The porphyrias are inherited or acquired disorders of specific enzymes in the heme biosynthetic pathway. Porphyrias have diverse neurologic manifestations with unknown mechanism. Some authors have proposed ischemic vasculopathy as a cause of neurologic deficits, which was supported by reversible MRI lesions in porphyrias. We report a rare case with reversible MRI findings in porphyria. A 27-year-old woman was presented with seizures and hallucinations. MRI revealed multiple lesions of both hemispheres. After treatment, MRI lesions showed marked resolution of signal abnormalities.
Adult ; Biosynthetic Pathways ; Female ; Hallucinations ; Heme ; Humans ; Magnetic Resonance Imaging* ; Neurologic Manifestations ; Porphyrias* ; Seizures