No abstract available.
Catheters*

A case is reported ofsystemic toxicity by topically applied podophyllin. The patient was a 18-year-old girl who was treated at private gynecological clinic with 25% podophyllin resin for multiple vulval condyloma acuminata. Her apparent podophyllin toxicity begun 4 hours after topical application, presenting gastrointestinal symptoms such as nausea, vomiting, diarrhea and abdominal distension, followed by tingling sensation on hands and feet with motor weakness predominantly of distal limbs. She had never experienced disturbance of consciousness or other CNS symptoms. The symptoms of severe peripheral neuropathy had been improved by 72 days followup when she had mild impairement of vibration and position sense and mild dorsiflexion weakness of the feet.
Adolescent ; Consciousness ; Diarrhea ; Extremities ; Female ; Follow-Up Studies ; Foot ; Hand ; Humans ; Nausea ; Peripheral Nervous System Diseases ; Podophyllin ; Podophyllum* ; Polyneuropathies* ; Proprioception ; Sensation ; Vibration ; Vomiting

A clinical study was done on 161 patients (male 94, female 67) with the first onset of seizure over the age of 16 who were admitted to Keimyung University Hospital from 1979 to 1983 in order to analyze the causative factors, the age distribution at onset, the seizure pattern and E.E.G. findings. The results were summarized as follows. 1. The etiological factors of 161 seizure patients revealed metabolic encephalophaties 75 cases (46.6%), cerebrovascular disease 26 cases (16.2%), unknown cause 21 cases (13%), CNS infectious disease 17 cases (10.6%), posttraumatic seizure 12 cases (7.5%), brain tumor proved by brain biopsy 8 (5%) and hysteric seizure 2 cases in order of frequency. 2. Among the 75 cases of metabolic encephalopathies, the most common cause was drug intoxication (34 cases), followed by alcohol withdrawal seizure (21 cases), water intoxication (5 cases), uremia and hypocalcemia (4cases respectively), hepatic encephalopathies (3 cases) and then hypoglycemia and anoxia (2 cases respectively) in order of frequency. Among the 26 cases of cerebrovascular disease, spontaneous subarachnoid hemorrhage was presented in 9 cases, intracerebral hemorrhage and cerebral infarction in 7 cases respectively and arteriovenous malformation in 3 cases. Among the 17 cases of CNS infectious diseae, meningitis was presented in 9 cases, Japanese B encephalitis in 3 cases, paragonimiasis in 2 cases, and then cerebral cysticercosis, tuberculoma, and focal cerebritis in 1 case respectively. Among the 8 cases of brain tumor, meningioma was presented in 5 cases, oligodendroglioma, glioblastoma multiforme and epidermoid cyst in 1 case respectively. 3. The mean age at the onset of each causes of seizure revealed metabolic encephalopathies 38 yrs. CNS infectious disease 33 yrs, posttraumatic seizure 34 yrs, arteriovenous malformation 23 yrs, brain tumor 42 yrs, and cerebrovascular disease 54 yrs. 4. The most frequent seizure pattern of 161 patients was the generalized seizure in 126 cases (78.3%) followed by the partial elementary seizure in 29 case and the partial seizure with secondary generalization in 6 cases. The incidence of partial seizure was slightly higher than the generalized seizure in brain tumor and CNS infectious disease. 5. There were no correlation between the E.E.G. degree and causative factors of seizure.
Adult* ; Age Distribution ; Alcohol Withdrawal Seizures ; Anoxia ; Arteriovenous Malformations ; Biopsy ; Brain ; Brain Diseases, Metabolic ; Brain Neoplasms ; Cerebral Hemorrhage ; Cerebral Infarction ; Communicable Diseases ; Cysticercosis ; Encephalitis, Japanese ; Epidermal Cyst ; Female ; Generalization (Psychology) ; Glioblastoma ; Hepatic Encephalopathy ; Humans ; Hypocalcemia ; Hypoglycemia ; Incidence ; Meningioma ; Meningitis ; Oligodendroglioma ; Paragonimiasis ; Seizures* ; Subarachnoid Hemorrhage ; Tuberculoma ; Uremia ; Water Intoxication

A clinical study was done on 16 cases of cerebellar hemorrhage and 3 cases of cerebellar infarction which were diagnosed with brain CT scan at Keimyung university Dongsan hospital from July 1981 to June 1985 and conclusions obtained are as follows. 1. The incidence of cerebellar hemorrhage and infarction was 3.5% and 0.6% of all spontaneous intracranial parenchymal hemorrhage and infarction, respectively. 2. The most prevalent age group was 7th decade and sex ratio was higher in male in cerebellar stroke. 3. Major single percipitating factor of cerebellar stroke was hypertension. 4. Most of cerebellar stroke showed catastrophic or sudden onset type. 5. The most common initial symptoms of cerebellar stroke were nausea and vomiting, followed by headache and dizziness or vertigo, in order of frequency. 6. The most common neurologic signs on admission were impaired consciousness, constricted pupil with preserved light reflex and cerebellar signs. 7. The common site of cerebellar hemorrhage was right hemisphere, followed by vermis and left hemisphere, in order of frequency, and that of cerebellar infarction was right posterior hemisphere. 8. The better the consciousness on admission, the better the outcome of cerebellar stroke. 9. The following parameters indicated good prognosis with medical therapy, so called benign cerebellar hemorrhage: clear consciousness on admission, gradual onset type, less than 20cc of hematoma, no or mild hydrocephalus, no ventricular hematoma, no vermis involvement on CT scan.
Brain ; Consciousness ; Dizziness ; Headache ; Hematoma ; Hemorrhage ; Humans ; Hydrocephalus ; Hypertension ; Incidence ; Infarction ; Male ; Miosis ; Nausea ; Neurologic Manifestations ; Prognosis ; Reflex ; Sex Ratio ; Stroke ; Tomography, X-Ray Computed ; Vertigo ; Vomiting

BACKGROUND: The human homologue of the SC2 gene from a human dermal papilla cell cDNA library has been isolated and designated hSC2. HSC2 protein also shares similarity with 5 -reductase, a protein important in testosterone metabolism. OBJECTIVE: Prior to knowing the functions of hSC2 in dermal papilla, we cloned it and analyzed its relative expression levels in adult tissues and cancer cell lines. METHODS: hSC2 was isolated from low abundant clones in dermal papilla cDNA library using cDNA array hibridization method. Full-length clone was sequenced and we studied its expression in different tissues by Northern blot hybridization. RESULTS: Sequence data reveals a single open reading frame, encoding a putative hydrophobic protein with a calculated molecular weight of 36 kDa. Its deduced amino acid sequences are almost 97.4% identical to t4ose of rat protein. Northern blot hybridization shows that hSC2 cDNA recognizes a 1.35 kb transcript that was expressed in various epithelial and mesenchymal tissues including testis and liver. CONCLUSION: We have cloned and analysed tissue distributions of hSC2. It was interesting that it had homology with 5α-reductase isozymes. Further studies will be needed to understand the involvement of hSC2 in androgen hormone signaling.
Adult ; Amino Acid Sequence ; Animals ; Blotting, Northern ; Cell Line ; Clone Cells ; Cloning, Molecular* ; DNA, Complementary ; Gene Library ; Humans ; Isoenzymes ; Liver ; Metabolism ; Molecular Weight ; Oligonucleotide Array Sequence Analysis ; Open Reading Frames ; Rats ; Testis ; Testosterone ; Tissue Distribution

Tracheobronchopathia osteochondroplastica is a rare and usually benign disorder characterized by cartilaginous and/or osseous submucosal nodules projecting into the laryngotracheobronchial lumen. It has been an incidental finding at autopsy but nowadays it is discovered during fiberoptic bronchoscopy or chest computed tomography. We describe a case of 61-year-old man who was diagnosed to have tracheobronchopathia osteochondroplastica due to unpredicted difficult intubation.
Autopsy ; Bronchoscopy ; Humans ; Incidental Findings ; Intubation ; Middle Aged ; Thorax

Parenteral reserpine was given intramuscularly to 32 hospitalized hypertensive patients: 10 hypertensive patients without renal insufficiency, 3 hypertensive patients with heart failure, 10 hypertensive patients of malignant phase or with uremia, and 9 hypertensive patients with cerebrovascular accident. Follwoings were the result. 1. In the majority of patients, the effective dose of reserpine was 2 to 3 mg. 2. Reserpine given intramuscularly lowered blood pressure in 2 to 4 hours, had its maximum effect in 3 to 6 hours and had a duration of 3 to more than 24 hours (average 9 hours). 3. When effective dose of reserpine was given, blood pressure was lowered significantly (more than 30mmHg in mean blood pressure) in 18 patients (81.7%) of 22 hypertensive patients without renal insufficiency, and in 4 patients (40%) of 10 hypertensive patients with renal insufficiency. 4. Major side effect was drowsiness which was more evident in the patients with renal insufficiency. 5. Reserpine administered parenterally is an effective and safe agent for the treatment of hypertensive emergencies on a short term basis especially in the patient without renal insufficiency.
Blood Pressure ; Emergencies ; Heart Failure ; Humans ; Renal Insufficiency ; Reserpine* ; Sleep Stages ; Stroke ; Uremia

No abstract available.
Gastrectomy* ; Stomach Neoplasms*

No abstract available.
Kidney Transplantation*

OBJECTIVES: OSAS (obstructive sleep apnea syndrome) is a common disorder and its consequences are often serious. It is important to detect the disorder early in the course for proper treatment. This study is to grasp the snoring clinic visitors' knowledge level of OSAS. METHODS: One hundred and seventy-nine visitors at the of snoring clinic of Seoul National University Hospital were surveyed by questionnaire about reasons of visit and knowledge of treatment methods of snoring and OSAS, diagnostic method, OSAS-related symptoms, and complications. RESULTS: Most of the respondents (89.4%) "have already heard about OSAS" and the major sources of information was the mass media (58.1%) such as television and radio. More than half (60.3%) were aware that snoring is closely related to OSAS. More than half (59.8%) recognized that a nocturnal polysomnograpy was necessary for proper diagnosis. Two thirds (67%) of the respondents noted surgery as a treatment for snoring. More than half (55.9%) answered that they would follow the doctor's advice on the treatment choice. Only 12.3% of respondents "have heard about nCPAP". No one chose nCPAP (nasal continuous positive airway pressure) as a treatment for either snoring or OSAS. About one third (34.6%) of the respondents were aware that OSAS is related to hypertension. Only 12.8% noted that OSAS is related to diabetes mellitus. CONCLUSION: Visitors at the snoring clinic were found to have substantially limited knowledge of health risks and proper treatments of OSAS. We suggest that it is crucially important to educate patients and offer easy-to-understand information on snoring and OSAS. We predict that provision of educaiton and information to patients and general public will faciliate the diagnosis and treatment of snoring and OSAS and reduce the related disorders such as hypertension, stroke, and diabetes mellitus.
Diabetes Mellitus ; Hand Strength ; Humans ; Hypertension ; Mass Media ; Surveys and Questionnaires ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive ; Snoring ; Stroke ; Television