2.Significance of chromogranin-A expression in the bile duct cancer.
Sun Whe KIM ; Woo Ho KIM ; Sam Je CHO ; Yong Hyun PARK
Journal of the Korean Cancer Association 1993;25(4):501-506
No abstract available.
Bile Duct Neoplasms*
;
Bile Ducts*
;
Bile*
3.A Study of Middle-Aged Women's Health Beliefs and Their Intention to Practice Health Behaviors to Prevent and Improve Hypertension.
Journal of Korean Academy of Adult Nursing 2007;19(1):109-120
PURPOSE: This study was conducted to investigate factors related to middle-aged women's health beliefs and their intention to practice health behaviors for preventing and improving hypertension. METHODS: The participants were 319 middle-aged(40-59 years) women who lived G city. Data was collected from January to February, 2005. Personal interviews were performed. The data was analyzed using t-test, ANOVA, Scheffe's multiple comparison test and hierarchial multiple regression analysis. RESULTS: Perceived susceptibility of health belief was high in those who had higher educational level, disease history and health education experience, significantly(p<0.05). Perceived seriousness was high in those who had higher educational level, middle economic status and health education experience, significantly(p<0.05). Perceived benefits was high in those who had higher educational level and perceived barriers was low in those who had disease history and hypertension, significantly(p<0.05). The subject's intention to practice health behaviors was significantly high in those who were younger, who had higher educational level and menopausal status(p<0.05). In hierarchial multiple regression analysis, the subject's intention was related to perceived seriousness, perceived benefit and educational level, significantly(p<0.05). CONCLUSION: It is necessary to develope the education programs which can increase the subject's health belief and intention to practice health behaviors towards hypertension in middle-aged women.
Education
;
Female
;
Health Behavior*
;
Health Education
;
Humans
;
Hypertension*
;
Intention*
;
Women's Health*
4.Pressor Effect of Intracerebroventricular Diphenhydramine and Ranitidine in Rabbits.
Han Ho CHO ; Soo Han KIM ; Sam Suk KANG ; Je Hyuk LEE ; Jung Hyun WOO
Journal of Korean Neurosurgical Society 1991;20(10-11):905-910
This study was undertaken to observe the effects of centrally administred antihistamines on the blood pressure. Diphenhydramine(DPH), a H1-receptor antagonist, and ranitidine(RAN), a H2-receptor antagonist were administered intracerebroventricularly(icv) on urethane-anesthetized rabbits. 1) Both DPH and RAN administered intraccebroventricularly increased blood pressure, however the intravenous(iv) adminstration of them did not affect blood pressure. The pressor response to icv DPH was dose-dependent, but that to icv RAN was not. 2) The pressor response to icv DPH(1mg) was either markedly attenuated or reversed to depressor response by the pretreatment with icv phentolamine(250,500ug), and iv chlorisondamine(0.1, 1mg/Kg) and iv phenoxybenzamine(1mg/Kg). In cord-sectioned rabbtis, icv RAN) 1mg) did not produce pressor response. 3) The pressor responsr to icv RAN(1mg) was not affected by the pretreatment with icv phentolamine(500ug), iv chlorisondamin(1mg/Kg) and iv phenoxybenzamine(1mg/Kg), and iv phenoxybenzamine(1mg/Kg). RAN also producted pressor response in cordsectioned rabbits. These results suggest that the pressor response to icv DPH is elecited by increasing peripheral sympathetic tone via the stimulation of central alpha-adrenoreceptors and the pressor response to icv RAN is produced by releasing some humoral facotr which can increase blood pressure.
Blood Pressure
;
Diphenhydramine*
;
Histamine Antagonists
;
Rabbits*
;
Ranitidine*
5.A Clinical Study in Patients with Membranous Obstruction of Internal Ostium and No Epiphora Who Underwent Endonasal Dacryocystorhinostomy.
Joon Sung PARK ; Tae Soo LEE ; Je Sam KIM
Journal of the Korean Ophthalmological Society 2004;45(4):533-539
PURPOSE: To investigate an extra passage of tears in patients with no epiphora and no visible ostium after endonasal dacryocystorhinostomy. METHODS: We reviewed charts of 13 patients who had undergone endonasal DCR from April 1992 to May 1999. All Patients had no epiphora and no visible internal ostium for the follow up period. Dye disappearance test, endonasal endoscopic evaluation, dacryocystogram, and primary Jones dye test were performed to evaluate whether another lacrimal passage is present or not. RESULTS: Postoperative dye disappearance tests were negative in all patients. Membranous obstruction was seen on the endoscopy in all patients. Fluorescein dye of the primary Jones dye test was undetected in corresponding areas of internal ostium near the middle turbinate in any patient, however the dye was seen at the inferior turbinate in seven eyes. Dacryocystogram showed normal lacrimal drainage in all patients. CONCLUSIONS: After the endonasal DCR, it was possible to drain the tear through normal nasolacrimal passage by reopenging the obstructed upper portions of the nasolacrimal duct.
Dacryocystorhinostomy*
;
Drainage
;
Endoscopy
;
Fluorescein
;
Follow-Up Studies
;
Humans
;
Lacrimal Apparatus Diseases*
;
Nasolacrimal Duct
;
Turbinates
6.Facial nerve palsy in a child: Bell’s palsy? Think again!
Malaysian Family Physician 2017;12(3):30-32
Introduction: Half of facial paralysis in children is idiopathic at origin. However, dismissing facialparalysis as being idiopathic without a thorough history and meticulous examination could bedisastrous as illustrated by this case.Case report: We report a case of sphenoid wing meningioma in a 4-year-old girl. She firstpresented with only facial asymmetry that was noticed by her mother. Examination suggested aleft upper motor neuron facial nerve palsy. A sphenoid wing meningioma was found on magneticresonance imaging (MRI) of her brain. She underwent craniotomy and total tumour excision.Histopathological examination of the tumour showed a grade 1 transitional type meningioma.Meningiomas in children are rare compared to the adult population. Presentations in childrenmay be delayed due to their inability to recognise or communicate abnormalities. Distinguishingbetween upper and lower motor neuron facial palsy is crucial in decision making for facial paralysisin children.
7.Studies on the Interactions of M1-, M2- Receptors with Nicotinic Receptors in Rabbit Sympathetic Ganglia.
Chun Sik RYU ; Sam Suk KANG ; Je Hyuk LEE ; Jong Keun KIM
Journal of Korean Neurosurgical Society 1994;23(11):1234-1243
Effects of a M1 receptor antagonist, pirenzepine, a M2 receptor antagonist, AF-DX116, and a nicotinic receptor antagonist, mecamylamine on the pressor responses to preganglionic sympathetic nerve stimulation(PNS) and McN-A-343 and DMPP in spinal(pithed) rabbits were investigated in order to elucidate a functional role of M1, M2 and nicotinic receptors in ganglionic transmission. Pirenzepine and AF-DX116 selectively inhibited the McN-A-343-induced pressor reponse in chlorisondamine-treated rabbit and the BCh-induced bradycardia, respectively. Electrical stimulations of preganglionic sympathetic outflow at T8 level produced increases in blood pressure. Pirenzepine(3 microgram/kg) significantly inhibited the PNS-induced pressor response and the degree of inhibition was not changed by increasing the doses to 100 microgram/kg. AF-DX116(100 microgram/kg) had no effect on the PNS-induced pressor response. Mecamylamine inhibited the PNS-induced pressor response in a dose-dependent manner. The inhibitory action of mecamylamine was significantly augmented by combined-treatment with pirenzepine(30 microgram/kg) but AF-DX116(100 microgram/kg) did not affect the inhibitory action of mecamylamine. McN-A-343 and DMPP elicited pressor response in the spinal rabbit. Pirenzepine and AF-DX116 dose-dependently inhibited the McN-A-343-induced pressor response but they did not affect DMPP-induced pressor response. Mecamylamine inhibited both pressor responses induced by Mc-N-343- and DMPP. These results suggest that not only nicotinic receptors but also M1 receptors play a facilitatory role in ganglionic transmission but M2 receptors do not contribute the transmission in spinal(pithed) rabbits.
(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride
;
Blood Pressure
;
Bradycardia
;
Dimethylphenylpiperazinium Iodide
;
Electric Stimulation
;
Ganglia, Sympathetic*
;
Ganglion Cysts
;
Mecamylamine
;
Pirenzepine
;
Rabbits
;
Receptors, Nicotinic*
8.Contractile and Inhibitory Effects of McN-A-343 and Acetylcholine on Isolated Arteries.
Gi Joong JUNG ; Sam Suk KANG ; Je Hyuk LEE ; Young Hong BAIK
Journal of Korean Neurosurgical Society 1990;19(3):406-412
Effect of acetylcholine(ACh) and McN-A-343 on porcine coronary artery and rabbit thoracic aorta were investigated in isolated preparations with or without intact endothelium. In the porcine coronary artery, ACh produced concentration dependent contraction which was greater in rings without the endothelium than in intact endothelial rings, but McN-A-343 did not alter the basel tension in both tissues. ACh relaxed contraction induced by 5-hydroxytryptamine(5-HT) in only intact endothelial rings, while NcN-A-343 inhibited the 5-HT induced tension in both preparations dose dependently. Carbachol elicited a prominent contraction in both tissues. The carbacol-induced tension was markedly inhibited by McN-A-343 in either rings with or without endothelium, while ACh contracted further the tension. ACh and McN-A-343 did not after the KCi induced tension, but clearly potentiated the contraction induced by Bay K 8644 in intact endothelial rings. In rabbit thoracic aorta, ACh elicited contraction in a concentration-dependent fashion which was potentiated by removal of endothelium, but McN-A-343 did not affect the basal tension of both rings. ACh inhibited the 5-HT-induced contraction in only intact endothelial ring, but McN-A-343 did not change the contraction of both rings. Conclusively, ACh produces endothelium-dependent relaxation in both arteries, while McN-A-343 elevated endothelium-independent inhibition to 5-HT or carbachol-induced tension.
(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride*
;
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
;
Acetylcholine*
;
Aorta, Thoracic
;
Arteries*
;
Carbachol
;
Coronary Vessels
;
Endothelium
;
Relaxation
;
Serotonin
9.Studies on the Changes of Blood Pressure and Heart Rate by Intracerebroventricular Bicuculline in Rabbits.
Jung Gil LEE ; Sam Suk KANG ; Je Hyuk LEE ; Jong Keun KIM
Journal of Korean Neurosurgical Society 1992;21(5):553-560
To elucidate the role of CNS GABA ergic system in the regulation of cardiovascular function, the effects of intracerebroventricular(icv) bicuculline(BIC), a selective GABAA antagonist, on blood pressure and heart rate were investigated in urethane anesthetized rabbits. 1) Icv BIC produced dose-dependent pressor and bradycardiac effect, while intravenous(iv) BIC had no effect on blood pressure and heart rate. 2) The pressor effect of BIC(10(g) was significantly attenuated by pretreatments with icv ketamine(5 mg) or icv diazepam(0.1 mg, 1 mg). Bilateral vagotomy and pretreatment with icv mecamylamine(0.2 mg), iv chlorisondamine(1 mg/kg), in phentolamine(1 mg/kg) did not affect the pressor action. 3) The bradycardiac effect of BIC(10(g) was abolished or reversed to slight tachycardia by bilateral vagotomy and pretreatment with icv ketamine(2.5 mg, 5 mg), icv diazepam(0.1 mg, 1 mg) and iv chlorisondamine(1 mg/kg). Neither icv mecamylamine(0.2 mg) nor iv phentolamine(1 mg/kg) affected the bradycardia. These results suggest that blockade of GABAA receptor produce pressor action which is associated with central excitatory amino acid system and produce reflex bradycardia induced by the pressor effect, and that sympathetic nervous system might not be involved in the pressor effect.
Bicuculline*
;
Blood Pressure*
;
Bradycardia
;
Excitatory Amino Acids
;
gamma-Aminobutyric Acid
;
Heart Rate*
;
Heart*
;
Rabbits*
;
Reflex
;
Sympathetic Nervous System
;
Tachycardia
;
Urethane
;
Vagotomy
10.Traumatic Epidural Hematomas of the Posterior Fossa.
Jin Ho CHO ; Sam Suk KANG ; Je Hyuk LEE ; Jung Hyun WOO
Journal of Korean Neurosurgical Society 1986;15(4):619-626
The authors represented an analysis on 10 patients with traumatic epidural hematomas of the posterior fossa who had treated successfully from January 1984 to October 1985. The result were summarized as follows ; 1) Age incidence comprised ranging from 4 to 62 years and 6 were males and 4 were females. 2) Site of hematoma was related with fracture site closely and bleeding source confirmed during operation was transverse sinus in 4 cases, occipital sinus in 1 case, fracture site in 3 cases and unknown in 2 cases and it had close relationship between fracture site and large venous sinus. 3) Outcome was good in most cases except death in 1 and moderate disability in 1 case. Factors contributing to outcome were early detection and adequate treatment and also associated supratentorial injury.
Female
;
Hematoma*
;
Hemorrhage
;
Humans
;
Incidence
;
Male
;
Skull Fractures