1.Age‑related changes in hematological and biochemical profiles of Wistar rats
Suresh PATEL ; Satish PATEL ; Ashvin KOTADIYA ; Samir PATEL ; Bhavesh SHRIMALI ; Nikita JOSHI ; Tushar PATEL ; Harshida TRIVEDI ; Jitendra PATEL ; Amit JOHARAPURKAR ; Mukul JAIN
Laboratory Animal Research 2024;40(1):84-95
Background:
Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research.Hematological and biochemical laboratory data are essential for evaluating specific variations in the physiological and functional profile of a laboratory animal. Establishing hematological and biochemical reference values for Wistar (han) rats at various age intervals was the goal of this work. Male and female Wistar rats (n = 660) of ages 6–8 weeks, 10–14 weeks and > 6 months were used in the experiment. Blood and serum were collected from these rats under fasting conditions.
Results:
We observed that the majority of hematological and biochemical parameters were significantly influenced by sex and age. Hematological changes were significantly correlated to aging were increased red blood cells, hemoglobin, hematocrit, neutrophils, monocytes and eosinophils in both sexes, as well as decreased platelet, mean corpuscular volume, mean corpuscular hemoglobin and lymphocytes in both sexes. White blood cells of male rats were considerably higher than those of female rats in all age ranges. For biochemistry, increase in glucose, total protein and creatinine were seen in both sexes, along with increases in urea in females and alanine aminotransferase in males.Age was significantly associated with decreased alkaline phosphatase in both sexes.
Conclusions
When using Wistar rats as a model, these reference values may be useful in evaluating the results.
2.Erratum: Serum bilirubin as a prognostic marker in patients with acute decompensated heart failure.
Jayakrishna CHINTANABOINA ; Matthew S HANER ; Arjinder SETHI ; Nimesh PATEL ; Walid TANYOUS ; Alexander LALOS ; Samir PANCHOLY
The Korean Journal of Internal Medicine 2013;28(4):513-513
There is a spelling mistake of an author's name, and they want to change to Samir Pancholy from Sameer Pancholy.
3.MEDICLOUD: a holistic study on the digital evolution of medical data
Astha Modi ; Nandish Bhayani ; Samir Patel ; Manan Shah
Digital Chinese Medicine 2022;5(2):112-122
The Corona Virus Disease 2019 (COVID-19) pandemic has taught us many valuable lessons regarding the importance of our physical and mental health. Even with so many technological advancements, we still lag in developing a system that can fully digitalize the medical data of each individual and make it readily accessible for both the patient and health worker at any point in time. Moreover, there are also no ways for the government to identify the legitimacy of a particular clinic. This study merges modern technology with traditional approaches, thereby highlighting a scenario where artificial intelligence (AI) merges with traditional Chinese medicine (TCM), proposing a way to advance the conventional approaches. The main objective of our research is to provide a one-stop platform for the government, doctors, nurses, and patients to access their data effortlessly. The proposed portal will also check the doctors’ authenticity. Data is one of the most critical assets of an organization, so a breach of data can risk users' lives. Data security is of primary importance and must be prioritized. The proposed methodology is based on cloud computing technology which assures the security of the data and avoids any kind of breach. The study also accounts for the difficulties encountered in creating such an infrastructure in the cloud and overcomes the hurdles faced during the project, keeping enough room for possible future innovations. To summarize, this study focuses on the digitalization of medical data and suggests some possible ways to achieve it. Moreover, it also focuses on some related aspects like security and potential digitalization difficulties.