrectal prostate biopsy(TR biopsy) is a definitive diagnostic procedure which is performed on patients who have DRE abnormalities or high PSA. However, TR biopsy can cause major complications such as urosepsis. In addition, there is no curative treatment for advanced prostate cancer(CaP). In this study, we evaluated the sensitivity and specificity of cancer detection by serum PSA level in CaP patients and assessed whether TR biopsy could be omitted in advanced CaP patients. MATERIALS AND METHODS: Three hundred patients who underwent TR biopsy due to high PSA or DRE abnormalities were included. The patients who had either pyuria, acute urinary retention, or history of indwelling catheterization were excluded. Through review of the medical records, we assessed the sensitivity, specificity and positive predictive value of cancer detection per 5ng/ml increase of PSA level. Cancer advance was assessed through radical prostatectomy and radiologic findings. RESULTS: Ninety-six patients had CaP and mean PSA was 124.0ng/ml. Among the 30 patients with tPSA above 55ng/ml, 29 had CaP and all these patients had advanced CaP in bone scan, MRI, CT and pathology of radical prostatectomy specimen. For PSA above 55ng/ml, sensitivity, specificity and positive predictive values were 30.2%, 99.5% and 96.7%, respectively. CONCLUSIONS: This study shows that PSA above 55ng/mL was 96.7% accurate in predicting the presence of CaP and that all the detected cancers were advanced or metastatic ones. As TR biopsy can be an invasive procedure in debilitated patients, it can be omitted in patients aged 75 or older with PSA above 55ng/mL, especially in case of positive bone scan findings.
Biopsy* ; Catheters, Indwelling ; Humans ; Magnetic Resonance Imaging ; Medical Records ; Pathology ; Predictive Value of Tests ; Prostate* ; Prostate-Specific Antigen ; Prostatectomy ; Prostatic Neoplasms* ; Pyuria ; Sensitivity and Specificity* ; Urinary Retention

No abstract available.
Analgesia*

No abstract available.
Ankle Fractures* ; Ankle*

PURPOSE: We determined the effects of silicone tube tip fixation on the nasal wall using an absorbable suture during silicone tube intubation in patients with congenital nasolacrimal duct obstruction. METHODS: Patients (55:71 eyes) diagnosed with congenital nasolacrimal duct obstruction and who underwent silicone tube intubation were divided into two groups: those in which the silicone tube was fixed to the nasal wall using an absorbable suture (fixed group) or not (non-fixed group). We investigated the percentage of silicone tube displacement, the time for displacement, the success of surgery, and the method of removing the silicone tube after surgery. RESULTS: The mean age, percentage of early displacement within 1 month, time to displacement, and success rate of surgery were 2.4 years, 0% (0/35), 1.4 months, and 100% (35/35) in the fixed group (35 patients) and 1.8 years, 44% (16/36), 0.8 months, and 97% (35/36) in the non-fixed group (36 patients), respectively. Both groups were able to remove the silicone tube simply through lacrimal punctum at the outpatient clinic. CONCLUSIONS In patients with congenital nasolacrimal duct obstruction, silicone tube fixation at the nasal wall after silicone tube intubation can prevent early displacement of silicone tubes within 1 month. This is a simple and effective technique because it removes the silicone tube through the lacrimal punctum without general anesthesia or intravenous anesthesia.

Purpose: To investigate the surgical outcomes of endonasal dacryocystorhinostomy with canalicular trephination in patients with canalicular obstruction. Methods: We retrospectively analyzed the medical records of 37 eyes from 32 patients who were diagnosed with canalicular obstruction between May 2010 and July 2022 and underwent endonasal dacryocystorhinostomy with canalicular trephination to evaluate the success rate and complications. Results: In the total patient group, 81.1% achieved complete success in which epiphora completely disappeared, 13.5% had partial success in which epiphora remained but improved, and 5.4% experienced failure in which tearing persisted or worsened. Complications included one case of dacryocystorhinostomy bony opening granuloma and one case of dacryocystorhinostomy bony opening inflammation. Conclusions Endonasal dacryocystorhinosomy with canalicular trephination is an effective method for treating canalicular obstruction, offering a high success rate and few complications. It can be considered before resorting to conjunctivodacryocystorhinostomy, which is a more conventional treatment.

We reviewed 67 cases of non-visualizing from September, 1979 to August, 1981. Among these, renal tuberculosis was the most common cause of non-visualizing kidney and renal or ureteral stone was thenext in number.
Kidney* ; Tuberculosis ; Tuberculosis, Renal ; Ureter

Cytomegalovirus(CMV) rarely causes cutaneous rnanifestations. But since the recent development of organ transplants and the increased prevalence of AIDS, various skin manifestations of CMV infection such as varicelliform eruptions, perineal hulcerations, papular, purpurc and vesiculobllous lesions are increasing in immunocompromised subjects, Perineal ulceration is a typical cytomegalovirus-induced skin manifestation which exhibits similar morphology to herpes simplex viral infection. We describe a case of CMV-induced ulcer on labia majora in an AIDS patient, proven by histologic findings and immunohistochemistry. The patient was treated with ganciclovir and the lesion improved two months later.
Cytomegalovirus* ; Ganciclovir ; Herpes Simplex ; Humans ; Immunohistochemistry ; Prevalence ; Skin Manifestations ; Transplants ; Ulcer*

BACKGROUND: Psoriatic lesions have reduced water-holding capacity and show increased transepidermal water loss (TEWL). The effect of D-PUVA therapy, which combines topical calcipotriol and PUVA therapy, on epidermal barrier function has not yet been evaluated. OBJECTIVE: The purpose of this study was to verify the change of TEWL in lesional and normal skin according to D-PUVA therapy in psoriasis patients. METHODS: TEWL was measured consecutively by TEWAMETER TM210®, in 13 psoriasis patients who received D-PUVA therapy. Clinical grading was done according to psoriasis severity index (PSI). RESULTS: TEWL of psoriatic lesion decreased as D-PUVA continued. TEWL of normal-looking skin gradually increased, although the increase was trivial. Clinical grading of scale and in-filtration followed the pattern of PSI in the decrease of TEWL, while that of erythema did not. CONCLUSION: In psoriatic plaques, TEWL was decreased according to the improvement. In normal-looking skin, D-PUVA therapy caused only a little effect on TEWL.
Erythema ; Humans ; Psoriasis ; PUVA Therapy ; Skin ; Water*