1.Systemic Lupus Erythematosus with Initial Presentation of Ascites.
Ji Min CHU ; San Ha KANG ; Ji Hyun SONG ; Kyu Hyun HAN ; Sun Young SHIN ; Tae Young YANG ; Jin Jung CHOI ; Sung Pyo HONG
The Ewha Medical Journal 2014;37(2):121-125
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown etiology and is characterized by presence of variable pathogenic auto-antibodies and multiple organ involvement. Serositis is common in SLE, but peritoneal involvement is relatively rare. This is a case report of 28-year-old female who initially presented with abdominal pain and ascites. After ruling out many other possibilities such as liver cirrhosis, neoplasm, and infectious etiologies, we confirmed SLE with clinical features, serologic tests and radiological findings. To conclude, her abdominal pain and ascites were caused by lupus peritonitis. After administration of corticosteroid therapy, her symptoms fairly improved.
Abdominal Pain
;
Adult
;
Ascites*
;
Female
;
Humans
;
Liver Cirrhosis
;
Lupus Erythematosus, Systemic*
;
Peritonitis
;
Serologic Tests
;
Serositis
2.Low Serum Testosterone Concentrations in Hospitalized Men with Poorly Controlled Type 2 Diabetes.
Kyung Soo KIM ; San Ha KANG ; Moon Jong KIM ; Soo Kyung KIM ; Yoo Lee KIM ; Won Keun PARK ; Seok Won PARK ; Yong Wook CHO
Endocrinology and Metabolism 2014;29(4):574-578
Our aim was to examine whether serum testosterone concentrations are in fact low in hospitalized men with poorly controlled type 2 diabetes compared with healthy men. In this study, 79 men aged 40 years or older (41 healthy men and 38 men with type 2 diabetes) were included. Total testosterone and sex hormone-binding globulin levels were measured. The average duration of diagnosed diabetes was 10.8 years and the mean glycated hemoglobin value was 10.8%. Total testosterone concentrations were lower in men with type 2 diabetes than in healthy men, after adjusting for age and body mass index (3.83+/-0.32 ng/mL vs. 5.63+/-0.31 ng/mL, P<0.001). In conclusion, this study shows that serum testosterone concentrations are lower in hospitalized men with poorly controlled type 2 diabetes than in healthy men. Therefore, men with poorly controlled type 2 diabetes should undergo further assessment for hypogonadism.
Body Mass Index
;
Diabetes Mellitus, Type 2
;
Hemoglobin A, Glycosylated
;
Humans
;
Hypogonadism
;
Male
;
Sex Hormone-Binding Globulin
;
Testosterone*
3.Splenic Infarction as the Initial Manifestation of Antiphospholipid Syndrome in a Systemic Lupus Erythematosus Patient.
Hye Yun JEONG ; San Ha KANG ; Ji Hyun SONG ; Sun Young SHIN ; Daniel MIN ; Kyu Hyun HAN ; Jin Jung CHOI
Korean Journal of Medicine 2014;86(5):651-654
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. In patients with SLE, the prevalence of antiphospholipid antibodies is considerably higher, and is largely responsible for thrombosis. Splenic infarction is a rare complication of arterial thrombosis in patients with SLE. It is important to consider splenic infarction in a patient with SLE complaining of left upper quadrant (LUQ) pain because of the possibility of severe infarction-related complications, such as subcapsular hemorrhage and splenic rupture. We report a case of solitary splenic infarction in a patient with SLE. The only symptom was LUQ pain of 3-day duration. Lupus anticoagulant activity was positive and abdominal-pelvic computed tomography (CT) was consistent with splenic infarction. She did not show any other evidence of thrombotic events. The patient was diagnosed with antiphospholipid syndrome that presented as a splenic infarction in a SLE patient.
Antibodies, Antiphospholipid
;
Antiphospholipid Syndrome*
;
Autoimmune Diseases
;
Hemorrhage
;
Humans
;
Lupus Coagulation Inhibitor
;
Lupus Erythematosus, Systemic*
;
Prevalence
;
Splenic Infarction*
;
Splenic Rupture
;
Thrombosis
4.A Case of Catamenial Hemoptysis Treated by Bronchial Artery Embolization.
Suk Pyo SHIN ; Chi Young PARK ; Ji Hyun SONG ; Hong Min KIM ; Daniel MIN ; Sang Hwan LEE ; San Ha KANG ; Gyeong Sik JEON ; Ji Hyun LEE
Tuberculosis and Respiratory Diseases 2014;76(5):233-236
Catamenial hemoptysis is a rare condition, characterized by recurrent hemoptysis associated with the presence of intrapulmonary or endobronchial endometrial tissue. Therapeutic strategies proposed for intrapulmonary endometriosis with catamenial hemoptysis consist of medical treatments and surgery. Bronchial artery embolization is a well-established modality in the management of massive or recurrent hemoptysis, but has seldom been used for the treatment of catamenial hemoptysis. We report a case of catamenial hemoptysis associated with pulmonary parenchymal endometriosis, which was successfully treated by a bronchial artery embolization.
Bronchial Arteries*
;
Embolization, Therapeutic
;
Endometriosis
;
Female
;
Hemoptysis*
5.A Case of Sjogren's Syndrome Associated with Common Variable Immunodeficiency.
San Ha KANG ; Hye Jeong CHO ; Hee Jin HONG ; So Dam HONG ; Bo Hye KIM ; Sang Yoon JUNG ; Jin Jung CHOI
Korean Journal of Medicine 2015;89(2):254-258
Common variable immunodeficiency (CVID) is a heterogeneous group of primary immune deficiencies in adults characterized by hypogammaglobulinemia, recurrent bacterial infections, and a higher incidence of autoimmune diseases. More than 25% of CVID patients also have autoimmune diseases such as autoimmune hemolytic anemia, immune thrombocytopenic purpura, rheumatoid arthritis, and systemic lupus erythematosus. However, the pathogenesis of autoimmunity in CVID remains obscure. We report a 56-year-old woman with CVID and Sjogren's syndrome. In addition to a long history of recurrent upper respiratory infections, acute gastroenteritis, and cellulitis, she has also suffered from persistent xerostomia and xerophthalmia for the past 10 years. Serologic studies revealed hypogammaglobulinemia (low levels of IgG, IgA, and IgM in serum) and the presence of anti-Ro antibodies, and salivary scintigraphy indicated salivary gland involvement. These findings led to a diagnosis of CVID and Sjogren's syndrome, which was treated by monthly intravenous immunoglobulin therapy.
Adult
;
Agammaglobulinemia
;
Anemia, Hemolytic, Autoimmune
;
Antibodies
;
Arthritis, Rheumatoid
;
Autoimmune Diseases
;
Autoimmunity
;
Bacterial Infections
;
Cellulitis
;
Common Variable Immunodeficiency*
;
Diagnosis
;
Female
;
Gastroenteritis
;
Humans
;
Immunization, Passive
;
Immunoglobulin A
;
Immunoglobulin G
;
Immunoglobulin M
;
Incidence
;
Lupus Erythematosus, Systemic
;
Middle Aged
;
Purpura, Thrombocytopenic, Idiopathic
;
Radionuclide Imaging
;
Respiratory Tract Infections
;
Salivary Glands
;
Sjogren's Syndrome*
;
Xerophthalmia
;
Xerostomia
6.A clinical study on the care of oral complications in the admission patients with major malignant tumors
Jong Bae KIM ; Ki Young NAM ; Won Gyun CHUNG ; Hie Jin NOH ; Sun Ok JANG ; Jae Ha YOO ; Sang Kwon HAN ; Goon Chull KANG ; Ji Young HA ; Jae Hyung CHUNG ; Byung Wook KIM
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 2004;26(1):53-60
San Medical Center, Wonju Christian Hospital and Il San Health Insurance Hospital, from Jan. 1, 2000, to Dec. 31, 2002. The malignant tumor of lung and bronchus was the most frequent incidence and the tumor of stomach, liver and biliary tract, rectum and colon were next in order of frequency. But, there was the most frequent dental consultation in the malignant tumor of head and neck, owing to the many oral diseases. Male prediction (69.7%) was existed in the admission patients with major malignant tumors and oral diseases. The most common age group of the admission patients with the malignant tumors and oral diseases was the sixty decade(29.8%), followed by the fifty, forty & seventy decade in order. In the content of chief complaints on the admission patients with major malignant tumors and oral complications, peak incidence was occurred as toothache (33.2%), followed by mucosal pain, mastication difficulty, dental extraction, oral bleeding in order. In the diagnosis group of oral complications in the patients with the malignant tumors, periodontitis, pulpitis, mucositis and xerostomia were more common. In the treatment group of oral complications in the patients, the most frequent incidence(32.6%) was showed in primary endodontic drainage(pulp extirpation, occlusal reduction and canal opening drainage) and followed by incision and drainage, scaling, medications & oral hygiene instruction, continuous oral dressing in order.]]>
Bandages
;
Biliary Tract
;
Bronchi
;
Colon
;
Diagnosis
;
Drainage
;
Gangwon-do
;
Head
;
Hemorrhage
;
Humans
;
Incidence
;
Insurance, Health
;
Liver
;
Lung
;
Male
;
Mastication
;
Mucositis
;
Neck
;
Oral Hygiene
;
Periodontitis
;
Pulpitis
;
Rectum
;
Retrospective Studies
;
Stomach
;
Toothache
;
Xerostomia
7.Clinical, Radiological and Pathological Exploration of Focal Nodular Hyperplasia of Liver Reported in Korea.
Ha Yan KANG ; Sung Soo LA ; Jae Hwan KONG ; Sang Seok LEE ; Doo San BAEK ; Sang Soo LIM ; Ki Chul SHIN ; Hyun Duk SHIN ; Se Young YUN ; Suk Bae KIM ; Jeong Eun SHIN ; Hong Ja KIM ; Il Han SONG
The Korean Journal of Gastroenterology 2008;52(6):376-383
BACKGROUND/AIMS: Focal nodular hyperplasia (FNH) is mandatory to be differentiated from other hepatic tumorous conditions such as hepatocellular carcinoma and adenoma. The purpose of this study was to explore the clinical, radiological and pathological features of FNH cases reported in Korea. METHODS: We have searched the journals from the web site "http://koreamed.org" using keywords "focal nodular hyperplasia" and "liver" - total of 38 cases of FNH, 37 cases from 17 published articles and one case from our experience confirmed histologically, were reviewed and analyzed. RESULTS: Thirty eight cases were diagnosed between gestational age of 36 weeks and 67 years. Seventeen female patients (45%) had no history of taking oral contraceptives. Twenty cases (52.6%) experienced clinical symptoms such as abdominal pain and palpable mass. Computed tomography revealed contrast-enhancement in 34 nodules (85%) and typical central stellate scar in 9 (22.5%) of 40 nodules. Magnetic resonance imaging showed T1 weighted low signal in 18 (60%) and T2 weighted high signal in 22 (73.3%) of 30 nodules. Six (60%) of 10 cases showed hypervascular staining on hepatic angiography. Among 38 cases, 32 (84.2%) cases had single nodule and their mean size was 3.9 cm (0.5-16 cm). Pathologically, fibrous septa, proliferation of bile ductules and arterial wall thickening were seen in most cases. CONCLUSIONS: Of all the FNH cases reported in Korea, there were some differences in clinical aspects of sex ratio, accompanying clinical symptoms, and relationship with oral contraceptives, compared with previous reports. Further prospective studies are needed by means of nation-wide clinical survey and analysis.
Adolescent
;
Adult
;
Aged
;
Child
;
Contraceptives, Oral
;
Female
;
Focal Nodular Hyperplasia/*diagnosis/pathology/radiography
;
Humans
;
Korea
;
Male
;
Middle Aged
;
Sex Factors
;
Tomography, X-Ray Computed
8.The Usefulness of 18 F-FDG PET to Differentiate Subtypes of Dementia:The Systematic Review and Meta-Analysis
Seunghee NA ; Dong Woo KANG ; Geon Ha KIM ; Ko Woon KIM ; Yeshin KIM ; Hee-Jin KIM ; Kee Hyung PARK ; Young Ho PARK ; Gihwan BYEON ; Jeewon SUH ; Joon Hyun SHIN ; YongSoo SHIM ; YoungSoon YANG ; Yoo Hyun UM ; Seong-il OH ; Sheng-Min WANG ; Bora YOON ; Hai-Jeon YOON ; Sun Min LEE ; Juyoun LEE ; Jin San LEE ; Hak Young RHEE ; Jae-Sung LIM ; Young Hee JUNG ; Juhee CHIN ; Yun Jeong HONG ; Hyemin JANG ; Hongyoon CHOI ; Miyoung CHOI ; Jae-Won JANG ; On behalf of Korean Dementia Association
Dementia and Neurocognitive Disorders 2024;23(1):54-66
Background:
and Purpose: Dementia subtypes, including Alzheimer’s dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of 18 F-Fluorodeoxyglucose Positron Emission Tomography ( 18 F-FDG PET) in differentiating these subtypes for precise treatment and management.
Methods:
A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of 18 F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the goldstandard clinical diagnosis for dementia subtypes.
Results:
From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88–0.98) and specificity was 0.84 (95% CI, 0.70–0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70–0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80–0.91) and the specificity was 0.88 (95% CI, 0.80–0.91). The studies mostly used case-control designs with visual and quantitative assessments.
Conclusions
18 F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.
9.Effects of Banxia Xiexin Decoction () on Cisplatin-Induced Apoptosis of Human A549 Lung Cancer Cells.
Ha-Rim KIM ; Guem-San LEE ; Mi-Seong KIM ; Do-Gon RYU ; Hong-Seob SO ; Hyoung-Chul MOON ; Young-Rae LEE ; Sei-Hoon YANG ; Kang-Beom KWON
Chinese journal of integrative medicine 2018;24(6):436-441
OBJECTIVETo examinie the synergistic effects of Banxia Xiexin Decoction (, Known as Banhasasim-tang in Korean) extract (BXDE) on cisplatin-induced cytotoxicity in the A549 human lung cancer cell lines.
METHODSA549 cells were treated with varying concentrations (50-200 μg/mL) of cisplatin and BXDE alone or in combination for 96 h. We used 1-(4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan assay and flow cytometry to analyze cell viability and apoptosis, respectively.
RESULTSThe exposure of cells to cisplatin and BXDE alone or in combination decreased cell viability dose- and time-dependently (P<0.05), which was found to be mediated by the apoptotic pathway as confirmed by the increase in the annexin V/propidium iodide- stained cell population and a ladder pattern of discontinuous DNA fragments. Furthermore, the apoptosis was inhibited by the pan-caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (z-VAD-FMK).
CONCLUSIONSBXDE significantly potentiated apoptotic effects of cisplatin in A549 cells. Moreover, apoptosis induced by BXDE might be the pivotal mechanism mediating its chemopreventative action against cancer.
A549 Cells ; Apoptosis ; drug effects ; Apoptosis Regulatory Proteins ; metabolism ; Caspase Inhibitors ; pharmacology ; Cisplatin ; pharmacology ; DNA Fragmentation ; drug effects ; Humans ; Plant Extracts ; pharmacology