OBJECTIVE: To analyze the effect of vertebroplasty on costal pain which develops following osteoporotic thoracic compression fractures (OTCFs). METHODS: The authors reviewed the medical records of 35 patients who underwent vertebral augmentation for the treatment of OTCFs over a five year period. The patients were divided into two groups: the costalgia group included patientswho had costal pain after a vertebral fracture and the non-costalgia group included patients without costalgia. To evaluate the effect of vertebroplasty on costal pain and factors related to costal pain, several factors including: vertebral body fracture type, pedicle injury, bone mineral density, the fracture level and clinical outcome were confirmed with magnetic resonance imaging and chart reviews. RESULTS: Among 35 patients, ten patients (28.6%) complained of costal pain with back pain. Only five of the ten patients (50%) had improved costal pain after a vertebroplasty. In the remaining 5 patients, the costal pain was improved through the use of medication including pain killers or a costal block during the follow-up period. Although the incidence of wedge deformity in the costal group was low(10%), there was no significant relationship to the incidence of costal pain statistically. Pedicle injury, bone mineral density and the fracture level had no significant relation to costal pain. CONCLUSION: The patients with wedge type, OTCFs may have a low incidence of costal pain as compared to those patients with bi-concave and crush deformities. The vertebroplasty effect on costal pain may not be effective. Therefore, before doing vertebroplasty, the surgeon should advise patients of this potential outcome in those treated for OTCFs.
Aged ; Back Pain ; Bone Density ; Congenital Abnormalities ; Follow-Up Studies ; Fractures, Compression ; Humans ; Incidence ; Intercostal Nerves ; Magnetic Resonance Imaging ; Medical Records ; Osteoporosis ; Spinal Fractures ; Vertebroplasty

OBJECTIVE: To analyze the effect of vertebroplasty on costal pain which develops following osteoporotic thoracic compression fractures (OTCFs). METHODS: The authors reviewed the medical records of 35 patients who underwent vertebral augmentation for the treatment of OTCFs over a five year period. The patients were divided into two groups: the costalgia group included patientswho had costal pain after a vertebral fracture and the non-costalgia group included patients without costalgia. To evaluate the effect of vertebroplasty on costal pain and factors related to costal pain, several factors including: vertebral body fracture type, pedicle injury, bone mineral density, the fracture level and clinical outcome were confirmed with magnetic resonance imaging and chart reviews. RESULTS: Among 35 patients, ten patients (28.6%) complained of costal pain with back pain. Only five of the ten patients (50%) had improved costal pain after a vertebroplasty. In the remaining 5 patients, the costal pain was improved through the use of medication including pain killers or a costal block during the follow-up period. Although the incidence of wedge deformity in the costal group was low(10%), there was no significant relationship to the incidence of costal pain statistically. Pedicle injury, bone mineral density and the fracture level had no significant relation to costal pain. CONCLUSION: The patients with wedge type, OTCFs may have a low incidence of costal pain as compared to those patients with bi-concave and crush deformities. The vertebroplasty effect on costal pain may not be effective. Therefore, before doing vertebroplasty, the surgeon should advise patients of this potential outcome in those treated for OTCFs.
Aged ; Back Pain ; Bone Density ; Congenital Abnormalities ; Follow-Up Studies ; Fractures, Compression ; Humans ; Incidence ; Intercostal Nerves ; Magnetic Resonance Imaging ; Medical Records ; Osteoporosis ; Spinal Fractures ; Vertebroplasty

It has been widely accepted due to its simplicity, safety and effectiveness to correct high myopia by epikeratoplasty. We evaluated clinical results of 23 cases of myopic epikeratoplasty over one year follow up. The uncorrected visual acuity improved in all cases and corrected visual acuity improved in 20 cases (91%). But, in 5 cases (22%), we experienced progressive loss of lenticular power more than 4 diopter of emmetropia and their clinical courses were also reviewed Two cases were both eyes of the same patient. The loss of lenticular power appeared as early in 5th week and even in 6th month postoperatively. We could not find any differences between this grolp of power loss and that of remained well corrected within 4 diopter of emmetropia, except preoperative spherical equivalent (-19 diopter vs -15 diopter), period of reepithelization (8.2 days vs 5.9 days), and mean age (25.8 years vs 31.1 years). But, only the difference of mean age was statistically significant (p<0.05). In addition, the surgical techniques the process of manufacturing tissue lenticule, and postoperative care might be document2d as possible factors.
Emmetropia ; Epikeratophakia* ; Follow-Up Studies ; Humans ; Myopia ; Postoperative Care ; Visual Acuity

The studies about factors influencing the retroprostheic membrane formation, one of major complications after keratoprosthesis implantation, and about histological characteristics of the retroprosthetic membrane were performed. The methods to inhibit formation and proliferation of membrane were also tried. Formation of the membrane according to corneal trephination size and the effects of lens removal to membrane formation were studied. The influence by the design of keratoprosthesis was also studied. Corticosteroid and SIMP (synthetic inhibitor of metalloproteinase) were applied topically to see the inhibitory effects of drugs to membrane. To evaluate the postoperative intraocular inflammation. Interleukin-1beta was assessed in the aqueous humor at postoperative 3 weeks. Regardless of trephination size, all trephination sites were replaced with opaque fibrous membranes. Histologically, in small trephination group (under 6mm) the membrane was regeneration of cornea showing corneal stromal fibroblast migration and proliferation and mature collagen. In large trephination group (over 7mm), the periphery of the membrane was compatible with corneal regeneration, but central portion was filled with granulation tissue. The removal of lens didn`t influenced the formation of membrane formation. In disc type keratoprosthesis implantation group, all the implants were extruded within 1 month due to retroprosthetic membrane formation. In cylinder type keratoprosthesis implantation group, the physical barrier of cylinder stopped the retroprosthetic membrane proliferation and spared the posterior surface of optic portion. The implants were not extruded for average 10 weeks. Corticosteroid and SIMP showed the effects of decreasing mature collagen formation in the membrane. The level of Interleukin-1beta at postoperative 3 weeks showed no difference according to different drugs and the highest level was checked in cylinder type keratoprosthesis implantation group.
Aqueous Humor ; Collagen ; Cornea ; Fibroblasts ; Granulation Tissue ; Inflammation ; Interleukin-1beta ; Membranes* ; Regeneration ; Trephining

Background : There is a substantial body of evidence that intraocular pressure increase with age among western population. However, Japanese study showed that intraocular pressure was inversely related with age. So we investigated whether intraocular pressure is related with age for Koreans. Methods : Between March, 1996 and February, 1997, 6201 subjects underwent comprehensive health examinationinthe Kyung Hee medical screening center in Seoul, Korea. The intraocular pressure was measured with pneumatonograpyh. At the same time blood pressure, body weight, height, serum osmolarity, fasting blood glucose, T3, T4, TSH(thyroid stimulating hormone), hematocrit measurements were performed. We selected 250 case randomly and investigated whether the distribution of C/D ration(cup/disk ratio), smoking status, alcohol drinking amount are uniform by aged group. So we measured C/D ratio by fundusphotograph and investigated smoking and drinking habits by questionnaires. Results : In the randomly sampled 250 cases, the amounts of smoking and alcohol consumption were lower in the elderly group. But, the C/D ration didn't show any difference between young and elderly group. In a multivariable analysis, both right and left intraocular pressure showed significantly inverse correlations with aged and visual acuity. Male had significantly higher intraocular pressure than female. Both right and left intraocular pressure showed significant positive correlations with body mass index, fasting blood glucose, hematocrit and systolic blood pressure. Diastolic blood pressure, serum osmolarity, T3 and T4 were not associated with intraocular pressure. TSH had significant positive correlation with right intraocular pressure, but no correlation with left intraocular pressure. Conclusion : Age was independently and inversely related with intraocular pressure for Koreans.
Aged ; Aging* ; Alcohol Drinking ; Asian Continental Ancestry Group ; Blood Glucose ; Blood Pressure ; Body Mass Index ; Body Weight ; Drinking ; Fasting ; Female ; Hematocrit ; Humans ; Intraocular Pressure* ; Korea ; Male ; Mass Screening ; Osmolar Concentration ; Surveys and Questionnaires ; Seoul ; Smoke ; Smoking ; Visual Acuity

OBJECTIVES: The purpose of the present study was to evaluate the effects of proanthocyanidin (PAC), a crosslinking agent, on the physical properties of a collagen hydrogel and the behavior of human periodontal ligament cells (hPDLCs) cultured in the scaffold. MATERIALS AND METHODS: Viability of hPDLCs treated with PAC was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The physical properties of PAC treated collagen hydrogel scaffold were evaluated by the measurement of setting time, surface roughness, and differential scanning calorimetry (DSC). The behavior of the hPDLCs in the collagen scaffold was evaluated by cell morphology observation and cell numbers counting. RESULTS: The setting time of the collagen scaffold was shortened in the presence of PAC (p < 0.05). The surface roughness of the PAC-treated collagen was higher compared to the untreated control group (p < 0.05). The thermogram of the crosslinked collagen exhibited a higher endothermic peak compared to the uncrosslinked one. Cells in the PAC-treated collagen were observed to attach in closer proximity to one another with more cytoplasmic extensions compared to cells in the untreated control group. The number of cells cultured in the PAC-treated collagen scaffolds was significantly increased compared to the untreated control (p < 0.05). CONCLUSIONS: Our results showed that PAC enhanced the physical properties of the collagen scaffold. Furthermore, the proliferation of hPDLCs cultured in the collagen scaffold crosslinked with PAC was facilitated. Conclusively, the application of PAC to the collagen scaffold may be beneficial for engineering-based periodontal ligament regeneration in delayed replantation.
Calorimetry, Differential Scanning ; Cell Count ; Collagen* ; Cytoplasm ; Humans ; Hydrogel* ; Periodontal Ligament ; Regeneration ; Replantation

OBJECTIVES: The purpose of this study was to determine the association between the bone mineral density (BMD) and severity of spinal osteoarthritis (spondylosis) in osteoporotic spinal compression fracture. METHODS: Fifty six patients were evaluated 66 cases had an osteoporotic thoracolumbar compression fracture between January 2008 and June 2010. The average patient age was 76.2 years (M/F : 8/48). Age and body mass index (BMI, kg/m2) were measured, and the BMD was performed using peripheral quantitative computed tomography (pQCT). Simple thoracolumbar (T-L) spine lateral radiography was evaluated for three criteria: presence of osteophytes, disc space narrowing and vertebral body sclerosis. The findings were graded 0 to 3 and analyzed statistically for a correlation with the BMD and fractured vertebrae. RESULTS: Acute compression fractures comprised of 15 cases and the most common site of acute fractures with old fractures was lumbar spine (L1; 30 cases, 45.4%). The average of BMI was 23.32 and BMD (T-score) was -4.47. Pearson's rho showed a positive association between the weight, height and the BMD (P < 0.01). In terms of the BMD versus spondylosis, there was a positive association with high score in the high order cortical bone. Compression fractures occurrence rate in the absent and present of spondylosis was 74.3% and 22.4%, and 69% occur in the spinal segmental with no bony spur with chi-square test (P < 0.01). CONCLUSION: In the present of spondylosis was high score of cortical BMD and low rate of compression fracture. Spondylosis could be one of a factor of the occurrence in acute and adjacent compression fracture after old fractures.
Body Mass Index ; Bone Density ; Fractures, Compression ; Humans ; Osteoarthritis, Spine ; Osteophyte ; Sclerosis ; Spine ; Spondylosis

OBJECTIVE: The purpose of this study was to evaluate the validity of the 3-dimensional (3D) superimposition method of digital models in patients who received treatment with rapid maxillary expansion (RME) and maxillary protraction headgear. METHODS: The material consisted of pre- and post-treatment maxillary dental casts and lateral cephalograms of 30 patients, who underwent RME and maxillary protraction headgear treatment. Digital models were superimposed using the palate as a reference area. The movement of the maxillary central incisor and the first molar was measured on superimposed cephalograms and 3D digital models. To determine whether any difference existed between the 2 measuring techniques, intra-class correlation (ICC) and Bland-Altman plots were analyzed. RESULTS: The measurements on the 3D digital models and cephalograms showed a very high correlation in the antero-posterior direction (ICC, 0.956 for central incisor and 0.941 for first molar) and a moderate correlation in the vertical direction (ICC, 0.748 for central incisor and 0.717 for first molar). CONCLUSIONS: The 3D model superimposition method using the palate as a reference area is as clinically reliable for assessing antero-posterior tooth movement as cephalometric superimposition, even in cases treated with orthopedic appliances, such as RME and maxillary protraction headgear.
Humans ; Incisor ; Molar ; Orthopedics ; Palatal Expansion Technique ; Palate ; Tooth Movement

From October, 1984 to December, 1988, 1177 cases of posterior chamber lens were implanted. Clinical study was done on 1030 cases which could be followed up for more than 2 months. The results were as follows: 1. The best corrected visual acuity of 0.5 or better was in 981 cases(95.2%) and 1.0 or better was in 676 cases(65.6%). 2. the best corrected visual acuity was achieved with the correction of average -1.07 +/- 1.28D by spherical equivalent. 3. The postoperative astigmatism was average 1.57 +/- 1.70D. 4. The difference between the calculated prediction of postoperative refraction and the actual postoperative refraction was less than 1.00D in 64.1% and calculated prediction tended to be biased toward hypermetropia with mean error of 0.37 +/- 1.21D.
Astigmatism ; Bias (Epidemiology) ; Hyperopia ; Visual Acuity

The risk of deep vein thrombosis (DVT) is well studied for some orthopedic surgery. However, the incidence of postoperative DVT is less well-defined in patients who have spinal surgery. In addition, there is insufficient evidence to suggest that screening patients before spinal surgery and to use of prophylactic method such as anticoagulants, compression stockings, and pneumatic compression device. We experienced a 78-year-old female patient of DVT after fusion operation with pedicular screws in T12 osteoporotic compression fracture. As risk of DVT after major spinal surgery is fairly low, it seems reasonable to consider prophylactic management after spinal surgery in old aged patients with difficult ambulation.
Aged ; Anticoagulants ; Female ; Fractures, Compression ; Humans ; Incidence ; Mass Screening ; Orthopedics ; Stockings, Compression ; Venous Thrombosis ; Walking