No abstract available.
Chromosome Aberrations* ; Oncogenes*

Nasal dorsal suppor may be weakened or lost during the corrective rhinoplasty procedures such as resection of dorsal deviation, osteotomies and reposition of deviated nasal bones, and incision, fracture, resection or scoring of the dorsal septal strut especially in the small flat noses. Partial or total augmentation of the nasal dorsum has an important role in the correction of asymmetry and restoration of aesthetic balance in the considerable amount of traumatic nasal deformities. We reviewed medical records, pre- and postoperative photographs of 53 patients with traumatic nasal deformities, which had been corrected by augmentation rhinoplasties. The majority of the patients were male (70%), ages of twenties and thirties (79%), injection by automobile accident, fist blows, and sports activities (76%), and were operated more than 3 years after injury (74%). Types of deformities were deviation only (47%), depression only (23%), deviation and depression (19%), deviation and hump (8%), and depression and widening (6%). At least two corrective procedures were needed in the deviated deformities and one procedure in the depressed deformities. Materials for augmentation were silicone implants in 55% and autogenous tissues in 45%. In terms of postoperative complications, displacement and/or absorption were observed in 6 of 24 (25%) autogenous augmentations and displacement and/or swelling in 8 of 29 (27.6%) silicone augmentations.
Absorption ; Automobiles ; Congenital Abnormalities* ; Depression ; Humans ; Male ; Medical Records ; Nasal Bone ; Nose ; Osteotomy ; Postoperative Complications ; Rhinoplasty* ; Silicones ; Sports

No abstract available.
Child* ; Humans ; Neurilemmoma* ; Neurofibromatosis 1

No abstract available.
Dandy-Walker Syndrome*

OBJECTIVE: The purpose of this study is to evaluate clinical and radiological outcomes analysis of the laminoplasty in the elderly patients, and to compare with the non-elderly patients. METHODS: A retrospective study of the short term result in patients who had treated with the laminoplasty for cervical spondylotic myelopathy (CSM) was performed. From January 2008 to December 2012, total 62 patients were operated with single open-door technique because of CSM; 28 patients were the elderly and 34 patients were the non-elderly. We evaluated some factors including sex, symptom duration, estimated blood loss during operation, operation time, hospitalization day, complications, pre- and postoperative modified Japanese Orthopedic Association (mJOA) score, recovery rate of mJOA score, achieved mJOA score, mean cervical canal width and expansion ratio of antero-posterior diameter in order to identify difference between the two group. Clinical outcomes were calculated with the recovery rate of mJOA score at the time of one year after operation. RESULTS: Mean age were 71.9 in the elderly group and 52.9 in the non-elderly group. Although postoperative mJOA score in the elderly group was lower than that of the non-elderly group, achieved mJOA score was statistically same between the two groups. Other clinical and radiological outcomes were also statistically same. CONCLUSION: We conclude that the laminoplasty also assures good clinical outcomes in the elderly patients with CSM, same as in the non-elderly group.
Aged* ; Asian Continental Ancestry Group ; Hospitalization ; Humans ; Orthopedics ; Retrospective Studies ; Spinal Cord Diseases*

BACKGROUND: Lambert-Eton myasthenic syndrome(LEMS) is characterized by the clinical triad of muscle weakness, hyporeflexia, and autonomic dysfunction. In contrast to myasthenia gravis.LEMS is not commonly associated with respiratory failure. Any case of respiratory failure in LEMS has not been reported in Korea. CASE DESCRIPTION: The first case is a 61-tear-old male complained of proximal muscle weakness and dysarthria associated with severe dry mouth for 3 month and developed respiratory failure. The second case is a 65-tear-old male who began complaining of muscle weakness, weight loss, dry mouth, and recurrent respiratory difficulty for 14 months. Repetitive nerve stimulation(RNS) test for ulnar nerve showed CMAP with low amplitude, a significant decremental response at the low rate stimulation and a marked incremental response at the high rate stimulation in the left abductor digiti muscles in both cases. The first case had small cell carcinoma of the lung, but the second case presented with respiratory failure in the absence of malignancy. CONCLUSION:We experienced two cases of LEMS presenting respiratory failure. To our knowledge, this is the first report of respiratory failure in LEMS in Korea.
Carcinoma, Small Cell ; Dysarthria ; Humans ; Korea ; Lambert-Eaton Myasthenic Syndrome* ; Lung ; Male ; Mouth ; Muscle Weakness ; Muscles ; Reflex, Abnormal ; Respiratory Insufficiency* ; Ulnar Nerve ; Weight Loss

BACKGROUND: Lambert-Eton myasthenic syndrome(LEMS) is characterized by the clinical triad of muscle weakness, hyporeflexia, and autonomic dysfunction. In contrast to myasthenia gravis.LEMS is not commonly associated with respiratory failure. Any case of respiratory failure in LEMS has not been reported in Korea. CASE DESCRIPTION: The first case is a 61-tear-old male complained of proximal muscle weakness and dysarthria associated with severe dry mouth for 3 month and developed respiratory failure. The second case is a 65-tear-old male who began complaining of muscle weakness, weight loss, dry mouth, and recurrent respiratory difficulty for 14 months. Repetitive nerve stimulation(RNS) test for ulnar nerve showed CMAP with low amplitude, a significant decremental response at the low rate stimulation and a marked incremental response at the high rate stimulation in the left abductor digiti muscles in both cases. The first case had small cell carcinoma of the lung, but the second case presented with respiratory failure in the absence of malignancy. CONCLUSION:We experienced two cases of LEMS presenting respiratory failure. To our knowledge, this is the first report of respiratory failure in LEMS in Korea.
Carcinoma, Small Cell ; Dysarthria ; Humans ; Korea ; Lambert-Eaton Myasthenic Syndrome* ; Lung ; Male ; Mouth ; Muscle Weakness ; Muscles ; Reflex, Abnormal ; Respiratory Insufficiency* ; Ulnar Nerve ; Weight Loss

Primary intramedullary oligodendroglioma is very rare, accounting for only about 1% of all intramedullary spinal cord tumor. We present a case of intramedullary oligodendroglioma in a 30-year-old women. Magnetic resonance image showed an intramedullary mass in the T11-L1 region. Decompressive laminectomy and partial mass removal was performed, however, neurologic state became worse. The histological examination revealed oligodendroglioma. The intramedullary oligodendroglioma, although it is a rare entity, must be considered in the differential diagnosis of spinal cord tumors.
Adult ; Diagnosis, Differential ; Female ; Humans ; Laminectomy ; Oligodendroglioma* ; Spinal Cord Neoplasms

Lovastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, which catalyzes the conversion of hydroxymethylglutaryl-coenzyme A to mevalonate, anearly and rate-limiting step in the synthesis of cholesterol. We studied the therapeutic effect and safety of lovastatin in 18 patients with nonfamilial primary hypercholesterolemia. Patients received 20mg/day lovastatin therapy as a single evening dose. If the total cholesterol level exceeded 200mg/dl after 2weeks of lovastatin therapy, the dosage of lovastatin was doubled. Mean percent total cholesterol level reductions from baseline were 26.4% and 31.9% after 4, and 8 weeks of lovastatin therapy respectively. Mean percent HDL-cholesterol level increase from baseline were 12% and 13% after 4, and 8 weeks of lovastatin therapy respectively. Adverse effects attributable to lovastatin were mild and temporary and no patient was withdrawn from therapy. We concluded that lovastatin was a well tolerated and effective agent for the treatment of nonfamilial primary hypercholesterolemia. Further studies are needed to establish the long-term safety and effectiveness of this drug.
Cholesterol ; Coenzyme A ; Humans ; Hypercholesterolemia* ; Lovastatin ; Mevalonic Acid ; Oxidoreductases

An increase in the dose of chemotherapy enhances the response of many experimental and clinical cancers, but the extent of chemotherapy dose escalation and repeated use is often limited by myelosuppression. The side effects of chemotherapy including bleeding and infection due to myelosuppression have resulted in delayed therapy and a reduction in the therapeutic dose, therefore it is necessary to overcome myelosuppression especially leukopenia in patients with gynecologic malignancies who recieved chemotherapy. This study is undertaken to investigate the clinical effects of rhG-CSF(recombinant human Granulocyte-colony stimulating factor) in 29 patients with gynecologic malignancy who recieved chemotherapy. It was given at a dose of 100 microgram bid/day subcutaneously until significantly increase of leukocyte count in leukopenic patient. The results showed, the rhG-CSF has significantly increased the number and function of leukocyte. The use of rhG-CSF was effective and useful to treat chemotherapy induced leukopenia and to accelerate the recovery from this complications.
Drug Therapy* ; Hemorrhage ; Humans* ; Leukocyte Count ; Leukocytes ; Leukopenia*