Objective To investigate the protective effect of Thymus vulgaris (T. vulgaris) leaves 70% alcoholic extract against alcohol-mediate hepatotoxicity rats. Methods The protective effect of T. vulgaris extract was investigated at dose of 500 mg/kg/day (as 0.1 of LD

Objective To evaluate in-vitro antioxidant, anti-inflammatory and antitumor abilities against human breast adenocarcinoma (MCF7) and human prostate cancer (PC3) as well as the suppressor effect of bacterial exopolysaccharide (BAEPS) on Ehrlich ascites carcinoma (EAC). Methods In-vitro antioxidants characters of BAEPS were determined using various methods, while anti-inflammatory activity was estimated against cyclooxygenase (COX-1 and COX-2). In-vitro study, anticancer against MCF7 and PC3 were assessed by the mitochondrial dependent reduction of yellow MTT. In in-vivo study against EAC progression, mice were inoculated with EAC cells and then were orally administered BAEPS at 200 mg/kg after 24 h (equals to 0.10 of determined LD

Objective: To investigate the antioxidant capacity of aqueous extract from Cordia dichotoma (C. dichotoma) fruits in-vitro and their effect on nutritional parameters in rats fed on high-fat diet. Methods: In-vitro antioxidant capacity of C. dichotoma extract were evaluated and compared to two standard materials, ascorbic acid and butylated hydroxytoluene. Metabolic experiments were set out using rats fed on high-fat diet. The extract was tested with two dosages: 0.5 and 1.0 g/kg body weight/ day for four weeks. Lipid constituents of diet and faeces and lipid profile of serum and liver were determined. Results: The administration of the C. dichotoma extract with two dosages caused a significant improvement in the lipid metabolism of rats, compared to the hyperlipidemic control which showed significant disturbance in lipid profile. C. dichotoma extract reduced total body weight gain and total feed intake, and enhanced the fresh and dry weight of faecal excretion. The superior effect was recorded with the high dosage of extract. C. dichotoma minimized fat and cholesterol intake significantly and maximized those in faecal excretions in comparison with hyperlipidemic control values, and low dosage was better than the high one. C. dichotoma extract at two dosages normalized the lipid profile of the serum and liver compared with hyperlipidemic control. Conclusions: The protective effect of C. dichotoma extract against hyperlipidemia may be attributed to the reduced ability of an animal to ingest and absorb fat and cholesterol, and enhanced ability to get rid of them in faecal excretion.