1.Societal risk perception of death among workers in a security company in Malaysia.
Jefferelli SB ; Rampal KG ; Aziz AJ ; Salim MB
The Medical Journal of Malaysia 2003;58(5):653-656
How people perceive risk influences their behaviour towards these risks. We do not know how workers perceive risk of dying from diseases or accidents. This study was conducted among 198 workers of a security company in Malaysia. The workers were asked to score on a Likert scale of 1 to 5 the perceived risk of death of Malaysians from selected causes of death. The highest perceived risks of death were, in order of ranking, motor vehicle accidents, cancer and diabetes mellitus whereas according to the certified causes of death in Malaysia the highest risks of death among the selected items were cardiovascular disease, cancer and stroke. The difference in perception and mortality data needs be addressed.
*Attitude
;
*Cause of Death
;
Malaysia
;
Risk Factors
2.A case report of point-of-care ultrasound directed thrombectomy: a reversible cause of cardiac arrest managed with extracorporeal membrane oxygenation cannulation
Megan HOFFER ; Salim AZIZ ; Keith BONIFACE ; Jenna E. AZIZ ; Ali POURMAND
Clinical and Experimental Emergency Medicine 2024;11(1):100-105
Extracorporeal membrane oxygenation (ECMO) has been increasingly employed in the emergency department for patients with a potentially reversible cause of cardiac arrest. We present the case of a young female patient with an in-hospital cardiac arrest who was found to have severe right heart strain on point-of-care ultrasound (POCUS), suggesting a massive pulmonary embolism. Rapid bedside diagnosis using ultrasound expedited bedside cannulation and initiation of ECMO as a bridge to surgical thrombectomy, and ultimately the patient survived with full neurologic function. With its ready availability and increasing acceptance by consultants, POCUS should be incorporated into cardiac arrest algorithms as the standard of care to rule in thrombotic and obstructive causes of cardiac arrest.
3.A case report of point-of-care ultrasound directed thrombectomy: a reversible cause of cardiac arrest managed with extracorporeal membrane oxygenation cannulation
Megan HOFFER ; Salim AZIZ ; Keith BONIFACE ; Jenna E. AZIZ ; Ali POURMAND
Clinical and Experimental Emergency Medicine 2024;11(1):100-105
Extracorporeal membrane oxygenation (ECMO) has been increasingly employed in the emergency department for patients with a potentially reversible cause of cardiac arrest. We present the case of a young female patient with an in-hospital cardiac arrest who was found to have severe right heart strain on point-of-care ultrasound (POCUS), suggesting a massive pulmonary embolism. Rapid bedside diagnosis using ultrasound expedited bedside cannulation and initiation of ECMO as a bridge to surgical thrombectomy, and ultimately the patient survived with full neurologic function. With its ready availability and increasing acceptance by consultants, POCUS should be incorporated into cardiac arrest algorithms as the standard of care to rule in thrombotic and obstructive causes of cardiac arrest.
4.A case report of point-of-care ultrasound directed thrombectomy: a reversible cause of cardiac arrest managed with extracorporeal membrane oxygenation cannulation
Megan HOFFER ; Salim AZIZ ; Keith BONIFACE ; Jenna E. AZIZ ; Ali POURMAND
Clinical and Experimental Emergency Medicine 2024;11(1):100-105
Extracorporeal membrane oxygenation (ECMO) has been increasingly employed in the emergency department for patients with a potentially reversible cause of cardiac arrest. We present the case of a young female patient with an in-hospital cardiac arrest who was found to have severe right heart strain on point-of-care ultrasound (POCUS), suggesting a massive pulmonary embolism. Rapid bedside diagnosis using ultrasound expedited bedside cannulation and initiation of ECMO as a bridge to surgical thrombectomy, and ultimately the patient survived with full neurologic function. With its ready availability and increasing acceptance by consultants, POCUS should be incorporated into cardiac arrest algorithms as the standard of care to rule in thrombotic and obstructive causes of cardiac arrest.
5.A case report of point-of-care ultrasound directed thrombectomy: a reversible cause of cardiac arrest managed with extracorporeal membrane oxygenation cannulation
Megan HOFFER ; Salim AZIZ ; Keith BONIFACE ; Jenna E. AZIZ ; Ali POURMAND
Clinical and Experimental Emergency Medicine 2024;11(1):100-105
Extracorporeal membrane oxygenation (ECMO) has been increasingly employed in the emergency department for patients with a potentially reversible cause of cardiac arrest. We present the case of a young female patient with an in-hospital cardiac arrest who was found to have severe right heart strain on point-of-care ultrasound (POCUS), suggesting a massive pulmonary embolism. Rapid bedside diagnosis using ultrasound expedited bedside cannulation and initiation of ECMO as a bridge to surgical thrombectomy, and ultimately the patient survived with full neurologic function. With its ready availability and increasing acceptance by consultants, POCUS should be incorporated into cardiac arrest algorithms as the standard of care to rule in thrombotic and obstructive causes of cardiac arrest.
6.Anticariogenic properties of Solanum ferox L. ethanol extract
Siti Zaleha Raduan ; Khairah Nasrin Abdul Khalid ; Mark Fitchell Ak Jihek ; Sivagami Ganasan ; Umi Syazana Salim ; Muhammad Wahizul Haswan Abdul Aziz
Annals of Dentistry 2019;26(1):22-29
Solanum ferox L. is a plant species which belongs to the Solanaceae family and the genus Solanum. The
Solanum genus was found to exhibit anticariogenic activity and was traditionally used to treat oral diseases.
However, there is no scientific study done specifically for Solanum ferox L. Hence the aim of the study is to
determine the anticariogenic properties of flesh and leaf of ethanolic extract of Solanum ferox L. Alkaloids,
flavonoids and tannins were detected in the leaf ethanolic extract via preliminary phytochemical screening.
The presence of these phytochemicals may contribute to the anticariogenic activity. Treatment with different
concentrations of flesh and leaf of ethanolic extract were used against Streptococcus pyogenes and
Staphylococcus aureus via the method of agar well diffusion to indicate zones of inhibition. The antibiofilm
activity of the flesh and leaf ethanolic extracts was tested. The flesh and leaf ethanolic extracts possess
antimicrobial activity dose-dependently and positive antibiofilm activity against respective pathogens. The
flesh ethanolic extract has stronger anticariogenic activity compared to leaf ethanolic extract against
respective pathogens. Streptococcus pyogenes exhibited higher susceptibility as compared to Staphylococcus
aureus. In conclusion, it has been shown that the ethanolic extract of Solanum ferox L. exhibit anticariogenic
properties against Streptococus pyogenes and Staphylococcus aureus.
7.Synchronous Occurrence of Bilateral Malignant Otitis Externa: Report of a Rare Case
Nur Adillah LAMRY ; Khairunnisak MISRON ; Tengku Mohamed Izam TENGKU KAMALDEN ; Azliana AZIZ ; Rosdan SALIM
Korean Journal of Family Medicine 2021;42(6):483-486
Malignant otitis externa (MOE) is a rare and potentially life-threatening disease of the ear and temporal bone. Bilateral simultaneous MOE is extremely rare. Due to bilaterally symmetrical facial nerve palsy, it can easily be missed at the initial presentation, causing delay in management. Here, we report a case of bilateral MOE managed aggressively with regular ear toileting, ear packing with a ribbon gauze soaked with topical antimicrobials, and long-term intravenous and oral antibiotics. The patient showed good improvement in pain control, facial nerve status, and ear findings.
8.Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Hamza Adel SALIM ; Vivek YEDAVALLI ; Basel MUSMAR ; Nimer ADEEB ; Muhammed Amir ESSIBAYI ; Kareem El NAAMANI ; Nils HENNINGER ; Sri Hari SUNDARARAJAN ; Anna Luisa KÜHN ; Jane KHALIFE ; Sherief GHOZY ; Luca SCARCIA ; Benjamin Y.Q. TAN ; Benjamin PULLI ; Jeremy J. HEIT ; Robert W. REGENHARDT ; Nicole M. CANCELLIERE ; Joshua D. BERNSTOCK ; Aymeric ROUCHAUD ; Jens FIEHLER ; Sunil SHETH ; Ajit S. PURI ; Christian DYZMANN ; Marco COLASURDO ; Xavier BARREAU ; Leonardo RENIERI ; João Pedro FILIPE ; Pablo HARKER ; Razvan Alexandru RADU ; Thomas R. MAROTTA ; Julian SPEARS ; Takahiro OTA ; Ashkan MOWLA ; Pascal JABBOUR ; Arundhati BISWAS ; Frédéric CLARENÇON ; James E. SIEGLER ; Thanh N. NGUYEN ; Ricardo VARELA ; Amanda BAKER ; David ALTSCHUL ; Nestor R. GONZALEZ ; Markus A. MÖHLENBRUCH ; Vincent COSTALAT ; Benjamin GORY ; Christian Paul STRACKE ; Mohammad Ali AZIZ-SULTAN ; Constantin HECKER ; Hamza SHAIKH ; David S. LIEBESKIND ; Alessandro PEDICELLI ; Andrea M. ALEXANDRE ; Illario TANCREDI ; Tobias D. FAIZY ; Erwah KALSOUM ; Boris LUBICZ ; Aman B. PATEL ; Vitor Mendes PEREIRA ; Adrien GUENEGO ; Adam A. DMYTRIW ;
Journal of Stroke 2024;26(3):434-445
Background:
and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed to evaluate the safety and efficacy in DMVO patients treated with either MT-IVT or IVT alone.
Methods:
This multinational study analyzed data from 37 centers across North America, Asia, and Europe. Patients with AIS due to DMVO were included, with data collected from September 2017 to July 2023. The primary outcome was functional independence, with secondary outcomes including mortality and safety measures such as types of intracerebral hemorrhage.
Results:
The study involved 1,057 patients before matching, and 640 patients post-matching. Functional outcomes at 90 days showed no significant difference between groups in achieving good functional recovery (modified Rankin Scale 0–1 and 0–2), with adjusted odds ratios (OR) of 1.21 (95% confidence interval [CI] 0.81 to 1.79; P=0.35) and 1.00 (95% CI 0.66 to 1.51; P>0.99), respectively. Mortality rates at 90 days were similar between the two groups (OR 0.75, 95% CI 0.44 to 1.29; P=0.30). The incidence of symptomatic intracerebral hemorrhage was comparable, but any type of intracranial hemorrhage was significantly higher in the MT-IVT group (OR 0.43, 95% CI 0.29 to 0.63; P<0.001).
Conclusion
The results of this study indicate that while MT-IVT and IVT alone show similar functional and mortality outcomes in DMVO patients, MT-IVT presents a higher risk of hemorrhagic complications, thus MT-IVT may not routinely offer additional benefits over IVT alone for all DMVO stroke patients. Further prospective randomized trials are needed to identify patient subgroups most likely to benefit from MT-IVT treatment in DMVO.
9.Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Hamza Adel SALIM ; Vivek YEDAVALLI ; Basel MUSMAR ; Nimer ADEEB ; Muhammed Amir ESSIBAYI ; Kareem El NAAMANI ; Nils HENNINGER ; Sri Hari SUNDARARAJAN ; Anna Luisa KÜHN ; Jane KHALIFE ; Sherief GHOZY ; Luca SCARCIA ; Benjamin Y.Q. TAN ; Benjamin PULLI ; Jeremy J. HEIT ; Robert W. REGENHARDT ; Nicole M. CANCELLIERE ; Joshua D. BERNSTOCK ; Aymeric ROUCHAUD ; Jens FIEHLER ; Sunil SHETH ; Ajit S. PURI ; Christian DYZMANN ; Marco COLASURDO ; Xavier BARREAU ; Leonardo RENIERI ; João Pedro FILIPE ; Pablo HARKER ; Razvan Alexandru RADU ; Thomas R. MAROTTA ; Julian SPEARS ; Takahiro OTA ; Ashkan MOWLA ; Pascal JABBOUR ; Arundhati BISWAS ; Frédéric CLARENÇON ; James E. SIEGLER ; Thanh N. NGUYEN ; Ricardo VARELA ; Amanda BAKER ; David ALTSCHUL ; Nestor R. GONZALEZ ; Markus A. MÖHLENBRUCH ; Vincent COSTALAT ; Benjamin GORY ; Christian Paul STRACKE ; Mohammad Ali AZIZ-SULTAN ; Constantin HECKER ; Hamza SHAIKH ; David S. LIEBESKIND ; Alessandro PEDICELLI ; Andrea M. ALEXANDRE ; Illario TANCREDI ; Tobias D. FAIZY ; Erwah KALSOUM ; Boris LUBICZ ; Aman B. PATEL ; Vitor Mendes PEREIRA ; Adrien GUENEGO ; Adam A. DMYTRIW ;
Journal of Stroke 2024;26(3):434-445
Background:
and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed to evaluate the safety and efficacy in DMVO patients treated with either MT-IVT or IVT alone.
Methods:
This multinational study analyzed data from 37 centers across North America, Asia, and Europe. Patients with AIS due to DMVO were included, with data collected from September 2017 to July 2023. The primary outcome was functional independence, with secondary outcomes including mortality and safety measures such as types of intracerebral hemorrhage.
Results:
The study involved 1,057 patients before matching, and 640 patients post-matching. Functional outcomes at 90 days showed no significant difference between groups in achieving good functional recovery (modified Rankin Scale 0–1 and 0–2), with adjusted odds ratios (OR) of 1.21 (95% confidence interval [CI] 0.81 to 1.79; P=0.35) and 1.00 (95% CI 0.66 to 1.51; P>0.99), respectively. Mortality rates at 90 days were similar between the two groups (OR 0.75, 95% CI 0.44 to 1.29; P=0.30). The incidence of symptomatic intracerebral hemorrhage was comparable, but any type of intracranial hemorrhage was significantly higher in the MT-IVT group (OR 0.43, 95% CI 0.29 to 0.63; P<0.001).
Conclusion
The results of this study indicate that while MT-IVT and IVT alone show similar functional and mortality outcomes in DMVO patients, MT-IVT presents a higher risk of hemorrhagic complications, thus MT-IVT may not routinely offer additional benefits over IVT alone for all DMVO stroke patients. Further prospective randomized trials are needed to identify patient subgroups most likely to benefit from MT-IVT treatment in DMVO.
10.Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Hamza Adel SALIM ; Vivek YEDAVALLI ; Basel MUSMAR ; Nimer ADEEB ; Muhammed Amir ESSIBAYI ; Kareem El NAAMANI ; Nils HENNINGER ; Sri Hari SUNDARARAJAN ; Anna Luisa KÜHN ; Jane KHALIFE ; Sherief GHOZY ; Luca SCARCIA ; Benjamin Y.Q. TAN ; Benjamin PULLI ; Jeremy J. HEIT ; Robert W. REGENHARDT ; Nicole M. CANCELLIERE ; Joshua D. BERNSTOCK ; Aymeric ROUCHAUD ; Jens FIEHLER ; Sunil SHETH ; Ajit S. PURI ; Christian DYZMANN ; Marco COLASURDO ; Xavier BARREAU ; Leonardo RENIERI ; João Pedro FILIPE ; Pablo HARKER ; Razvan Alexandru RADU ; Thomas R. MAROTTA ; Julian SPEARS ; Takahiro OTA ; Ashkan MOWLA ; Pascal JABBOUR ; Arundhati BISWAS ; Frédéric CLARENÇON ; James E. SIEGLER ; Thanh N. NGUYEN ; Ricardo VARELA ; Amanda BAKER ; David ALTSCHUL ; Nestor R. GONZALEZ ; Markus A. MÖHLENBRUCH ; Vincent COSTALAT ; Benjamin GORY ; Christian Paul STRACKE ; Mohammad Ali AZIZ-SULTAN ; Constantin HECKER ; Hamza SHAIKH ; David S. LIEBESKIND ; Alessandro PEDICELLI ; Andrea M. ALEXANDRE ; Illario TANCREDI ; Tobias D. FAIZY ; Erwah KALSOUM ; Boris LUBICZ ; Aman B. PATEL ; Vitor Mendes PEREIRA ; Adrien GUENEGO ; Adam A. DMYTRIW ;
Journal of Stroke 2024;26(3):434-445
Background:
and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed to evaluate the safety and efficacy in DMVO patients treated with either MT-IVT or IVT alone.
Methods:
This multinational study analyzed data from 37 centers across North America, Asia, and Europe. Patients with AIS due to DMVO were included, with data collected from September 2017 to July 2023. The primary outcome was functional independence, with secondary outcomes including mortality and safety measures such as types of intracerebral hemorrhage.
Results:
The study involved 1,057 patients before matching, and 640 patients post-matching. Functional outcomes at 90 days showed no significant difference between groups in achieving good functional recovery (modified Rankin Scale 0–1 and 0–2), with adjusted odds ratios (OR) of 1.21 (95% confidence interval [CI] 0.81 to 1.79; P=0.35) and 1.00 (95% CI 0.66 to 1.51; P>0.99), respectively. Mortality rates at 90 days were similar between the two groups (OR 0.75, 95% CI 0.44 to 1.29; P=0.30). The incidence of symptomatic intracerebral hemorrhage was comparable, but any type of intracranial hemorrhage was significantly higher in the MT-IVT group (OR 0.43, 95% CI 0.29 to 0.63; P<0.001).
Conclusion
The results of this study indicate that while MT-IVT and IVT alone show similar functional and mortality outcomes in DMVO patients, MT-IVT presents a higher risk of hemorrhagic complications, thus MT-IVT may not routinely offer additional benefits over IVT alone for all DMVO stroke patients. Further prospective randomized trials are needed to identify patient subgroups most likely to benefit from MT-IVT treatment in DMVO.