1.Randomized trail of nasal synchronized intermittent mandatory ventilation compared with nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome.
Wei-Wei GAO ; San-Zhi TAN ; Yun-Bin CHEN ; Yong ZHANG ; Yue WANG
Chinese Journal of Contemporary Pediatrics 2010;12(7):524-526
OBJECTIVETo compare the efficacy of nasal synchronized intermittent mandatory ventilation (nSIMV) and nasal continuous positive airway pressure (nCPAP) in preterm infants with respiratory distress syndrome (RDS).
METHODSFifty preterm infants with RDS who received pulmonary surfactant were randomized to nSIMV and nCPAP groups after extubation. Clinical signs, symptoms and blood gas results following nSIMV or nCPAP were compared in the two groups.
RESULTSCompared with the nCPAP group, the nSIMV group had a lower incidence of failure respiratory support (24% vs 60%; P<0.05), a lower incidence of hypercarbonia (12% vs 40%; P<0.05) and a lower incidence of hypoxia (24% vs 36%; P<0.05).
CONCLUSIONSnSIMV is more effective in respiratory support in preterm infants with RDS.
Continuous Positive Airway Pressure ; methods ; Humans ; Infant, Newborn ; Infant, Premature ; Intermittent Positive-Pressure Ventilation ; methods ; Respiratory Distress Syndrome, Newborn ; therapy
2.Transurethral bipolar plasmakinetic enucleation and resection versus transurethral bipolar plasmakinetic resection of the prostate for BPH: a randomized controlled trial on the incidence of postoperative urinary incontinence.
Jun-Feng LIU ; Chun-Xiao LIU ; Zhao-Hui TAN ; San-Xiang LI ; Xing-Zhi LI ; Ning CHI
National Journal of Andrology 2014;20(2):165-168
OBJECTIVETo compare the incidence rates of postoperative urinary incontinence between transurethral bipolar plasmakinetic enucleation and resection of the prostate (PKERP) and transurethral bipolar plasmakinetic resection of the prostate (PKRP), and provide evidence for the clinical application of PKERP.
METHODSTotally, 180 BPH patients were equally and randomly assigned to undergo PKERP and PKRP, respectively. We measured the urinary incontinence of the patients by pad test at 24 hours after extubation and every week after surgery for 4 weeks. Meanwhile, we recorded and compared the PSA level, prostate volume, Qmax, residual urine, IPSS, QOL, and the results of pad test between the two groups before and after surgery.
RESULTSThe incidence rates of urinary incontinence in the PKERP and PKRP groups were 35.56% and 18.89% (P < 0.01) at 24 hours after extubation, 20.00% and 7.78% at 1 week after surgery (P < 0.05), and 3.33% and 2.22% at 2 weeks. There was no significant difference in the severity of urinary incontinence between the two groups at any time point (P > 0.05). No permanent urinary incontinence was observed in either group.
CONCLUSIONCompared with PKRP, PKERP has a higher incidence rate of short-term urinary incontinence in the treatment of BPH, but not that of genuine incontinence, with similar severity and recovery time.
Aged ; Humans ; Incidence ; Male ; Postoperative Complications ; epidemiology ; Prostatic Hyperplasia ; surgery ; Single-Blind Method ; Transurethral Resection of Prostate ; adverse effects ; methods ; Urinary Incontinence ; epidemiology
3.Analysis of Chemical Components in Supernatant and Precipitate of Sanajon Oral Liquid Based on UPLC-Q-TOF-MSE Technology
Hao-zhou HUANG ; Min QIU ; Jin-fa TANG ; Meng-Qi LI ; Hai-yan LIU ; San-hu FAN ; Peng TAN ; Li HAN ; Jun-zhi LIN ; Ding-kun ZHANG
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(14):143-151
Objective:To analyze the main chemical components in the supernatant and precipitate of Sanajon oral liquid, so as to provide basis for establishing its quality standard and precipitation control technology. Method:UPLC-Q-TOF-MSE was used to analyze the chemical components in the supernatant and precipitate of this oral liquid. The analysis was performed on Waters ACQUITY UPLC BEH C18 column (2.1 mm×100 mm, 1.7 μm) with the mobile phase of 0.1% formic acid solution (A) and acetonitrile (B) for gradient elution (0-1 min, 2%B; 1-2 min, 2%-5%B; 2-4 min, 5%-7%B; 4-6 min, 7%-24%B; 6-10 min, 24%-42%B; 10-12 min, 42%-54%B; 12-15 min, 54%-76%B; 15-18 min, 76%-100%B), the flow rate was set to 0.3 mL·min-1, the column temperature was 30 ℃, the injection volume was 2 µL. The mass spectrographic analysis was used with electrospray ionization (ESI), sample MS data was acquired by time-dependent MSE in negative ion mode, the collection range was
4.Strategies and ideas of comprehensive development and utilization of medicine and food homologous variety Phyllanthus emblica.
Hao-Zhou HUANG ; Fei RAN ; Qing-Chu TAN ; Ding-Kun ZHANG ; Meng-Qi LI ; San-Hu FAN ; Peng TAN ; Jin PEI ; Li HAN ; Jun-Zhi LIN
China Journal of Chinese Materia Medica 2021;46(5):1034-1042
Phyllanthus emblica is a kind of traditional medicine and medicinal and edible plant, with rich variety resources and high development value. It is a key poverty alleviation variety in China at present. As P. emblica processing industry is rising gradually in recent years, in order to fully develop and utilize its industrial resources, this paper systematically introduces current comprehensive development and utilization of P. emblica, discusses the problems in P. emblica processing industry, and puts forward comprehensive development and utilization strategies and industrial models in terms of cultivation, breeding, grading, quality evaluation and waste recycling, so as to provide a certain reference for promoting the high-quality development of P. emblica industry in China.
China
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Medicine
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Medicine, Traditional
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Phyllanthus emblica
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Plant Breeding
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Plant Extracts
5.Effect of electrical stimulation at auricular points combined with sound masking on the expression of CREB, BDNF and TrkB in the auditory cortex of tinnitus rats.
Song-Bai YANG ; Li-Yan PENG ; Zhi-Gang MEI ; Ling-Jing TAN ; Ya-Guang HUANG ; Zhi-Tao FENG ; San-Jin CAI ; Wen-Han MA ; Ding-Qi ZHANG
Chinese Acupuncture & Moxibustion 2019;39(6):637-642
OBJECTIVE:
To explore the effect of electrical stimulation at auricular points (EAS) combined with sound masking on the expression of cAMP-response element binding protein (CREB), brain-derived neurotrophic factor (BDNF) and tyrosine receptor kinase B (TrkB) in the auditory cortex of tinnitus rats.
METHODS:
A total of 27 adult male SD rats were randomly divided into a control group, a model group and an EAS group. The rats in the model group and the EAS group were intervened with intraperitoneal injection of sodium salicylate to induce tinnitus model, while the rats in the control group were intervened with injection of 0.9% NaCl solution. After the model was successfully established, the rats in the EAS group were treated with electrical stimulation at "Shenmen" (TF) and "Yidan" (CO), combined with sound masking; the treatment was given once a day for 15 days. The gap prepulse inhibition of acoustic startle (GPIAS) and prepulse inhibition (PPI) testing were performed using the acoustic startle reflex starter package for rats. The expression of BDNF, TrkB, CREB and p-CREB in the auditory cortex of each group were measured with Western Blot analysis.
RESULTS:
① Compared with the control group, the GPIAS values in 12 kHz, 16 kHz, 20 kHz and 28 kHz were significantly decreased in the model group (all <0.05); compared with the model group, GPIAS values in 12 kHz, 16 kHz, 20 kHz and 28 kHz were significantly increased in the EAS group (all <0.05). ② Compared with the control group, the expression of BDNF and p-CREB in the model group was significantly increased (<0.01), and the expression of TrkB in the model group was significantly increased (<0.05); the differences of expression of BDNF, TrkB, CREB and p-CREB between the model group and the EAS group had no statistics significance (all >0.05).
CONCLUSION
EAS could improve the GPIAS values of high-frequency background sound in tinnitus rats, which may be related with the upregulation of the BDNF/TrkB/CREB signaling pathway in the auditory cortex, leading to the reversion of the maladaptive plasticity.
Acupuncture Points
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Animals
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Auditory Cortex
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Brain-Derived Neurotrophic Factor
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metabolism
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Cyclic AMP Response Element-Binding Protein
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metabolism
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Electric Stimulation
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Male
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Rats
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Rats, Sprague-Dawley
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Receptor, trkB
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metabolism
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Tinnitus
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metabolism
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therapy
6.Effect of Removing Core on Quality of Phyllanthi Fructus
Chuan-hong LUO ; Sheng-jie HUANG ; Qi-qi HU ; Peng TAN ; Hua-mei GOU ; Xi-chuan WEI ; Hao-zhou HUANG ; San-hu FAN ; Jun-zhi LIN ; Ding-kun ZHANG ; Li HAN
Chinese Journal of Experimental Traditional Medical Formulae 2021;27(9):147-156
Objective:The differences of chemical compositions and pharmacological activities between the core and pulp of Phyllanthi Fructus were investigated by chemical analysis and
7.Research progress of Phyllanthi Fructus and prediction of its Q-markers.
Hao-Zhou HUANG ; Jing-Cai CHEN ; Ding-Kun ZHANG ; Meng-Qi LI ; Qin-Chi XIAN ; San-Hu FAN ; Peng TAN ; Wan-Min MAO ; Feng LIN ; Jun-Zhi LIN ; Li HAN
China Journal of Chinese Materia Medica 2021;46(21):5533-5544
Phyllanthi Fructus, a unique Chinese and Tibetan medicinal plant with both edible and medical values, has high potential of cultivation and development. The resources of Phyllanthi Fructus in China are rich, mainly distributed in Yunnan, Sichuan, Fujian, Guangdong, Guangxi, etc. Phyllanthi Fructus is widely used in the clinical practice of Chinese medicine and plays an important role in Tibetan medicine, Uyghur medicine, Yi medicine, and Mongolian medicine. Phyllanthi Fructus mainly contains phenolic acids,tannins, terpenes, sterols, fatty acids, flavonoids, amino acids and other compounds. Modern pharmacological studies show that Phyllanthi Fructus has antioxidant, anticancer, blood lipid-lowering, liver protective, antimicrobial, anti-inflammatory, and immune regulatory activities. In this paper, the research status of Phyllanthi Fructus was reviewed from the aspects of herbal textual research,chemical composition, and pharmacological action. The quality markers(Q-markers) of Phyllanthi Fructus were predicted and analyzed from the aspects of biogenic pathway, specificity and measurability of chemical components, efficacy, properties, new clinical uses, drug-food homology, and transformation of polyphenols. The results will provide a scientific basis for the quality control, quality evaluation, and standard formulation of Phyllanthi Fructus.
China
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Drugs, Chinese Herbal
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Fruit
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Medicine, Tibetan Traditional
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Quality Control