1.Effect of Insulin-like Growth Factor-I on Renal Function During Compensatory Renal Hypertrophy in Neonatal Rates.
Chul Kyu CHO ; Tong Choon PARK ; Sang Won HAN
Korean Journal of Urology 2000;41(10):1163-1171
No abstract available.
Hypertrophy*
3.Detection of the anti-neural antibodies in the sera of leprosy patients.
Joo Young PARK ; Jung Koo YOUN ; Sang Nae CHO ; Woo Ick YANG ; Choon Myung KOH
Journal of the Korean Society for Microbiology 1992;27(3):239-251
No abstract available.
Antibodies*
;
Humans
;
Leprosy*
4.Clinical Application of Arthroscopy in the Patients with Internal Derangement of the Knee
Sang Cheol SEONG ; Choon Ki LEE ; Se Hyun CHO ; Han Koo LEE ; Moon Sik HAHN
The Journal of the Korean Orthopaedic Association 1982;17(6):1164-1170
We applied arthroscopy in the diagnosis of thirty four patients with internal derangement of the knee from March to August, 1982. Its results were compared with clinical diagnosis and arthrographic findings. We also performed arthrofomy in twenty nine patients and the final diagnosis enabled us to evaluate the diagnostic accuracy of each method. The accuracy of clinical diagnosis was 63.4%. Arthrographic findings were correct in 77.8%. The diagnostic accuracy of arthroscopy was 92.3% with one false negative case. Unnecessary operations were avoided in five patients with the assistance of negative findings of arthroscopy. Arthrography and arthroscopy were complementary in the diagnosis of internal derangement of the knee.
Arthrography
;
Arthroscopy
;
Diagnosis
;
Humans
;
Knee
;
Methods
5.A Case of Prolonged Hypoglycorrhachia after Subarachnoid Hemorrhage.
Yong Won CHO ; Jeong Geun LIM ; Sang Doe YI ; Young Choon PARK
Journal of the Korean Neurological Association 1994;12(3):574-576
After subarachnoid hemorrhage, transient hypoglycorrhachia is not unusual but prolonged hypoglycorrhachia has been reported rarely. We report a 67-year-old woman who show prolonged hypoglycorrhachia for more than one month after subarahnoid hemorrhage without evidences of infection and malignancy.
Aged
;
Female
;
Hemorrhage
;
Humans
;
Subarachnoid Hemorrhage*
6.The Clinical Significance of Blink Reflex in Diabetics.
Yong Won CHO ; Jeong Geun LIM ; Sang Doe YI ; Young Choon PARK
Journal of the Korean Neurological Association 1994;12(3):491-497
Blink reflex (BR) was known as a useful test fordetection of brainstem lesions and cranial neuropathy. We performed BR test in 52 non-insulin dependent diabetics, and the results were compared with 26 controls. In diabetics, 23 patients (44.2%) had abnormal results with delayed R1 in 20 (38.5%), delayed ipsilateral R2 in 6 (11.5%) and delayed contralateral R2 in 4 (7.7%). BR abnormalities were related to age and presence of peripheral neuropathy, but not related to duration of diabetes and fasting blood sugar level. It is suggested that BR test could be an additional electrodiagnostic tool for the diabetic neuropathy, especially to evaluate a subclinical brainstem or cranial nerve involvement.
Blinking*
;
Blood Glucose
;
Brain Stem
;
Cranial Nerve Diseases
;
Cranial Nerves
;
Diabetic Neuropathies
;
Fasting
;
Humans
;
Peripheral Nervous System Diseases
7.Alteration of Akt, p-Akt, ERK, and p-ERK Proteins Expression in the Kidney of Hypokalemic Rat.
Choon Sang BAE ; Hye Jung CHO ; Kyu Yoon AHN
Korean Journal of Physical Anthropology 2017;30(3):87-98
Hypokalemia causes metabolic alkalosis and morphological changes of the kidney. K⁺ balance is regulated not only by ion channels or pump gene, but also by various genes including NF-E2-related factor 2 (Nrf2). Previous study suggested the possibility that Akt and ERK kinase may be involved in Nrf2 transcriptional gene activation. In present study, we investigate the alterations of Akt, p-Akt, ERK, p-ERK protein in both normal kidney and K⁺-deficient diet kidney using Western blot analysis, and immunohistochemisrty. Our western blot data showed that the expression of Akt and p-Akt was increased gradually in K⁺-depleted diet (from 1W-3W) compared to normal group. The expression of ERK and p-ERK was markedly increased in K⁺-depleted diet 2W in comparison with normal group. Based on our immunostaining results, Akt protein immunoreactivity was prominently increased in outer medullary collecting duct, especially in K⁺-depleted diet 2 weeks. The localization of p-Akt proteins in K⁺-depleted groups was not different from normal group, but the immunoreactivity was significantly increased in distal convoluted tubule, macula densa and outer medullary thick ascending limb in K⁺-depleted diet 1 and 2 weeks groups. ERK protein immunoreactivity was prominently increased in outer medullary collecting duct, especially in K⁺-depleted diet 2 and 3 weeks. The localization of p-ERK proteins in K⁺-depleted groups was not different from normal group, but the immunoreactivity was prominently increased in the nucleus of outer medullary collecting duct especially in K⁺-depleted diet 2 weeks. Taken together, we suggest that the expression of p-Akt was gradually increased in K⁺-depleted groups of kidney, but the expression of p-ERK was markedly increased in K⁺-depleted diet 2 week group. Hence, the promotion of AKT and ERK phosphorylation in hypokalemic condition may be involved in the regulation of ion channels, ion transporters and subsequent intracellular signal transduction.
Alkalosis
;
Animals
;
Blotting, Western
;
Diet
;
Extremities
;
Hypokalemia
;
Ion Channels
;
Ion Transport
;
Kidney*
;
NF-E2-Related Factor 2
;
Phosphorylation
;
Phosphotransferases
;
Rats*
;
Signal Transduction
;
Transcriptional Activation
8.Analysis of the Wrist Motion Using 3
Han Koo LEE ; Moon Sang CHUNG ; Choon Ki LEE ; Jae Myeung CHUN ; Byung Hwa YOON ; Tae Joon CHO
The Journal of the Korean Orthopaedic Association 1989;24(1):117-126
The wrist joint is composed of midcarpal, radiocarpal and distal radioulnar joints. It is difficult to analyze the motion of these joints by the simple roentgenogram. We reconstructed three dimensional images of the wrist and distal radius from computerized tomogram using a new interactive graphics software written in Pascal and Turbo Graphic. There were 10 normal wrists in neutral position, and two normal and one abnormal wrists in ulnar-radial deviation and one normal wrist in flexion-extension were analyzed in this study. For simplification, the images were reformatted for the scaphoid, the proximal carpal row, the distal carpal row and the distal radius. We established the three dimensional references for wrist by defining the Z axis as the long axis of radius, the X axis as a line which is in horizontal plane and parallel to the anterior cortex of distal radius about 2 cm proximal to the articular surface and the Y axis as the automatically defined line perpendicular to both X and Z axes. We measured the angles between the X-axis and the reference lines of scaphoid and each carpal rows. The scaphoid was internally rotated by 60,0 degrees from X axis, the proximal carpal row by 7.0 degrees and the distal carpal row by 25.6 degrees each. There was only minimal change in the angles during the ulnar and radial deviation. The pattern of angles in abnormal wrist was different from those in normal wrists. In flexion-extension, the angle of distal carpal row was changed significantly, which means there was some error in selecting the reference line of distal carpal row as an axis of motion, or in measuring the angles, or it can be suggested that there is some rotational motion of distal carpal row on the Z axis. The proximal poles of the scaphoid and the triquetrum were displaced ventrally during flexion and dorsally during extension.
Imaging, Three-Dimensional
;
Joints
;
Radius
;
Wrist Joint
;
Wrist
9.A Case of Adult Onset Still's Disease with Severe Pneumonitis Treated with Anakinra.
Soung Ha CHO ; One Zoong KIM ; Sang Woo CHO ; Dong Min LIM ; Su Kyoung AN ; Choon Kwan KIM
Korean Journal of Medicine 2014;87(2):245-250
Adult onset Still's disease (AOSD) is a systemic autoinflammatory disorder that presents with recurrent fever, extreme fatigue, and joint pain. Pulmonary involvement is not uncommon and, although rare, severe pneumonitis can progress to respiratory failure. Still's disease-associated pneumonitis is generally treated with immunosuppressive agents, but improvement in our understanding of systemic inflammatory processes led us to explore alternative agents. Anakinra is an interleukin-1 receptor antagonist used to treat autoinflammatory disorders resistant to immunosuppressive therapy. Several case reports have demonstrated efficacy of anakinra in treating AOSD, but its relevance in cases complicated with severe pneumonitis has not been examined. Our patient's disease activity was not controlled with systemic steroids and cyclophosphamide. Treatment with anakinra led to a dramatic clinical response. This is the first reported case of AOSD with severe pneumonitis refractory to conventional therapy successfully treated with anakinra.
Arthralgia
;
Cyclophosphamide
;
Fatigue
;
Fever
;
Immunosuppressive Agents
;
Interleukin 1 Receptor Antagonist Protein*
;
Interleukin-1
;
Pneumonia*
;
Respiratory Insufficiency
;
Steroids
;
Still's Disease, Adult-Onset*
10.Subacute Delayed Ascending Myelopathy after Spinal Cord Injury from Flexion-distraction Injury of Low Thoracic Spine: A Case Report.
Sang Jae PARK ; Jae Hwan CHO ; Sang Ik SHIN ; Bong Soon CHANG ; Choon Ki LEE
Journal of Korean Society of Spine Surgery 2013;20(3):123-128
STUDY DESIGN: A case report. OBJECTIVES: To report a rare case of subacute delayed ascending myelopathy. SUMMARY OF LITERATURE REVIEW: After low spinal cord injury, the cord injury may proceed to a proximal level and lead to subacute delayed ascending myelopathy. The patient suffered from orthostatic hypotension, weakness and sensory loss in the upper extremities and dyspnea. MRI showed more proximal progression of the spinal cord injury. There is no prevention or treatment for this condition. MATERIALS AND METHODS: A 62-year-old man fell from heights and had 11th thoracic spine flexion-distraction injury. Upon arrival at the hospital, he was found to suffer from lower extremity weakness and sensory loss, but showed no neurologic symptom in his upper extremities. Two days later, we performed posterior instrumentation with fusion, and no postoperative neurologic symptom change was detected. One week after the fall, he suffered from dyspnea, upper extremity weakness and sensory loss. MRI was taken and we discovered that his spinal cord injury had proceeded to the 2nd cervical spine level. RESULTS: Three months later, he showed little improvement in his upper extremity motor power, but not to the extent of the previous low spinal injury. CONCLUSION: Physicians should pay attention to the upper extremity and respiratory function of the patient with low spinal cord injury, because the level of spinal cord injury may proceed to a proximal level.
Dyspnea
;
Humans
;
Hypotension, Orthostatic
;
Lower Extremity
;
Middle Aged
;
Neurologic Manifestations
;
Spinal Cord
;
Spinal Cord Diseases
;
Spinal Cord Injuries
;
Spine
;
Upper Extremity