1.A case of leiomyosarcoma of ovary.
Jeon Ju LIM ; Sam Youl PARK ; Sung Rak SON ; Jung Kun KIM ; Hwan Ju CHOI
Korean Journal of Obstetrics and Gynecology 1993;36(7):1615-1619
No abstract available.
Female
;
Leiomyosarcoma*
;
Ovary*
2.A case of recurrent advanced germ cell tumor.
Tae Sik MOON ; Sam Yuel PARK ; Jeon Ju LIM ; Sung Rak SON ; Jung Gun KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):3221-3225
No abstract available.
Germ Cells*
;
Neoplasms, Germ Cell and Embryonal*
3.The Variation of Position of the Conus Medullaris in Korean Adults - A Magnetic Resonance Imaging Study -.
Sung Pil JOO ; Soo Han KIM ; Jung Kil LEE ; Tae Sun KIM ; Shin JUNG ; Sam Suk KANG ; Je Hyuk LEE
Journal of Korean Neurosurgical Society 2001;30(4):451-455
OBJECTIVES: There have been several studies documenting the changing level of the conus throughout infancy and childhood, but there is only a little detailed study that documents the range of conus positions in a living adult population, especially in Korean, without spinal deformity. METHODS: we made a sequential study of magnetic resonance images of the lumbar spine to determine the variation in position of the conus medullaris in 650 living korean adults population without spinal deformity who checked MRI to identify the cause of low back pain. The study population consisted of patients over the age of 16 years. A T1-weighted, midline, sagittal image was reviewed for identifying the postion of conus. This location was recorded in relation to the upper, middle, or lower third of the adjacent vertebral body or the adjacent intervertebral disc. RESULTS: The study group consisted of 305 men(47%) and 345 women(53%) with a mean age 45.9 years(range, 16-79 years). The conus existed commonly at the middle third of L1(131cases, 20.2%), at the L1-2 intervertebral space(129cases, 19.8%), and the lower third of L1(123cases, 18.9%). The mean position of conus was the lower third of L1(range, middle third of T12 to middle third of L3). Conclusions:The mean position of conus was at the lower third of L1(range, middle third of T12 to middle third of L3). This results was same as that of foreign study. Our results of living korean adult population could allow for safe clinical procedures such as lumbar puncture, spinal anesthesia, and help to explain the differences among observed neurologic injuries from fracture-dislocation at the thoracolumbar junction.
Adult*
;
Anesthesia, Spinal
;
Congenital Abnormalities
;
Conus Snail*
;
Humans
;
Intervertebral Disc
;
Low Back Pain
;
Magnetic Resonance Imaging*
;
Spinal Puncture
;
Spine
4.Clinical effect of ifosfamide based regimens for the management of recurrent or persistent gynecologic malignancy.
Ki Sung KIM ; Kyung Tae KIM ; Sam Hyun CHO ; Jung Bae YOO ; Yoon Young HWANG ; Hyung MOON ; Jae Uk LEE
Journal of the Korean Cancer Association 1993;25(5):687-695
No abstract available.
Ifosfamide*
5.The Expression and Correlation of Cyclin E, P21WAF1Protein and P53 Variant Protein in Colorectal Adenoma and Carcinoma.
Jong Woo KIM ; Hee Jung AHN ; Sung Woo CHOI ; Dae Ho AHN ; Jae Sam CHUNG ; Kyung Po LEE
Journal of the Korean Society of Coloproctology 1998;14(1):51-58
Cyclins are proteins that activate different cyclin-dependent kinases(CDKs) and promote the cell cycles. Their correlations with several human cancers have been identified. Cyclin E, as one of G1 cylins, produces DNA replication through the progression of cell cycle G1 --> S phase. In contrast, cyclin-dependent kinase inhibitors(CDKI) bound with cyclin E-cdk2 complex control the cell cycle and inhibit the cell proliferation. P21(WAF1) proteins, which are CDKIs, are transcripted by a p53 gene and participate in the cell cycle inhibition. Variant p53 proteins produced by a mutated p53 gene lose the ability to control of the cell cycle resulting in cell proliferation. This study is aimed to reveal the expressions of cyclin E, p21(WAF1) protein, p53 variant protein in colorectal adenomas and carcinomas, and also reveal their correlations in the process of carcinogenesis. Twenty-one colorectal adenomas or adenomatous polyps, and thirty colorectal carcinoma tissues were obtained by operative resections or endoscopic polypectomies. Immuno histochemical stains of the above-mentioned three proteins and a statistical analysis of their correlations were made. The results were as follows: 1. P21 proteins were expressed in the upper-one third layer of all normal colonic mucosa, but cyclin E and variant p53 protein were not identified. 2. Cyclin E was expressed in 23.8% of adenomas and 76.7% of carcinomas. Variant p53 protein was expressed in 71.4% of adenomas and 83.3% in carcinomas. The degree of positivity of variant p53 expression was correlated with cancer staging. P21 protein was expressed in all adenomas, similar to normal mucosa, but was not expressed in 43.3% of carcinomas. 3. Expression of cyclin E was increased as to the positivity of variant p53 proteins but the correlations of p21 proteins and cyclin E, and p21 proteins and variant p53 proteins were not identified. Cancer staging was not correlated with the expressions of the three proteins. In conclusion, it can be thought that the overexpression of cyclin E and variant p53 proteins, and the loss of p21 proteins are related with the colorectal carcinogenesis. We can also identify the relationship of cyclin E and variant p53 proteins.
Adenoma*
;
Adenomatous Polyps
;
Carcinogenesis
;
Cell Cycle
;
Cell Proliferation
;
Colon
;
Colorectal Neoplasms
;
Coloring Agents
;
Cyclin E*
;
Cyclins*
;
DNA Replication
;
Genes, p53
;
Humans
;
Mucous Membrane
;
Neoplasm Staging
;
Phosphotransferases
;
S Phase
6.A Case of Acute Aortic Dissection with Dynamic ST Changes in Electrocardiogram.
Chung Mee YOUK ; Namho LEE ; Soo Hyun PARK ; Sam KIM ; Sung Won JUNG ; Jee Soo KIM ; Dae Gyun PARK
Korean Circulation Journal 2001;31(2):251-255
Acute aortic dissection is the most common catastrophic illness of the aorta. Left untreated, about 75% of patients with dissections involving the ascending aorta die within 2 weeks of an acute episode, but survival may be significantly improved by the timely institution of diagnostic modalities and appropriate medical and surgical therapy. But, approximately 10-20% of patients with acute aortic dissection present with a clinical picture of acute myocardial infarction. This sometimes can not only delay the diagnosis and adequate treatment of acute aortic dissection but also inappropriately treat with thrombolytic agents and anticoagulants which result in rapid deterioration of clinical condition of patient. We report a case of acute aortic dissection with dynamic ST changes in electrocardiogram which resulted in delay of accurate diagnosis and adequate treatment of acute aortic dissection.
Anticoagulants
;
Aorta
;
Catastrophic Illness
;
Diagnosis
;
Electrocardiography*
;
Fibrinolytic Agents
;
Humans
;
Myocardial Infarction
7.Recurrent Pulmonary Thromboembolism Treated with Urokinase.
Kyung Chang PARK ; Jee Soo KIM ; Sam KIM ; Chung Mi YOUK ; Sung Won JUNG ; Nam Ho LEE ; Dae Gyun PARK
Korean Circulation Journal 2000;30(10):1285-1290
The symptoms and signs of acute pulmonary arteries thrombosis are nonspecific. So clinical suspicion is the most important in the diagnosis. Treatment of pulmonary thromboembolism include anticoagulant, thrombolytic agent, or surgical intervention. We experienced a case of recurrent pulmonary thromboembolism without coagulation defect and any risk factor except old age and obese. Initially we treated with heparin, but clinical symptoms were aggravated. After we changed to urokinase (total 330 million IU/2 days), the pulmonary arteries obstruction were resolved and clinical symptoms were improved without any complications. So we report this clinical experience with review of articles.
Diagnosis
;
Heparin
;
Pulmonary Artery
;
Pulmonary Embolism*
;
Risk Factors
;
Thrombosis
;
Urokinase-Type Plasminogen Activator*
8.A Case of Erythrodermic Form of Mycosis Fungoides.
Moo Kyu SUH ; Yeol Oh SUNG ; Ki Seong YOON ; Kyoung Yim HA ; Jung Ran KIM ; Yeon Hee OH ; Sam KWON
Korean Journal of Dermatology 1998;36(1):111-115
We report a case of an erythrodermic form of mycosis fungoides in a 68-year-old male, who showed generalized erythroderma with scales for 3 months. Lymphadenopathies in the inguinal and neck areas were present. Histopathological findings showed epidermotropism, perivascular atypical lymphocyte infilteration in the upper dermis, and dermatopathic lymphadenopathy in the inguinal lymph node. T cell markers were positively stained in the immunohistochemical study. These clinicopathological features were consistent with an erythrodermic form of mycosis fungoides(TNM IIl). The patient was treated with PUVA therapy and low dose chemotherapy.
Aged
;
Dermatitis, Exfoliative
;
Dermis
;
Drug Therapy
;
Humans
;
Lymph Nodes
;
Lymphatic Diseases
;
Lymphocytes
;
Male
;
Mycosis Fungoides*
;
Neck
;
PUVA Therapy
;
Weights and Measures
9.Stenting of Symptomatic Middle Cerebral Artery Stenosis: Case Report.
Pyoung JEON ; Yong Sam SHIN ; Sung Ryoung LIM ; Sun Jung KIM
Korean Journal of Cerebrovascular Disease 2002;4(2):155-158
Percutaneous balloon angioplasty has been reported to be useful in the treatment of intracranial atherosclerotic arterial stenosis. However, arterial dissection with increased risk of acute closure and stroke has limited its widespread implementation. Stenting of the intracranial vasculature recently has been shown to be feasible in a variety of circumstance. However, stenting of middle cerebral artery has been limited because of difficulty with tracking stents across the carotid siphon. We report a case of successful percutaneous stenting of a symptomatic middle cerebral artery stenosis using a balloon-expandible flexible coronary stent.
Angioplasty
;
Angioplasty, Balloon
;
Constriction, Pathologic*
;
Middle Cerebral Artery*
;
Stents*
;
Stroke
10.Clinicopathologic Characteristics of Mucinous Gastric Adenocarcinoma.
Sung Joon KWON ; Jae Jung PARK ; Seung Sam PAIK
Journal of the Korean Surgical Society 2004;66(6):472-477
PURPOSE: Clinicopathological characteristics of mucinous gastric adenocarcinomas (MGC) are unclear. Also, whether the surgical results of a MGC are unfavorable is still controversial. A tumor is defined as a MGC when more than 30% of the tumor area has mucin pools. Also, MGC are subdivided into the well-differentiated (WD) and poorly differentiated (PD) types, according to the degree of glandular formation of the tumor cells. To clarify the significance of MGC, the clinicopathological profiles and prognoses of patients were studied. METHODS: Thirty-four patients with MGC and 1, 036 with non-mucinous gastric adenocarcinomas (NMGC) who were operated on between 1992 and 2002 at the Department of Surgery, Hanyang University Hospital, were included. Patients were evaluated with regard to age, gender, tumor location, size, depth of wall invasion, lymph node status, distant metastasis, stage at presentation, lymphatic and vascular permeation, operative curability, and preoperative serum levels of CEA and CA19-9. RESULTS: MGC tumors, compared with NMGC tumors, had larger sizes (8.0 vs. 5.9 cm), more frequent incidences of T2 or more invasion (91 vs. 66%), positive lymph node metastasis (85 vs. 57%), distant metastasis (18 vs. 6%), stage III and IV (74 vs. 45%), noncurative surgery (32 vs. 10%), lymphatic permeation (88 vs. 63%), and abnormal serum CEA level (32 vs. 14%). However, the overall survival rate of those patients with a MGC was not significantly different from that of those with a NMGC. With a MGC, there was no significant correlation between the degree of mucin content and the prognosis. Conversely, the survival rate was higher in the WD than in the PD types (100 vs. 45%, P=0.0185). CONCLUSION: The mucinous histological type itself is of no prognostic significance in patients with gastric carcinomas. The biological behavior of MGC is determined by the degree of glandular formation of the tumor cellss (i.e., histologic differentiation).
Adenocarcinoma*
;
Humans
;
Incidence
;
Lymph Nodes
;
Mucins*
;
Neoplasm Metastasis
;
Prognosis
;
Stomach Neoplasms
;
Survival Rate