1.Longevity Science and Longevity Culture.
Journal of the Korean Medical Association 2001;44(8):806-812
No abstract available.
Longevity*
2.Longitudinal Study of Aging.
Journal of the Korean Medical Association 1997;40(10):1307-1312
No abstract available.
Aging*
;
Longitudinal Studies*
3.Immunohistochemical distribution of transglutaminase isoenzymes in the fracture site and epiphyseal plate.
Myung Chul LEE ; Sang Cheol SEONG ; Kye Yong SONG ; Sang Chul PARK
The Journal of the Korean Orthopaedic Association 1993;28(4):1427-1435
No abstract available.
Growth Plate*
;
Isoenzymes*
4.Expression of Osteocalcin and Transglutaminase C during Fracture Healing and Distraction Osteogenesis in Rat's Tibia
In Ho CHOI ; Sang Cheol SEONG ; Myung Chul LEE ; Gye Yong SONG ; Sang Chul PARK
The Journal of the Korean Orthopaedic Association 1994;29(5):1311-1325
Incorporation of bromodeoxyuridine(BrdU) and expression of osteocalcin and transglutaminase C(TGase C) during fracture healing and distraction osteogenesis were investigated in the rat with immunohistochemical studies. Transverse osteotomy was made at the proximal tibia. Bilateral dynamic mini-fixator was applied to immobilize the fracture and also to lengthen the leg. Distraction was started, at the rate of 0.25 mm twice daily, from the 4th operative day and continued for 7 days. Animals were killed for immunohistochemical studies on the 1st, 3rd, 5th, 7th, 14th, 28th, 42nd, 56th, and 84th day after osteotomy or distraction. Longitudinal histologic sections of the healing bone were stained with monoclonal antibodies against BrdU, osteocalcin, and TGase C. Radiologically, complete fracture healing was achieved in 6 weeks after osteotomy, while neo-osteogenesis was successfully achieved in the distracted gap in 7 weeks after the completion of distraction, During active healing stage of the fracture and distraction osteogenesis, BrdU was mainly expressed in the perisoteal and endosteal osteoprogenitor cells while osteocalcin was expressed in the proliferating osteoprogenitor cells, osteoblast, osteocyte, osteoid matrix, and chondrocyte. The expression of BrdU and osteocalcin in the mesenchymal cells from the surrounding soft tissues around the osteotomy site was negligible. At the site of enchondral bone formation, TGase C was expressed in the cytomplasm of more centrally located and matured chondrocytes, while oseocalcin was mainly expressed in the cytoplasm of peripherally located chondrocyte. These findings may suggest that osteocalcin participates in early phase of enchondral bone formation, while TGase C in the late phase, suggesting the role of TGase C in matrix stabilization. At the site of intramern-branous bone formation, the expression of TGase C was weakly positive in both osteoprogenitor cell and osteoblast. The reason of the difference in the expression of TGase C between the enchondral bone formation and intrarnembranous bone formation should be further investigated. Fracture healing and distraction osteogenesis was predominantly induced by intramembranous ossification rather than enchondral ossification. Periosteal osteoprogenitor cells appeared to initiate and to lead bone formation after osteotomy and distraction. Active proliferation and differentiation of osteoprogenitor cell ocurred during entire periods of distraction. Also, active osteoid matrix formation and mineralization was started from the 5th day of distraction and continued thereafter for further 4 weeks after completion of the lengthening. These findings indicate that preservation of the periosteum is essential to achieve successful fracture healing and distraction osteogenesis.
Animals
;
Antibodies, Monoclonal
;
Bromodeoxyuridine
;
Chondrocytes
;
Cytoplasm
;
Fracture Healing
;
Leg
;
Miners
;
Osteoblasts
;
Osteocalcin
;
Osteocytes
;
Osteogenesis
;
Osteogenesis, Distraction
;
Osteotomy
;
Periosteum
;
Rats
;
Tibia
5.MR Findings of Brain Abscess.
Sang Joon KIM ; Dae Chul SUH ; Man Soo PARK
Journal of the Korean Radiological Society 1994;31(2):211-216
PURPOSE: To analyze the imaging features of brain abscess. MATERIALS AND METHODS: MR studies of nine patients with surgically verified brain abscess were retrospectively reviewed. RESULTS: The shape of abscesses were round(n=6), multilobulated(n=2) or triangular(n=1). All lesions were located in corticomedullary junction and extended into white matter. On gadolinium-DTPA enhanced images, smooth rim-like(n=6) or irregular thick enhancement(n=3) of abscess wall was noted. Budlike projection from the abscess capsule was found in 4 cases. The signal intensity of abscess capsule was either hyperintense (n=5) or isointense(n=4) relative to white matter on Tl-weighted images, and hypointense(n=6), isointense (n=2) or mixed hypo and isointense(n=l) on T2-weighted images. Satellite nodules were found in 2 cases. PNS inflammation(n=2), meningitis(n=1), ventriculitis(=2) and subdural empyema(n=1) were associated CONCLUSION: The MR features of brain abscess included characteristic intensity of abscess capsule, budlike projection from the abscess wall, moderate amount of peripheral edema, satellite nodules, and associated meningitis, ventriculitis or PNS infection. The morphology of abscess wall was not specific for the diagnosis of brain abscess.
Abscess
;
Brain Abscess*
;
Brain*
;
Diagnosis
;
Edema
;
Humans
;
Meningitis
;
Retrospective Studies
6.Partial purification and characterization of host celluar protease of chicken embryo infected with influenza virus.
Mee Yoen PARK ; Chul Yong SONG ; Sang In CHUNG
Journal of the Korean Society of Virology 1993;23(1):47-55
No abstract available.
Chickens*
;
Embryonic Structures*
;
Influenza, Human*
;
Orthomyxoviridae*
7.The Role of Anitiplatelet Antibody and the Therapeutic Effect of High-Dose I.V. gamma-globulin in Childhood Idiopathic Thrombocytopenic Purpura.
Kyu Chul CHOI ; Sang Ho PARK ; Yong Mook CHOI
Journal of the Korean Pediatric Society 1988;31(2):212-219
No abstract available.
gamma-Globulins*
;
Purpura, Thrombocytopenic, Idiopathic*
8.Clinical Approach for Visual Achievement in Amblyopia Treatment.
Sang Chul PARK ; Kyoung Hee LEE ; Ju Reon LEE
Journal of the Korean Ophthalmological Society 1991;32(9):802-808
We retrospectively studied 60 amblyopic patients who had been treated for 12 months or more. They were divided into three age groups; below 5.5 years, 5.5 years to 8 years and 8 years or more, and visual improvements were compared with three age groups. The visual improvements were 5 line increase in both of below 5.5 year group and 5.5 year to 8 year age group and 3 line increase in 8 year and older group. In all three age groups, two-thirds of the improvements were achieved during the first three months of treatment There was no difference in visual improvement according to amblyopic type(strabismic, anisometropic, strabismic and anisometropic amblyopia). Treatment failures seemed to be the later onset of treatment, eccentric fixation and large anisometropic difference.
9.Idiopathic Thrombocytopenic Purpura in Children.
Kyu Chul CHOI ; Sang Ho PARK ; Yong Mook CHOI
Journal of the Korean Pediatric Society 1987;30(6):664-670
No abstract available.
Child*
;
Humans
;
Purpura, Thrombocytopenic, Idiopathic*
10.Effect of low dose ethanol on experimental hepatocarcinogenesis.
Sang Chul PARK ; Sahng June KWAK ; Kye Yong SONG
Journal of the Korean Cancer Association 1991;23(2):161-168
No abstract available.
Ethanol*