1.Some important aspects of the palatal pleomorphic adenoma.
Singapore medical journal 1981;22(6):358-360
3.Clear cell carcinoma of minor salivary gland--case report.
Irulandy PONNIAH ; Palani SURESHKUMAR ; Kaliappan KARUNAKARAN
Annals of the Academy of Medicine, Singapore 2007;36(10):857-860
INTRODUCTIONClear cell carcinoma is a rare low-grade carcinoma that almost exclusively occurs in the minor salivary glands. This tumour is one of the new additions in the recent World Health Organization (WHO) classification of salivary gland tumours.
CLINICAL PICTUREA 50- year-old woman presented with a gradually enlarging painless submucosal mass of 3 months' duration over the left side of the palate.
TREATMENT AND OUTCOMEA preoperative diagnosis of primary clear cell carcinoma of salivary gland with focal surface epithelial dysplasia was rendered after thorough clinical examination to rule out renal origin. The lesions were excised with wide surgical margins and 3 years into the postoperative period, the patient was disease-free.
CONCLUSIONWe report a case of clear cell carcinoma of intra-oral minor salivary gland and draw comparisons with metastatic clear cell carcinoma of renal origin.
Adenocarcinoma, Clear Cell ; pathology ; surgery ; Female ; Humans ; Middle Aged ; Salivary Gland Neoplasms ; pathology ; surgery ; Salivary Glands, Minor
4.Clinicopathological and genetic characteristics of bronchial sialadenoma papilliferum: report of four cases.
Lin LIANG ; Chun Yan WU ; Li Ping ZHANG ; Li Kun HOU ; Zheng Wei DONG ; Wei WU ; Jie Lu LIN ; Yan HUANG ; Hui Kang XIE
Chinese Journal of Pathology 2022;51(3):212-217
Objective: To investigate the clinicopathological, immunophenotypic, and molecular genetic features of bronchial sialadenoma papilliferum (BSP). Methods: Four cases of BSP collected at the Shanghai Pulmonary Hospital from May 2018 to June 2021 were retrieved and analyzed. These cases were evaluated for their clinical, histological, immunohistochemical (IHC) and genomic features. The patients were followed up and relevant literature was reviewed. Results: All four patients were male, aged from 55 to 75 years (mean 62 years), with tumor diameter of 6 to 21 mm (mean 13.5 mm), and lesions were located in the left lower lobe (n=2), right lower lobe (n=1), and trachea (n=1). They were characterized by a combination of surface exophytic endobronchial papillary proliferation and an endophytic two-cell layered ductal structure. IHC staining showed that CK7 and EMA were strongly positive in ductal epithelium; p63, p40, CK5/6 were positive in ductal and papillary basal cells; SOX10 was positive in ductal epithelium and basal cells; S-100 was positive in basal cells and ductal epithelium in two cases. Next generation sequencing showed that two cases harbored BRAF V600E mutation. Conclusions: BSP is an extremely rare primary lung tumor arising from the salivary gland under bronchial mucosa. The primary treatment choice of this tumor is complete surgical resection. The diagnosis and differential diagnosis of this tumor depend on classic histomorphologic and IHC features, and BRAF V600E gene mutation can be detected.
Aged
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China
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Epithelium/pathology*
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Neoplasms, Glandular and Epithelial/pathology*
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Salivary Gland Neoplasms/surgery*
5.Primary Polymorphous Low-Grade Adenocarcinoma of Lung Treated by Sleeve Bronchial Resection: A Case Report.
Kyu Do CHO ; Ji Han JUNG ; Deog Gon CHO ; Min Seop JO ; Jinyoung YOO ; So Hyang SONG ; Byoung Yong SHIM ; Chi Hong KIM ; Hoon Kyo KIM
Journal of Korean Medical Science 2007;22(2):373-376
We report a surgical case of primary polymorphous low-grade adenocarcinoma (PLGA) of the minor salivary gland-type of the lung. A PLGA originating from the right upper lobar bronchial inlet was successfully treated by sleeve right upper lobectomy. PLGAs are thought to be indolent tumors that are preferentially localized to the palate, and they affect the minor salivary glands almost exclusively. Until now, two cases of distant metastases to the lung have been reported in the English literature. To the best of our knowledge, only one case of PLGA of minor salivary glandtype of the lung without evidence of a previous oropharyngeal primary tumor has been reported in the English literature. But the case was not a single lesion; it was bilateral tumors accompanied by tumors of the cervical lymph nodes. We report here the first case of a single primary PLGA of the minor salivary gland-type of the lung, which was successfully treated by sleeve bronchial resection of right upper lobe.
Treatment Outcome
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Salivary Gland Neoplasms/pathology/*surgery
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Lung Neoplasms/pathology/*secondary/*surgery
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Humans
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Female
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Bronchi/*surgery
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Aged
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Adenocarcinoma/pathology/*secondary/*surgery
6.Nasal endoscope surgery of acinic cell carcinoma of salivary gland on nasal septum: a case report.
Yuanyuan TANG ; Xiuzhen SUN ; Jizhe WANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2016;30(3):249-251
A 67-year-old male patient was admitted because of "the right side nasal obstruction repeatedly for 4 years". He got nasal obstruction 4 years ago, especially for the right side nasal cavity, sometimes got blood in his nasal discharge, then the symptom relieved after accepting treatment in local hospital. During the 4 years, the symptom repeatedly occurrence. Three days before hospitalization, the CT examination indicated abnormal things in his nasal cavity and the bone of his nasal sinus had been destroyed. Some abnormal organism were sent to pathological examination, and the report indicated it is acinic cell carcinoma of salivary gland. During the nasal endoscope surgery, a red goiter was found in his nose with its surface crude and brittle. Then we cut the goiter by nasal endoscope, during the operation we find the bottom of the goiter is on the nasal septum. Two weeks after the operation, the patient received the radiation therapy. One year after the operation he doesn't get the abnormal symptom and the nasal MRI not found recidivation.
Aged
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Carcinoma, Acinar Cell
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surgery
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Endoscopy
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Humans
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Magnetic Resonance Imaging
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Male
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Nasal Cavity
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pathology
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Nasal Obstruction
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Nasal Septum
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surgery
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Nasal Surgical Procedures
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Paranasal Sinuses
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pathology
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Salivary Gland Neoplasms
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surgery
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Salivary Glands
;
pathology
7.Congenital salivary gland anlage tumor: report of a case.
Long LIN ; Hong-Feng TANG ; Yue-Feng SUN ; Wei-Zhong GU ; Hua-Ying YE
Chinese Journal of Pathology 2009;38(10):711-712
Actins
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metabolism
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Adenoma, Pleomorphic
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congenital
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Fibrosarcoma
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metabolism
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pathology
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Humans
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Infant
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Male
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Nasopharyngeal Neoplasms
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congenital
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metabolism
;
pathology
;
surgery
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Rhabdomyosarcoma
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metabolism
;
pathology
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Salivary Gland Neoplasms
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congenital
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metabolism
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pathology
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surgery
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Vimentin
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metabolism
8.Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma.
Li HAO ; Nong XIAO-LIN ; Chen QI ; Yang YI-PING ; Li JIA-QUAN ; Li YAN-NING
International Journal of Oral Science 2010;2(1):35-44
AIMTo detect the expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) in salivary adenoid cystic carcinoma (SACC) tissues, as well as to determine the correlation between growth factor expression and prognosis in SACC.
METHODOLOGYMedical records of 63 patients surgically treated for SACC between January 1988 and October 2005 were reviewed. Immunohistochemistry was performed to examine the expression of NGF and VEGF in tumor tissues. Kaplan-Meier analysis and Cox's proportional hazard regression model were applied to assess predictors of survival.
RESULTSNGF and VEGF were overexpressed in SACC tissues, compared with those in normal salivary tissues (P < 0.05), and the staining intensity of these two factors was stronger in groups of solid subtype, advanced TNM stage, perineural invasion and recurrence. Patients with high-expression of NGF and VEGF, solid subtype, advanced stage, perineural invasion, recurrence and extended resection alone had worse survival rates (P < 0.05).
CONCLUSIONNGF and VEGF are expressed increasingly in the tissues of SACC cases with invasion and metastasis. NGF expression and VEGF expression are independent
Adult ; Aged ; Carcinoma, Adenoid Cystic ; pathology ; surgery ; Cranial Nerves ; pathology ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; pathology ; Neoplasm Staging ; Nerve Growth Factor ; analysis ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Salivary Gland Neoplasms ; pathology ; surgery ; Salivary Glands ; pathology ; Salivary Glands, Minor ; pathology ; Survival Rate ; Vascular Endothelial Growth Factor A ; analysis ; Young Adult
9.Malignant mixed tumor in the salivary gland of a cat.
Heejaung KIM ; Munekazu NAKAICHI ; Kazuhito ITAMOTO ; Yasuho TAURA
Journal of Veterinary Science 2008;9(3):331-333
The presence of a malignant mixed tumor, also known as a carcinosarcoma, in the salivary gland is very rare. Such mors, which are typically aggressive, are characterized by the presence of carcinomatous and sarcomatous components. 9-year-old neutered female domestic short-haired cat presented with swelling in the right mandibular lesion that had rapidly enlarged over the previous 3 weeks. Physical examination revealed a large, fluctuated and painless subcutaneous swelling that was associated with a firm mass. Radiographs of the head revealed a soft-tissue density that involved faint circular calcific opacity. Contrast-enhanced computed tomography revealed that the peripheral capsulated cystic area had a contrast enhanced region without bone lysis. The cat received a total excision of the mass and postoperative radiotherapy. Histopathological analysis of the mass revealed that it was a malignant mixed tumor. Metastasis to the lung was discovered 7 weeks later, at which time treatment was stopped.
Adenocarcinoma/pathology/surgery/*veterinary
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Animals
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Cat Diseases/*pathology/*radiography
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Cats
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Chondrosarcoma/pathology/surgery/*veterinary
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Fatal Outcome
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Female
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Lung/pathology/radiography
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Radiography, Thoracic/veterinary
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Salivary Gland Neoplasms/pathology/radiography/*veterinary
10.Analysis of postoperative survival rates of mucoepidermoid carcinoma in salivary gland.
Chun-zhi LI ; Mo-yi SUN ; Xiao-hui ZHANG ; Xiao-long LUO ; Wen-bin SUN
Chinese Journal of Stomatology 2006;41(12):709-712
OBJECTIVEThe pathologic slides and clinical data of 119 patients with mucoepidermoid carcinoma (MEC) of salivary glands were reviewed. All patients underwent surgical therapy in Department of Oral and Maxillofacial Surgery, College of Stomatology, Fourth Military Medical University. The postoperative overall observed survival rates and specific survival rates were statistically caculated, and the correlative clinicopathologic factors influencing the prognosis were evaluated.
METHODSStatistical analysis was performed using the SPSS 10.0 software. The survival rates were obtained by the Kaplan-Meier method. The clinicopathologic parameters were evaluated using log rank test (univariate analysis) and Cox proportional hazards regression model (multivariate analysis).
RESULTSThe overall observed survival rates of this group were 92.53%, 87.52% and 85.39% at 5, 10 and 15 years respectively after surgical therapy. Univariate analysis demonstrated that the factors correlated with lower in survival rates were patient's age (> or = 40 years), advanced clinical stage (TNM III, IV stage) and the poorly differentiated tumors (P < 0.05). The survival rates of male patients with MEC in the major salivary glands were significantly lower than those of female patients (P = 0.008). The degree of differentiation, TNM stage and preoperative symptoms were three important prognostic factors that were selected into the Cox proportional hazards regression model.
CONCLUSIONSMost patients with highly differentiated MEC in salivary glands had a favorable outcome after receiving adequate surgical treatment. The degree of differentiation and the TNM stage of MEC in the salivary glands are two useful factors to evaluate the prognosis of these neoplasms.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Mucoepidermoid ; mortality ; pathology ; surgery ; Child ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Salivary Gland Neoplasms ; mortality ; pathology ; surgery ; Survival Rate ; Young Adult