Objective: To detect P53 and Ki-67 protein,human papill om a virus (HPV),cytomegalovirus(CMV) and Epstein-Barr virus(EBV)in the warts of o ral mucosa from HIV-positive patients.Methods: The expression P53 and Ki-67 protein,HPV,EBV and CMV were detected by immunohistochemistry and PCR in 34 cases of oral mucosa warts from HIV-positve patients,33 cases of oral epithelia dysplasia and 45 cases of oral squamous cell carcinoma. Results:(1)The expression of P53 and Ki-67 protein in the cases of oral mucosa warts from HIV-positive patients were 23%and 76% re spectively,lower than those in oral suquamous cell carcinoma lesions from non- HIV individuals(62.8% and 97.8% respectively,P0.05).(2)The HPV infection in the warts of oral mucosa from HIV -positive patients was 88.2%,much higher than in oral suquamous cell carcinoma lesions (35.6%) and in dysplastic lesions (9.1%) from non-HIV individuals(P