1.Effect of devascularization on estrogen receptor levels in DMBA induced rat breast cancer.
Sang Seol JUNG ; Se Jeong OH ; In Chul KIM
Journal of the Korean Surgical Society 1991;41(1):9-13
No abstract available.
9,10-Dimethyl-1,2-benzanthracene*
;
Animals
;
Breast Neoplasms*
;
Breast*
;
Estrogens*
;
Rats*
2.Glomus Tumor in The Infrapatellar Fat Pad: A Case Report.
Sang Cheol SEONG ; Sang Hoon LEE ; Gu Il JEONG ; Myung Chul LEE
Journal of the Korean Knee Society 2001;13(2):236-239
No Abstract Available.
Adipose Tissue*
;
Glomus Tumor*
3.Comparative Study of Glycolic Acid vs. Jessner's Solution in Patients with Facial Acne.
Seok Woo KIM ; Sang Eun MOON ; Jeong Aee KIM ; Hee Chul EUN ; Sue Kyung PARK
Korean Journal of Dermatology 1999;37(5):580-584
BACKGROUND: Glycolic acid has become an important and popular agent for chemical peel. Even though many clinicians perform superficial chemical peel to treat facial acne with glycolic acid, as yet there has been no well-controlled clinical trinls for the comparison of this new peeling agent and Jessner's solution. OBJECTIVE: To compare these two chemical peelI agents, our study was focused on three aspects : 1) treatment effects (acne improvement), 2) side effects (erythema, exfoliation), 3) patients preferences of the treatments. METHOD: Sixteen patients with facial acne vulgaris were treated with 70% glycolic acid and Jessner's solution on each side of the face simultaneously. Treatments were repeated biweekly with acne grading. Patient's subjective preferences were asked after the treatment.
Acne Vulgaris*
;
Humans
4.Clinical experience of cartilage allograft.
Kyung Suck KOH ; Doo Young OH ; Jeong Hoon KANG ; Sang Hoor HAN ; Kun Chul YOON
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(4):573-580
Bony defect is one of the most common problems in craniomaxillofacial surgery. Although aurogenous bone graft is the best choice for the treatment of bone defect, it provides many problems such as donor site morbidity, irregular absorption, and limited amount of harvest. To overcome the shortcomings of autogenous bone graft many bone substitutes have been introduced. The ideal bone substitution is to have characteristics such as cheap, easy to obtain, rapid fusion to recipient bone, hard structure, long maintenance of shape and volume, low infection rate, and low exposure rate. Among those bone substitutes which have been widely used we chose lyophilized cartilage allograft because of low antigenecity, low resorption rate, easiness of carving and ling term preservation. From August 1993 to August 1997, 66 patients had been performed craniomaxillofacial reconstruction with lyophilized cartilage allograft. Orbital wall reconstruction and correction of enophthalmos were 24, correction of cleft lip and nose deformity were 19, temporal augmentations were 7, and others 16. Complications such as infection, exposure were not common. And partially removed cartilage was proved some calcification. Radiologic follow-up presented well positioned lyophilized cartilage allograft. Two radiologic works revealed haziness of bone density at the site of cartilage allograft. This suggests the ossification of lyophilized cartilage allograft. Together with liw infection rate, low exposure rate, and good framework for osteoconduction, lyophilized cartilage allograft are regarded as one of the good bone substitutes.
Absorption
;
Allografts*
;
Bone Density
;
Bone Regeneration
;
Bone Substitutes
;
Cartilage*
;
Cleft Lip
;
Congenital Abnormalities
;
Enophthalmos
;
Follow-Up Studies
;
Humans
;
Nose
;
Orbit
;
Tissue Donors
;
Transplants
5.Effect of Epidural Autologous Blood Patch on the Prevention of Post-dural Puncture Headche after Spinal Anesthesia.
Keon Sang LEE ; Yoon Soo KIM ; Jeong Ae LIM ; Po Soon KANG ; Ye Chul LEE
Korean Journal of Anesthesiology 1998;35(5):933-938
Background: Post-dural puncture headache (PDPH) is one of the well-known complication of spinal anesthesia. Epidural blood patch is the treatment of choice for PDPH but is rarely used for the prevention of PDPH after spinal anesthesia. The purpose of this study is to observe the effectiveness of epidural blood patch for prevention of PDPH and to evaluate the complications after epidural blood injection. Methods: Three hundred patients (ASA I or II) receiving spinal anesthesia were studied. They were randomly devided into two groups. Patients in Group I, the control group, were maintained in a supine position for 24 hour after spinal anesthesia. Patients in Group II, the study group, received 3 ml of autologous blood in the epidural space after spinal anesthesia. PDPH was evaluated for 5 days. The incidence, location, onset, and duration of headache in the patients presenting with PDPH were measured for 5 days, and the complications following epidural blood patch in Group II were observed for 2 weeks. Results: The incidence of PDPH in group I was 11%, but 0% in group II. There were no specific complications following epidural blood patch in Group II. Conclusions: This study suggest that the 3 ml epidural autologous blood patch is an useful method for the prevention of PDPH in patients with spinal anesthesia.
Anesthesia, Spinal*
;
Blood Patch, Epidural
;
Epidural Space
;
Headache
;
Humans
;
Incidence
;
Post-Dural Puncture Headache
;
Punctures*
;
Supine Position
6.Seropositive Rate to Yersinia enterocolitica - pseudotuberculosis complex among Patients with Acute Gastroenteritis in Children , 1994-1997.
Sang In CHUNG ; Won Yong KIM ; Ki Jeong KIM ; Chul Soon CHOI
Journal of the Korean Society for Microbiology 1997;32(6):701-715
To investigate incidence of acute gastroenteritis (AGE) caused by Yersinia enterocolitica and Y. pseudotuberculosis (referred to as Y. enterocolitica-pseudotuberculosis complex) in children, seropositive rates to major 8 serotypes of Y. enterocolitica-pseudotuberculosis complex antigens among 467 sera of three groups of subjects (298 acute gastroenteritis; AGE, 108 miscellaneous pediatric diseases; MPD, and 61 healthy medical students; HMS) were investigated by bacterial agglutination test using standardized, heat-killed, phenolized, smooth 0 antigens. In addition, cross-reactions between yersinia agglutinins and Widal agglutinins in patients with AGE caused by Y. enterocolitica-pseudotuberculosis complex were examined in paired serum specimens. Seropositive rates to Y. enterocolitica-pseudotuberculosis complex among three groups, AGE, MPD, and HMS, were 36.5%, 13.8%, and 14.7%, respectively. Of 109 seropositive AGE patients, the most common type-specific agglutinin which showed predominating agglutinin titer to one of 8 serotypes of Y. enterocolitica-pseudotuberculosis complex antigens was PO4b (27.5%), followed by PO2a (23.8%), EO3 (16.5%), PO5a (13.7%), PO5b (9.1%), PO3 (4.5%), EO9 (2.7%), and POlb (1.8%), in orders. The Widal agglutinins cross-reacted to Y. pseudotuberculosis PO4b antigen, but the yersinia agglutinins were differentiated from Widal agglutinins by rising agglutinin titers in paired serum specimens taken one to three weeks apart. In conclusion, acute gastroenteritis caused by Y. pseudotuberculosis in children must be regarded as a fairly common enteric disease in children.
Agglutination Tests
;
Agglutinins
;
Child*
;
Gastroenteritis*
;
Humans
;
Incidence
;
Phenol
;
Students, Medical
;
Yersinia enterocolitica*
;
Yersinia*
7.IMMEDIATE BREAST RECONSTRUCTION AFTER MASTECTOMY FOR BREAST CANCER.
Byoung Chul CHOI ; Sung Eun KIM ; Sang Hyun WOO ; Jae Ho JEONG ; Jung Hyun SEUL
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(4):748-760
No abstract available.
Breast Neoplasms*
;
Breast*
;
Female
;
Mammaplasty*
;
Mastectomy*
8.Solitary Ancient Schwannoma in Upper Arm: A Case Report.
Yun Tae LEE ; Chul KIM ; Sang Hoon PARK ; Jeong Hae KIE
The Journal of the Korean Bone and Joint Tumor Society 2013;19(1):37-41
Ancient schwannoma is a variant of schwannoma and is characterized slowly growing tumor with degenerative change. And it is reported that schwannoma is relatively rare in extensor area. As a rare cause of solitary ancient schwannoma in extensor area of upper arm, we report it.
Arm
;
Neurilemmoma
9.Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line.
Experimental & Molecular Medicine 1999;31(2):83-88
Increased expression of Transglutaminases 2 (TGase 2, TGase C) was observed in PC-14 human lung cancer cells in association with doxorubicin resistance and the reduction of the enzyme expression was correlated with the increasing cytotoxicity of the drug (Han and Park, 1999). Hydrogen peroxide was suggested to be a key mediator for doxorubicin-induced DNA fragmentation leading to apoptosis. A possible role of hydrogen peroxide as a putative mediator of TGase 2 expression in the doxorubicin sensitive PC-14 cells was examined. TGase 2 expression was increased in PC-14 cells treated with doxorubicin in a dose-dependent manner resulting in the concomitant increase of reactive oxygen species. The rise of TGase 2 expression by doxorubicin treatment was inhibited by N-acetylcysteine or glutathione treatment, while direct addition of hydrogen peroxide to PC-14 cells induced TGase 2 expression. These results suggest that generation of hydrogen peroxide induced by doxorubicin treatment is one of the key factors in an enhancement of TGase 2 expression in PC-14 cells.
Acetylcysteine/pharmacology
;
Antineoplastic Agents/pharmacology*
;
Doxorubicin/pharmacology*
;
Enzyme Induction
;
Gene Expression Regulation, Enzymologic
;
Glutathione/pharmacology
;
Human
;
Hydrogen Peroxide/pharmacology
;
Hydrogen Peroxide/metabolism*
;
Lung Neoplasms/enzymology*
;
Protein-Glutamine gamma-Glutamyltransferase/biosynthesis*
;
Reactive Oxygen Species/metabolism
;
Tumor Cells, Cultured/drug effects
10.Downregulation of Reactive Oxygen Species in Apoptosis.
Journal of Cancer Prevention 2016;21(1):13-20
Generation of reactive oxygen species (ROS) by diverse anti-cancer drugs or phytochemicals has been closely related with the induction of apoptosis in cancers. Also, the downregulation of ROS by these chemicals has been found to block initiation of carcinogenesis. Therefore, modulation of ROS by phytochemicals emerges as a crucial mechanism to regulate apoptosis in cancer prevention or therapy. This review summarizes the current understanding of the selected chemical compounds and related cellular components that modulate ROS during apoptotic process. Metformin, quercetin, curcumin, vitamin C, and other compounds have been shown to downregulate ROS in the cellular apoptotic process, and some of them even induce apoptosis in cancer cells. The cellular components mediating the downregulation of ROS include nuclear factor erythroid 2-related factor 2 antioxidant signaling pathway, thioredoxin, catalase, glutathione, heme oxygenase-1, and uncoupling proteins. The present review provides information on the relationship between these compounds and the cellular components in modulating ROS in apoptotic cancer cells.
Apoptosis*
;
Ascorbic Acid
;
Carcinogenesis
;
Catalase
;
Curcumin
;
Down-Regulation*
;
Glutathione
;
Heme Oxygenase-1
;
Metformin
;
Negotiating
;
Phytochemicals
;
Quercetin
;
Reactive Oxygen Species*
;
Thioredoxins