1.A new trincallane derivative from Salacia hainanensis Chun et How.
Zheng-Hong GUO ; Rong-Gang XI ; Xiao-Bo WANG ; Li-Jun WU ; Hui-Yuan GAO
Acta Pharmaceutica Sinica 2009;44(10):1123-1126
Chemical constituents of the roots and stem of Salacia hainanensis Chun et How were isolated and purified with column chromatography on silica gel, Sephadex LH-20 and preparative HPLC. Their structures were elucidated based on physicochemical and spectral spectroscopic analysis. Depending on the activities of anti-alpha-glucosidase and inhibiting AGEs (advanced glycation end products, AGEs) formation in vitro, nine compounds were identified as 26, 27-dihydroxy-7, 24-tirucalladien-3-one (1), abruslactone A (2), lupeol (3), 21alpha, 30-dihydroxy-D: A-friedooleanan-3-one (4), 15alpha-hydroxyfriedelan-3-one (5), friedelin (6), mangiferin (7), epicatechin (8) and beta-sitosterol (9), separately. Among them, compound 1 is a new compound, and compound 2 was isolated from the Salacia genus for the first time, while, compounds 3, 4, 5, 8 were obtained from this plant for the first time.
Catechin
;
analogs & derivatives
;
chemistry
;
isolation & purification
;
Molecular Structure
;
Pentacyclic Triterpenes
;
chemistry
;
isolation & purification
;
Plant Roots
;
chemistry
;
Plant Stems
;
chemistry
;
Plants, Medicinal
;
chemistry
;
Salacia
;
chemistry
;
Steroids
;
chemistry
;
isolation & purification
;
Triterpenes
;
chemistry
;
isolation & purification
;
Xanthones
;
chemistry
;
isolation & purification