1.Bacterial drug resistance situation and clinical features of urinary tract infection in children
Jianhua YU ; Shuwan ZHANG ; Kai JIA ; Weina YANG ; Lu WANG ; Juan WANG ; Huijun CAI ; Jiahua LIU ; Sancheng CAO
International Journal of Laboratory Medicine 2015;(5):633-635
Objective To analyze the basic clinical characteristics,auxiliary diagnostic indexes,bacterial infection spectrum and drug resistance of child urinary tract infection to provide the basis for the prevention,diagnosis and treatment of child UTI.Methods The clinical data in the inpatients with UTI or complicating UTI in our hospital from January 2012 to March 2014 were collected. The repeated strains were excluded.The differences in the pathogens between the patients with complicated UTI and the patients with non-complicated UTI were comprehensively analyzed.Results The onset peak of child UTI for the first time was 0 -0.5 years old.Escherichia coli ,Klebsiella and Pseudomonas aeruginosa are the major pathogens of child UTI,in which 110 strains were Escherichia coli,accounting for 52.9%.The enterobacteriaceae pathogens of UTI had higher sensitivity to carbapenems antibacterial drugs,with the resistance rate of less than 10%;the resistance rate of others detected antibacterial drugs was more than 20%.Con-clusion UTI in the children inpatients of this area has higher drug resistance rate,in the treatment of child UTI,the antibacterial drugs should be rationally used by combining the bacterial drug resistance situation in the local place and the disease severity in or-der to avoid the aggravation of bacterial drug resistance.
2. Report of antimicrobial resistance surveillance program in Chinese children in 2016
Chuanqing WANG ; Aimin WANG ; Hui YU ; Hongmei XU ; Chunmei JING ; Jikui DENG ; Ruizhen ZHAO ; Chunzhen HUA ; Yinghu CHEN ; Xuejun CHEN ; Ting ZHANG ; Hong ZHANG ; Yiping CHEN ; Jinghong YANG ; Aiwei LIN ; Shifu WANG ; Qing CAO ; Xing WANG ; Huiling DENG ; Sancheng CAO ; Jianhua HE ; Wei GAO ; Shuzhen HAN
Chinese Journal of Pediatrics 2018;56(1):29-33
Objective:
To analyze the antimicrobial resistance profile in Chinese children.
Methods:
This was a prevalence survey. From January 1 through December 31, 2016, the isolates were collected from 10 tertiary children hospitals in China. Antimicrobial susceptibility testing was carried out by routine laboratory methods. The penicillin susceptibility of
3. Clinical characteristics and antimicrobial resistance of pneumococcal infections from 9 children's hospitals in 2016
Chao FANG ; Xuejun CHEN ; Mingming ZHOU ; Yinghu CHEN ; Ruizhen ZHAO ; Jikui DENG ; Chunmei JING ; Hongmei XU ; Jinhong YANG ; Yiping CHEN ; Hong ZHANG ; Ting ZHANG ; Sancheng CAO ; Huiling DENG ; Chuanqing WANG ; Aimin WANG ; Hui YU ; Shifu WANG ; Aiwei LIN ; Xing WANG ; Qing CAO
Chinese Journal of Pediatrics 2018;56(8):582-586
Objective:
To describe the clinical characteristics of pneumococcal infections and drug resistance of
4.Distribution characteristics and drug resistance of carbapenem-resistant Enterobacteriaceae in chil-dren from 2016 to 2017
Bingjie WANG ; Fen PAN ; Hong ZHANG ; Ting ZHANG ; Hongmei XU ; Chunmei JING ; Chuanqing WANG ; Aimin WANG ; Hui YU ; Shuzhen HAN ; Aiwei LIN ; Shifu WANG ; Qing CAO ; Xing WANG ; Chunzhen HUA ; Yinghu CHEN ; Xuejun CHEN ; Jikui DENG ; Ruizhen ZHAO ; Huiling DENG ; Sancheng CAO ; Jianhua HAO ; Wei GAO ; Yiping CHEN ; Jinhong YANG
Chinese Journal of Microbiology and Immunology 2019;39(8):583-590
Objective To investigate the distribution and drug resistance of carbapenem-resistant Enterobacteriaceae ( CRE) isolated from children in China. Methods CRE strains were collected in 10 ter-tiary children's hospitals of China from January 1, 2016 to December 31, 2017. Antimicrobial susceptibility of the clinical strains was detected with disk diffusion method ( KB method) and automated method. The re-sults were analyzed according to the Clinical and Laboratory Standards Institute ( CLSI) Standards published in 2017. WHONET 5. 6 software was used to retrospectively analyze the distribution characteristics and drug resistance of these strains. Results A total of 3065 CRE clinical strains were isolated from children with an overall prevalence of 7. 7% and among them, 13. 5% were isolated in neonatal group and 5. 8% in non-neo-natal group. The detection rate of CRE in 2017 was higher than that in 2016 (9. 7% vs 5. 7%). Among the 3065 CRE strains, there were 1912 strains of Klebsiella pneumoniae (62. 0%), 667 strains of Escherichia coli (22. 0%), 206 strains of Enterobacter cloacae (7. 0%), 56 strains of Klebsiella aerogenes (1. 8%) and 47 strains of Serratia marcescens (1. 5%). Most of the strains were isolate in neonatology departments including neonatal intensive care units (NICU) and intensive care units (ICU), accounting for 44. 8% and 19. 7%, respectively. Respiratory tract (61. 8%), urine (19. 4%) and blood (5. 7%) specimens were the main sources of CRE isolates. Results of antimicrobial susceptibility test showed that the CRE strains were highly resistant to carbapenem antibiotics such as imipenem, meropenem and ertapenem, as well as penicillins and most cephalosporins (79. 6%-100%), especially those isolated in the neonatal group (P<0. 05). Children had relatively low resistance rates to aminoglycosides such as amikacin (19. 7%) and fos-fomycin (11. 9%), fluoroquinolones such as levofloxacin (37. 7%) and ciprofloxacin (43. 3%), and tige-cycline (3. 8%). Currently, no polymyxin B-resistant strains were isolated. Conclusions The prevalence of common CRE strains in children in 2017 was higher than that in 2016, especially in newborns. Drug re-sistance in CRE strains isolated from neonates to common antibiotics was more severe, suggesting that great attention should be paid to it and timely measures should also be taken.
5. A multicenter clinical study on 1 138 cases of invasive pneumococcal disease in children from 2012 to 2017
Liang ZHU ; Wenhui LI ; Xinhong WANG ; Kun TAN ; Qingfeng FANG ; Qingxiong ZHU ; Kangkang WU ; Qiaozhi YANG ; Aiwei LIN ; Huiling DENG ; Jing BI ; Jing LIU ; Shiyong ZHAO ; Yun LIU ; Shujun JING ; Yumin WANG ; Lianmei LI ; Qing ZHAO ; Kaihu YAO ; Xi WANG ; Li JIA ; Fang WANG ; Jikui DENG ; Jing SUN ; Chunhui ZHU ; Kai ZHOU ; Jun LIANG ; Xiuzhen NIE ; Sancheng CAO ; Dongmeng WANG ; Shuangjie LI ; Xuexia CHEN ; Juan LI ; Yi WANG ; Lan YE ; Yanhong ZHANG ; Fang DONG ; Zhi LI ; Yonghong YANG ; Gang LIU
Chinese Journal of Pediatrics 2018;56(12):915-922
Objective:
To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD).
Methods:
By retrieving the laboratory information system in 18 children′s hospitals from 2012 to 2017, the children with IPD were enrolled.